Sandalore - Chemical Used In Perfumes To Mimic Sandalwood Triggers Growth?

[Armando Jose]

Where are the results of the Sandalore trials in the Canary Islands??? Why must everything take so f*****g long?? if it failed, they should just say it failed!!

https://www.barcelonahair2019.org/pdf/WCHR-2019-Abstract-Book.pdf
TOPICAL SANDALORE®, A SPECIFIC OR2AT4-STIMULATING ODORANT,

AMELIORATES FEMALE TELOGEN EFFLUVIUM:

RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL TRIAL

F Jimenez, E López, M Bertolini 2, M Alam, C Ward 2,

J Chéret 2, G Westgate 3, F Rinaldi 4, R Paus 5

1. Mediteknia Clinic, Las Palmas; 2. Monasterium Lab, Germany; 3. Westgate Cons., Bedford, UK;

4. Giuliani S.p.A.; 5. Dept Dermatology, University of Miami, USA

Introduction & Objectives

Human hair follicles (HFs) express the olfactory

receptor OR2AT4, whose specific stimulation ex

vivo (in organ hair culture) by the synthetic sandalwood-

like odorant, Sandalore®, prolongs anagen,

and suppresses apoptosis by up-regulating intrafollicular

IGF-1 mediated signalling.

To study whether this effect of Sandalore® is clinically

relevant, we conducted a randomized, double-

blinded, placebo-controlled, prospective clinical

trial involving 60 female volunteers affected by

telogen effluvium with a defined, substantial degree

of hair shedding.

Material and Methods

Thirty patients clinically diagnosed as telogen effluvium

were randomly assigned to a verum group

applying once daily a solution containing 1% Sandalore

®, and 30 patients with telogen effluvium

were included in a placebo group that applied a solution

containing natural sandalwood oil (placebo),

which has the same odor as Sandalore® but does

not stimulate OR2AT4. The trial period consisted

of 24 weeks. The main study read-out parameters

were the degree of hair shedding, hair density,

anagen/catagen-telogen ratio (phototrichogram),

hair mass index (cross sectioned trichometry), hair

thickness, patient self-assessment questionnaire

and clinical evaluation.

Results

Sandalore® 1% ameliorated clinical signs of telogen

effluvium, namely it reduced hair shedding, increased

hair volume and increased the percentage

of anagen HFs over time significantly more than

placebo, and showed a trend towards increasing

the ratio of terminal/vellus hairs.

Hair shaft thickness and density were not affected.

Most of the anti-hair shedding effects were seen

already after 8 weeks and maintained at week 24.

Subjectively, individuals in the treatment group

were more satisfied than in the placebo group regarding

hair appearance and overall Results.

Conclusion

This clinical trial confirmed the anagen-maintaining

effects of Sandalore® seen ex vivo and provides the

first evidence that a cosmetic odorant can positively

impact on human hair growth in vivo, encouraging

the use of topical olfactotherapy with Sandalore®

as adjunct therapy of hair disorders characterized by excessive hair shedding.

 

[enzomafia1]

What is the best vehicle for sandalore? How to make a topical lotion using this thing?

 

[cryingariver]

https://www.barcelonahair2019.org/pdf/WCHR-2019-Abstract-Book.pdf
TOPICAL SANDALORE®, A SPECIFIC OR2AT4-STIMULATING ODORANT,

AMELIORATES FEMALE TELOGEN EFFLUVIUM:

RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL TRIAL

F Jimenez, E López, M Bertolini 2, M Alam, C Ward 2,

J Chéret 2, G Westgate 3, F Rinaldi 4, R Paus 5

1. Mediteknia Clinic, Las Palmas; 2. Monasterium Lab, Germany; 3. Westgate Cons., Bedford, UK;

4. Giuliani S.p.A.; 5. Dept Dermatology, University of Miami, USA

Introduction & Objectives

Human hair follicles (HFs) express the olfactory

receptor OR2AT4, whose specific stimulation ex

vivo (in organ hair culture) by the synthetic sandalwood-

like odorant, Sandalore®, prolongs anagen,

and suppresses apoptosis by up-regulating intrafollicular

IGF-1 mediated signalling.

To study whether this effect of Sandalore® is clinically

relevant, we conducted a randomized, double-

blinded, placebo-controlled, prospective clinical

trial involving 60 female volunteers affected by

telogen effluvium with a defined, substantial degree

of hair shedding.

Material and Methods

Thirty patients clinically diagnosed as telogen effluvium

were randomly assigned to a verum group

applying once daily a solution containing 1% Sandalore

®, and 30 patients with telogen effluvium

were included in a placebo group that applied a solution

containing natural sandalwood oil (placebo),

which has the same odor as Sandalore® but does

not stimulate OR2AT4. The trial period consisted

of 24 weeks. The main study read-out parameters

were the degree of hair shedding, hair density,

anagen/catagen-telogen ratio (phototrichogram),

hair mass index (cross sectioned trichometry), hair

thickness, patient self-assessment questionnaire

and clinical evaluation.

Results

Sandalore® 1% ameliorated clinical signs of telogen

effluvium, namely it reduced hair shedding, increased

hair volume and increased the percentage

of anagen HFs over time significantly more than

placebo, and showed a trend towards increasing

the ratio of terminal/vellus hairs.

Hair shaft thickness and density were not affected.

Most of the anti-hair shedding effects were seen

already after 8 weeks and maintained at week 24.

Subjectively, individuals in the treatment group

were more satisfied than in the placebo group regarding

hair appearance and overall Results.

Conclusion

This clinical trial confirmed the anagen-maintaining

effects of Sandalore® seen ex vivo and provides the

first evidence that a cosmetic odorant can positively

impact on human hair growth in vivo, encouraging

the use of topical olfactotherapy with Sandalore®

as adjunct therapy of hair disorders characterized by excessive hair shedding.

Nice! Great find Armando. so is any company going to pounce on this? shouldn't this be easily brought to market since Sandalore is already approved for other things? I'm curious what dosage they used. and why for some us, originally it worked and then it failed.

 

[Armando Jose]

applying once daily a solution containing 1% Sandalore

 

[cryingariver]

applying once daily a solution containing 1% Sandalore

ok... so in a 60 ml empty bottle of rogaine... 1% equals 0.6 ml. I have to use 0.6 ml of sandalore. they say 'solution'. what's in the rest of the solution?

 

[NotInmywatch]

I sent the author of that abstract an email regarding if they're going to try it for Androgenetic Alopecia
she never replied, I guess it's out of the question now
but for many of us that have both Androgenetic Alopecia and Telogen Effluvium it will help a little

 

[frankzappa]

Can anyone confirm this? Or find a resource to confirm this?
I'd happily see if taking IGF-1 somehow will help especially since I am using Sandalore.

Kind Regards,
Nick

It's called MK677. It's currently a research chemical but widely used in the fitness industry for it's anti catabolic effects. It's not FDA approved yet.

 

[frankzappa]

Every study on the topic has shown that we want to increase IGF-1 on the scalp without increasing it systematically. The latter has been linked to increased hairloss.

Interesting, what is the theory behind why that happens? The MK677 drug is widely used among recreational bodybuilders and users are reporting getting great hair and skin from it. As far as I understand, hair loss occurs when the balance of IGF-1 vs DHT is offset in the hair follicles to favour DHT.

The reason I ask what the theory is behind higher IGF-1 levels causing hair loss is because usually obese people may have increased IGF-levels and if it's based on some kind of epidemiology study it could be due to obesity causing other problems.

 

[cryingariver]

I sent the author of that abstract an email regarding if they're going to try it for Androgenetic Alopecia
she never replied, I guess it's out of the question now
but for many of us that have both Androgenetic Alopecia and Telogen Effluvium it will help a little

why didn't they also test this with males? why only females?? and did they specify anywhere what's in their magic "solution"? 1% Sandalore in a solution... what's in the solution?

 

[mr_robot]

why didn't they also test this with males? why only females?? and did they specify anywhere what's in their magic "solution"? 1% Sandalore in a solution... what's in the solution?

The difference between the test and placebo is the 1% Sandalore, if you read it they say the placebo is another perfume with a similar smell.

 

[cryingariver]

The difference between the test and placebo is the 1% Sandalore, if you read it they say the placebo is another perfume with a similar smell.

Right, I got that. but did they specify what exactly is in the solution? what did they mix the 1% sandalore with?

 

[mr_robot]

Right, I got that. but did they specify what exactly is in the solution? what did they mix the 1% sandalore with?

If you use minoxidil just mix it in with that, it will work fine the vehicle isn't important.

 

[cryingariver]

If you use minoxidil just mix it in with that, it will work fine the vehicle isn't important.

hmmmmmmmmmmmm. i'll try it again. I used to use 4 drops of sandalore in PG and Everclear alcohol; it worked at first but then it failed, I lost more hair. I'm currently using Zix followed up by minoxidil. I guess i can throw in 1% sandalore to the minoxidil and see what happens.

 

[mr_robot]

hmmmmmmmmmmmm. i'll try it again. I used to use 4 drops of sandalore in PG and Everclear alcohol; it worked at first but then it failed, I lost more hair. I'm currently using Zix followed up by minoxidil. I guess i can throw in 1% sandalore to the minoxidil and see what happens.

Note this is n't going to grow you new hair, its will just prolong anogen phase hence why tested on people with Telogen Effluvium which occurs more in women than men. I'm using it at 5% for months, if it caused severe sheeding I'd be bald by now.

 

[cryingariver]

https://www.barcelonahair2019.org/pdf/WCHR-2019-Abstract-Book.pdf
TOPICAL SANDALORE®, A SPECIFIC OR2AT4-STIMULATING ODORANT,

AMELIORATES FEMALE TELOGEN EFFLUVIUM:

RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL TRIAL

F Jimenez, E López, M Bertolini 2, M Alam, C Ward 2,

J Chéret 2, G Westgate 3, F Rinaldi 4, R Paus 5

1. Mediteknia Clinic, Las Palmas; 2. Monasterium Lab, Germany; 3. Westgate Cons., Bedford, UK;

4. Giuliani S.p.A.; 5. Dept Dermatology, University of Miami, USA

Introduction & Objectives

Human hair follicles (HFs) express the olfactory

receptor OR2AT4, whose specific stimulation ex

vivo (in organ hair culture) by the synthetic sandalwood-

like odorant, Sandalore®, prolongs anagen,

and suppresses apoptosis by up-regulating intrafollicular

IGF-1 mediated signalling.

To study whether this effect of Sandalore® is clinically

relevant, we conducted a randomized, double-

blinded, placebo-controlled, prospective clinical

trial involving 60 female volunteers affected by

telogen effluvium with a defined, substantial degree

of hair shedding.

Material and Methods

Thirty patients clinically diagnosed as telogen effluvium

were randomly assigned to a verum group

applying once daily a solution containing 1% Sandalore

®, and 30 patients with telogen effluvium

were included in a placebo group that applied a solution

containing natural sandalwood oil (placebo),

which has the same odor as Sandalore® but does

not stimulate OR2AT4. The trial period consisted

of 24 weeks. The main study read-out parameters

were the degree of hair shedding, hair density,

anagen/catagen-telogen ratio (phototrichogram),

hair mass index (cross sectioned trichometry), hair

thickness, patient self-assessment questionnaire

and clinical evaluation.

Results

Sandalore® 1% ameliorated clinical signs of telogen

effluvium, namely it reduced hair shedding, increased

hair volume and increased the percentage

of anagen HFs over time significantly more than

placebo, and showed a trend towards increasing

the ratio of terminal/vellus hairs.

Hair shaft thickness and density were not affected.

Most of the anti-hair shedding effects were seen

already after 8 weeks and maintained at week 24.

Subjectively, individuals in the treatment group

were more satisfied than in the placebo group regarding

hair appearance and overall Results.

Conclusion

This clinical trial confirmed the anagen-maintaining

effects of Sandalore® seen ex vivo and provides the

first evidence that a cosmetic odorant can positively

impact on human hair growth in vivo, encouraging

the use of topical olfactotherapy with Sandalore®

as adjunct therapy of hair disorders characterized by excessive hair shedding.

so what's the hold up?? if Sandalore @ 1% works, why doesn't some company market this already? why doesn't the company who did this study sell it?

 

[alscarmuzza]

so what's the hold up?? if Sandalore @ 1% works, why doesn't some company market this already? why doesn't the company who did this study sell it?

Try the shampoo. It's 1%.

 

[cryingariver]

Try the shampoo. It's 1%.

doesn't work. if it did, the whole forum would be all over it. I ask again, why isn't there any company jumping on the Sandalore results and make a product that works? what is the hold up??

 

[alscarmuzza]

doesn't work. if it did, the whole forum would be all over it. I ask again, why isn't there any company jumping on the Sandalore results and make a product that works? what is the hold up??

doesn't work. if it did, the whole forum would be all over it. I ask again, why isn't there any company jumping on the Sandalore results and make a product that works? what is the hold up??

It's patented. Any derivative development would have to be in concert with the holder I assume. Others are not going make a product that they don't have the rights for. No money in that.

 

[cryingariver]

It's patented. Any derivative development would have to be in concert with the holder I assume. Others are not going make a product that they don't have the rights for. No money in that.

oh great! i wonder why the company that owns the patent doesn't release it as a hairless product.... i'm sure they have word of the trials in the canary islands and the results.

anyway!!!... so it was tested at 1% sandalore. if i take a 60ml bottle of an empty rogaine, I fill it up with 60 ml of PG and Everclear... 1% sandalore = 12 drops? I was using 4 drops months ago... maybe it wasn't enough.

 

[alscarmuzza]

oh great! i wonder why the company that owns the patent doesn't release it as a hairless product.... i'm sure they have word of the trials in the canary islands and the results.

anyway!!!... so it was tested at 1% sandalore. if i take a 60ml bottle of an empty rogaine, I fill it up with 60 ml of PG and Everclear... 1% sandalore = 12 drops? I was using 4 drops months ago... maybe it wasn't enough.

I wouldn't discount the shampoo. It's a low risk way to incorporate it. I don't think that there are enough people using it to give us an impression either way. So, I think it's worth a try for at least 6 months. I have my recipe for my topical in a previous post; it's a pretty simple recipe. With both of these, you would have something to try without too much of an investment. In my previous post I gave my impressions on it's efficacy. Mind you, that was before the Canary islands info came out. Seems that my impressions were on target