Scalp Threading With Polydioxanone Monofilament Threads: A Novel, Effective And Safe Modality.

[whatevr]

As far as I know it's always been Chemyo.

https://www.selfhacked.com/blog/tempol/

Generally it acts as an anti-inflammatory, and antioxidant from what I understand.

I was GREATLY surprised to find out it has some anti-AR properties as well:

https://www.ncbi.nlm.nih.gov/pubmed/22172488

"Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist. Inhibition of AR by Tempol was mediated, in large part, by its ability to decrease AR protein via increased degradation, in the absence of any inhibitory effects on other nuclear receptors."

Now that is really interesting.

 

[whatevr]

I keep wondering where the private groups are getting all their reliable sh*t from. Seems almost impossible to trust anyone apart from the most expensive online chemical compound traders like sigma. Anyway, I agree with you for the most part. I do feel like hormones have their role to play, but for some of us it’s not enough. I think for aggressive hairloss you really need to take a multifactorial approach which means the dht/androgen, fibrosis, inflammation and PDG angles all at once. Your best possible chance at stopping loss I believe would be <dht (fina, duta, estrogen if you’re insane enough) <androgens (ru, spironolactone, cb, bical, flut etc), <inflammation (ceti, keto, sulfa, curcumin etc), <fibrosis (wounding), <pdg2 (seti, fevi, TM, castor, sulfa), >pge2 (actual pge2, castor, sulfa, stemox), >growth factors (LiCl, VPA etc), >vasodilation and blood flow (minoxidil, wounding, peppermint, massage).
List goes on, but aggressive hairloss means an aggressive approach. I think for men MTF regimens actually seem to work the best, but that’s totally impractical for the regular male who wants to keep his penis. Could always try Pantostin or estriol cream but there are always mild risks of systemic absorption. For women, well no one seems to give enough of a f*** to delve deep into the problem to see what works beyond anti androgens and minoxidil. So I guess I’m going to TRY to find out. I’m jumping on the seti bandwagon myself soon. I’m also making my own topical estrogen. Probably gonna get da cancers because I already take the pill but oh well. Anyway so I reckon I’m going to start low at 200mg seti 100mg 2 x daily and gradually up it to see if there’s a sweet spot maybe to stop shedding. I can grow hair, I know that, but I also have a f*** load of shedding which has never stopped, not for 4 years, and I do have a lot of miniturisation.. hopefully the duta, estrogen and “daro” (gonna switch to 8% ru prolly), kicks that sh*t to the curb. I read stories about how seti totally stops shedding and I makes me salivate. I think the day that I lose less than 150 hairs I will cry. With joy. And then probably have a panic attack about the posibility of it returning the following day.
f*** I hate this sh*t.

Alibaba and assorted Chinese sites, there's no other place that makes all these research chems. It all comes from China one way or the other.
Hormones are just upstream of growth factors, I posted a study where they injected a cocktail of growth factors ( no hormone inhibitors at all, no 5-AR, no AR, nothing ) and they saw good regrowth. It shouldn't be necessary to touch hormones at all once we finally have access to cutting edge proteins and peptides at an affordable price so that we can do this sh*t at home.

I'm not really interested in treatments which affect libido (or brain function) anymore. I've already gone down that route with estrogen, and it doesn't make much sense to have hair on your head when your sh*t downstairs doesn't work and you don't feel like doing anything. We need to find solutions that actually allow us to LIVE NORMALLY, as if we had no hair loss at all. That is the end goal. f*** having to compromise vital functions for hair. That should not be acceptable in this day and age.

Pantostin/alfatradiol is garbage. I have some at home. It is a weak 'estrogen' and 5-AR inhibitor but not really. Basically it doesn't do sh*t, it's practically sugar water. I don't think there's a single case of Androgenetic Alopecia that was ever helped by that, at least not in the concentration that they sell it in, and if you go higher, you might as well take Finasteride. Estriol probably either, all that stuff is too weak and probably do more harm than good in other parts of your body.

The only things I see hope in at the short term at this point:
1. PGD2 (and other prostaglandin) inhibitors
2. PGE2 topically
3. Anything that can powerfully upregulate VEGF, IGF-1 and FGF-9, or even those things applied topically or injected
4. Anything that can powerfully lower inflammation and autoimmunity within the hair follicle
5. Maybe JAK/STAT inhibitors

 

[ALightInTheDark]

Wounding on its own is largely worthless. It's good for increasing absorption of other USEFUL topicals though.

Did he go through érythema and 1.5mm every 2-3 weeks ?
If not, he can't claim he is wounding since he doesn't properly do it

 

[Georgie]

Alibaba and assorted Chinese sites, there's no other place that makes all these research chems. It all comes from China one way or the other.
Hormones are just upstream of growth factors, I posted a study where they injected a cocktail of growth factors ( no hormone inhibitors at all, no 5-AR, no AR, nothing ) and they saw good regrowth. It shouldn't be necessary to touch hormones at all once we finally have access to cutting edge proteins and peptides at an affordable price so that we can do this sh*t at home.

I'm not really interested in treatments which affect libido (or brain function) anymore. I've already gone down that route with estrogen, and it doesn't make much sense to have hair on your head when your sh*t downstairs doesn't work and you don't feel like doing anything. We need to find solutions that actually allow us to LIVE NORMALLY, as if we had no hair loss at all. That is the end goal. f*** having to compromise vital functions for hair. That should not be acceptable in this day and age.

Pantostin/alfatradiol is garbage. I have some at home. It is a weak 'estrogen' and 5-AR inhibitor but not really. Basically it doesn't do sh*t, it's practically sugar water. I don't think there's a single case of Androgenetic Alopecia that was ever helped by that, at least not in the concentration that they sell it in, and if you go higher, you might as well take Finasteride. Estriol probably either, all that stuff is too weak and probably do more harm than good in other parts of your body.

The only things I see hope in at the short term at this point:
1. PGD2 (and other prostaglandin) inhibitors
2. PGE2 topically
3. Anything that can powerfully upregulate VEGF, IGF-1 and FGF-9, or even those things applied topically or injected
4. Anything that can powerfully lower inflammation and autoimmunity within the hair follicle
5. Maybe JAK/STAT inhibitors

I read one long *** paper/study last night that showed estrogen-B upregulates VEGF and Igf-1. https://academic.oup.com/edrv/article/27/6/677/2355194

Anyway I agree that t shouldn’t take virtually mutilating your insides in order to grow hair. I’m currently doing this to no avail and I feel no doctor gives a sh*t that a 25’year old woman is absolutely smashing her body with hormones. They just don’t give a single f***. Not even when I tell them that this makes me feel suicidal. Most of them laugh.
I’m seriously hoping that fevi/pge2 is a winning combo, and with that more people will start to use it and prices will come down. I hope.

 

[whatevr]

I read one long *** paper/study last night that showed estrogen-B upregulates VEGF and Igf-1. https://academic.oup.com/edrv/article/27/6/677/2355194

Right, among other things, and if you look at the pics in this study I posted: https://www.hairlosstalk.com/intera...or-enhancement-of-human-hair-regrowth.112436/

That's pretty much estrogen-like regrowth, minus the whole growing tits and your dick not working parts.

Anyway I agree that t shouldn’t take virtually mutilating your insides in order to grow hair. I’m currently doing this to no avail and I feel no doctor gives a sh*t that a 25’year old woman is absolutely smashing her body with hormones. They just don’t give a single f***. Not even when I tell them that this makes me feel suicidal. Most of them laugh.
I’m seriously hoping that fevi/pge2 is a winning combo, and with that more people will start to use it and prices will come down. I hope.

The last time I went to a dermatologist for my hair loss, it was a female doctor. She was actually more open minded about it than all the other male cretins who just laughed it off and told me to deal with it and accept it. She prescribed me topical estrogen. That's probably the most useful thing that any derm has ever done for my hair loss. But alas...

 

[Aliens]

I'm using 830 nm and 660 nm LED lights.
I've also ordered TEMPOL and Baicalin.
Thinking of getting into Seti group buy.
And getting PGE2 as well.

I'm focusing on INFLAMMATION and GROWTH FACTORS these days.

I do not find pics of people who used tempol do you have any?

 

[whatevr]

I do not find pics of people who used tempol do you have any?

There are no pictures anywhere on the Internet because not many people tried it, and if they tried it on its own it is probably not strong enough to maintain or regrow, hence, what would they take pictures of. I'm not counting on it to do anything on its own. It's just a part of my new regimen.

 

[Aliens]

There are no pictures anywhere on the Internet because not many people tried it, and if they tried it on its own it is probably not strong enough to maintain or regrow, hence, what would they take pictures of. I'm not counting on it to do anything on its own. It's just a part of my new regimen.

Oh yeah ok it coulf act synergystically with the rest of the regimen.
Maybe you should open a topic with what you are trying and the results. Would be awesome!

 

[whatevr]

Oh yeah ok it coulf act synergystically with the rest of the regimen.
Maybe you should open a topic with what you are trying and the results. Would be awesome!

Believe me if it does anything useful at all, you and the rest of the forum will know everything about it.

 

[Georgie]

Right, among other things, and if you look at the pics in this study I posted: https://www.hairlosstalk.com/intera...or-enhancement-of-human-hair-regrowth.112436/

That's pretty much estrogen-like regrowth, minus the whole growing tits and your dick not working parts.



The last time I went to a dermatologist for my hair loss, it was a female doctor. She was actually more open minded about it than all the other male cretins who just laughed it off and told me to deal with it and accept it. She prescribed me topical estrogen. That's probably the most useful thing that any derm has ever done for my hair loss. But alas...

That study you posted is incredible. I bet it would cost a f*****g arm and a leg and probably won’t be commercially available in the next 10 years if ever. I’ve seen things like this way too many times that have amounted to 0. I mean, I suppose the bio chems around could try to figure out how to produce the stuff and anyone with a nursing or medical degree can easily perform subcut injections, but it’s a lot of sourcing, money and work. I’m pretty sure some of the people on the private forums have looked into it. I’d have to go back and read the threads.
Tbh if it came out tomorrow throughout clinics i would be on that sh*t like white on rice. That’s how desperate I feel. But yeah, worth looking into at least, or sending a few very encouraging emails to indicate that there’s interest surrounding the procedure/product.

Yeah I’ve had both male and female derms, gps, endos and gynos. Every single one of them has either refused to acknowledge the problem until I’ve brought medical documentation as proof of my conditions, or have said WORD FOR WORD “You could always wear a wig”, “you should stop stressing. You’ll make it worse”, “Yeah that’s unfortunate. Use Rogaine”.
I’m at the end of the tether hey, mentally.

 

[Georgie]

Right, among other things, and if you look at the pics in this study I posted: https://www.hairlosstalk.com/intera...or-enhancement-of-human-hair-regrowth.112436/

That's pretty much estrogen-like regrowth, minus the whole growing tits and your dick not working parts.



The last time I went to a dermatologist for my hair loss, it was a female doctor. She was actually more open minded about it than all the other male cretins who just laughed it off and told me to deal with it and accept it. She prescribed me topical estrogen. That's probably the most useful thing that any derm has ever done for my hair loss. But alas...

Also what was the topical E you were prescribed?

 

[champpy]

So according to the other thread that just got posted (can't copy and paste it for some reason) the missing ingredient from my threading experiment was valproic acid.
sh*t f***.
So now the threads need to be laced with VPA in order to acheive regrowth. I know thats something the clinic i visited does not have access to.
Damn sh*t f***

 

[Georgie]

So according to the other thread that just got posted (can't copy and paste it for some reason) the missing ingredient from my threading experiment was valproic acid.
sh*t f***.
So now the threads need to be laced with VPA in order to acheive regrowth. I know thats something the clinic i visited does not have access to.
Damn sh*t f***

Why not just use topical daily?

 

[champpy]

Why not just use topical daily?

I havent really looked into it. Is that something thats readily available or does it have to be bought off the black market.

 

[whatevr]

Also what was the topical E you were prescribed?

Estradiolbenzoate, Alpicort F.

 

[kiwi666]

Why not just use topical daily?

What topical?

Also to @champpy you’re awesome. Totally appreciate what you’re doing.

If you can get the stuff somewhere you should. You’d be the forum proof we all need

 

[champpy]

What topical?

Also to @champpy you’re awesome. Totally appreciate what you’re doing.

If you can get the stuff somewhere you should. You’d be the forum proof we all need

Im just worried that it would need to be applied subdermally in the same location as the threads. Thats something i cannot do at home

 

[Georgie]

I havent really looked into it. Is that something thats readily available or does it have to be bought off the black market.

Oh man really? Let me get you the study!
https://www.ncbi.nlm.nih.gov/m/pubmed/24533507/

It’s part of the pdg protocol. It’s supposed to stimulate follicle stem cell neogensis after wounding, so the idea is to wound once weekly and use it topically every day. 8.3% is equivalent to 83mg/ml water I believe. You can buy the tablets from in house pharmacy or alldaychemist.

I honestly thought you’d be using Licl, VPA, stemox and maybe seti because they are really a huge part of the wounding/regrowth process.

 

[Georgie]

Estradiolbenzoate, Alpicort F.

Ahh yes. I looked into that but it’s hard to find and also looks like quite a low dose. I’m just making my own although I think it’s starting to f*** with my insides.

 

[Arrade]

Ahh yes. I looked into that but it’s hard to find and also looks like quite a low dose. I’m just making my own although I think it’s starting to f*** with my insides.

Aren't u like a 10/10 face and body? I hate to see anyone hurt themselves