So this diagram... So a decrease of PGD2 can cause an increase chance of prostate cancer? So taking seti is practically increasing my chances of prostate cancer?
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The Oral Seti Results Update Thread
- Thread starter Alex Contee
- Start date
Hey can anyone tell me what's the lowest price they were quoted for a gram of seti?
the prices i got were 5.8-6.8/gram depending on the quantity of purchase, anyone got a better deal?
Also to people who are already using seti what would you say is a solid amount to take daily for maintenance ( i know that 2 doses of 1gram a day is best but that's quite expensive to handle).
the prices i got were 5.8-6.8/gram depending on the quantity of purchase, anyone got a better deal?
Also to people who are already using seti what would you say is a solid amount to take daily for maintenance ( i know that 2 doses of 1gram a day is best but that's quite expensive to handle).
Sanchez1234
Experienced Member
- Reaction score
- 311
Nobody got results?Why not using it topically ???
- Reaction score
- 133
Hey can anyone tell me what's the lowest price they were quoted for a gram of seti?
the prices i got were 5.8-6.8/gram depending on the quantity of purchase, anyone got a better deal?
Also to people who are already using seti what would you say is a solid amount to take daily for maintenance ( i know that 2 doses of 1gram a day is best but that's quite expensive to handle).
You find a good supplier?
1) what u linked is from this https://www.sciencedirect.com/science/article/pii/S0306987714000279 and as u can see from the title it is a medical hypotheses , and not something tested and confirmed . Although i do believe in a connection between pgd2 and dht , i have yet to see a study on their relation
2)cool story mate , whatever.
3)0.25% w/v sounds tiny , but it is not tiny , as 1 ml contains 2.5 mg of finasteride .
some people report sides because h&w dosage is huge (2.5 % ) , not sure why they chose it
google p3074 phase 2 and see how 0.22 and 0.44 mg with their vehicle topically behave , when you say all attempts failed which attempts do u speak of ?
4)after 3 theres is a 4 usually
5) I ve read a ton of stuff on HairLossTalk.com btt hlh over the years , and a good deal of them are dubious , some are pure trash . If you want to make bold statements you better link reliable sources . Otherwise you should phrase them to not sound like facts , because you might educate readers on false info
1) No, that sciencedirect study actually hypothesizes that increased levels of DHT and thus PGD2 in those w/ Androgenetic Alopecia may have developed to protect those men from prostate cancer. Not anything I was talking about. The chart cited in that hypothesis, showing downstream metabolites of ARA though, is based on many proven studies thus why I liked just the chart. I don't suppose you believe there's a connection between pgd2 and dht b/c it just seems, oh I don't know, logical, even though we don't yet know for sure?
2) You asked for clarification, I answered. Way to be a petty c***.
3) Yes, phase 2 showed smaller doses reduced scalp DHT by less, and went systemic less. Still went systemic. ~50% scalp reduction for 24 - 48% serum reduction is not exactly a success IMO either.
4) I was obviously responding to your bullet points w/ the same #) as yours. Since you didn't have anything to really say w/ your 4), I didn't either. Please see my point 2) above if need be.
5) Yes, I agree that the public hairloss forums are cesspools of general idiocy, misinformation, and anecdotal reports at best. Maybe you should reread Pigeon's previous post, then TK421's reply to his, and then read my reply to TK421 in actual context. It was obviously the most simple and straight fwd way to explain why, logically, Seti probably wouldn't work for someone if Fina already didn't.
"showing downstream metabolites of ARA though, is based on many proven studies thus why I liked just the chart" link them , i didnt find any .1) No, that sciencedirect study actually hypothesizes that increased levels of DHT and thus PGD2 in those w/ Androgenetic Alopecia may have developed to protect those men from prostate cancer. Not anything I was talking about. The chart cited in that hypothesis, showing downstream metabolites of ARA though, is based on many proven studies thus why I liked just the chart. I don't suppose you believe there's a connection between pgd2 and dht b/c it just seems, oh I don't know, logical, even though we don't yet know for sure?
2) You asked for clarification, I answered. Way to be a petty c***.
3) Yes, phase 2 showed smaller doses reduced scalp DHT by less, and went systemic less. Still went systemic. ~50% scalp reduction for 24 - 48% serum reduction is not exactly a success IMO either.
4) I was obviously responding to your bullet points w/ the same #) as yours. Since you didn't have anything to really say w/ your 4), I didn't either. Please see my point 2) above if need be.
5) Yes, I agree that the public hairloss forums are cesspools of general idiocy, misinformation, and anecdotal reports at best. Maybe you should reread Pigeon's previous post, then TK421's reply to his, and then read my reply to TK421 in actual context. It was obviously the most simple and straight fwd way to explain why, logically, Seti probably wouldn't work for someone if Fina already didn't.
You dont state things as facts because they sound logical to you , thats not how science works.
Serum DHT was reduced by only -24/-26% with 100 and 200 μL , The doses of 100 and 200 μL P-3074 resulted in a -47/-52% scalp DHT reduction , so 25 % serum with 50 % scalp doesnt look good to you ? Oh yeah you wrote 24-48 to prove your point , you took the numbers from 300/ 400 ml although the point of the study was the efficacy of the 100/200 ml as easily seen by the conclusion :
CONCLUSIONS:
The novel finasteride 0.25% solution applied o.d. at the doses of 100 and 200 μL results in an appropriate inhibition of scalp DHT potentially minimizing the untoward sexual side-effects linked to a systemic DHT reduction.
Your original post stated that topical finasteride doesnt work , which you dont know if it does , and also stated that setipiprant works (which we still dont know if and how well it works, allergan studies are not out yet ) , but you say its effect is relative to finasteride's , since you target pgd2 instead of dht, believing that dht acts through and upregulates pgd2 (which you dont know if it is true and to what extent) .
I called you out because you stated your beliefs as facts , and still do .
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Seems like it's either lyphar or lewis who is the contact of zhe chem or w/e he's called, people on the forum have bought from both andYou find a good supplier?
got it tested which turned out good as far as I've heard.
"showing downstream metabolites of ARA though, is based on many proven studies thus why I liked just the chart" link them , i didnt find any .
You dont state things as facts because they sound logical to you , thats not how science works.
Serum DHT was reduced by only -24/-26% with 100 and 200 μL , The doses of 100 and 200 μL P-3074 resulted in a -47/-52% scalp DHT reduction , so 25 % serum with 50 % scalp doesnt look good to you ? Oh yeah you wrote 24-48 to prove your point , you took the numbers from 300/ 400 ml although the point of the study was the efficacy of the 100/200 ml as easily seen by the conclusion :
CONCLUSIONS:
The novel finasteride 0.25% solution applied o.d. at the doses of 100 and 200 μL results in an appropriate inhibition of scalp DHT potentially minimizing the untoward sexual side-effects linked to a systemic DHT reduction.
Your original post stated that topical finasteride doesnt work , which you dont know if it does , and also stated that setipiprant works (which we still dont know if and how well it works, allergan studies are not out yet ) , but you say its effect is relative to finasteride's , since you target pgd2 instead of dht, believing that dht acts through and upregulates pgd2 (which you dont know if it is true and to what extent) .
I called you out because you stated your beliefs as facts , and still do .
Yes, those results are sh*t IMO. 50% scalp reduction may be enough to stop some people's loss and may not for others. All these years and there still isn't an effective, sideless topical finasteride on the market. Who knows, maybe it'll happen some day but I really don't care either way and I see no point in arguing about it further. Will leave it to the rest of this forum to complain about their mostly imaginary sides while waiting for their topical holy grail.
And where did I state that Seti works? Where did I state its effect is relative to finasteride? As facts? Maybe if I had posted "ALL FACTS" instead of "THUS LOGIC" at the end of my "finasteride or dutasteride = less DHT = less PGD2. Seti/fevi = less PGD2." blurb then you might have a point. As it stands, you're complaining about my wording. B/c my wording made YOU interpret what I said as if it was factual and not a probable deduction. When taken out of context. Thread derailed enough. Get over it.
And for the record, we actually do know dht upregulates pgd2. Here's a study showing such: www.mdpi.com/1422-0067/19/2/556/pdf And yes, to what extent pgd2 is the culprit of Androgenetic Alopecia we don't yet know, thus why we're all waiting to see Allergan's results, and again what this thread is supposed to be about.
Why did you quit pigeon? If you achieved maintenance why would you stop?Lol, I quit fina because of sides and went to seti.
No, I'm off it for 2 months now. Been on it for 7 months although at a very low dose 200mg/day. Look a page or two back to know my results.
Sure, I agree, I'm not a scientist, just my theory. Anyway we'll know official results soon enough I hope since trials ended.
Used 2g seti for 1 month : a lot of itch (which I haven't had for years, I have very mild Hairloss) and had more shed than before. Also had trouble sleeping. So made me decide to stop.
After 3 months I started again, but now with just 0.5 g a day. : no itch, it stopped hairs falling out and no sleeping problems.. So this gives me hope. Btw it's the same batch of seti.
Perhaps it is dose depending on the aggressiveness of your Androgenetic Alopecia. Maybe to much suppresion of pgd2 is also not good, maybe it is the ratio of pgd2 and pge2.? Who knows...
After 3 months I started again, but now with just 0.5 g a day. : no itch, it stopped hairs falling out and no sleeping problems.. So this gives me hope. Btw it's the same batch of seti.
Perhaps it is dose depending on the aggressiveness of your Androgenetic Alopecia. Maybe to much suppresion of pgd2 is also not good, maybe it is the ratio of pgd2 and pge2.? Who knows...
- Reaction score
- 85
Had maintenance for a long time but after 6 months+ had a shed that lasted more than a month. Was running out of supply, etc.
And wanted to quit for a while to see if I there were any changes.
So you took seti for 6 months and had maintenance, stopped and then had a shed that lasted more than a month. Is your hair doing worse now that your off seti and what are you taking?
Ahh I see. Yeah I’ve actually been in seti for like 5 months now? No itch at all. About to run out and ordered 100g more. Going to see how my hair looks at the end of the year and determine if I’ve actually held my ground.Had maintenance for a long time but after 6 months+ had a shed that lasted more than a month. Was running out of supply, etc.
And wanted to quit for a while to see if I there were any changes.
- Reaction score
- 133
Any updates from you guys?
I am taking seti for a month now, shedding lots of long healthy hairs now.
Is the shedding going to stop?
Got my seti from kane.
Is your shedding worse or the same?
My shed lasted up to my 5th week I think? I shed a few healthy hairs as well.Any updates from you guys?
I am taking seti for a month now, shedding lots of long healthy hairs now.
Is the shedding going to stop?
Got my seti from kane.
- Reaction score
- 12
I just got 1 gram of PGE2, I'll by trying it as prescribed in this thread.
1mg PGE2 with 3 ml distilled water every 2-3 days plus micro needling.
I've been trying to verify this method of delivery for PGE2 if anyone has other methods or is using this one at this frequency let me know.
Thanks!
1mg PGE2 with 3 ml distilled water every 2-3 days plus micro needling.
I've been trying to verify this method of delivery for PGE2 if anyone has other methods or is using this one at this frequency let me know.
Thanks!
- Reaction score
- 133
I am also on finasteride for 18 months so I dont really know which one induced the shed.
But I cant remember to have such a shed before on finasteride only. Just maintenance on finasteride.
Well the shed is worse, I definitely lost ground.
I hope the hair regrows..
Did you mostly shed minituarized hairs while being on Seti?
Did it help with your itching?