South Korean Scientists Has Developed A New Type Of Biochemical Material To Prevent Hair Loss

[br1]

Another university hairloss product..

Lets wait.......

 

[vernon]

Another university hairloss product..

Lets wait.......

yeah, quota for november fulfilled

next balding cure incoming in early december

 

[trunks]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818757/bin/EMMM-8-375-s001.pdf

Instruction for synthesis of KY - 02327

Interesingly estrogen modulates CXXC5 expression.

https://www.ncbi.nlm.nih.gov/pubmed/27886276

 

[Oppenheimer]

group buy?

 

[ALightInTheDark]

Estrogen is really GOAT for hair. AA properties, PGE2, FGF9, IGF1, and now this.
Just lack of WNT and this is what we need without systemic side effects.

 

[UberBaldaten]

Do you guys think micro doses of topical finasteride/dutasteride + estrogen once every few months would induce follicle regeneration ?

 

[NewUser]

http://www.yonhapnews.co.kr/bulletin/2017/11/20/0200000000AKR20171120080600017.HTML

They mention full regrowth. ...
Based on this finding, the researchers have developed a biochemical substance, PTD-DBM, that prevents CXXC from binding with the Dishevelled protein. When the substance was applied on the bare skin of laboratory mice, they saw new hair follicle growth.

Great news Xaser! Yes Elaine Fuchs(renowned U-Chicago cancer researcher and skin biologist) did a lot of work on Wnt-Beta catenin. I remember she discovered something important with respect to disheveled and hair growth years ago. This looks legit as far as I can tell. Based on approval time for another topical drug for toenail fungus, Jublia, we could see this topical by 2023 if it sails through phases 1-3 similarly. Tonnes of cope in the pipeline!

 

[OFXMBLD]

by 2023 if it sails through phases 1-3 similarly.

Five more years (tm) unless we can figure out how to have it made independently or purchase it for research and test it ourselves.

 

[NewUser]

“Disrupting the CXXC5-Dishevelled interaction with a competitor peptide activated the Wnt/β-catenin pathway and accelerated hair regrowth and wound-induced hair follicle neogenesis,” the paper said.

And they are claiming not just prevention but accelerated re-growth and neogenesis! That's new HF.

 

[Almsoo7]

The irony I see so far from all those researchers is that they claim it's very effective and a potential breakthrough but you see them slick bald. Something seems wrong.

 

[NewUser]

They're the only people trying to do something about baldness while transplant butchers and quacks fool the poor bastards into thinking they're going to get luscious locks of hair again.

 

[Almsoo7]

I see alot of forum users experimenting untested drugs on themselves so I wonder if the researchers will do the same to themselves.

 

[JeanLucBB]

The entire mouse study system is flawed. If we keep studying mice we're going to cure every possible mouse disease, but 80% of drugs that work in mice don't work in humans. How many that don't work in mice would work in humans? We need to study humans if we want to find human cures, but that's never going to happen. So we have to make-do with our furry friends and hope that eventually we run into something that works on both mice and humans.

They aren't smart enough to figure this out.

 

[ALightInTheDark]

The entire mouse study system is flawed. If we keep studying mice we're going to cure every possible mouse disease, but 80% of drugs that work in mice don't work in humans. How many that don't work in mice would work in humans? We need to study humans if we want to find human cures, but that's never going to happen. So we have to make-do with our furry friends and hope that eventually we run into something that works on both mice and humans.

This is called pre-clinical and Phase I studies. It's not flawed, this is the procedure.
Phase II and III are for humans. If it doesn't work on mice, it won't on humans. Then you can add chimp and pigs.
Then,test it on humans.
Phase IV is post-commercialisation.

And to your 80% I don't know where you've got this, but all studies and researchs are done like this.
And yes this is never going to happen because it's called safety I prefer to be alive and have the chance to see a cure than dyin' bald because they didn't test it on animals previously.

The problem is not mice, the problems is the time they need to get approval from FDA and other agencies.

 

[vernon]

This is called pre-clinical and Phase I studies. It's not flawed, this is the procedure.
Phase II and III are for humans. If it doesn't work on mice, it won't on humans. Then you can add chimp and pigs.
Then,test it on humans.
Phase IV is post-commercialisation.

And to your 80% I don't know where you've got this, but all studies and researchs are done like this.
And yes this is never going to happen because it's called safety I prefer to be alive and have the chance to see a cure than dyin' bald because they didn't test it on animals previously.

The problem is not mice, the problems is the time they need to get approval from FDA and other agencies.

the problem is that companies need a working product first tbh, and not just a hype baloon for attracting investors.

why ignore the elephant in the room

 

[ALightInTheDark]

the problem is that companies need a working product first tbh, and not just a hype balloon for attracting investors.

why ignore the elephant in the room

The problem is not the hype. The proble here is SAFETY. Safety first, effectiveness after.
You don't drive a car without belts/airbag in aren't you?

 

[vernon]

The problem is not the hype. The proble here is SAFETY. Safety first, effectiveness after.
You don't drive a car without belts/airbag in aren't you?

almost all of those failed treatments easily pass the safety test, but when effectiveness needs to be demonstrated, all kinds of complications magically arise. come up with a working solution and you ll cruise through trials and nobody will have a problem waiting for a couple of years to get it.

"administration" problem exists, but its also conveniently used as an excuse. system of financing (and the financial issue itself) of those startups and public institute research is where the problem lies, imho. makes it more important to know how to advertise and hype a POTENTIAL treatment up than to be advanced in actual science.

is FDA regulation the reason Follica is still mumbling about "hoping to start the initiation of the organisation of the optimization study for their pivotal trial" in late 2017? of course not.

 

[d3nt3dsh0v3l]

B

almost all of those failed treatments easily pass the safety test, but when effectiveness needs to be demonstrated, all kinds of complications magically arise. come up with a working solution and you ll cruise through trials and nobody will have a problem waiting for a couple of years to get it.

"administration" problem exists, but its also conveniently used as an excuse. system of financing (and the financial issue itself) of those startups and public institute research is where the problem lies, imho. makes it more important to know how to advertise and hype a POTENTIAL treatment up than to be advanced in actual science.

is FDA regulation the reason Follica is still mumbling about "hoping to start the initiation of the organisation of the optimization study for their pivotal trial" in late 2017? of course not.

Bro testing on humans before animals is trying to run before learning to crawl.

The protocol is slow, but the order makes sense. Don't forget that there are innocent human lives ar stake, also.

 

[vernon]

B


Bro testing on humans before animals is trying to run before learning to crawl.

The protocol is slow, but the order makes sense. Don't forget that there are innocent human lives ar stake, also.

no, I m not denying that.

just saying its not administrations fault that companies cant come up with a treatment and delay trials on their own

 

[ALightInTheDark]

almost all of those failed treatments easily pass the safety test, but when effectiveness needs to be demonstrated, all kinds of complications magically arise. come up with a working solution and you ll cruise through trials and nobody will have a problem waiting for a couple of years to get it.

"administration" problem exists, but its also conveniently used as an excuse. system of financing (and the financial issue itself) of those startups and public institute research is where the problem lies, imho. makes it more important to know how to advertise and hype a POTENTIAL treatment up than to be advanced in actual science.

is FDA regulation the reason Follica is still mumbling about "hoping to start the initiation of the organisation of the optimization study for their pivotal trial" in late 2017? of course not.

Because this is a POTENTIAL.
Not a PROVED cure So you hype to fund it, and then proved. If you can,cool, market will open its doors for ya.
It doesn't ? You've make money,so it's all cool,try again.
This is real life and not Hair Heaven. Not everyone care about baldness and sucess of baldness cure.