The Natural
Established Member
- Reaction score
- 13
"Arachidonate 5-lipoxygenase (5-LOX) is a human enzyme, member of the lipoxygenase family. It transforms Essential Fatty Acids (EFAs) into leukotrienes, which are lipid mediators, responsible for the effects of an inflammatory response. 5-LOX is a current target for pharmaceutical intervention in a number of diseases. 5- LOX inhibitors are also being developed actively researched as hair loss treatments.
There is currently a patent for a 5-Lox inhibitor held by L'Oreal that claims to increase scalp hair growth.
Boswellia Serrata - An herb used in Ayurvedic medicine, has been shown to suppress 5-Lipoxygenase, and other pro-inflammatory factors.
Curcumin - It has been observed that Indian women who use large quantities of tumeric (Curcumin) in their cooking experience an onset on hypertrichosis, (dense hair growth). Curcumin potently inhibits the activity of 5-LOX, along with TGF-B, and both 5 alpha reductase enzymes.
Ginkgo Biloba Extract-In addition to preventing the age related decrease in micro-capillary perfusion to the hair follicle matrix (essential in prevention/treatment of senescent thinning), Ginkgo also reduces levels of tgf-b1 and inhibits 5-LOX.
Nizoral (Ketoconazole) Shampoo- Ketoconazole has been shown to be a potent 5-LOX inhibitor in several studies. This property may be more central to its role in combating hair loss than its ability to inhibit DHT binding. 2 % Nizoral Shampoo has been recommended for years in our treatment protocol, and should be used by all who are concerned with hair loss 2-3 times a week.
Benoxaprofen- a nonsteriodal anti-inflamatory, sold in the U.S. as Oraflex, was a 5-LOX inhibitor that was actually shown to regrow hair. Eli Lilly suspended sales of the drug in 1982 after it reportedly caused several deaths."
There is currently a patent for a 5-Lox inhibitor held by L'Oreal that claims to increase scalp hair growth.
Boswellia Serrata - An herb used in Ayurvedic medicine, has been shown to suppress 5-Lipoxygenase, and other pro-inflammatory factors.
Curcumin - It has been observed that Indian women who use large quantities of tumeric (Curcumin) in their cooking experience an onset on hypertrichosis, (dense hair growth). Curcumin potently inhibits the activity of 5-LOX, along with TGF-B, and both 5 alpha reductase enzymes.
Ginkgo Biloba Extract-In addition to preventing the age related decrease in micro-capillary perfusion to the hair follicle matrix (essential in prevention/treatment of senescent thinning), Ginkgo also reduces levels of tgf-b1 and inhibits 5-LOX.
Nizoral (Ketoconazole) Shampoo- Ketoconazole has been shown to be a potent 5-LOX inhibitor in several studies. This property may be more central to its role in combating hair loss than its ability to inhibit DHT binding. 2 % Nizoral Shampoo has been recommended for years in our treatment protocol, and should be used by all who are concerned with hair loss 2-3 times a week.
Benoxaprofen- a nonsteriodal anti-inflamatory, sold in the U.S. as Oraflex, was a 5-LOX inhibitor that was actually shown to regrow hair. Eli Lilly suspended sales of the drug in 1982 after it reportedly caused several deaths."