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Lyphar , you?
The Oral Seti Results Update Thread
- Thread starter Alex Contee
- Start date
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So, is it working ?
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- 320
Of course it is, it's a CRTH2 blocker.
Why don't you test it yourself? Everyone is different
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Still quite expensive and even if i'm eager to finally stop 5AR after 13 years, i guess i'm too coward to drop it right away and go to another regimen.
Kinda trapped in my own fear
Not for me, but even finasteride didn't work for me. Are you currently on fina or dutasteride? I don't think it's worth adding seti to your regimen if you're already getting results from anti androgens.
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Yep, been somewhat maintaining for 13 years on finasteride and Keto 2% shampoo, but the sides from finasteride really start to piss me off, i feel off and completely exhausted, free T is low, i really need to get off this sh*t now, been waiting long enough, tired of messing with my hormones
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PGD2 promotes AR and AKT signal via DP2, thus, PGD2 and DP2 signal plays a critical role in AR expression.
And it acts lower on the chain
If you're so afraid you can still take fina once or twice/week + seti.
And I agree it's still a lil expensive but in 2 yo max, price will drop for sure
We're near bro
If you're no longer able to handle the sides of fina then I'd recommend giving seti a try. Have you tried topical fina? Some people claim to get the benefits without the sides. I was really interested in topical fina recently, but now I'm having doubts it would do anything for me since I never got any results from oral fina.
So based on that logic, if oral fina doesn't work than neither would topical fina and dutasteride, right?
No, topical fina doesn't generally work b/c DHT is still running through your bloodstream and hitting your follicles from below. dutasteride blocks both types of 5AR whereas finasteride only blocks type 2. finasteride or dutasteride = less DHT = less PGD2. Seti/fevi = less PGD2. Thus logic.
That is a typical kind of post in here , but :
What are your sources about the connection between dht and pgd2 ?
Why would a paracrine hormone like dht damage you through the serum levels ? and what would be the impact of serum dht ?
These are opinions but they are stated like facts , which is potentially misleading to viewers
i've just ordered lyphar's seti. had bad sides from finasteride (sexual sides) so i had to quit two years ago. i am on minoxidil alone and my hairloss is getting much worse the past few months.
Stupid question: i have an appotintment in one month with a dermatologist/hair specialist. they also have a lab there... do you think i can ask them if they can test the seti for purity ? i dont trust online labs like jashonik (something like that).
Also would you recommend to do a check-up after some months with a doctor ? what should i look out for ?
this will be my last option, if this doesen't work i have to get a hair system.
Stupid question: i have an appotintment in one month with a dermatologist/hair specialist. they also have a lab there... do you think i can ask them if they can test the seti for purity ? i dont trust online labs like jashonik (something like that).
Also would you recommend to do a check-up after some months with a doctor ? what should i look out for ?
this will be my last option, if this doesen't work i have to get a hair system.
it has been proved for years now that only DHT 5ar-reduced in the follicle hits.
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So, Kane has two types of Seti — sodium seti and just seti. Would there be any issues buying the regular seti from Kane? Seems that’s the easiest method, provided it’s pure, right? I was thinking I could buy my first 100g from Kane, and trial at 500mg/twice a day for 3 months. If I don’t see any positive results within first 80 days, I’ll try and buy from Lyphar and up dosage to 1g/twice a day.
Would anyone advise against this? I’m in my early stages of hair loss (receding faster on one side than the other), and want to be proactive! I’m going in for another derm appt next week... hoping to get on finasteride, but a little bit nervous about the sides.
Would anyone advise against this? I’m in my early stages of hair loss (receding faster on one side than the other), and want to be proactive! I’m going in for another derm appt next week... hoping to get on finasteride, but a little bit nervous about the sides.
Sanchez1234
Experienced Member
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Just do 2grams a day from lyphar. If it works you could lower dose
You can find multiple sources/studies showing that pgd2 is a downstream metabolite of dht if you just google it, or even search in this very forum. It is a fact and one that is (or should be) widely known on a hairloss forum, especially here in the New Research section.
Nowhere did I state that dht damages you through serum levels? I stated that topical fina generally doesn't work--reason being that it always goes systemic to some extent and thus decreases serum level of dht. Even HandW's recent attempt at a topical showed 5 - 40% reduction in serum dht w/ those patients they did blood tests on. Here's a good example that shows how the body cannot keep up w/ 5ar production vs. fina, whether topically or orally, as it is a suicide inhibitor (also a fact btw): https://imgur.com/a/YNrdd
And we know both seti/fevi are pgd2 receptor antagonists. Also facts.
While specifically replying to a post re: logic, i.e. making a possible or probable conclusion based on known facts so far, should have been enough of a caveat, I'm still not sure where you think what I stated was just opinions anyway?
1)I said sources , not tell me to google it or that its common knowledge, i mean actual research to back your claims.Since you found out about the conection it is not hard to give me the link to the study.
2)"Nowhere did I state that dht damages you through serum levels?" vs "topical fina doesn't generally work b/c DHT is still running through your bloodstream and hitting your follicles from below"
3)what you linked was research on 2.25 mg of topical finasteride , that is definitely going to go systemic with the common vehicles.
4)I didnt say anything about seti / fevi but yeah i believe you
5)Unless you have conducted research on a big enough sample and for a considerable amount of time , or you can link someone else's research confirming what you say is true , then it is just your opinion . I am also not convinced that what you were based were indeed facts , more like broscience and forum urban legends ! Still waiting for your sources though !
1)I said sources , not tell me to google it or that its common knowledge, i mean actual research to back your claims.Since you found out about the conection it is not hard to give me the link to the study.
2)"Nowhere did I state that dht damages you through serum levels?" vs "topical fina doesn't generally work b/c DHT is still running through your bloodstream and hitting your follicles from below"
3)what you linked was research on 2.25 mg of topical finasteride , that is definitely going to go systemic with the common vehicles.
4)I didnt say anything about seti / fevi but yeah i believe you
5)Unless you have conducted research on a big enough sample and for a considerable amount of time , or you can link someone else's research confirming what you say is true , then it is just your opinion . I am also not convinced that what you were based were indeed facts , more like broscience and forum urban legends ! Still waiting for your sources though !
1) Here's a post here on HairLossTalk.com showing a diagram of what Kythera's current study/hypothesis (and this thread) is all about that I was able to find through google: https://www.hairlosstalk.com/interact/threads/setipiprant-frequently-asked-questions.111509/
But I'll admit I mispoke above. I didn't mean to say PGD2 is directly downstream from DHT, but rather DHT increases PTGDS, which in turn increases PGD2 downstream from ARA. Here's an easy diagram to visualize my initial statement that less DHT = less PGD2:
2) By "hitting" I didn't mean "damaging", if that's what you're getting at. You've got blood vessels all throughout your scalp, and they're attached to and "feed" your follicles. Good luck putting something on your scalp that will reach your follicles and not your bloodstream. So you don't have to google that:
3) That's a quarter of a percent solution. TINY. Here's the full study, which concludes that, "A strong and similar inhibition of plasma DHT was found after 1 week of treatment with the topical and tablet finasteride formulations, albeit finasteride plasma exposure was significantly lower with the topical than with the oral product (p<0.0001)."
https://www.researchgate.net/profil...ndrogen-levels-in-healthy-male-volunteers.pdf Again, b/c finasteride is a suicide inhibitor, plasma exposure in any amount is still plasma exposure. That's why people continue to report sides on HandW's topical product, and why other attempts at a topical DHT-inhibitor have all failed so far.
5) If a study's already been posted in this very forum, do you honestly expect users to repost it every time they make mention of it? It's not my job to educate you. You can either read up yourself (like I did) or you can continue to stay in the dark and shout "broscience" at your leisure. Totally your call, man.
1) what u linked is from this https://www.sciencedirect.com/science/article/pii/S0306987714000279 and as u can see from the title it is a medical hypotheses , and not something tested and confirmed . Although i do believe in a connection between pgd2 and dht , i have yet to see a study on their relation
2)cool story mate , whatever.
3)0.25% w/v sounds tiny , but it is not tiny , as 1 ml contains 2.5 mg of finasteride .
some people report sides because h&w dosage is huge (2.5 % ) , not sure why they chose it
google p3074 phase 2 and see how 0.22 and 0.44 mg with their vehicle topically behave , when you say all attempts failed which attempts do u speak of ?
4)after 3 theres is a 4 usually
5) I ve read a ton of stuff on HairLossTalk.com btt hlh over the years , and a good deal of them are dubious , some are pure trash . If you want to make bold statements you better link reliable sources . Otherwise you should phrase them to not sound like facts , because you might educate readers on false info
2)cool story mate , whatever.
3)0.25% w/v sounds tiny , but it is not tiny , as 1 ml contains 2.5 mg of finasteride .
some people report sides because h&w dosage is huge (2.5 % ) , not sure why they chose it
google p3074 phase 2 and see how 0.22 and 0.44 mg with their vehicle topically behave , when you say all attempts failed which attempts do u speak of ?
4)after 3 theres is a 4 usually
5) I ve read a ton of stuff on HairLossTalk.com btt hlh over the years , and a good deal of them are dubious , some are pure trash . If you want to make bold statements you better link reliable sources . Otherwise you should phrase them to not sound like facts , because you might educate readers on false info