Study: A new RU58841 for Topical Application?

[Petchsky]

I have been feeling optimistic about hairloss for a while now and it just gets better...Cloning, now RU58841 (RUM) f*** me its a good time to be going bald. Looks like we chaps shall keep our hair, or what we have left, till we decide we don't want it...if ever! ha ha ha harrrr!

:shifty:

 

[giggsy]

RUM

Fellas

Below is the information in relation to the vendor of RU. We need a guinea pig on this forum to give it a shot. I have read positive testimonials on this stuff:

Mr. H.Z. Owense
Faith Eagle Ltd.
Shenzhen City, China

Email: szietrir@public.szptt.net.cn or htpharm@public.szptt.net.cn
Fax: 0086-755-83164680
Website: http://www.faitheaglepharm.com

RU58841 in material powder form

Net Price at USD30.-/gram & the shipping cost to each consignee at USD70.- for European area or USD90.- for USA & Canada

Payment: 50% value by T/T in advance when ordering and the rest 50% value by T/T in advance just before our shipment, no credit card accepted

Availability: 30-40days after our receiving the first 50% prepayment

Packing: Each in brown plastic-bottles

 

[HairlossTalk]

Thanks giggsy!

HairLossTalk.com

 

[HairlossTalk]

I think you misunderstood me, HairLossTalk.com. Not trying to offend you in any way. Not disappointet in YOU, just sad that it wasn't worth more than a comparison to spironolactone. I just thought it was kind of a wonder drug. Guess I was wrong. Sorry if it came out the wrong way!

Just ignore me. I hadn't had my morning eggs yet.

HairLossTalk.com

 

[Brasileirao]

Re: RUM

Fellas

Below is the information in relation to the vendor of RU. We need a guinea pig on this forum to give it a shot. I have read positive testimonials on this stuff:

Mr. H.Z. Owense
Faith Eagle Ltd.
Shenzhen City, China

Email: szietrir@public.szptt.net.cn or htpharm@public.szptt.net.cn
Fax: 0086-755-83164680
Website: http://www.faitheaglepharm.com

RU58841 in material powder form

Net Price at USD30.-/gram & the shipping cost to each consignee at USD70.- for European area or USD90.- for USA & Canada

Payment: 50% value by T/T in advance when ordering and the rest 50% value by T/T in advance just before our shipment, no credit card accepted

Availability: 30-40days after our receiving the first 50% prepayment

Packing: Each in brown plastic-bottles

Is this the actual stuff mentioned in that study...

If so, perhaps I will give it a try....

Then again, I may not need it.......

Your opinions...should I or should I not!

Paki

 

[giggsy]

RUM

I believe that this is the stuff...this is the website i found it on after a google search:

http://www.farrellmanual.com/topical/ru.htm

 

[elguapo]

I think the 3rd para of HairLossTalk.com's original message states:

In contrast to native RU58841, the more lipophilic RU-myristate and nile red can be loaded into the lipid particles by hot homogenization.

This implies that the "-M" part is rather important, as in the entire method behind the success of the study. So I doubt that site offers the same thing.

Bad thing about this site is that we are all taking some other treatment, so one of us would have to stop treatment for some time before trying out another. Ain't gonna be me! I loves my finasteride!!!

 

[Bryan]

I want to make a couple of very minor corrections to what HairLossTalk.com said, and then I'll make a general comment or two about "RUM":

Drug targeting to the sebum gland and derma papillae, however, may allow topical antiandrogen treatment in men (if they can keep it localized to the follicle's structures, it may be safer). Accomplishing this may be possible by particulate carrier systems such as solid lipid nanoparticles, SLN, which are known to support dermal targeting (they've found something that can take the active ingredient and target only the local follicle structures. they're called liposomes)

It may or may not be actual "liposomes" that these researchers are talking about. There seems to be more than just one kind of these particulate carriers in existence, depending on various factors like their size and exact chemical structure. For example, I see the term "nanosome" being bandied about on some hairloss sites for what are apparently even TINIER particles than liposomes. I don't really know if the term these guys are using (solid lipid nanoparticles, or SLN) are liposomes, nanosomes, or something else entirely. Maybe someone else who is more interested in that general technology can clarify that for us. Where is Jacob when we need him?? :wink:

Methods:
The New Antiandrogen prodrug called RU58841-myristate was developed for topical therapy. (I believe this is a new version of RU58841 intended for topical application for hair loss sufferers). Ester cleavage was proved, receptor affinity and local tolerability were compared to RU58841. (they made sure it did all the same things as orally ingested RU).

Nobody would ever orally ingest RU. RU is _exclusively_ intended for topical use, whether it's the original version or the altered "RUM" form.

What they mean in that last sentence above is that they proved that when the altered "RUM" form of RU58841 (which has no antiandrogenic properties itself) penetrates into cells, enzymes in the cells break it back down into the standard RU58841 form, which then goes on to have the expected potent antiandrogenic effect. They're essentially saying, don't worry, it turns back into RU58841 once it enters the cell!

The additional comments I have are the following:

1) There's nothing new about the idea of using topical RU58841 in liposomes (or whatever the exact kind of carrier particle it is that they're using). In fact, that's what one of the published RU studies used a few years ago! The anonymous guy who posted his before-and-after RU pics over on HLH a while back also used liposomal RU. I'm sure he got the idea from that earlier study.

2) The truly novel and original idea these guys had was altering the standard RU molecule by linking it to a molecule of myristic acid (a fatty acid). What they're claiming is that it improves the ability of the RU molecule (along with the attached fatty acid) to penetrate through the skin by making the whole molecule a little more "fatty". They're saying that even though the combination molecule is not ITSELF an antiandrogen, enzymes within the cell eventually separate the two parts of the molecule again, and the lone RU then goes about its normal and well-known job of efficiently blocking androgen receptors.

Bryan

 

[Guest]

Re: RUM

Below is the information in relation to the vendor of RU. We need a guinea pig on this forum to give it a shot. I have read positive testimonials on this stuff:

Mr. H.Z. Owense
Faith Eagle Ltd.
Shenzhen City, China

???

This H.Z.Owense fella has been emailing me for the past year or so:

Hi again, I noticed that I didn't get a response from my last email to you. I'm using a new tool called Plaxo to update my address book. Your information will not be shared with anyone else. You do not need to download any software or register to send me your information. Please take a moment to review the information below and click the button to correct or confirm your contact information. If you want to update your address book too, get Plaxo at http://www.plaxo.com/downloads.

Thanks,
H. Z. Owense


I have always just deleted his emails (they are always like the one above) tthinking it was some junk mail, but it seems I am a memeber of a secret RU sect ?

I don't remember signing up to anything ?

anyhow here is his email address: htpharm@public.szptt.net.cn


Ty

 

[Buffboy]

So Bryan, what's your take on this RUM-thing? Is it worth the waiting, I mean do you think it will work better than finasteride?

 

[Bryan]

So Bryan, what's your take on this RUM-thing? Is it worth the waiting, I mean do you think it will work better than finasteride?

Whether or not RUM is really an improvement over ordinary RU58841, I have no idea. I have an agnostic attitude toward it. We'll have to see what further testing says about that.

All I can say about RU58841 (in general) versus finasteride is that RU was more effective than finasteride in the stumptailed macaque tests, so unless and until evidence comes out to the contrary, I would probably bet that the same would be true in humans.

Bryan

 

[Buffboy]

So Bryan, what's your take on this RUM-thing? Is it worth the waiting, I mean do you think it will work better than finasteride?

Whether or not RUM is really an improvement over ordinary RU58841, I have no idea. I have an agnostic attitude toward it. We'll have to see what further testing says about that.

All I can say about RU58841 (in general) versus finasteride is that RU was more effective than finasteride in the stumptailed macaque tests, so unless and until evidence comes out to the contrary, I would probably bet that the same would be true in humans.

Bryan

That's the answer I wanted to hear!

Do you think anyone will go through FDA-trials with it? Who owns the patents?

 

[jimmystanley]

HairLossTalk.com...what are your thoughts about taking this product on, promoting it, and selling it through your website?

 

[Bryan]

HairLossTalk.com...what are your thoughts about taking this product on, promoting it, and selling it through your website?

Oh my god...it's even farther away from being a "product" than regular RU58841.

Bryan

 

[jimmystanley]

so...what does that mean exactly? we can't use it for a while?

 

[HairlossTalk]

it's even farther away from being a "product" than regular RU58841.

Yep. Someone will probably come along and pretend they have some of the stuff just to make money off people, but I posted this study purely for the purpose of making our users aware of whats going on hair research. Not because I wanted to make money. I don't work like that.

HairLossTalk.com

 

[jimmystanley]

why not do both? at least u will be giving us something we can get excited about.

 

[HairlossTalk]

Im here first and foremost to educate and help people. The money thing is just a plus that I feel blessed for. It hadn't even crossed my mind to try and sell the stuff. I just got excited by the study and wanted others to read it. Besides, its not available.

HairLossTalk.com

 

[jimmystanley]

how has it not crossed your mind? not meaning to disrespect or anything....but i think every guy on here would agree that we would find it very helpful to see some movement towards us getting to try some...?

 

[HairlossTalk]

I didnt say I wasnt interested in helping you get some. I said (twice now) that it wasn't my focus to try and make money off the discovery of this study. My focus was to share it.

HairLossTalk.com