the new studied drugs

[Aplunk1]

I thought Curis was being developed as shots into the scalp-- I must be wrong.

 

[powersam]

as to the follicle dying off, i thought it there had been some reasonably conclusive studies done to show they dont die off. something about a patch of bald skin being planted onto another part of the body and the hair growing back. i'll try find the study

 

[erovc]

Hey everyone,

Does anyone know about how long it'll take them to finish the human studies and have the product available to the public? Thanx.

erovc

 

[Felk]

So I'm thinking this Curis thing sounds like another Rogaine/minoxidil. Reasoning? Well, it's a hair growth stimulator. You'll have to take it for life. It's topical and non-systemic which tells me that it's efficacy will be hard to materialize. I mean, look at some of the regimens you all use... you claim maintainance or regrowth, but you really have to stare at a scalp to see a difference in most cases. I'm sure that Curis reads exactly like Rogaine did in its early stages of development. However, depending on a thing or two, it may work!
.

well u are partially right or wrong.

He is partially right or wrong? Wow... you're really going out on a limb there.

My thoughts exactly :lol:

 

[seekinghair]

Beautiful, beatiful, news guys...

Curis Reaches First Preclinical Milestone in Hair Growth Program with Procter & Gamble
3/21/2006 9:00:00 AM EST
Curis, Inc. (NASDAQ: CRIS), a therapeutic drug development company, today announced that it has reached the first preclinical milestone in a hair growth program with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company (NYSE: PG). The program is focused upon the potential development of a topical Hedgehog agonist for hair growth disorders, such as male pattern baldness and female pattern hair loss. As part of the initial agreement signed in September of 2005, P&G agreed to pay Curis up to $2.8 million in preclinical milestones. The first of two preclinical milestones has now been successfully completed.

"This first preclinical milestone represents the successful completion of several initial steps toward our goal of bringing a topical Hedgehog agonist into the clinic for the treatment of hair growth disorders," said Daniel R. Passeri, President and Chief Executive Officer of Curis, Inc. "We are pleased by the progress that the joint research team has made, particularly since our collaboration with Procter & Gamble began only five months ago. We are hopeful that this will be the first of several development achievements that will allow Curis and Procter & Gamble to advance a Hedgehog agonist into clinical development and ultimately succeed in providing an effective treatment for hair growth disorders. Under our collaboration with P&G, Curis has retained an option to co-develop this product from IND filing through Phase II trials. We believe that this co-development structure provides an opportunity for Curis to create additional value for our shareholders."

 

[Aplunk1]

Beautiful, beatiful, news guys...

Curis Reaches First Preclinical Milestone in Hair Growth Program with Procter & Gamble
3/21/2006 9:00:00 AM EST
Curis, Inc. (NASDAQ: CRIS), a therapeutic drug development company, today announced that it has reached the first preclinical milestone in a hair growth program with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company (NYSE: PG). The program is focused upon the potential development of a topical Hedgehog agonist for hair growth disorders, such as male pattern baldness and female pattern hair loss. As part of the initial agreement signed in September of 2005, P&G agreed to pay Curis up to $2.8 million in preclinical milestones. The first of two preclinical milestones has now been successfully completed.

"This first preclinical milestone represents the successful completion of several initial steps toward our goal of bringing a topical Hedgehog agonist into the clinic for the treatment of hair growth disorders," said Daniel R. Passeri, President and Chief Executive Officer of Curis, Inc. "We are pleased by the progress that the joint research team has made, particularly since our collaboration with Procter & Gamble began only five months ago. We are hopeful that this will be the first of several development achievements that will allow Curis and Procter & Gamble to advance a Hedgehog agonist into clinical development and ultimately succeed in providing an effective treatment for hair growth disorders. Under our collaboration with P&G, Curis has retained an option to co-develop this product from IND filing through Phase II trials. We believe that this co-development structure provides an opportunity for Curis to create additional value for our shareholders."

Hooray!! I f*****g love P&G.

 

[seancashmere]

sorry to burst your bubbles guys

But this thing is not "curable." As depressing as it is, but I'm sure many of you have already come to that realization. There's no reason to love Proctor & Gamble any more than you love your proctologist. Curis won't do it, like Dutasteride didn't, like finasteride didn't, like minoxidil didn't. The closest thing known to man that has any efficacy is gin and tonic as far as I'm concerned. In short, don't get your hopes up.

If this was curable, then diabetes would be, asthma would be, cancer would be, AIDS would be, sickle cell anemia would be, herpes would be and even the common cold would be curable. In fact, what is curable? If there's anything at all, it's insignificant. Maybe one day there'll be a male pattern baldness vaccine/innoculation, but until that day there's no hope for us or our offspring. Sorry. :-x

 

[elguapo]

Under our collaboration with P&G, Curis has retained an option to co-develop this product from IND filing through Phase II trials. We believe that this co-development structure provides an opportunity for Curis to create additional value for our shareholders.

Can somebody explain this to me? Does it mean that P&G is sort of "leasing" the product through Phase II trials, and when Phase III trials commence, P&G will completely own the product? And if so, why? Is it because Curis is still a starter company, and doesn't have the money to bring the product through the entire FDA approval process?

 

[seancashmere]

Quote:
Under our collaboration with P&G, Curis has retained an option to co-develop this product from IND filing through Phase II trials. We believe that this co-development structure provides an opportunity for Curis to create additional value for our shareholders.


Can somebody explain this to me? Does it mean that P&G is sort of "leasing" the product through Phase II trials, and when Phase III trials commence, P&G will completely own the product? And if so, why? Is it because Curis is still a starter company, and doesn't have the money to bring the product through the entire FDA approval process?

I think it's because Curis doesn't have the capital umph to market it. Besides marketing, P&G has every facet of capacity to retail a new drug. They can support customers, educate physicians on drug usage, answer to the FDA, QA drug manufacturing, et al. There are a lot of logistics involved and Curis is likely only able to research and develop.

 

[DP]

Re: sorry to burst your bubbles guys

But this thing is not "curable." As depressing as it is, but I'm sure many of you have already come to that realization. There's no reason to love Proctor & Gamble any more than you love your proctologist. Curis won't do it, like Dutasteride didn't, like finasteride didn't, like minoxidil didn't. The closest thing known to man that has any efficacy is gin and tonic as far as I'm concerned. In short, don't get your hopes up.

If this was curable, then diabetes would be, asthma would be, cancer would be, AIDS would be, sickle cell anemia would be, herpes would be and even the common cold would be curable. In fact, what is curable? If there's anything at all, it's insignificant. Maybe one day there'll be a male pattern baldness vaccine/innoculation, but until that day there's no hope for us or our offspring. Sorry. :-x

get a grip man - give it a chance.. it's good to be realistic, it probably isn't the cure but don't be such a pessimist... comments like yours tend to discourage others reading this site for some hope

 

[Aplunk1]

I agree with DP.

Stop being so pessimistic, seancashmere.

 

[Felk]

"always look on the briiiiiiiiight side of life" *eric idle voice*

Seriously though, check it out....

http://healthclock.healthology.com/focu ... ide&spg=FI

So even if the treatments dont work for us, not only should we not discourage ourselves from getting our hopes up, we actually should be positive anyway... for heart health

 

[seancashmere]

"always look on the briiiiiiiiight side of life" *eric idle voice*

Seriously though, check it out....

http://healthclock.healthology.com/focu ... ide&spg=FI

So even if the treatments dont work for us, not only should we not discourage ourselves from getting our hopes up, we actually should be positive anyway... for heart health

Sorry, but my heart doesn't grow hair. What I NEED is folicle health.
APlunk1, sorry man, but you're dellusional. Like me, I'm sure you've scoured these boards, the Internet and whatever readings you could find on this. And like me, you're still getting progressively balder. Fellas, if there was a "real" solution to this thing, there wouldn't be rich bald men. They'd have found the "cure" long ago and stopped this disaster in its tracks. New research is only being done to acheive what past snake oils have, a wad from our collective wallets. Egads men, have you not read the article, the "milestone" is only in relation to Curis' stock potential and bonus income. They'd probably just stabilized the vehicle that will carry whatever finitely usefull chemical they plan to have us apply. It probably was just a matter of whether it be water or petroleum jelly based. It's all esoteric and highly ineffectual. Again, I apologize for giving you all the dosage of reality you unfortunately lack.

 

[Aplunk1]

You don't know sh*t about reality.

You're a complete ***. Don't even try to understand me, or some of the psychological traumas, that I've been through in the past.

You're attitude is that of judgmental. Don't be such a nuisance and leave these forums for people who want to communicate.

 

[Slartibartfast]

Under our collaboration with P&G, Curis has retained an option to co-develop this product from IND filing through Phase II trials. We believe that this co-development structure provides an opportunity for Curis to create additional value for our shareholders.

Can somebody explain this to me? Does it mean that P&G is sort of "leasing" the product through Phase II trials, and when Phase III trials commence, P&G will completely own the product? And if so, why? Is it because Curis is still a starter company, and doesn't have the money to bring the product through the entire FDA approval process?

They've licensed the product to P&G, who have agreed to make a series of 'milestone' payments to Curis at various stages of the drug's development, in addition to a royalty fee should the product reach the market. I suspect the "co-development structure" refers to an option that Curis can choose to exercise, whereupon they will shoulder some (presumably half) of the cost of phase I and II trials in return for a higher royalty fee - exercising said option may also affect (ie. reduce) the milestone payments Curis receive.

Slarti

 

[Felk]

Sorry, but my heart doesn't grow hair. What I NEED is folicle health.
APlunk1, sorry man, but you're dellusional. Like me, I'm sure you've scoured these boards, the Internet and whatever readings you could find on this. And like me, you're still getting progressively balder. Fellas, if there was a "real" solution to this thing, there wouldn't be rich bald men. They'd have found the "cure" long ago and stopped this disaster in its tracks. New research is only being done to acheive what past snake oils have, a wad from our collective wallets. Egads men, have you not read the article, the "milestone" is only in relation to Curis' stock potential and bonus income. They'd probably just stabilized the vehicle that will carry whatever finitely usefull chemical they plan to have us apply. It probably was just a matter of whether it be water or petroleum jelly based. It's all esoteric and highly ineffectual. Again, I apologize for giving you all the dosage of reality you unfortunately lack.

Sorry but it is you whose grasp on reality is faulty. Actually, i shouldn't be saying sorry as this is beneficial advice for you.

Firstly, since my father is a philosopher, who specialises in realism, rationality and critical thinking, he has taught me when someone is basing statements on reality. Your "reality" is based on observation (always a shaky base) of a tiny sample space of "rich bald men" and therefore completely unpredictable. In addition is it completely coloured by your way of perceiving things.

However though the question "Why are there so many rich bald men?" is a good one, your sudden conclusion of "there is no real treatment for male pattern baldness!" unfortunately is not. Other possible factors you failed to take into account are the stressful lives that rich businessman lead, their boosted success with women due to their money (thus removing the need for their hair), the fact that they are older and didnt have access to treatments we do now.

Sorry, but my heart doesn't grow hair. What I NEED is folicle health.
APlunk1, sorry man, but you're dellusional.

Now from an eastern philosopher's perspective that was the perfect example of delusion, in this case a disabilitating obsession over your hair. Your delusions tell your mind that you can't be happy without hair, and the idea of losing it causes you pain. Actually, the only thing you need to be happy is a mind. Happiness is something that occurs in the mind, therefore the key to true happiness must be within the mind. You might think that you need your hair to be happy and feel good, but, actually, you do not.

Now the reason im not apologising for telling you this is that the realisation that the pain we experience from male pattern baldness is actually caused by an attachment to our hair, something we can learn to deal with and prevent just like any other negative emotion, brings about a great sense of peace and freedom. True happiness has nothing to do with hair, it has to do with the heart and mind

Honestly, in 20 years time you will look back and see how you were now and do you really believe you will think "god... im so glad i was doubtful about treatments... im so glad i didnt have any hope for my hair... i would have been so dissapointed" No, you will think, "god... what was i so worried about back then?!?" Actually, you wont think any of these, you will simply look back with fondness at your younger days, (and, possibly, your head of hair ) and perhaps wish you were young and trouble-free again (an unrealistic view from back then, but one that allows us to live in the present happily, without fear and anxiety)

Anyway, enough of the that, i got diverted You're right, there is no "real" cure, but there are treatments, and these new ones look promising

 

[Solo]

Amen.

 

[seancashmere]

seancashmere wrote:

Sorry, but my heart doesn't grow hair. What I NEED is folicle health.
APlunk1, sorry man, but you're dellusional. Like me, I'm sure you've scoured these boards, the Internet and whatever readings you could find on this. And like me, you're still getting progressively balder. Fellas, if there was a "real" solution to this thing, there wouldn't be rich bald men. They'd have found the "cure" long ago and stopped this disaster in its tracks. New research is only being done to acheive what past snake oils have, a wad from our collective wallets. Egads men, have you not read the article, the "milestone" is only in relation to Curis' stock potential and bonus income. They'd probably just stabilized the vehicle that will carry whatever finitely usefull chemical they plan to have us apply. It probably was just a matter of whether it be water or petroleum jelly based. It's all esoteric and highly ineffectual. Again, I apologize for giving you all the dosage of reality you unfortunately lack.


Sorry but it is you whose grasp on reality is faulty. Actually, i shouldn't be saying sorry as this is beneficial advice for you.

Firstly, since my father is a philosopher, who specialises in realism, rationality and critical thinking, he has taught me when someone is basing statements on reality. Your "reality" is based on observation (always a shaky base) of a tiny sample space of "rich bald men" and therefore completely unpredictable. In addition is it completely coloured by your way of perceiving things.

However though the question "Why are there so many rich bald men?" is a good one, your sudden conclusion of "there is no real treatment for male pattern baldness!" unfortunately is not. Other possible factors you failed to take into account are the stressful lives that rich businessman lead, their boosted success with women due to their money (thus removing the need for their hair), the fact that they are older and didnt have access to treatments we do now.

Quote:
Sorry, but my heart doesn't grow hair. What I NEED is folicle health.
APlunk1, sorry man, but you're dellusional.


Now from an eastern philosopher's perspective that was the perfect example of delusion, in this case a disabilitating obsession over your hair. Your delusions tell your mind that you can't be happy without hair, and the idea of losing it causes you pain. Actually, the only thing you need to be happy is a mind. Happiness is something that occurs in the mind, therefore the key to true happiness must be within the mind. You might think that you need your hair to be happy and feel good, but, actually, you do not.

Now the reason im not apologising for telling you this is that the realisation that the pain we experience from male pattern baldness is actually caused by an attachment to our hair, something we can learn to deal with and prevent just like any other negative emotion, brings about a great sense of peace and freedom. True happiness has nothing to do with hair, it has to do with the heart and mind

Honestly, in 20 years time you will look back and see how you were now and do you really believe you will think "god... im so glad i was doubtful about treatments... im so glad i didnt have any hope for my hair... i would have been so dissapointed" No, you will think, "god... what was i so worried about back then?!?" Actually, you wont think any of these, you will simply look back with fondness at your younger days, (and, possibly, your head of hair ) and perhaps wish you were young and trouble-free again (an unrealistic view from back then, but one that allows us to live in the present happily, without fear and anxiety)

Anyway, enough of the that, i got diverted You're right, there is no "real" cure, but there are treatments, and these new ones look promising

Very good stuff there Felk. I tip my brim. However, like my observations of rich bald men (which I thought was clearly hyperbole or fudging perceptions to get a point across) your "happiness is in the mind" theory is just as suspect. Although my observations are anecdotal, they're still real world observations, not haphazard play on semantics or sugar coated idle ruminations. Your "happiness is in the mind" routine works for those who are, for the most part, already happy. My colloqiums in reality actually play out in real life. It's like the difference from just practicing medicine out of med school as opposed to practicing medicine with 30 years experience (the right way isn't always what's described in the text, it's what's best applied in the office). I'm only begging to differ, I'm not saying you're wrong. This is all opinion. I feel I'm enlightening the board to a more practical sense of going about this thing... you on the other hand prefer the optimistic outlook. It's cool by me but essentially neither one of us will get the desired results (more hair)! I'll down a beer in your name though!

 

[powersam]

you are talking about philosophy, semantics and anecdotal evidence in a topic where all that matters is science, properly documented science. haircounts, dht levels, inflammation levels, percentages of success and side effects. these are what matter in the hairloss game, not your perception of reality or your happy state of mind.

there are many avenues showing promise and many which have already shown they can halt and reverse the balding process. as to a cure? i think a cure is available today, by following a multifaceted approach using treatments available and using modern medicine to diagnose other conditions which may be exacerbating the hairloss such as thyroid conditions and insulin resistance.

 

[Aplunk1]

there are many avenues showing promise and many which have already shown they can halt and reverse the balding process. as to a cure? i think a cure is available today, by following a multifaceted approach using treatments available and using modern medicine to diagnose other conditions which may be exacerbating the hairloss such as thyroid conditions and insulin resistance.

I second this.