Yeah dude. You're quite literally just saying sh*t. You have no clue what any of that means, yet you're so confident.
It's weird.
Might as well get on brotzu man, only thing that works.
The Cb (breezula [clascoterone]) Community Thread
- Thread starter Screeech
- Start date
Yeah dude. You're quite literally just saying sh*t. You have no clue what any of that means, yet you're so confident.
It's weird.
Might as well get on brotzu man, only thing that works.
That's fair. I guess it's annoying when people just say sh*t without the footnote that it's all speculation. We don't know sh*t about any of it or what it means.
I just have questions like:
Did the effectiveness actually drop off? Is that what that means? Technically we do not know. We just really don't know. What if they were going through a shed?
Why would they push forward if it already shows to drop off and completely lose effectiveness? This company has millions at stake. They wouldn't. Yet, these researchers with PhD's focusing in this field are moving forward. What are we missing as armchair forum hair experts?
Kudos to you for calling the trinov bullshit. That sh*t was annoying.
I try to understand his videos but a lot of it goes over my head - he's saying it doesn't bind as well as RU58841 but has lower chances of going systemic?
Hi i find the video very clear and instructive. This guys know very well the science behind androgens and hair loss.
Baisically he tries to explain that.
AR competitiveness
1- DHT very competitive to AR 3 to 10 times higher than Test
2- TEST Baseline
3- RU equal to Test, so 3 times less
4- CB the lowest half or event lower of the competitiveness of Test.
CB bind less to AR not very competitive but produce less systemic effect, desnt bind easily to other AR in different tissues.
$295
el_duterino
Senior Member
- Reaction score
- 396
That is not correct
The affinity of bicalutamide for the AR is relatively low as it is approximately 30 to 100 times lower than that of DHT , which is 2.5- to 10-fold as potent as an AR agonist as testosterone in bioassays and is the main endogenous ligand of the receptor in the prostate gland.
BICA is about 2 to 4 times stronger in binding to the AR than hydroxy flutamide, which is about as potent as RU54481. So RU is quite far from T
None of these synthetic anti androgen are as potent as DHT or even close to T.
They work because their number is superior to DHT or T by an order of several thousands or millions more.
Imagine throwing an army of a 1000 elderly women armed with pocket knives against one soldier armed with a shot gun and guess who will win the fight..
- Reaction score
- 3
Thanks for your post, really helped me a lot. I'm thinking of adding CB instead of the RU I'm using currently.
However there are many Stemoxydine product (Serioxyl, Neogenic, Kerastase, Redken Cerafill, Garnier) and I'd like to add 5% CB as well as 5% minoxidil so I only need to apply the lotion once a day. Which one of these products can hold the most ingredients do you think?
- Reaction score
- 14
After an informal chat with my family doctor I got the impression that (1) selected compounding pharmacies should be able to prepare an emulsion or lotion from the acne cream and (2) possibly even increase the concentration of the active ingredient. Nothing certain yet because we didn't discuss Winlevi specifically, just the general principles. Anyway, if that will be the case the question is how much will the cream plus compounding service cost?
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infinitepain
Experienced Member
- Reaction score
- 357
For how long?
I've seen the theory that chronically using receptor agonists may result in catastrofic hairloss long term due increased sensitivity (so this would include RU as well). Haven't seen it refuted so im reluctant to start treatments with those compounds.
- Reaction score
- 32
I’m not sure this is 100% the truth. Wouldn’t transgenders have to perpetually increase dosage forever if this was true?
I think what really happens is that with ageing our we naturally become more sensitive to androgens therefore treatments become less efficacious.
That's what happens when you use antagonists your receptors upregulate by making new receptors and existing ones become more sensitive to try to compensate for the loss of activity. But your body usually cant compensate enough and the drug wins.
- Reaction score
- 5
3 months aprox.
It's not my case, only used Finas for a short period of time.
I'm norwood 1.5 maybe 2 with diffuse thining especially in front.
Well, we all know that the first problem of all of us are the androgens.
Maybe some other aspects making a little difference. In my case,
I have DBT 1 this probably can acelerate the loss, but I need to be honest, if it wasn't for Androgenetic Alopecia I would have a full head of hair.
Sorry for my english.
i used cb from wuhan for 6 month on 8% 2 times a day, it slowes down my hairloss about 30%, without sides......now i use kanes cb, after 3 weeks no hairloss anymore, went down from 8 % to 3 % once a day, and still no hairlos (since 2 months)...but maybee sides (drye eye), i'm not sue it's about the cb.....maybee somebody got the same side effect, maybee it's only tempoary ?...who knows about...i don't like to stop the cb because for me it's a miracle in hairloss.....