Setipiprant Does Work, But Only On Really Really High Doses.

[Chromeo]

What's BBB?

Blood-brain barrier.

 

[westonci]

I believe this is kanes response.

Would salt seti be useless orally? the structure looks different. How much of an effect would this difference have?

Setipiprant (base /acid version)
molecular formula: C24H19FN2O3
molecular weight: 402.42

Setipiprant sodium(salt form)
molecular formula: C24H18FN2NaO3
molecular weight: 424.4

Could reported oral seti side be from these changes?

C24H18FN2NaO3

https://i.imgur.com/kLj15S4.png

 

[Sanchez1234]

Sorry, was away for 2 days. But this is Kane response. Don't know what to think. Is it good batch? Why does he send salt without asking if there are multiple seti choices? Is it reasonable to ask for a part refund if i send it back?


Hi, friend,

Regarding this setipiprant batch and your test report from your tester, we have to explain as below.It`s very crucial.

1.We have two forms of setipiprant, base form and salt form( sodium form, which can be dissolved in ethanol easily)
Many customers want salt form because they cant dissolve base/acid version of setipiprant in ethanol. It`s why we sell both, and stop base form now, as every customer requests the salt form.

Please check details as below.
Setipiprant (base /acid version)
molecular formula: C24H19FN2O3
molecular weight: 402.42

Setipiprant sodium(salt form)
molecular formula: C24H18FN2NaO3
molecular weight: 424.4

Structures as below.

2.
1) HPLC report is used to confirm the purity in usual. NMR and LCMS used for confirm the chemical structure in usual.
2) HPLC report of base form and salt form can be almost identical if they`re tested in same time.=, same conditions. With correct buffer etc.

So you tester said his HPLC can confirm our sample is not setipiprant, it`s not correct.
And the fact is , what he tested is not setipiprant base form ,it`s setipiprant salt form.

3. We used the attached literature of synthesis route to produce setipiprant base, and produce setipiprant sodium is very simple.
You can find the standard datas of HNMR of base form in literature. and I attached the HNMR of our setipiprant base form. You can find our Setipiprant is correct. Forward these reports to any PHD with the right expertise for interpretation and they will confirm this.

However, you can`t use this HNMR data of base form to compare with setipiprant sodium form. HNMR reports of base form and salt form are different.
I also attached two batches HNMR reports of salt form.

4. It is clear now that your tester don`t know it`s salt form that you have sent him, and not sure of even same sample in different time,the retention time can be different.

5. Ask your tester to run a HNMR and or LCMS on your sample, that is the only way to get proper chemical structure identification of this compound. Have this raw data analyzed by someone with expertise in this field.

6. If He won't do it, does not have the capabilities or equipment to do it, then we advice you to send a sample to a lab who is able to do a HNMR + LCMS test to get a proper chemical structure confirmation.

7. We are 100% confident that it is the right form of setipiprant- salt with high purity (+- 99%), And would like to help you with partly covering the testing cost in this case if you wish to reach out to a professional facility. they should be able to 1. Do a HNMR, LCMS and , 2. do a proper interpretation.

This is the only way to to get this compound identified/tested property.

Finally,we guarantee you wont face any loss. If u find it`s not correct chemical or purity not good,we can make refund or exchanging new batch.It`s always our service agreement.

We hope that you get this compound properly tested.

If u have any question, please let us know.


Attached our lab tests for base + sodium form + literature.

Warm regards,
Kane

 

[Sanchez1234]

So exactly the same message.

@Swoop just like you predicted

@westonci do you know what kind of form you are using now?

And do you know what monty did with his seti?

 

[Sanchez1234]

https://ibb.co/gWY7Vb = reaction Janoshik

Images are not loading?!

 

[westonci]

https://ibb.co/gWY7Vb = reaction Janoshik

Images are not loading?!

https://i.imgur.com/7p6axja.png

 

[ALightInTheDark]

https://image.noelshack.com/fichiers/2017/40/6/1507397206-pg-source.png

If you want to try something for PG take a look at this

 

[ALightInTheDark]

So misoprostol

If we can source a good PGE2 and PGE1 and Anti CRTH2 yes,you can take it I think

 

[rupture]

So you use non salted for oral dose ?

 

[ALightInTheDark]

What do you mean?

Sorry,I was confused in this one haha. I mean,It's a PGE2 analog so in theory you can take it topically.
But I've seen quickly than Misoprostol in only in pills and injection solution. So for topically..

 

[rupture]

Anyone have Kanes email , I tried it on his site but not working for me

 

[cocona]

Sorry,I was confused in this one haha. I mean,It's a PGE2 analog so in theory you can take it topically.
But I've seen quickly than Misoprostol in only in pills and injection solution. So for topically..

Same issue I'm having with Cetirizine. Widely available yet just as difficult to get as Seti. Unless you want to grind up pills and get a solution manually.


From wikiedia:

Pharmacology[edit]
Misoprostol, a prostaglandin analogue, binds to myometrial cells to cause strong myometrial contractions leading to expulsion of tissue. This agent also causes cervical ripening with softening and dilation of the cervix. Misoprostol binds to and stimulates prostaglandin E1receptors, prostaglandin EP3 receptor and prostaglandin EP4 receptor but not Prostaglandin EP1 receptor and therefore is expected to have a more restricted range of physiological and potentially toxic actions than prostaglandin E2 or other analogs which activate all four prostaglandin receptors.[38]

 

[Afro_Vacancy]

Same issue I'm having with Cetirizine. Widely available yet just as difficult to get as Seti. Unless you want to grind up pills and get a solution manually.

Is that you in your pic? Your hair seems pretty good, but I might be getting fooled by the bangs.

 

[cocona]

Is that you in your pic? Your hair seems pretty good, but I might be getting fooled by the bangs.

Yes, but it's a wig unfortunately

Here's my thread Getting there, slowly.

 

[Sanchez1234]

So, is the issue regarding Kane's seti cleared now?

Not yet, this is the latest.

 

[Sanchez1234]

Okay, so you're going to do some more tests? Hope we'll then have some confirmation if it's legit or not.

I think so, but i depends on the price.

 

[SamFT]

Looks like this sh*t doesn't work. You are wasting your time and money.

You're an idiot

 

[SamFT]

Then prove me wrong. Show me at least 1 full recovery on it. I mean not some vellus sh*t, but good thick hair on whole area.

1 full recovery? Are you f*****g dumb? Well guess what I've never seen a full recovery on finasteride so I guess that doesn't work either then.
Look at his pictures you can see them darkening and getting thicker considering when you look at the black hairs on his temple forming as well. It takes years for people to lose hair giving up cause it's taking forever is such a unintelligent decision to make. Nothing out there is going to give someone a full recovery in under a year. Think what you want though I can't wait for fevi to come out

 

[westonci]

Then prove me wrong. Show me at least 1 full recovery on it. I mean not some vellus sh*t, but good thick hair on whole area.

Give it some time.

For what ever reason Im getting better growth in the last 8 weeks on high dose oral seti than I did all of the previous 14 months on topical seti.

 

[shookwun]

I can't be the only one who thinks spending hundreds a month on this is a collusal waste of time. My as well spend the funds on a proven solution aka hair transplant.


Mental masturbation ITT