Sandalore - Chemical Used In Perfumes To Mimic Sandalwood Triggers Growth?

[fugged]

Thanks cryingariver, doesn't sound like its really been a good thing for you??

 

[cryingariver]

Thanks cryingariver, doesn't sound like its really been a good thing for you??

it's been both good and bad. first regrowth, followed by massive shed, followed by maintaining for the past 10 months. Rogaine, in my personal experience, would not have been able to maintain for 10 months. I only use 4-6 drops in my 60ml bottle, which is way lower than the 1% they used in studies. 1% = 12 drops. maybe I should've been using 12 drops this entire time? it somewhat scares me putting in 12 drops.

 

[fugged]

Not knowing what to do is a b**ch, isn't it

 

[fugged]

Ive been using minoxidil for like 20 years, granted off and on, but I do shed after stopping and hair looks limper and worse, so it seems to have "maintained" something for me, everyone is different.

 

[wencurebro]

I missed something. when was it resolved that too much sandalore doesn't cause hairloss? maybe i missed it, if you can please elaborate where you got that from.

as this dude explained it, the paper was talking about the Sandalore+Phenirat solution when they talked about the OR2AT4 knock-down (which causes the adverse effects)

It doesn't say that a high concentration of Sandalore causes these opposite effects.It says that the OR2AT4 knock-down causes these effects. OR2AT4 is being knocked-down by Phenirat, not by Sandalore. As stated in the paragraph above they co-admistered Sandalore with Phenirat. "The Sandalore effects on the HF can be partially antagonized by Phenirat only in the presence of Sandalore". So the counter-effects of Phenirat are especially notably in the presence of high-dose Sandalore, since high-dose Sandalore = high effects = highly notably if counteracted by Phenirat.
This is what that article says, it doesn't say that high-dose Sandalore actually caused the OR2AT4 knock-down

Also, when you check the article again where those people took the quotes from (https://www.nature.com/articles/s41467-018-05973-0) they took this sentence out in the updated version (probably because of the misinterpretations)

 

[cryingariver]

as this dude explained it, the paper was talking about the Sandalore+Phenirat solution when they talked about the OR2AT4 knock-down (which causes the adverse effects)



Also, when you check the article again where those people took the quotes from (https://www.nature.com/articles/s41467-018-05973-0) they took this sentence out in the updated version (probably because of the misinterpretations)

oh! so hypothetically speaking, you can use 40 drops of sandalore (not that you would) mixed with PG / Ethyl Alcohol / Rogaine, or whatever mix you want, and it won't cause hair loss since Phenirat is not present?

 

[Capone]

oh! so hypothetically speaking, you can use 40 drops of sandalore (not that you would) mixed with PG / Ethyl Alcohol / Rogaine, or whatever mix you want, and it won't cause hair loss since Phenirat is not present?

Only one to find out, give it a lash

 

[wencurebro]

oh! so hypothetically speaking, you can use 40 drops of sandalore (not that you would) mixed with PG / Ethyl Alcohol / Rogaine, or whatever mix you want, and it won't cause hair loss since Phenirat is not present?

yes, they never stated that high-dose Sandalore would cause hairloss, that was misinterpreted by someone and then spread like a virus b/c people are incapable of doing their own research.
Sandalore is a OR2AT4 agonist whereas Phenirat is a OR2AT4 antagonist

 

[nick123]

Is anyone else still using Sandalore? It would be good to get an update from them.

I still am maintaining with Vanicream/Sandalore mixture and want to move onto an alcohol/pg/sandalore solution but i still can't seem to source ethanol in the UK that isn't Isopropyl

 

[BetaBoy]

yes, they never stated that high-dose Sandalore would cause hairloss, that was misinterpreted by someone and then spread like a virus b/c people are incapable of doing their own research.
Sandalore is a OR2AT4 agonist whereas Phenirat is a OR2AT4 antagonist

So maybe you could clear it up for everyone, what exactly were the authors getting at when they said this in the Supplementary Discussion 2:

notably in the presence of high-dose Sandalore® – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and up-regulated hair matrix keratinocyte apoptosis) and intrafollicular IGF-1 production

 

[nick123]

Not sure if anyone actually knows this yet, since i couldn't find it posted but

The pharmaceutical company: Giuliani has released their Signal Revolution range some of these products contain Sandalore I believe (not sure which ones as they don't have listen ingredients on them)

You can find the range here: https://www.bioscalin.it/prodotti/signal-revolution

I think they also sell a bunch of other nonsense like shampoos etc, but I think the products containing Sandalore is "Bioscallin Signal Revolution Foam Men". It seems you can get these from italian pharmacies/ebay/amazon atm.

 

[wencurebro]

So maybe you could clear it up for everyone, what exactly were the authors getting at when they said this in the Supplementary Discussion 2:

notably in the presence of high-dose Sandalore® – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and up-regulated hair matrix keratinocyte apoptosis) and intrafollicular IGF-1 production

First of all, the authors took this sentence out of their published article and rephrased it due to the misinterpretations.
Sencondly, it is terribly ripped out of context missing the sentences prior to that. When you rip it out of context like this it seems like they talk about Sandalore when addressing the OR2AT4 knock-down. What this paragraph says is that the OR2AT4 knock-down (induced by Phenirat, not Sandalore), which induces the adverse effects, is especially notably in the presence of high-dose Sandalore (i.e. high Sandalore -> high effects -> highly notably countereffects by Phenirat).
Btw, their "high dose" Sandalore was 500µm, which is 0.01% (they used Sandalore in a concentration of 50µm and 500µm and 500µm is the "high dose" which had best effects and also showed the greatest countereffects when co-administered with Phenirat

 

[nick123]

I'm trying to make a Ethanol/PG/Sandalore solution in an effort to move away from my Vanicream/Sandalore solution.

Ethanol is extremely hard to source in the UK.
Does anyone know if this will work? https://www.ebay.co.uk/itm/1000-ml-...659167?hash=item262dc540df:g:e5AAAOSwIbVeA1ZJ

 

[Seuxin]

Hello guys, i bought sandalore on Amazon (100% Pure sandalore) and lt's very weird...it has really no smell....what is wrong with this ?

 

[Armando Jose]

100% pure sandalore and don´t smell,....., not real sandalore

 

[Seuxin]

100% pure sandalore and don´t smell,....., not real sandalore

Do you got pure sandalore ? yours has smell ?

 

[Armando Jose]

I have pure sandalwood and it smell very intense, I suposse that sandalore (syntethic sandalwood used in air fresheners) must be similar

 

[Seuxin]

I have pure sandalwood and it smell very intense, I suposse that sandalore (syntethic sandalwood used in air fresheners) must be similar

You're using pure sandalwood on your head ? But are you aware pure sandalwood doesn't have the biochemical effect on the hair...Ony sandalore had this effect so you have to use real sandalore

Btw, since i love sandalwood smell i woud like to buy one to put in my face cream...What is the brand you use ?

 

[Armando Jose]

No, I don´t use pure sandalwood n my head C), only a small amount mixed with cream.
I buyed 150 ml some years ago from India, expensive but gorgeous, but I think that right now is forbiden to sell

 

[Seuxin]

Yeah but sandalwood has no effect on hair, it's sandalore which has effect. Even if the smell is the same, it's chemically totally different.