Setipiprant Does Work, But Only On Really Really High Doses.

[Georgie]

What is alienating you from your own image,is most probably the regimen that you're on and not hair loss.
Every logical endocrinologist would freak out with your regimen.
Diane-35 is not the safest drug on the market,anti-androgens(5ar-inhibitors and AR blockers)are not recommended for female hair loss and oral minoxidil will make a woman hairy and ugly in the long run(not to mention the cardiovascular damage).
A rational and sustainable regimen for a young female who's diagnosed with hypogonadism and experiences hair loss, would be:
-2mg bio-identical estradiol
-50mg spironolactone
-2% topical minoxidil 2xED
This regimen has a low side-effect risk,will not be burdening for your organism and most probably it will make you look healthy and beautiful again.
Just a friendly advice,with every good intention from side.

Whilst that regimen would be great, it wouldn’t not work for me.
I am on the pill because I went through menopause at 21 and have no estrogen. It is HRT.

I cannot take spironolactone because it makes me lose weight, gives me heart palpitations and I become very weak and tired, even at 50mg.

The oral minoxidil I take was prescribed to me by my deem, because my hairloss is fast and aggressive. When I was initially prescribed this back in 2015, I was a nw2 after having only had a year of hairloss. It regrew my hairline. The choice of oral minoxidil was also made because my hairloss has affected my eyelashes and eyebrows. I can’t wax or shave anything else I don’t want.

The current regimen I use is so aggressive because being on the pill, minoxidil (topical and oral) and 200mg spironolactone never stopped my hairloss. I cannot take flutamide because I don’t want the liver issues. I need to act fast because hair biopsy and dermoscopy reveals that I gave up to 80% miniturisation of hair follicles.

 

[Calchas]

Whilst that regimen would be great, it wouldn’t not work for me.
I am on the pill because I went through menopause at 21 and have no estrogen. It is HRT.

I cannot take spironolactone because it makes me lose weight, gives me heart palpitations and I become very weak and tired, even at 50mg.

The oral minoxidil I take was prescribed to me by my deem, because my hairloss is fast and aggressive. When I was initially prescribed this back in 2015, I was a nw2 after having only had a year of hairloss. It regrew my hairline. The choice of oral minoxidil was also made because my hairloss has affected my eyelashes and eyebrows. I can’t wax or shave anything else I don’t want.

The current regimen I use is so aggressive because being on the pill, minoxidil (topical and oral) and 200mg spironolactone never stopped my hairloss. I cannot take flutamide because I don’t want the liver issues. I need to act fast because hair biopsy and dermoscopy reveals that I gave up to 80% miniturisation of hair follicles.

No sane doctor would prescribe Diane 35 as a first line HRT med for menopause.
And please tell me it wasn't a doctor who prescribed you anti-androgens for menopause,because he should lose his license.Actually,
many menopausal women are prescribed androgens as a supplementary treatment to estradiol and progestins.
Also,long term use of oral minoxidil, will eventually induce hypertrichosis and your hairline will probably reach your eyebrows.
But anyway...
Your life,your choice.

 

[Georgie]

No sane doctor would prescribe Diane 35 as a first line HRT med for menopause.
And please tell me it wasn't a doctor who prescribed you anti-androgens for menopause,because he should lose his license.Actually,
many menopausal women are prescribed androgens as a supplementary treatment to estradiol and progestins.
Also,long term use of oral minoxidil, will eventually induce hypertrichosis and your hairline will probably reach your eyebrows.
But anyway...
Your life,your choice.

My gyn put me on Diane because I am so young and need the huge dose of estrogen, as my bone density is already very bad.

I got the anti androgens and 5AR’s from other more stupid doctors who just gave me what I wanted. My gyn refused.
I have high DHEAS by the way.

 

[itsAlright]

I wouldnt use Kanes seti orally. Left is original seti, and right is Kanes salted seti

View attachment 76601

I wish it wasn't just under a decade since I last took chemistry, granted I doubt chemistry would help in understanding biochemistry at this level. If I end up buy Setipiprant from [any source], my main goal will be to not be poisoned, after that I can worry about whether I want salt on my Seti fries or not.

 

[Pelopeleon]

Im somewhat happy about fevipiprant being released in 2019, way earlier than Seti.

I know It will be first for asthma, but I think the hairloss community is smart enough, and they will manage to get some doctors prescriptions for hairloss. Theres also some cool doctors out there who may take the iniciative to do so.

If seti is good, fevi is even better, and is the real replacement to finasteride.

 

[IdealForehead]

No sane doctor would prescribe Diane 35 as a first line HRT med for menopause.
And please tell me it wasn't a doctor who prescribed you anti-androgens for menopause,because he should lose his license.Actually,
many menopausal women are prescribed androgens as a supplementary treatment to estradiol and progestins.
Also,long term use of oral minoxidil, will eventually induce hypertrichosis and your hairline will probably reach your eyebrows.
But anyway...
Your life,your choice.

Glad you're saying this too. I just saw your posts and I have been telling @Georgie the exacy same thing this past week.

Ie. Stop diane, stop spironolactone, stop dutasteride, and get on bioidentical hormones.

I have suggested she take the bioidentical hormones 6-12 months to let her system stabilize, then do a trial of gradual complete discontinuation to see if her body can start producing hormones naturally again after that.

I think she could keep the minoxidil for a year for some further growth stimulation benefit then stop, but otherwise we are basically in agreement on the oral drugs.

I don't want to go too far off topic here. I just want to highlight that you and I have independently come to the exact same conclusion regarding the problems with her female hormones and the right remedy.

Diane 35 is a terrible hrt in this case. Bioidentical hormones will work much better at more natural levels and replace exactly what's missing. Nothing more.

 

[jgray201]

@Georgie I can confirm that long term use of oral minoxidil, at a low dose, does not result in your hairline reaching your eyebrows.

 

[Georgie]

@Georgie I can confirm that long term use of oral minoxidil, at a low dose, does not result in your hairline reaching your eyebrows.

Lol I have been using it myself since 2015 with no such issues

 

[Calchas]

Glad you're saying this too. I just saw your posts and I have been telling @Georgie the exacy same thing this past week.

Ie. Stop diane, stop spironolactone, stop dutasteride, and get on bioidentical hormones.

I have suggested she take the bioidentical hormones 6-12 months to let her system stabilize, then do a trial of gradual complete discontinuation to see if her body can start producing hormones naturally again after that.

I think she could keep the minoxidil for a year for some further growth stimulation benefit then stop, but otherwise we are basically in agreement on the oral drugs.

I don't want to go too far off topic here. I just want to highlight that you and I have independently come to the exact same conclusion regarding the problems with her female hormones and the right remedy.

Diane 35 is a terrible hrt in this case. Bioidentical hormones will work much better at more natural levels and replace exactly what's missing. Nothing more.

Yeah,i just advised her to rationalize her regimen a bit, for the good of her health.Perhaps our suggestions may not be the ideal(as we don't have a full hormonological profile in our hands),but at least they are more rational and less dangerous.

I remember,more than a year ago,there was someone antydht in this forum who was on a very extreme mtf regimen and he had started losing contact with reality.I attempted to bring him to his senses, but he wasn't listening.I hope he's alright though,and hasn't irreversibly damaged his health.
Perhaps these people can't realise that some stranger can be truly interested and worried for the health of someone who they don't know.

 

[Calchas]

@Georgie I can confirm that long term use of oral minoxidil, at a low dose, does not result in your hairline reaching your eyebrows.

Generalized hypertrichosis and hair growth in the region between the eyebrow and hairline is a common side effect of minoxidil.
The fact that it is common, doesn't mean that it will happen to every single one who's using it.

 

[Jonnyyy]

@westonci 500mg daily oral pretty much maintained and thickened up for you but later on you said you need at least 1gram for seti to be beneficial at all if your hairloss is aggressive. I'm guessing by aggressive you mean those that go from Norwood 1 to 7 in like 3-5 years?

 

[Paul Ford]

@westonci It would be great if you could compile all the pertinent info and make a new thread to serve as a FAQ on all things Seti. I have read through both threads (this one and the other one that is 50+ pages). On one page you'll see how to buy the Seti, a different page has the safety and efficacy, different pages have results, different page has how to make it into a pill, etc. I am sure I and others would try this if the information was more concise. The more people we get on board, the more data we can gather.

Regardless, I was wondering how long the process is to make a months worth of pills and how long you can keep the pills at room temperature. I know you want to keep the majority of the supply in the freezer. I am trying to determine how inconvenient it is to do this (as I don't want to buy if I won't commit).

Also, like Jonnyyy stated; it seems like you and Pigeon maintained at far less than 1G, yet that is what you are recommending just maintenance.

Thanks,

 

[timberman]

I just received my 100g of Seti from Lyphar. Will get my batch tested by Janoshik before I start. Will keep track of progress and let you guys know. Hope it can replace my finasteride regimen!

 

[SimonC]

@westonci It would be great if you could compile all the pertinent info and make a new thread to serve as a FAQ on all things Seti. I have read through both threads (this one and the other one that is 50+ pages). On one page you'll see how to buy the Seti, a different page has the safety and efficacy, different pages have results, different page has how to make it into a pill, etc. I am sure I and others would try this if the information was more concise. The more people we get on board, the more data we can gather.

Regardless, I was wondering how long the process is to make a months worth of pills and how long you can keep the pills at room temperature. I know you want to keep the majority of the supply in the freezer. I am trying to determine how inconvenient it is to do this (as I don't want to buy if I won't commit).

Also, like Jonnyyy stated; it seems like you and Pigeon maintained at far less than 1G, yet that is what you are recommending just maintenance.

Thanks,

Man, you're reading my thoughts. I wanted to propose exact same today

The FAQ would be extremely helpful. I prepared some questions:

1) What is the science behind Seti? Why it works?
2) Should I take it orally or apply topically?
3) What is optimal oral dose?
4) What is optimal topical dose?
5) Seti is the powder! How can I prepare it?
6) When should I expect results?
7) Side effects?
8) Where I can buy it and how much does it cost?
9) Can I combine Seti with other treatments?
10) How long will Seti work for me?
11) Do any companies study Seti? Any progress on that?
12) Do we have pictures which show effectiveness of Seti?

I listed the most common questions and added a couple specific from my side.

Yes, most questions have been already answered in this thread.

It's totally fine to have some questions unanswered, our goal is to get rid of identical questions which are asked by people over and over.

I'm going to contribute and search for some answers in Westonci's threads.

Anyone can feel free to add new questions to FAQ and answers.

Also, I would like to ask guys who are taking Seti to share resulting pictures if they didn't do that yet. It can significantly help us. Also, other people can help to determine and evaluate the real progress. Please, we really need this.

Ultimately, we need to have Westonci and other Seti users reviewed all these questions and answers in order to make sure that all information is correct and we didn't miss anything. Moreover, there are few questions which only Seti users can answer.

Hope it will work out.

 

[mowingdown]

Well I'd buy on Kane but the fact that their price summarizer is broken (tells you different prices depending on previous selection), it instills little confidence in an overseas purchase. Anyone know a better outlet to purchase from?

 

[soo]

Is this stuff going to become cheap in the near future? There were some news with Novartis, but I can't remember. I'm from Switzerland, so that would be great news

 

[westonci]

Man, you're reading my thoughts. I wanted to propose exact same today

The FAQ would be extremely helpful. I prepared some questions:

1) What is the science behind Seti? Why it works?
2) Should I take it orally or apply topically?
3) What is optimal oral dose?
4) What is optimal topical dose?
5) Seti is the powder! How can I prepare it?
6) When should I expect results?
7) Side effects?
8) Where I can buy it and how much does it cost?
9) Can I combine Seti with other treatments?
10) How long will Seti work for me?
11) Do any companies study Seti? Any progress on that?
12) Do we have pictures which show effectiveness of Seti?

I listed the most common questions and added a couple specific from my side.

Yes, most questions have been already answered in this thread.

It's totally fine to have some questions unanswered, our goal is to get rid of identical questions which are asked by people over and over.

I'm going to contribute and search for some answers in Westonci's threads.

Anyone can feel free to add new questions to FAQ and answers.

Also, I would like to ask guys who are taking Seti to share resulting pictures if they didn't do that yet. It can significantly help us. Also, other people can help to determine and evaluate the real progress. Please, we really need this.

Ultimately, we need to have Westonci and other Seti users reviewed all these questions and answers in order to make sure that all information is correct and we didn't miss anything. Moreover, there are few questions which only Seti users can answer.

Hope it will work out.

@westonci It would be great if you could compile all the pertinent info and make a new thread to serve as a FAQ on all things Seti. I have read through both threads (this one and the other one that is 50+ pages). On one page you'll see how to buy the Seti, a different page has the safety and efficacy, different pages have results, different page has how to make it into a pill, etc. I am sure I and others would try this if the information was more concise. The more people we get on board, the more data we can gather.

Regardless, I was wondering how long the process is to make a months worth of pills and how long you can keep the pills at room temperature. I know you want to keep the majority of the supply in the freezer. I am trying to determine how inconvenient it is to do this (as I don't want to buy if I won't commit).

Also, like Jonnyyy stated; it seems like you and Pigeon maintained at far less than 1G, yet that is what you are recommending just maintenance.

Thanks,

https://www.hairlosstalk.com/intera...equently-asked-questions.111509/#post-1613243

 

[jgray201]

@westonci When would you consider growing your hair out? Obviously for comparative purposes it is great that you keep it the same length. But as you start to get regrowth and thickening i wondered if you will consider growing the hair on top more?

 

[jonnywalker93]

Well I'd buy on Kane but the fact that their price summarizer is broken (tells you different prices depending on previous selection), it instills little confidence in an overseas purchase. Anyone know a better outlet to purchase from?

Don't buy Seti from Kane. He sells a slightly altered version as westonci has already pointed out several times. You can contact Lyphar on Alibaba. They were used by other members before and sell legit Seti.

 

[SimonC]

https://www.hairlosstalk.com/intera...equently-asked-questions.111509/#post-1613243

You are just AWESOME! Thank you for this tremendous work!