Sandalore - Chemical Used In Perfumes To Mimic Sandalwood Triggers Growth?

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jared garnith

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I'm sure this has been asked before but I'm new to this thread and was wondering the best site to purchase sandalore that delivers to the US? thanks
 
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portaljar

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recedingyt said:
So I mixed everything up very roughly. I'd estimate I'm using a 1-1.5% mixture because the containers I mixed the vanicream and the Sandalore in did not have measurements but it should be fine. It mixed shockingly easily with just a simple mixing spoon that came with the containers I ordered. I started by putting the 1mL of Sandalore in the empty container, adding about 10-15mL of vanicream, stirring, and repeated that until I felt I was close to 100mL total (the containers only hold 120mL and I left what I eyeballed to be 20mL of space empty lol). Has a very perfume-y smell to it but not overpowering by any means and the vanicream was super easy to rub in and apply even with my super long hair, although I'm only applying it to the first 5cm or so of my hairline and my temples. I'm pretty confident it mixed well because I can feel a somewhat odd sensation on the areas I applied it to... not quite a burn, but I can tell it's more than lotion up there lol. I suppose I'll update how it goes eventually. Cost me like $35 to get a huge supply of this stuff so even if it doesn't work it's not a huge bust as long as my hair doesn't fall out.

Slight side note / why I'm not the best candidate to base results off of:

It's been a long time since I updated anyone here about my hair journey. Long story hopefully not as long - I ran into some insurance issues, some health issues relating to my work pushing me beyond my physical limits while on hormones, and major depression issues that resulted in a lapse of me taking my hormones. I was very sporadic with them, sometimes I'd take them for a week and then stop for 2-3 months. Other times I'd take them a couple days a week for a couple months. I had a period of time where I didn't take any hormones for about 6 or 7 months. During this time I was also relatively inconsistent with minoxidil. Never as bad as I was with my hormones but I was only applying my minoxidil 3-4 days a week most weeks. During this time I was mostly consistent with my dutasteride, although I did have a few missed doses and at one point I ran out and had to use finasteride for about a month.

Luckily I didn't lose that much ground but the hair quality was overall worse and the areas which I was previously slick bald on like the temples and the area in like the middle of the scalp directly behind the hairline definitely thinned out noticeably.

As of 2 months ago I started being pretty religious again with my hormones and my minoxidil. As of about 2 weeks ago I started using Stemoxydine on the hairline. I've been dermarolling with LiCL inconsistently as well, although I plan to make that a 2x/week affair here soon. All in all, I've got too much happening with treatments to put any would-be success solely on the shoulders of Sandalore with any degree of certainty, but I will still give an opinion on it as a treatment when I feel appropriate to make a judgment.

The last 2-3 months has been a period of intense shedding and if Sandalore could stop that and hopefully thicken up existing hair and hair I expect to come back with my newfound consistency in my regimen, I would consider it a success for me.
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thank you for sharing your story, hopefully we will find something that will stop the fall and if it also regenerates we will celebrate it!
 
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portaljar

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portaljar

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Capone said:
Amazon one had bad reviews.. no scent off it. I’m not sure what it’s suppose to smell like.
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Sandalore may not smell like everyone thinks, but it is completely independent of the effect that chemical molecule has on other receptors

https://academic.oup.com/chemse/article/29/6/483/295730

Structure–odor relationship
Why do not all members of the tested sandalwood odorants activate the same OR? First, it needs to be mentioned that sensory analyses have been done with human panellists only (Bajgrowicz and Fráter, 2000), and that no sensory psychophysical studies were conducted with rats to determine whether rats are likely to perceive the tested sandalwood compounds as being olfactively similar. However, taking into account that the rat OR repertoire is 2–3 times larger than the human one, there is a high chance that rats can smell the compounds and that at least some ORs respond to previously identified sandalwood olfactophores (Godfrey et al., 2004).

β-Santalol is the main odor vector of natural sandalwood oil, and its building blocks are a bulky rigid moiety, a flexible spacer and an OH group at the other end of the spacer. It is known that the size, substitution and possibly the electronic density within the spacer have an impact on both the intensity as well as the quality of sandalwood-like compounds derived from campholenic aldehyde (Fráter et al., 1998; Bajgrowicz and Fráter, 2000). In the search for more potent synthetic substitutes for sandalwood oil as perfume ingredient, the double bond in the spacer region was replaced with a cyclopropane ring (as in Javanol®). Introduction of this ring allowed the rigidification of the structure, while keeping an electron-rich structural feature, isoelectronic to a double bond present in other commercially available sandalwood substitutes (Ebanol®, Radjanol®). In this study, we have identified endogenous ORs present in rat ORNs, for which receptor activation was dependent on the presence of a double bond or its substitution with a cyclopropane ring within the spacer region. Sandalore®, despite having a sandalwood character, was the sole member of the sandalwood family that did not activate these particular ORs. So far, Sandalore® is the only tested molecule without that electron-rich structural feature in the spacer and more compounds need to be tested to draw final conclusions.
 
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ScentlessApprentice

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turfboy said:
I'm using a 70-75ml metal container with diffuse sprayer

Ingredients in order

17ml ethanol (70% solution)
3 drops sandalore
2 drops ethoxydiglycol
dab of PEG-40 hydrogenated castor oil

AFTER all these ingredients are in container shake well and let sit for a few hours to dissolve (overnight probably couldn't hurt)

Then add 45 ml of distilled water

Shake well and allow time to dissolve further.

That's it;

Apply twice daily.

Shake vigorously before spraying/applying
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How greasy is this mix? I just started using 0.25 mL in a 60mL bottle of rogaine liquid. I switched to foam years ago bc of greasiness of rogaine. After using the mixture a couple times, I forgot how much I hated the liquid. I'm looking for a non greasy formula.
 
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INT

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Starting tomorrow:

I added 0.6 ml of Sandalore to a minoxidil bottle which I filled halfway with 30 ml of 70% ethanol.
Tomorrow I will add 24 ml of distilled water.

Any thoughts on these proportions?

Dermapen is also arriving next week!
 
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Palmer

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INT said:
Starting tomorrow:

I added 0.6 ml of Sandalore to a minoxidil bottle which I filled halfway with 30 ml of 70% ethanol.
Tomorrow I will add 24 ml of distilled water.

Any thoughts on these proportions?

Dermapen is also arriving next week!
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30 + 24 + 0'6 = 54'6ml. You will need to add 5'4ml of something
 
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INT

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Palmer said:
30 + 24 + 0'6 = 54'6ml. You will need to add 5'4ml of something
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Ups my bad. What I meant to say was

30 ml of ethanol
0.6 ml of sandalore
29,4 ml or distilled water

= 1% sandalore in a 60 ml mix of 50% ethanol and 50% distilled water.
 
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recedingyt

recedingyt

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Capone said:
Amazon one had bad reviews.. no scent off it. I’m not sure what it’s suppose to smell like.
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The one I ordered from Amazon definitely had a strong smell when undiluted, and it's still pretty strong as a 1% Sandalore/Vanicream mixture. Not sure if quality varies from order to order or if the smell has any indication of quality but regardless....
 
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portaljar

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ScentlessApprentice said:
How greasy is this mix? I just started using 0.25 mL in a 60mL bottle of rogaine liquid. I switched to foam years ago bc of greasiness of rogaine. After using the mixture a couple times, I forgot how much I hated the liquid. I'm looking for a non greasy formula.
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you could replace the castor oil with propylene glycol, when drying, leave your hair clean
whatevr said:
Who came up with this Vanicream? What's wrong with a simple ethanol/PG mix?
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I also work with the mixture of alcohol 70 / pg and a little distilled water for sandalore 1% and you only have to up or lower the amount of pg according to whether the scalp is more or less fatty.

I think if it's easier, it will work better
 
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