ANy other ways to boot the Superoxide Dismutase activity??
to test the hypothesis that SOD/gliadin improves antioxidant defenses in humans as well as animals, German scientists subjected 20 volunteers to an hour of hyperbaric oxygen treatment. During the procedure, 100% oxygen was forced into the bloodstream at two and a half times the normal atmospheric pressure. Hyperbaric oxygen treatment, though medically necessary on occasion, is known to induce oxidative stress. This stress may be quantified by measuring breaks that occur in strands of DNA and by monitoring levels of isoprostanes, which indicate oxidative damage to cellular membranes. Hyperbaric oxygen treatment is also known to reduce levels of antioxidant enzymes, such as red blood cell SOD and catalase.41 In a randomized, double-blind, placebo-controlled study, scientists demonstrated that supplementation with SOD/gliadin significantly decreased the oxidative damage resulting from hyperbaric oxygen treatment. The investigators found that an orally effective SOD/wheat gliadin mixture can protect against DNA damage, while also preventing elevations in isoprostane levels. These findings suggest that SOD may therefore be considered a powerful antioxidant.4
A previous experiment by another research team also found that hyperbaric oxygen treatment induces breaks in DNA strands. In an effort to reduce this oxidative damage, the scientists administered oral antioxidants such as vitamin E or N-acetylcysteine prior to treatment, but these measures failed to protect against oxidative damage induced by hyperbaric oxygen treatment. This discrepancy would seem to indicate that effective protection against oxidative stress requires increased levels of the primary antioxidant SOD, as opposed to a boost in secondary antioxidant levels.42 Conclusion
Primary antioxidants such as superoxide dismutase are our first and most important line of defense against highly reactive, potentially destructive oxygen-derived free radicals. Researchers believe that SOD decreases with aging,43,44 and evidence suggests that boosting falling SOD levels may help guard against disease and extend life span.45
Two Studies, Striking Results
Although SOD’s benefits are well established, an orally ingested supplement that can boost SOD levels has eluded scientists for decades. After initial research revealed impressive results, however, Life Extension conducted two pilot studies (one open-label trial, one placebo-controlled trial) to help determine whether a novel plant-based extract called SODzyme™—derived from the sprouts of corn, soy, and wheat—could boost the body’s endogenous SOD levels and reduce chronic pain in aging adults.
Because free radicals are thought to contribute to chronic pain, it thus follows that antioxidants may offer pain relief. SOD activity in the blood lowers levels of the superoxide radical, which in turn diminishes levels of the inflammatory agent, hydrogen peroxide.
In the first open-label Life Extension study, 12 middle-aged volunteers of both sexes took 2000 mg daily of SODzymeâ„¢ for two weeks. SODzymeâ„¢ boosted serum SOD levels by 30% on average while lowering blood levels of hydrogen peroxide by 47%.22 This is significant, because hydrogen peroxide may contribute to the inflammation of arthritis. While immune cells use bursts of hydrogen peroxide to kill viruses and bacteria, excess hydrogen peroxide may contribute to inflammation and arthritis.23,24
The 12 subjects in this study, whose average age was 58, did not suffer from arthritis but were beginning to experience normal age-related decline in their SOD levels. Two weeks of oral SODzymeâ„¢ supplementation restored their serum and blood levels of SOD to youthful parameters. Furthermore, supplementation with SODzymeâ„¢ boosted activity of blood catalase, another crucial antioxidant enzyme, by an impressive 47%.22 If these subjects continue to use SODzymeâ„¢ and thus maintain or further boost their blood levels of SOD, they should remain well protected against arthritic diseases, as suggested by the numerous studies correlating low SOD levels with pain and arthritis.9-11
A second pilot study (placebo-controlled) conducted by Life Extension examined SODzyme™’s effects on adults diagnosed with inflammatory conditions such as arthritis. This placebo-controlled, 3-arm study involving 30 subjects over 4 weeks tested placebo, probiotic SODzyme™ and non-probiotic SODzyme™. A dramatic 71% response (clinically defined as a meaningful decrease in pain as measured by a validated pain assessment instrument) in the probiotic SODzyme™ group vs. a 30% response in the non-probiotic group was observed. No differences were observed in the placebo group. One of the study’s most remarkable findings was that those who were suffering the most pain at the study’s onset experienced the greatest pain relief benefit from SODzyme™.25
We need to find supplements to boost SOD, Catalase and gluthatione..
[youtube:36inviyv]http://www.youtube.com/watch?v=pqzALkJYbiM[/youtube:36inviyv]
LOL!