A link or correlation does not equal causation. A very very important fact in medicine where you see on Tuesdays more men die in car accidents, and start suggesting that men should not drive on Tuesdays even though its pure ignorance. Studies find false conclusions all the time because you take groups of people and find lots of relationships that may or may not really mean anything.
Some "way 316606" Stuff Is Making Headlines Today.
- Thread starter MomoGee
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A link or correlation does not equal causation. A very very important fact in medicine where you see on Tuesdays more men die in car accidents, and start suggesting that men should not drive on Tuesdays even though its pure ignorance. Studies find false conclusions all the time because you take groups of people and find lots of relationships that may or may not really mean anything.
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I look at it this way:
It is safe enough to be deemed “not an excessive risk” in tests already done, and has also been deemed safe enough to be picked up by the Italian pharma company for further trials and potential marketing.
There are obviously no guarantees at all, and we all take it at our own risk. I can’t say “no, you won’t get cancer”, because we simply do not have this sort of comprehensive data yet, but we know that the risks it poses are at least low.
It is safe enough to be deemed “not an excessive risk” in tests already done, and has also been deemed safe enough to be picked up by the Italian pharma company for further trials and potential marketing.
There are obviously no guarantees at all, and we all take it at our own risk. I can’t say “no, you won’t get cancer”, because we simply do not have this sort of comprehensive data yet, but we know that the risks it poses are at least low.
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Also guys I’m unsure if it’s already been posted in this thread, but here is the full study. Shows:
1: Works just like csa but superior
2: Upregulates b-catenin/WNT through suppression of SFRP1
3: Promotes hair shaft elongation virtually straight away (compared with control)
4: “In addition, WAY-316606 is highly selective against other closely related SFRP family members (SFRP2 and SFRP5). For example, at 2 μM, WAY-316606 inhibits SFRP1 activity by about 40%, whereas SFRP2 and SFRP5 activity is only inhibited by about 5% and about 2%, respectively. Moreover, this Wnt disinhibition technique may be a safer long-term therapeutic strategy for stimulating β-catenin activity in the human HF. Because inhibiting SFRP1 by WAY-316606 only facilitates Wnt signalling through ligands that are already present in the human HF, this ‘ligand-limited’ strategy for promoting human hair growth may circumvent potential oncological risks typically associated with β-catenin stabilisation”
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705
The only thing that we cannot say is whether or not it can thicken hair shafts to turn a vellus hair into a terminal hair, but then again when you look at the photos I posted earlier, he clearly has new dark hairs on his temple point which extend out further than in the previous photo. Also, we have seen people use Csa before and turn into yeti’s. There’s a video on YouTube of a guy taking it for a kidney transplant and he talks about how he’s grown really thick, dark hair on his eyebrows and eyelashes etc.
Let’s hope it meets the claim of “more effective than minoxidil” (what was said about csa).
1: Works just like csa but superior
2: Upregulates b-catenin/WNT through suppression of SFRP1
3: Promotes hair shaft elongation virtually straight away (compared with control)
4: “In addition, WAY-316606 is highly selective against other closely related SFRP family members (SFRP2 and SFRP5). For example, at 2 μM, WAY-316606 inhibits SFRP1 activity by about 40%, whereas SFRP2 and SFRP5 activity is only inhibited by about 5% and about 2%, respectively. Moreover, this Wnt disinhibition technique may be a safer long-term therapeutic strategy for stimulating β-catenin activity in the human HF. Because inhibiting SFRP1 by WAY-316606 only facilitates Wnt signalling through ligands that are already present in the human HF, this ‘ligand-limited’ strategy for promoting human hair growth may circumvent potential oncological risks typically associated with β-catenin stabilisation”
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705
The only thing that we cannot say is whether or not it can thicken hair shafts to turn a vellus hair into a terminal hair, but then again when you look at the photos I posted earlier, he clearly has new dark hairs on his temple point which extend out further than in the previous photo. Also, we have seen people use Csa before and turn into yeti’s. There’s a video on YouTube of a guy taking it for a kidney transplant and he talks about how he’s grown really thick, dark hair on his eyebrows and eyelashes etc.
Let’s hope it meets the claim of “more effective than minoxidil” (what was said about csa).
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We know it's a particular angle to attack male pattern baldness.
"When systemic, you will inhibit the SFRP1 in tissues around your body."/ "inhibiting a tumor suppressor" ye by definition that's what it does but to what extent if it goes systematic? it's not like you wanted to inhibit it and were inhibiting 100% of it. but I see what you mean
for sure but these are all possible theories until it's proven otherwise.
on the other side conclusions also say male pattern baldness is multifacotrial. hence why I think there is no cure yet.. and that the most probable one will be hair cloning. that shows how complicated it is. and even such drug as this one WAY drug: lets say it works crazy in studies, I guess there will be people who won't respond
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Well, the only guy to use it at 5mg/ml twice a day noted increased body hair growth. If not placebo, then it seems to be going systemic at this dose with potent effects. This does not sit right with me, and I would for sure use a much lower dose. It's still n=1 so we may just need to wait and see for the others to try it.
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What you guys don't want to see is that things are not black and white.
Regenerative medicine and cancer research are just two sides of the same coin. Both exploit the same pathways to make certain tissues either grow or not.
We got licl, vpa, at some point real WAY(private forums still on it, while you are better off to put together and get it third party tested from a source which are not Chinese or Georgie related - in cased you ever see any of the powder). Samumed is also entering finally phase 3 now, though I am not sur me what pathway this one works through. CXXC5 inhibitor looks also promising but still faaar way away.
I remind you of one of cotsarelis first findings "When there is a wound the skin has to make a decision "Do I make hair or skin?", If there is a lot of wnt around, then it goes for hair.
Crth2 inhibitor (enhances chances for neogenesis by a lot, this is where everything begins), with some pge2, wounding and all the winter signaling you can get we finally should get was we want. Some ppl started also to test the fgf9 cocktails as well, so let's hope we get to see some results of that soon as well. Once thing I am missing is a real 15-PGDH inhibitor, just Google sulfa benox and sunburns and how big of a potential these inhibitors carry for hair and
Regenerative medicine in future.
Regenerative medicine and cancer research are just two sides of the same coin. Both exploit the same pathways to make certain tissues either grow or not.
We got licl, vpa, at some point real WAY(private forums still on it, while you are better off to put together and get it third party tested from a source which are not Chinese or Georgie related - in cased you ever see any of the powder). Samumed is also entering finally phase 3 now, though I am not sur me what pathway this one works through. CXXC5 inhibitor looks also promising but still faaar way away.
I remind you of one of cotsarelis first findings "When there is a wound the skin has to make a decision "Do I make hair or skin?", If there is a lot of wnt around, then it goes for hair.
Crth2 inhibitor (enhances chances for neogenesis by a lot, this is where everything begins), with some pge2, wounding and all the winter signaling you can get we finally should get was we want. Some ppl started also to test the fgf9 cocktails as well, so let's hope we get to see some results of that soon as well. Once thing I am missing is a real 15-PGDH inhibitor, just Google sulfa benox and sunburns and how big of a potential these inhibitors carry for hair and
Regenerative medicine in future.
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You seem to have bought into the bizarre crap they’re saying about me on P H G. Just for the record, I have no idea why the admin seem to think I’m a Chinese/Wuhan shill (a label they seem to give out quite generously to people), and any “ill feelings” they have towards me regarding my banning over that group buy, was entirely due to their inability to listen to me when I said “I can’t access the shop”. Anyway, all of that aside, I’m not forcing anyone to use WAY, or the WAY that I did the GB for. I’m literally just orchestrating a more economical means for a small group of us to try it out for ourselves, because believe it or not, my only intention is to regrow my hair.
I know it’s easy to get caught up in the bizarre neo-nazi environment on P H G but it may do you some good to have opinions and thoughts of your own too.
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Oh, and if you want to actually get into regenerative medicine. Forget all of that and think about how you’re actually going to clone a new hair or create entirely new arrector pili muscles and undo scarring fibrosis, because once it’s detached and the follicle is scarred, that’s it.
Aside from Tsuji’s method, the only other possible way to is through Irreversible electroporation, which essentially kills off tissue to a depth at which it will regenerate new follicles. So if you have extensive fibrosis it’s essentially undone by this. Proven to induce healthy tissue growth in humans with liver scarring and cancer, and proven to regrow new terminal hairs in mice. There’s no other way (aside from cloning) to create a brand new, healthy hair with attached sebaceous gland and arrector pili. Good luck though.
Aside from Tsuji’s method, the only other possible way to is through Irreversible electroporation, which essentially kills off tissue to a depth at which it will regenerate new follicles. So if you have extensive fibrosis it’s essentially undone by this. Proven to induce healthy tissue growth in humans with liver scarring and cancer, and proven to regrow new terminal hairs in mice. There’s no other way (aside from cloning) to create a brand new, healthy hair with attached sebaceous gland and arrector pili. Good luck though.
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on webmd unfortunately a lot of people said csa only made their body hair grow more while not altering their normal hair or even causing their normal hair to fall which I find odd, maybe it triggers telogen effluvium like minoxidil, but this is based off a few reports and I'm sure way would work much better as said anyways
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Couldn't one just use taurine or serrapeptase to remove scar tissue?
https://raypeatforum.com/community/...ffective-than-finasteride-for-hair-loss.8284/
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Nope. You need to get past the layer of the dermis where the sebaceous gland and arrector pili lie in order for them them to regenerate. Tsuji works because it’s total hair organ (follicle + sebaceous gland + arrector pili) cloning. There is no other way to regenerate these necessary features
Of the hair organ at present, so after a time no matter how many AA’s or growth stims you use, no matter how often or deep you wound, it won’t bring back the dead hair organ. Once there is scarring and the hair doesn’t have attachments to blood supply and sebaceous glands it’s end game. That’s why hairloss will never be stopped until we can clone healthy hair.
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I’ve read accounts of people experiencing shedding and excessive hair growth.
Maybe it depends on the individual, or maybe people with healthy hair don’t really notice scalp hair growth given that their hair is already full and normal.
We DO know that when csa was tested for male pattern baldness it regrew hair. We know that WAY is stronger so their is greater potential again, also we have seen someone already growing scalp hair.
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thanks for the info
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You can remove fibrosis from the lungs or liver with taurine, I don't see why it wouldn't work for the scalp.
I wasn't talking about topical application.
I thought it wasn't proven the hair follicle was dead, but just in a deeper dormancy state?
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Where’s everybody’s money you took bro?
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Didn’t realise this guy was still active. For anybody who doesn’t know, @Arrade stole a huge sum of money from numerous members for a group buy on which he never produced. He stopped responding to everyone involved and kept the money for himself.
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The name's Elector
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I don't know why you all think I have money that I sent to someone at Stanford University
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hey Georgie just wondering when are you going to start using way on yourself I'm just eager to hear about any results
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In the next couple of weeks when it arrives. The dude already using it is supposed to update but is completely useless and literally never does