South Korean Scientists Has Developed A New Type Of Biochemical Material To Prevent Hair Loss
- Thread starter Xaser94
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distracted
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The science of all this goes over my head, but just based on the credentials of the researchers involved isn't this pretty incredible?
Look up the guy who heads this lab. This could be big for us depending on how the FDA equivalent regulatory body works in Korea.
Look up the guy who heads this lab. This could be big for us depending on how the FDA equivalent regulatory body works in Korea.
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I've just read through this study, and for a layman, I'm impressed with the lucidity, logic and efficiency of this study.
My understanding is this first thing about this study is it's not just another "wnt pathway induces hair growth" study. Everybody and their mother at this point knows that disruption of the wnt pathway in dermal papilla cells (DPC)results in imparied hair growth, but they've identified a protein (CXXC5) that interacts with one of the specific elements (Dvl) of the wnt pathway to disrupt it. So they know precisely what is disrupting it and where precisely it is being disrupted.
Then they've shown that CXXC5 is expressed highly in DP cells taken from human scalps with Androgenetic Alopecia. Then they've show that by disrupting CXXC5's ability to interact with Dvl by using a peptide (PTD-BDM) that "get's there before it", kind of how Finasteride does with 5ar, that wnt signaling resumes and the cell resumes its normal functioning, so normal hair growth.
Then they've shown that combining PTD-BDM and a wnt pathway activator (like VPA) makes the effect even more powerful. This is good stuff.
Then they've shown that combining PTD-BDM and a wnt pathway activator and wounding can induce follicle neogenesis.
They're actually dropping new science here. To my understanding what were looking at could be Androgenetic Alopecia's achilles heel.
My understanding is this first thing about this study is it's not just another "wnt pathway induces hair growth" study. Everybody and their mother at this point knows that disruption of the wnt pathway in dermal papilla cells (DPC)results in imparied hair growth, but they've identified a protein (CXXC5) that interacts with one of the specific elements (Dvl) of the wnt pathway to disrupt it. So they know precisely what is disrupting it and where precisely it is being disrupted.
Then they've shown that CXXC5 is expressed highly in DP cells taken from human scalps with Androgenetic Alopecia. Then they've show that by disrupting CXXC5's ability to interact with Dvl by using a peptide (PTD-BDM) that "get's there before it", kind of how Finasteride does with 5ar, that wnt signaling resumes and the cell resumes its normal functioning, so normal hair growth.
Then they've shown that combining PTD-BDM and a wnt pathway activator (like VPA) makes the effect even more powerful. This is good stuff.
Then they've shown that combining PTD-BDM and a wnt pathway activator and wounding can induce follicle neogenesis.
They're actually dropping new science here. To my understanding what were looking at could be Androgenetic Alopecia's achilles heel.
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@Armando Jose since you are one of the oldest member who joined this fourm, was it always like that with new studies that never see the light?
Do you think we are close to cure or at least a better treatment?
Do you think we are close to cure or at least a better treatment?
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Kang-Yell Choi will be a speaker at Asia-Pacific Dermatology Meet august 2018 Tokyo, Japan according to this tweet https://twitter.com/Derma2018/status/925577856989593600
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We MUST contact with him.
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Awesome news, that materializes the treatment a bit more in my eyes
Not sure if this was posted
https://encrypted.google.com/patents/WO2017061710A1?cl=en
There is a list suitable compounds.
https://encrypted.google.com/patents/WO2017061710A1?cl=en
There is a list suitable compounds.
It'll make Riken have competition
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Inb4 massive Seppukus in Riken institute if this works
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perhaps in the distant future this new drug will be the (poor-middle) man's treatment like finasteride while tsuji method will provide permanent results with a higher cost without a need to treat Androgenetic Alopecia
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Undergo hair follicle primordiums grafts or rub/inject a product to get our real follicles back
Choice is obvious
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shave that ugly combover bobby : D
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did you trim the fat around your company ?
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Of course, they are lazy and slow, they make me sad to look at, professor Xavier is still here tho
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I saw an opportunity haha