Stemson is going to use minipigs in the next stage of their hair cloning research

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Joxy

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"Stem cell-based therapeutics poised to become mainstream option”​


In conversation with Dr Koji Tanabe, Founder and CEO, I Peace, Inc., The United States/Japan


Can you elaborate I Peace’s cost-effective proprietary stem cell synthesis solution and its manufacturing scale?

The key advantage of iPSCs is the ability to create pluripotent cells from an individual’s own cells. Furthermore, iPSCs can multiply indefinitely and evolve into any type of cell, making iPSCs an ideal tool for transplant and regenerative medicine and drug research. However, clinical applications of iPSCs to date, utilise heterogenic transplantation. It is because manufacturing of just one line of iPSCs requires a cost intensive clean room to be occupied for several months. Manufacturing process complexities also pose a barrier to cost reduction and mass production.

In contrast, I Peace has developed a proprietary, fully automated closed system for iPS manufacturing, enabling cost-effective production of multiple lines of iPSCs from multiple donors in a single room. Within a few years, we expect to manufacture several thousand lines of iPSCs simultaneously in a single room. With this technology, I Peace can efficiently generate an ample supply of various iPSCs for heterogenic transplant, while also fostering a society where everyone can bank their own iPSCs for potential medical use.

Full article: https://www.biospectrumasia.com/opi...utics-poised-to-become-mainstream-option.html
 
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froggy7

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Joxy said:

"Stem cell-based therapeutics poised to become mainstream option”​


In conversation with Dr Koji Tanabe, Founder and CEO, I Peace, Inc., The United States/Japan


Can you elaborate I Peace’s cost-effective proprietary stem cell synthesis solution and its manufacturing scale?

The key advantage of iPSCs is the ability to create pluripotent cells from an individual’s own cells. Furthermore, iPSCs can multiply indefinitely and evolve into any type of cell, making iPSCs an ideal tool for transplant and regenerative medicine and drug research. However, clinical applications of iPSCs to date, utilise heterogenic transplantation. It is because manufacturing of just one line of iPSCs requires a cost intensive clean room to be occupied for several months. Manufacturing process complexities also pose a barrier to cost reduction and mass production.

In contrast, I Peace has developed a proprietary, fully automated closed system for iPS manufacturing, enabling cost-effective production of multiple lines of iPSCs from multiple donors in a single room. Within a few years, we expect to manufacture several thousand lines of iPSCs simultaneously in a single room. With this technology, I Peace can efficiently generate an ample supply of various iPSCs for heterogenic transplant, while also fostering a society where everyone can bank their own iPSCs for potential medical use.

Full article: https://www.biospectrumasia.com/opi...utics-poised-to-become-mainstream-option.html
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that is why we are far away from Stemsons cure
 
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werefckd

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Boom!! Stemson is putting the funding to work and hiring aggressively, love it

They are going after it folks, the fight is on!

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werefckd

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That’s the fist time they use the “iPSC organoid” term in their job postings. It’s an indication that the pre clinical research is moving forward
 
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werefckd

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$ 22.5 million in funding, top tier investors from the industry, research team steadily growing.

In 20 years of lame attempts and straight out charlatanism, this is the first time we are getting a legit shot at the cure, period
 
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werefckd

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By the way, in case some people are not getting it, I will explain what is going on in very simple terms:

The faster they hire, the closer they get to starting clinical trials
 
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froggy7

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werefckd said:
By the way, in case some people are not getting it, I will explain what is going on in very simple terms:

The faster they hire, the closer they get to starting clinical trials
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there is no guarantee of success at the moment, far from human trials and it would be in the middle of this year so nothing to get excited about
 
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jan_miezda

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werefckd said:
That’s the fist time they use the “iPSC organoid” term in their job postings. It’s an indication that the pre clinical research is moving forward
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I think the fact they want to make an organoid is bad news. Remember tissuse did the same thing. They wanted to make it so they could better study hair follicle neogensis. It means stemsom might be at a similar roadblock or when the cultured cells are implanted even in the spheroid they don’t produce a follicle

maybe they want the produce the follicles in the onoids where they can monitor follicle neogensis more closely . And then when a robust follicle is produced they will transplant that onto a patients scalp. They can also detect cancerous cell lines that way as well
 
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werefckd

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I understand your concern but organoid is a generic/umbrella term and was used in a different context here compared to tissuse.

If you click on the job postings and read the descriptions you will see that when they use the word organoid they are referring to the hair follicles progenitors, not fake skin.

This is about the “hair germ” that was created in vitro (“cloned”) and that will become an organ (hair) once implanted on the skin, hence the term organoid.

For the skin, they are not using “organoid skin”, they are implanting it on live animals.

My take about those job postings is that they are hiring people for the stages after the cell differentiation and reprogramming too, because you only can assemble the follicle organoid after you already have produced the cells you need for that.
 
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froggy7

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werefckd said:
I understand your concern but organoid is a generic/umbrella term and was used in a different context here compared to tissuse.

If you click on the job postings and read the descriptions you will see that when they use the word organoid they are referring about the hair follicles progenitors, not fake skin.

This is about the “hair germ” that was created in vitro (“cloned”) and that will become an organ (hair) once implanted on the skin, hence the term organoid.

For the skin, they are not using “organoid skin”, they are implanting it on live animals.

My take about those job postings is that they are hiring people for the stages after the cell differentiation and reprogramming too, because you only can assemble the follicle organoid after you already have produced the cells you need for that.
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all indications are that hair cloning is far away
 
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froggy7

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scientist_0005 said:
you are just a broken clock constantly posting the same sh*t and negativity
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you have to face the truth, the progrs is very slow, there is no mention of human attempts, I will not be surprised if in 50 years baldness will still be a problem, as for me, the only sensible option for 30+ is cryonics and waiting for a better perfect body with beautiful hair
 
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scientist_0005

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jan_miezda said:
I think the fact they want to make an organoid is bad news. Remember tissuse did the same thing. They wanted to make it so they could better study hair follicle neogensis. It means stemsom might be at a similar roadblock or when the cultured cells are implanted even in the spheroid they don’t produce a follicle

maybe they want the produce the follicles in the onoids where they can monitor follicle neogensis more closely . And then when a robust follicle is produced they will transplant that onto a patients scalp. They can also detect cancerous cell lines that way as well
Click to expand...
there is no spheriod the idea of the spheroid goes back to the idea of culturing DP cells taken directly from the patient to maintain their inductivity in vitro. however stemson is using IPCS and they culture the neural crest intermediate or the stem cells directly not the other way around. also an organoid is basically just a precursor of an organ with a bunch of differentiated specialized cells. the way i understand it is that all attrmpts at hair cloning have used organoids, when you jzst inject the DP cells in the scalp i think not much happens because this is not the state and environment your scalp was during embryogenesis. there, two types of tissue, the mesechyme and the epithelium interact with each other leading to the formation of a prefollicle that rhen gets engulfed by epithelial cells. in the organoid they use the designed DP cells and put them together with epithelial stem cells so the DP cells can direct the epithelial stem cells in which kind of cell of the hair matrix they should differentiate and proliferate. i think this is needed in humans. stemsons approach of using ipcs is completely unique, tissue was most certaintly not doing it and there could be a host of issues they got wrong speculation is ppintless but its definitely not "bad" news
 
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