RIKEN Announcement: Succeeded in Developing Tech for HF Regenerative Medicine: Study to be Published Feb 10

[jan_miezda]

regenerative medicine will be a great option in the future. imagine the implication. people will drink and live unhealthy lifestyles if they know they can just go and get a new liver or kidney

 

[Pls_NW-1]

https://www.reddit.com/r/tressless/comments/mfnd4t/_/gsth3de

By the way... xD

 

[Pls_NW-1]

wrassman drunkman cuckman this guy changes his opinions every time it suits him, hes dogshit level surgeon, and is still treated like some type of mentor on tressless Dx

Yeah he is really weird. Sometimes he says that cloning never happened and won't happen, sometimes he says it happened 3 decades ago... and sometimes he even denies Tsuji's and terskikh's work, saying it does not even exist, that it's all fake. Weird guy imo.

Same goes for the australian doctors xD

 

[trialAcc]

wrassman drunkman cuckman this guy changes his opinions every time it suits him, hes dogshit level surgeon, and is still treated like some type of mentor on tressless Dx

Yeah, sometimes he has some good things to say to people who are just starting but then he openly will say things like you should never shed on finasteride. What kind of hair doctor that has been around for 2-3 decades doesn't know that finasteride causes shedding in almost the majority of people when they start.

 

[eeyore]

https://www.reddit.com/r/tressless/comments/mfnd4t/_/gsth3de

By the way... xD

He said that with no source and I can't find one either.

 

[MrV88]

Any idea why it will start one year after funding and not earlier? Recruitment etc? A crowdfunding progress bar would be much nicer, but guess we have no idea when they will be done with it.

薄毛の悩みに“希望の光”…！ 髪の毛を再生する「研究最前線」は“ここまで”来ている！（辻 孝） @gendai_biz

人類にとって悩みの1つである「薄毛」や「脱毛症」。再生医療の技術を使ってその“難題”に挑む研究の「現在地」は…

gendai.ismedia.jp

very interesting article. The Japanese government will not cover the cost of the study as it is a cosmetic treatment. Studies will start about a year after funding. The studies will take 1.5 years, after which it can be commercialized. The studies were originally supposed to start in June 2020 (would then be almost available). With Kyocera, a way has been found to scale the treatment.

Tsuji believes he will be the first to successfully restore hair. (apparently also before Stemson)

They create a density of 120 hairs per cm2, Tsuji seems confident that his treatment will working

 

[Pls_NW-1]

薄毛の悩みに“希望の光”…！ 髪の毛を再生する「研究最前線」は“ここまで”来ている！（辻 孝） @gendai_biz

人類にとって悩みの1つである「薄毛」や「脱毛症」。再生医療の技術を使ってその“難題”に挑む研究の「現在地」は…

gendai.ismedia.jp

very interesting article. The Japanese government will not cover the cost of the study as it is a cosmetic treatment. Studies will start about a year after funding. The studies will take 1.5 years, after which it can be commercialized. The studies were originally supposed to start in June 2020 (would then be almost available). With Kyocera, a way has been found to scale the treatment.

Tsuji believes he will be the first to successfully restore hair. (apparently also before Stemson)

They create a density of 120 hairs per cm2, Tsuji seems confident that his treatment will working

Meanwhile donations will close around 2024. And those definitely won't be enough to support studies and commercialization and whatsoever. Stemson marked the year 2027, + expecting 4-7 +/- years of delayment.

They probably won't have a big time-wise difference in terms of delivering a cure.

 

[pegasus2]

Can't wait. It is such a relief knowing I'm actually going to have all my hair back one day

regenerated hair grew from the skin of the mouse on the 21st day of transplantation, and the arrector pili muscle and nerve fibers were connected in the same manner as natural hair, and it was normal.

We controlled the number of regenerated hair follicles by controlling the size of the regenerated hair follicle primordium. In this way, it was possible to change the density at the time of transplantation and regenerate with a density of 124 hairs per square centimeter, which is equivalent to human hair.

Since "hair follicle regenerative medicine" uses somatic stem cells isolated from the patient's own hair follicles, it falls under "type 2 regenerative medicine, etc." and is approved by the Specified Certified Regenerative Medicine Committee and the Minister of Health, Labor and Welfare

With the funding of clinical research, the research can be started within a year. The first target is androgenetic alopecia, whose mechanism is clear, and the period will be about one and a half years.

If this clinical study reveals its safety and efficacy, it can be implemented in society as a paid clinical study.

 

[trialAcc]

Can't wait. It is such a relief knowing I'm actually going to have all my hair back one day

So they're planning to start trials within a year and they will last a year and a half? Followed by a broader trial where it is offered to trial subjects who apply?

 

[eeyore]

So they're planning to start trials within a year and they will last a year and a half? Followed by a broader trial where it is offered to trial subjects who apply?

Yeah, not really sure what this means "If this clinical study reveals its safety and efficacy, it can be implemented in society as a paid clinical study."

However, they said they'd start their trials within a year of receiving the necessary funding, not just within a year, so who knows how that'll go.

 

[Pls_NW-1]

If its 120 invidual hairs, then it will be amazing, but if its 120 hairs from multiples then thats just normal transplant density.

You mean many hairs coming out from a single pore? I somehow can't understand this.

 

[trialAcc]

Incidentally, the article says 124 hairs per cm2. That is completely sufficient.


I didn't understand that 100 percent either. I hope this is due to translation problems. Due to the rapid introduction in Japan, I think that a market approval is meant.

because they want to test safety and effectiveness directly in the first study. J.Hewitt only wanted to conduct one study too

I think you're right, it would be the equivalent of a drug being commercialized in the USA after phase 2 due to orphan drug status but phase 3 continues on people who are just taking the drug because they need it. By the sounds of it they can start offering it after 1 trial.

 

[pegasus2]

I knew people would complain about the density. East Asians have an average density of 111 hairs/cm². The guy in that video has really fine hair. They can control the density meaning they can increase it for caucasians who have thinner hair strands with higher density. The density they are talking about is for Japanese patients, and it's significantly higher than normal Japanese density.

Edit: they are talking about conditional approval. They still have to follow up on patients, but they will be able to treat as many as they want.

 

[trialAcc]

If its 120 invidual hairs, then it will be amazing, but if its 120 hairs from multiples then thats just normal transplant density.

Normal transplant density at the front, maybe. It isn't achieved all over the scalp though.

If this could allow for unlimited hair to a max 120~ it would still be a successful innovation. Some people end up with 40~50 hairs per/sqcm on their crowns due to lacking donor. Anyways, they specifically said "normal human density", so I'm assuming they do not mean transplant density.

 

[pegasus2]

"Some may think that it's just hair. However, it is a more serious problem for people with thinning hair and alopecia than you can imagine.

Many people who are conscious of thinning hair generally have an impact on their mental and behavioral effects from stress and complex, such as "because they are only looking at their heads" and "cannot interact with people with confidence". Is said to come out."

Takashi Tsuji 48, based on his experience on Hairlosstalk.com

He took one look at this forum and concluded hair loss causes mental illness

 

[Pls_NW-1]

So what I understood, they can commercialize after one trial? But... how? They don't even have a proper company, or not even a proper structure to do so... did I miss something!? They are just a research institute.

 

[trialAcc]

I know man, Im just venting because Tsuji doesnt really bring anything new to me, other than better looking donor.

Lol you're insane if you think that unlimited grafts doesn't bring anything to you. The whole problem with transplants is the limited donor.

 

[trialAcc]

So what I understood, they can commercialize after one trial? But... how? They don't even have a proper company, or not even a proper structure to do so... did I miss something!? They are just a research institute.

Commercialize is a broad term. One or two clinics in Japan offering this is "commercialization".

But yes, you are correct, and that's been my problem with Tsuji from the beginning. Stemson is already working on commercialization planning for scale, they've brought hair transplant surgeons onto the board and teams to develop the procedure and already have potential distributors/facilitators via Allergan. They've created multiple products to be able to get the procedure out more quickly to higher paying customers, etc.

What exactly has Tsuji planned, at all?

 

[MrV88]

Commercialize is a broad term. One or two clinics in Japan offering this is "commercialization".

But yes, you are correct, and that's been my problem with Tsuji from the beginning. Stemson is already working on commercialization planning for scale, they've brought hair transplant surgeons onto the board and teams to develop the procedure and already have potential distributors/facilitators via Allergan. They've created multiple products to be able to get the procedure out more quickly to higher paying customers, etc.

What exactly has Tsuji planned, at all?

Some pages ago there was a story about a bankrupt company (Kyocera?) that was going to scale up the whole thing, after that many lost hope etc, they had a plan, but the plan failed. Tsuji ain't the fastest guy.

 

[pegasus2]

Some pages ago there was a story about a bankrupt company (Kyocera?) that was going to scale up the whole thing, after that many lost hope etc, they had a plan, but the plan failed. Tsuji ain't the fastest guy.

Kyocera is far from bankrupt, and they are still working with RIKEN. It is Organ tech that was supposed to conduct the trials but went under. Who exactly is faster than Tsuji? Tsuji has been ready for human clinical trials since 2020, He will probably still beat Stemson to human trials, and almost certainly beat them to market.