Safest Antiandrogen For Your Dick - Bicalutamide

[Maave]

What's up. I've been on bicalutamide 100mg and raloxifene 60mg for 7 months. No ED issues at all, no shrinkage, libido is normal, etc. (I still have gyno signs so I'm probably going to increase raloxifene dose to 90mg). But yeah, dick works fine. I haven't been posting here because I'm just waiting for hair growth. It's damn slow.

Wikipedia states these side effects for men https://en.wikipedia.org/wiki/Bicalutamide#Side_effects

• breast changes
• physical feminization and demasculinization in general
• including reduced body hair growth
• decreased muscle mass and strength
• feminine changes in fat mass and distribution
• reduced penile length,
• decreased semen/ejaculate volume

may occur in men.[87][90][18][91]

Confirms some of these side effects
https://books.google.co.uk/books?id=_4SwO2dHcAIC&pg=PA1297&redir_esc=y#v=onepage&q&f=false

I posted this in a diff thread but I'll expand on it. The citations for that sentence are all ADT papers which lump bica in with other ADT methods like GnRH agonists and physical castration. BIG DIFFERENCE. Those other methods reduce T production which kills all of its derivatives - like DHT, E, and some other neurosteroids which all affect libido and erection. Bicalutamide only blocks the androgen receptors while preserving T production, so the testes are still active (preventing testicular atrophy) and so are the neurosteroids (which enable erections to prevent penile atrophy). The wiki is wrong, lumping bica with castration is lazy. Search for "bicalutamide monotherapy" to get accurate results. Here's an example:

Effect of Casodex on sleep-related erections in patients with advanced prostate cancer.
https://www.ncbi.nlm.nih.gov/m/pubmed/1378907/

No significant modifications in regard to number of nocturnal penile tumescence episodes, maximum penile circumference and total rigidity time were found before and after therapy. Only 1 patient reported a decrease in sexual drive and libido.

I have a somewhat reasonable theory that erections - especially spontaneous/nocturnal erections - "exercise" your penis and maintain penile length. Various studies suggest but don't outright state that nocturnal erections maintain penile tissue and prevent atrophy. In the Sildenafil (Viagara) studies below they found that increasing bloodflow at night with Sildenafil improved metrics during the day. My conclusion: Anti-androgen treatments that reduce spontaneous or nocturnal erections can cause shrinkage. From that conclusion I chose bica. Bicalutamide has one of the lowest chances of sexual dysfunction and erectile issues.

Effect of penile size on nocturnal erections: evaluation with NPTR testing with men having micropenis
https://www.ncbi.nlm.nih.gov/m/pubmed/15690064/

Comparison of the results of NPTR of control group with study group revealed that number and duration of erectile episodes (P < 0.001), duration of tip rigidity > 60% (P < 0.01), TAU tip and TAU base (P = 0.001), and RAU base (P = 0.01) were found to be significantly lower in men with micropenis. In conclusion, our study showed that men with micropenis are associated with decreased nocturnal erectile activity.

How Your Penis Exercises While You Sleep
https://prostate.net/articles/how-to-exercise-your-penis/

Overview of Contemporary Penile Rehabilitation Therapies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531200/

Investigators found that the 50 mg group did not experience any loss of smooth muscle compared with baseline, and the 100 mg group actually showed an increase of smooth muscle content when compared to the baseline. There was no control group, and no clinical correlation between smooth muscle preservation and erectile function is made in this study.

The study found that the groups receiving daily Sildenafil were able to have return of rigidity (R > 55%) at seven times the nadir value compared to minimal improvement in the control group. This improvement of erection was also seen by the investigators for RAU (rigidity-activated unit—a time-intensity measurement that represents the area under the rigidity curve during a qualified event), with the additional finding that the 100 mg group experienced continued improvement after the discontinuation phase, while the 50 mg group began to experience decline in RAU.

 

[DHTcel]

What's up. I've been on bicalutamide 100mg and raloxifene 60mg for 7 months. No ED issues at all, no shrinkage, libido is normal, etc. (I still have gyno signs so I'm probably going to increase raloxifene dose to 90mg). But yeah, dick works fine. I haven't been posting here because I'm just waiting for hair growth. It's damn slow.


I posted this in a diff thread but I'll expand on it. The citations for that sentence are all ADT papers which lump bica in with other ADT methods like GnRH agonists and physical castration. BIG DIFFERENCE. Those other methods reduce T production which kills all of its derivatives - like DHT, E, and some other neurosteroids which all affect libido and erection. Bicalutamide only blocks the androgen receptors while preserving T production, so the testes are still active (preventing testicular atrophy) and so are the neurosteroids (which enable erections to prevent penile atrophy). The wiki is wrong, lumping bica with castration is lazy. Search for "bicalutamide monotherapy" to get accurate results. Here's an example:

Effect of Casodex on sleep-related erections in patients with advanced prostate cancer.
https://www.ncbi.nlm.nih.gov/m/pubmed/1378907/


I have a somewhat reasonable theory that erections - especially nocturnal erections - "exercise" your penis and maintain penile length. Various studies suggest but don't outright state that nocturnal erections maintain penile tissue and prevent atrophy. In the Sildenafil (Viagara) studies they found that increasing bloodflow at night with Sildenafil improved metrics during the day.

Effect of penile size on nocturnal erections: evaluation with NPTR testing with men having micropenis
https://www.ncbi.nlm.nih.gov/m/pubmed/15690064/


How Your Penis Exercises While You Sleep
https://prostate.net/articles/how-to-exercise-your-penis/

Overview of Contemporary Penile Rehabilitation Therapies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531200/

whats up homie! I missed you brah

 

[Feelsbadman.jpg]

This is a good thread. Everyone here should listen to what DHTcel is advocating, seriously. If you care about hair, you need to take drastic measures. I would go so far as to say that bicalutamide alone is really too mild. If you are serious, you need to combine it with Dutasteride which will make bica much more effective since it will no longer have to compete with DHT.

In addition, estrogen should be added to stimulate growth and down regulate androgen receptors. This is important since with any pure anti-androgen, you will get upregulation of androgen receptors. Adding estrogen will help combat this.

@DHTcel Have you considered adding estrogen to your regimen? Small amounts should be fine with no sides. Just increase gradually. At your age, you have the potential for full recovery.

 

[HLV]

This is a good thread. Everyone here should listen to what DHTcel is advocating, seriously. If you care about hair, you need to take drastic measures. I would go so far as to say that bicalutamide alone is really too mild. If you are serious, you need to combine it with Dutasteride which will make bica much more effective since it will no longer have to compete with DHT.

In addition, estrogen should be added to stimulate growth and down regulate androgen receptors. This is important since with any pure anti-androgen, you will get upregulation of androgen receptors. Adding estrogen will help combat this.

@DHTcel Have you considered adding estrogen to your regimen? Small amounts should be fine with no sides. Just increase gradually. At your age, you have the potential for full recovery.

DHTcel is seventeen years old. In many parts of the world he’s
not trusted to have a drivers license or even to purchase alchohol. How then can he be trusted to advocate potentially dangerous drugs which may damage people’s health,
Possibly irreversibly.

HLV

 

[Ikarus]

DHTcel is seventeen years old. In many parts of the world he’s
not trusted to have a drivers license or even to purchase alchohol. How then can he be trusted to advocate potentially dangerous drugs which may damage people’s health,
Possibly irreversibly.

HLV

@DHTcel is insanely educated and bases his information from facts. Unless you can explain why bicalutamide is potentially dangerous?

 

[HLV]

@DHTcel is insanely educated and bases his information from facts. Unless you can explain why bicalutamide is potentially dangerous?

There have been other posters here explaining the dangers of it. No need to ask me to repeat it.

HLV

 

[Ikarus]

This is a good thread. Everyone here should listen to what DHTcel is advocating, seriously. If you care about hair, you need to take drastic measures. I would go so far as to say that bicalutamide alone is really too mild. If you are serious, you need to combine it with Dutasteride which will make bica much more effective since it will no longer have to compete with DHT.

In addition, estrogen should be added to stimulate growth and down regulate androgen receptors. This is important since with any pure anti-androgen, you will get upregulation of androgen receptors. Adding estrogen will help combat this.

@DHTcel Have you considered adding estrogen to your regimen? Small amounts should be fine with no sides. Just increase gradually. At your age, you have the potential for full recovery.

I wouldn't say bicalutamide is too mild, but it's just like any other anti-androgen; they have to be used in combination with something to have a viable effect. Which is why it's a great form of treatment for transgender women: bicalutamide and estrogen have a synergetic effect, and it leads to significant feminisation and other desirable traits which a transgender woman would want. Additionally, it prevents up-regulation of androgen receptors which means an orchiectomy can still be done in the future without issues.

Currently I am using bicalutamide and estrogen, and dutasteride. I can definitely emphasise that the gynecomastia is becoming definite, which can be recognised due to the increased pain in my nipples. I do not recommend that anyone uses estrogen in combination with bicalutamide unless they are fine with gynecomastia, especially since SERMs can only do so much. In my opinion, bicalutamide and dutasteride is enough for most since it will lead to a viable enough increase of estrogen to provide regrowth; people will just have to stick to using it permanently, or until they ever feel comfortable with the idea of being bald.

 

[Ikarus]

There have been other posters here explaining the dangers of it. No need to ask me to repeat it.

HLV

One person said that bicalutamide turns you into a woman, and then they backed down from their claim.

 

[HLV]

One person said that bicalutamide turns you into a woman, and then they backed down from their claim.

Page 4 of this thread. Itchymadscalp among others who actually uses it and warns about its dangers.

HLV

 

[Ikarus]

Page 4 of this thread. Itchymadscalp among others who actually uses it and warns about its dangers.

HLV

He is just emphasising that there isn't much knowledge on its long-term use, but there is no evidence to back up his claim. I don't think most people should use bicalutamide, and I will never believe that it should be used for standard practice. However, I believe it should be seen as an option for particular men with greatly aggressive hair loss. And, it should definitely be used as an option to treat androgenic alopecia/hirsutism/acne within women. And, it should definitely be an option for transgender women in combination with estrogen. And, it should definitely be used as therapy for non-binary patients.

 

[Ikarus]

So you agree normal men should stay the fck away from this poison then?

If you are balding in your mid-twenties, you should use dutasteride. If you are balding in your teenage/early-adult years, you should consider the use of bicalutamide. If you were using dutasteride and it's losing its effectiveness, you should consider the use of bicalutamide. If you are a woman suffering with androgenic alopecia/hirsutism/acne, you should consider the use of bicalutamide instead of spironolactone/cyproterone acetate/flutamide. If you are transgender, you should consider the use of bicalutamide instead of spironolactone/cyproterone acetate. It shouldn't be used as standard practice since most men are not balding during their teenage/early-adult years, and since most men don't desire a neotenic appearance.

Don't twist my words, and I highly suggest you don't comment on threads which are based around oral anti-androgens. Your opinion is biased, and is based upon your negative experience with finasteride.

 

[Derelict]

Lol at saying my opinon is biased meanwhile you don't care about sex and have no problem turning into a woman. I took fina for 2 years, my opinion is from my own personal experience with that poison.

I would advise you to not advise anyone, you're misleading healthy young men into thinking there are almost no risks when taking anti androgens.

And lol at advising men to jump on duta the moment they're balding.

To anyone on the edge ask yourself this question; Do you want a normal healthy sex life? Yes, don't take any oral AA's. Only care about hair? Take it. And if you're a virigin and balding don't take it since you do not know what a normal sex life is. Look at other options.

Don't listen to fringe people like Ikarus who have no problem turning in a transexual.

Im a virgin, and can't see myself getting in to a relationship anytime in the near future, but im still able to get erect when needed while on dutasteride and spironolactone, im sorry you had a bad experience with finasteride but until tsuji or something comes along it's the only way to tackle hairloss. I really wish you could take finasteride without debilitating sides, wishing you all the best. Btw i experienced far more sexual sides on anti-depressants than i ever have with AA's. Im desperate to get a full head of hair and willing to go as far as needed to get it. Dutasteride and minoxidil just wasn't cutting it.

 

[HLV]

Your opinion is biased, and is based upon your negative experience with finasteride.

Ikarus to be fair your opinion has always been biased as well. You’ve had a positive experience with all these drugs which is why you promote them so strongly. You are also in the minority of men who have no libido and don’t care about sex. Try to understand that.

HLV

 

[Ikarus]

Lol at saying my opinon is biased meanwhile you don't care about sex and have no problem turning into a woman. I took fina for 2 years, my opinion is from my own personal experience with that poison.

I would advise you to not advise anyone, you're misleading healthy young men into thinking there are almost no risks when taking anti androgens.

And lol at advising men to jump on duta the moment they're balding.

To anyone on the edge ask yourself this question; Do you want a normal healthy sex life? Yes, don't take any oral AA's. Only care about hair? Take it. And if you're a virigin and balding don't take it since you do not know what a normal sex life is. Look at other options.

Don't listen to fringe people like Ikarus who have no problem turning in a transexual.

Show me a study which proves that bicalutamide has a similar negative effect on sexual function compared to other anti-androgens.

 

[Derelict]

Thanks man, I wish you and every man who's balding the best but I look at the total picture especially after my experience.

And yeah post SSRI syndrome is legit and it's known to have bad sexual side effects, just like fina/duta. A friend of mine took xanax for a long period and almost experienced the same things I had, fortunately he recovered almost completely.

I want to warn you, for some it's fast for others it takes a longer time to get side effects and believe me, sex is completely different on fina. Sex is incredibely important for a good relationship, it will be a hard time to keep your girl if you can't perform.

I encourage you to use every alternative there is first. For example zix (it's basically a topical AA) or microneedling/minoxidil combo. And if you're balding aggressively, get a hair system. Oral AA's shouldn't be taken by young men under 30-35.

And it's not just my opinion, more than 50% had side effects from fina/duta on this forum, there's a thread with a poll. Different hairloss forums have around the same percantage from my experience. I'm following this sh*t for almost 10 years now too...

Whatever you do, good luck man.

Im still needling away, switched from the pen to a roller though because the pen kept pulling out lots of hairs. I know what im taking isn't for everyone and alot would find potential sides too scary to try but like i said, so far i have no problems and hope that will last.

 

[Ikarus]

Ikarus to be fair your opinion has always been biased as well. You’ve had a positive experience with all these drugs which is why you promote them so strongly. You are also in the minority of men who have no libido and don’t care about sex. Try to understand that.

HLV

@DHTcel is using bicalutamide and hasn't had an effect on his sexual function, neither do patients who use it as mono-therapy. In all honesty, the main 'concern' with bicalutamide isn't its effect on sexual function. It's more so the gynecomastia and neoteny which occurs; most men don't want that.

 

[Derelict]

@DHTcel is using bicalutamide and hasn't had an effect on his sexual function, neither do patients who use it as mono-therapy. In all honesty, the main 'concern' with bicalutamide isn't its effect on sexual function. It's more so the gynecomastia and neoteny which occurs; most men don't want that.

How is your gyno in bica, is it noticeable through t-shirts etc or is it not that bad yet?

 

[Ikarus]

How is your gyno in bica, is it noticeable through t-shirts etc or is it not that bad yet?

I definitely have gynecomastia. Although, it's mainly due to myself using estradiol; it was there prior to using bicalutamide, when I was using spironolactone and estradiol. Bicalutamide has definitely made it more evident though, since bicalutamide additionally raises estrogen.

 

[HLV]

@DHTcel is using bicalutamide and hasn't had an effect on his sexual function, neither do patients who use it as mono-therapy. In all honesty, the main 'concern' with bicalutamide isn't its effect on sexual function. It's more so the gynecomastia and neoteny which occurs; most men don't want that.

How long has he been on it for?

 

[Ikarus]

How long has he been on it for?

Long enough for side effects to occur, especially since spironolactone/cyproterone acetate have a rapid effect on sexual function.