Setipiprant For Hair Loss - Mega Thread

[Manchboy]

If 50% gets excreted, what would be an ideal oral dose than gauging from what we know so far? It's really impractical for me to apply a topical but I am interested in taking seti orally. Would 200mg orally be enough?

 

[Dench57]

If 50% gets excreted, what would be an ideal oral dose than gauging from what we know so far? It's really impractical for me to apply a topical but I am interested in taking seti orally. Would 200mg orally be enough?

I guess that depends on how much you can afford, seen as side effects appear to be negligible in doses up to 1000mg. I think most people are using 100mg-200mg orally, purely because of cost. I'm not convinced this amount will be enough considering trials by the company are being done with oral doses of 500-1000mg.

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Screw it, I just joined the 2nd group buy. Fingers crossed.

 

[Manchboy]

Where did you find out the oral dosage that they're using in the trials? Also how did you get on the group buy? I can't seem to PM

 

[Dench57]

Here is the presentation about Setipiprant. Should be all you need to know.

I'll ask on the ******** forum about trying to get access for anyone else wanting to join.

 

[Manchboy]

Okay thanks, realing wanting to get this onto my regime! I can't seem to pm so if I can get on ******** that would be great

 

[Heat06]

Here is the presentation about Setipiprant. Should be all you need to know.

I'll ask on the ******** forum about trying to get access for anyone else wanting to join.

I plan on taking this orally, just deliberating on joining this Group Buy right now. I have a part of me that's saying this stuff is coming from China and you're planning on ingesting it? Also others from another forum are getting in my head and warning me prior to proceeding, but everything I have read deems this safe to take.

How much do YOU plan on packing into a gel pill assuming that's the route you take? I agree orally would be ideal on my end as well.

 

[mfried]

Also would be interesting if anyone buying who has cystic acne could give info on any improvements there.

 

[Vlatch]

Two weeks in :

This stuff definitely does something positive against inflammation. I've had a seborrheic dermatitis and a constantly inflammed scalp for 13 years, and with seti it feels a lot better.

I've taken oral doses -in capsules- between 80mg and 200mg a day and it feels better with 200mg. You also have to know that I am very slim (60kg for 1.82m), so I usually need a smaller dose of medication than the average male population.

To be continued !

 

[Dench57]

I plan on taking this orally, just deliberating on joining this Group Buy right now. I have a part of me that's saying this stuff is coming from China and you're planning on ingesting it? Also others from another forum are getting in my head and warning me prior to proceeding, but everything I have read deems this safe to take.

How much do YOU plan on packing into a gel pill assuming that's the route you take? I agree orally would be ideal on my end as well.

I understand your scepticism but it is being third party tested and coming from as reliable and trusted source as you can hope to expect. If you look at the safety profile, it's been through 8 human trials already for asthma (orally ingested). Doses of 1000mg and the small percentage of people who got sides had dry mouth, sleepiness, nausea etc. We'll only be using doses of 100mg-200mg (unless you're filthy rich) so those side effects will be lessened. Sounds better to me than the sexual risks of hormone-altering drugs like 5AR inhibitors and anti-androgens. Of course we don't really know about long-term inhibition of PGD2.

I'll be using oral, probably doses of 150-200mg (50% gets excreted when used orally so thats really 75mg-100mg) purely because I'm going travelling and won't be able to commit to a topical regimen. I would recommend topical if you want to get more bang for your buck.

Two weeks in :

This stuff definitely does something positive against inflammation. I've had a seborrheic dermatitis and a constantly inflammed scalp for 13 years, and with seti it feels a lot better.

I've taken oral doses -in capsules- between 80mg and 200mg a day and it feels better with 200mg. You also have to know that I am very slim (60kg for 1.82m), so I usually need a smaller dose of medication than the average male population.

To be continued !

Thanks for the update, please keep us posted. This is huge news, especially for me personally. Lot of people on ******** on similar doses also reporting reduction in inflammation and reduction of oil on the face and scalp. Correlates with our theory that PGD2 is the key inflammatory component of male pattern baldness, downstream from DHT. Man I wish I had money to burn, wonder what could be possible with double or triple these doses.

Anything that reduces scalp inflammation can only be good for hair so these are promising early signs.

 

[whatwhat]

I understand your scepticism but it is being third party tested and coming from as reliable and trusted source as you can hope to expect. If you look at the safety profile, it's been through 8 human trials already for asthma (orally ingested). Doses of 1000mg and the small percentage of people who got sides had dry mouth, sleepiness, nausea etc. We'll only be using doses of 100mg-200mg (unless you're filthy rich) so those side effects will be lessened. Sounds better to me than the sexual risks of hormone-altering drugs like 5AR inhibitors and anti-androgens. Of course we don't really know about long-term inhibition of PGD2.

I'll be using oral, probably doses of 150-200mg (50% gets excreted when used orally so thats really 75mg-100mg) purely because I'm going travelling and won't be able to commit to a topical regimen. I would recommend topical if you want to get more bang for your buck.



Thanks for the update, please keep us posted. This is huge news, especially for me personally. Lot of people on ******** on similar doses also reporting reduction in inflammation and reduction of oil on the face and scalp. Correlates with our theory that PGD2 is the key inflammatory component of male pattern baldness, downstream from DHT. Man I wish I had money to burn, wonder what could be possible with double or triple these doses.

Anything that reduces scalp inflammation can only be good for hair so these are promising early signs.

what is ********? Can you link where people are discussing the reduced inflammation?

 

[big_head]

Fingers crossed...though if this does work and if/when it hits the market, I doubt I will be able to afford it. A hair transplant plus finasteride might still be the most cost effective for the non-rich over the next 10 years (not that hair transplant are cheap, but at 1000+ a year, seti could wind up costing double a hair transplant + finasteride)

 

[massa]

People please, lets have some realism here Seti alone wont regrow hair, its just one of many pieces you have to take into account such as PGE2 and DHT and many others that people are only just discovering. Just taking Seti probably wont do much unless you combine it with a growth factor like PGE2 or minoxidil, and you'd still most likely have to be on dutasteride/finasteride tooto remove DHT (the main culprit). These Seti threads on here are getting out of hand, like we've already found the cure or something. No-one even knows the proper dose for seti yet we might all be taking too little.

 

[ryan82]

People please, lets have some realism here Seti alone wont regrow hair, its just one of many pieces you have to take into account such as PGE2 and DHT and many others that people are only just discovering. Just taking Seti probably wont do much unless you combine it with a growth factor like PGE2 or minoxidil, and you'd still most likely have to be on dutasteride/finasteride tooto remove DHT (the main culprit). These Seti threads on here are getting out of hand, like we've already found the cure or something. No-one even knows the proper dose for seti yet we might all be taking too little.

You have gave the answer why this threat is so big " No-one even knows the proper dose for seti yet we might all be taking too little"

:laugh:

 

[massa]

I wouldn't be surprised if when Kythera releases it (5 yrs time obviously) the dose is 500mg-1g a day. Its safe at this dose and none of us on the seti GB are going this high obviously due to the cost.

Its just like CB, we know it works yet people are forced to use only 1% not 5% as 1 gram is about $150 dollars which not many people can afford and its difficult to produce this at 99%+ purity.

 

[Wolf Pack]

Interesting. PGD2 may be high in the scalp of balding people, but what of those on finasteride and responding to it? I reckon it won't be high in these individuals. Otherwise if finasteride just lowered DHT in good respondents but this had no subsequent impact on PGD2, then hair maintenance/growth wouldn't be possible. That's assuming PGD2 is actually critical in the miniaturisation process as much as DHT.

 

[Vlatch]

Interesting. PGD2 may be high in the scalp of balding people, but what of those on finasteride and responding to it? I reckon it won't be high in these individuals. Otherwise if finasteride just lowered DHT in good respondents but this had no subsequent impact on PGD2, then hair maintenance/growth wouldn't be possible. That's assuming PGD2 is actually critical in the miniaturisation process as much as DHT.

DHT and testosterone (in a smaller degree) are responsible for PGD2 production, so of course lowering DHT will lower PGD2 production.
The point is, DHT isn't the direct culprit for hair loss, so it doesn't have to be inhibited if PGD2 is.

That's the theory anyway, I hope it'll prove to be right.

Here is Kythera's presentation on Setipiprant, look at page 8 :
http://files.shareholder.com/downlo...6-9D97-631C0F6B7C97/KYTH-105_setipiprant_.pdf

Page 7 also offers valuable informations about the dosage. The units aren't specified in the graph but it shows that at a dosage 10 times below the the dose needed for the effect of setipiprant to plateau, it still has a positive effect on hair growth.

So even if the most effective dose was 1g/day, taking 100mg/day would be far from pointless.

 

[Parsia]

I wouldn't be surprised if when Kythera releases it (5 yrs time obviously) the dose is 500mg-1g a day. Its safe at this dose and none of us on the seti GB are going this high obviously due to the cost.

Its just like CB, we know it works yet people are forced to use only 1% not 5% as 1 gram is about $150 dollars which not many people can afford and its difficult to produce this at 99%+ purity.

I agree with you Massa , thats why I didn't start seti in my regimen , the dose is around 500mg-1g , So how can 100-150 mg would help me ? and as you mentioned it just
PGD2 blocker and doesn't mean give you regrowth ( Maybe very slight like finasteride ) , So we need PGE2 increaser or other growth stimulants , All in All use that 100-150 mg doesn't looks very promising to me , the proper dosage is maybe the same as a trail , I wish the best for all seti guys on forum who start it , But prefer to be realistic about that.

 

[Vlatch]

I agree with you Massa , thats why I didn't start seti in my regimen , the dose is around 500mg-1g , So how can 100-150 mg would help me ? and as you mentioned it just
PGD2 blocker and doesn't mean give you regrowth ( Maybe very slight like finasteride ) , So we need PGE2 increaser or other growth stimulants , All in All use that 100-150 mg doesn't looks very promising to me , the proper dosage is maybe the same as a trail , I wish the best for all seti guys on forum who start it , But prefer to be realistic about that.

Read my previous post.

 

[Ziggyz123]

What's going to happen when the supply runs out? Will the body bring inflammation back the same or even worse? I have the funds to purchase about 75g of seti, but I'm afraid that once i run out and if there isn't another group buy in time, my inflammed scalp will be even worse than before..

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What's going to happen when the supply runs out? Will the body bring inflammation back the same or even worse? I have the funds to purchase about 75g of seti, but I'm afraid that once i run out and if there isn't another group buy in time, my inflammed scalp will be even worse than before..

 

[MoMoney]

What's going to happen when the supply runs out? Will the body bring inflammation back the same or even worse? I have the funds to purchase about 75g of seti, but I'm afraid that once i run out and if there isn't another group buy in time, my inflammed scalp will be even worse than before..

- - - Updated - - -

What's going to happen when the supply runs out? Will the body bring inflammation back the same or even worse? I have the funds to purchase about 75g of seti, but I'm afraid that once i run out and if there isn't another group buy in time, my inflammed scalp will be even worse than before..

guys, on the next group buy why dont we all pitch in some money and send a member here enough seti to take 1000-1500mg a day. so then if it works for him we know if we should all up dosage. I think this is a great idea. i wouldnt mind even being the test dummy lol.