Stemson is going to use minipigs in the next stage of their hair cloning research

[werefckd]

Would it be a 1 time thing where a NW6 can get a full head of hair for the rest of his life at the cost of $30k?

30k would be just for the manufacturing of the cells. Stemson would still need to assembly those cells in the right way too into thousands of units, and implant each one of them into our scalps

But yea it would turn a NW6 into whatever Norwood you would want. Don’t know about the other questions. Don’t know if it would be a 1 time thing, maybe we will need to do some maintenance each 5-10 years but it is just a guess.

 

[eeyore]

Presumably this is where they are getting their asses kicked at the moment
View attachment 170822View attachment 170823

Do you know what date and where we can see their presentations? Also, any idea how far a "dose" of ipsc cells would go as far as Stemson's applications?

 

[froggy7]

we didn't really learn anything interesting from Stemson this year

 

[froggy7]

I know I shouldn’t post this because you guys are going to run wild with this…

If you thought the imaginary tsuji treatment was expensive, how about this:

Getting one dose of clinical grade cells derived from iPSC currently costs ONE MILLION DOLLARS, lol

They expect the price to fall to $30K by 2025, which is a fraction of that but still a lot.

My guess is Stemson will likely subsidize their treatment in the beginning and run at a loss with the help of venture funding in order to scale. We will see, as long as the treatment works then anything else is possible

View attachment 170865

haha people from here seriously thinks the treatment will be for the average joe

 

[coolio]

The average Joe would like to get his hair back for the the price of buying a different brand of shampoo. Everybody on this forum is willing to pay more than the average Joe is. Much more.

That means any new treatments will be priced low enough for us to afford it, if they possibly can. The only way we might get priced out of a new treatment is if the technology makes it impossible for the company do it affordably.

They won't choose to keep guys like us priced out. Not for very long.

 

[froggy7]

The average Joe would like to get his hair back for the the price of buying a different brand of shampoo. Everybody on this forum is willing to pay more than the average Joe is. Much more.

That means any new treatments will be priced low enough for us to afford it, if they possibly can. The only way we might get priced out of a new treatment is if the technology makes it impossible for the company do it affordably.

They won't choose to keep guys like us priced out. Not for very long.

i hope so....

 

[trialAcc]

The average Joe would like to get his hair back for the the price of buying a different brand of shampoo. Everybody on this forum is willing to pay more than the average Joe is. Much more.

That means any new treatments will be priced low enough for us to afford it, if they possibly can. The only way we might get priced out of a new treatment is if the technology makes it impossible for the company do it affordably.

They won't choose to keep guys like us priced out. Not for very long.

What health care solution is priced for the average joe? The average person in the USA can't even afford insulin without insurance because of how it's priced. Any hair solution will not have insurance.

The reason we don't have better solutions available is exactly because of the problem we've highlighted here. Normal people want to regrow/keep their appearance for 9$ a month. The real cost is probably closer to 900$ a month (like HMI will be priced), which is far more then the average person can afford.

This results in most developments being shelved due to to profitability forecasting.

 

[froggy7]

What health care solution is priced for the average joe? The average person in the USA can't even afford insulin without insurance because of how it's priced. Any hair solution will not have insurance.

The reason we don't have better solutions available is exactly because of the problem we've highlighted here. Normal people want to regrow/keep their appearance for 9$ a month. The real cost is probably closer to 900$ a month (like HMI will be priced), which is far more then the average person can afford.

This results in most developments being shelved due to to profitability forecasting.

there are no ugly people, there are only poor people, soon there will be no bald people, just poor people, there are also studies on the regeneration of growth plates and maybe short adults will be able to grow to their dream height - but all this will be for rich people, not for ordinary joe

 

[surfer9]

Man, I don't have enough donor. It's a joke. You can fix hairloss with hair transplant.... but for me I can't cos my hairloss is too fakked.

Maybe I find some dark brown sand and glue it to my head so it looks like a buzzcut.

 

[genericwhitemale]

Man, I don't have enough donor. It's a joke. You can fix hairloss with hair transplant.... but for me I can't cos my hairloss is too fakked.

Maybe I find some dark brown sand and glue it to my head so it looks like a buzzcut.

It depends really.

My friends brother had a transplant at 26, he was basically completely bald NW7 by 23/24. Didn't have much donor either as that had diffused too, but he went to Turkey and got a transplant and he looks a ton better than before even though he's still basically bald.

The difference is he now has a hairline and some limited density on top so even if you have major balding and thin donor there is some hope. Althogh if you are like froggy up there and only a dense NW0 is acceptable, then yeah, your pretty much doomed...

 

[Joxy]

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors​

The application of induced pluripotent stem cells (iPSC) in advanced therapies is increasing at pace, but concerns remain over their clinical safety profile. We report the first ever application of doggybone DNA (dbDNA™) vectors to generate human iPSC. dbDNA™ vectors are closed-capped linear double-stranded DNA gene expression cassettes that contain no bacterial DNA and are amplified using a chemically defined, cGMP compliant methodology. We achieved comparable iPSC reprogramming efficiencies using transiently expressing dbDNA™ vectors with the same iPSC reprogramming coding sequences as the state-of-the-art OriP/EBNA1 episomal vectors but, crucially, in the absence of p53 shRNA repression. Moreover, persistent expression of EBNA1 from bacterially-derived episomes resulted in stimulation of the interferon response, elevated DNA damage and increased spontaneous differentiation. These cellular activities were diminished or absent in dbDNA-iPSC resulting in lines with a greater stability and safety potential for cell therapy.

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors

Thornton et al. have applied novel doggybone cDNA technology to generate transiently maintained gene delivery vectors containing no bacterial motifs to generate induced pluripotent stem cells (iPSCs). When compared to episomal OriP/EBNA1, our vectors generated safer, more stable colonies at an...

www.cell.com

Full article: https://www.cell.com/molecular-ther...m/retrieve/pii/S232905012100156X?showall=true

 

[Chads don't bald]

there are no ugly people

That's not true, just look in the mirror

jk

 

[Diffused_confidence]

I thought this company had a shot but now it just seems like another tsuji. These people aren't curing sh*t here.

 

[froggy7]

I thought this company had a shot but now it just seems like another tsuji. These people aren't curing sh*t here.

this company is a long way from completing preclinical studies, and they didn't promise anything, so we can't blame them

 

[froggy7]

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors​

The application of induced pluripotent stem cells (iPSC) in advanced therapies is increasing at pace, but concerns remain over their clinical safety profile. We report the first ever application of doggybone DNA (dbDNA™) vectors to generate human iPSC. dbDNA™ vectors are closed-capped linear double-stranded DNA gene expression cassettes that contain no bacterial DNA and are amplified using a chemically defined, cGMP compliant methodology. We achieved comparable iPSC reprogramming efficiencies using transiently expressing dbDNA™ vectors with the same iPSC reprogramming coding sequences as the state-of-the-art OriP/EBNA1 episomal vectors but, crucially, in the absence of p53 shRNA repression. Moreover, persistent expression of EBNA1 from bacterially-derived episomes resulted in stimulation of the interferon response, elevated DNA damage and increased spontaneous differentiation. These cellular activities were diminished or absent in dbDNA-iPSC resulting in lines with a greater stability and safety potential for cell therapy.

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors

Thornton et al. have applied novel doggybone cDNA technology to generate transiently maintained gene delivery vectors containing no bacterial motifs to generate induced pluripotent stem cells (iPSCs). When compared to episomal OriP/EBNA1, our vectors generated safer, more stable colonies at an...

www.cell.com

Full article: https://www.cell.com/molecular-therapy-family/methods/pdf/S2329-0501(21)00156-X.pdf?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S232905012100156X?showall=true

we are many many years from the therapy, as long as Sesmson solves the problems, after all their treatment can cause cancer, you have hair and you die after a year: D it will not be 5 or 10 years only much longer, let's face it gentlemen our generation was unlucky just

 

[froggy7]

A telescopic model of the development of hair follicles

RIKEN scientists have untangled the process of hair development, a finding that could lead to new therapies for hair loss

www.riken.jp

 

[froggy7]

Careers : Stemson Therapeutics

A Radical Solution for Hair Growth

stemsontx.com

many wise men on this forum, maybe you will speed up the medicine when applying for work - it will be in 5 years

 

[surfer9]

It depends really.

My friends brother had a transplant at 26, he was basically completely bald NW7 by 23/24. Didn't have much donor either as that had diffused too, but he went to Turkey and got a transplant and he looks a ton better than before even though he's still basically bald.

The difference is he now has a hairline and some limited density on top so even if you have major balding and thin donor there is some hope. Althogh if you are like froggy up there and only a dense NW0 is acceptable, then yeah, your pretty much doomed...

I have SMP. I'd like to get some hair into the NW6 scalp area. Nothing major, just some hair that will make it stand out a bit more, look more realistic. I'd still buzz it down I won't have enough density to grow it out... and happy to use beard hair if necessary.

I have sent photos to some surgeons and I'm gradually getting some responses back. Harley Street clinic was just like 'We've reviewed your photos - come in for a consultation'..... ok. Dr Ball has come back to me and said the outcome won't be worth the cost, but also stated they've never worked on something like this at their clinic. I guess they know a combined SMP / FUE transplant to give an illusion of a buzz cut is prob not ideal for them from a marketing stand point. They want to show off clients who have had their bald heads covered in thick hair......

So I sit awaiting other's responses now.

 

[trialAcc]

I thought this company had a shot but now it just seems like another tsuji. These people aren't curing sh*t here.

So you come here to whine about it?

This company is not only doing extremely complex work, but they are also the only one's doing what they are doing. Why not have some patience and let the company that's only growing/expanding take their shot instead of whining about every approach that doesn't go perfectly?

 

[froggy7]

So you come here to whine about it?

This company is not only doing extremely complex work, but they are also the only one's doing what they are doing. Why not have some patience and let the company that's only growing/expanding take their shot instead of whining about every approach that doesn't go perfectly?

everyone wants them to succeed, the price is not important, what is important is success and the awareness that you can have beautiful hair again