The Role Of Estrogen In The Preservation And Regrowth Of Frontotemporal Hairline

Saulus

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Fuckin hell frontal hair is everything once you reach norwood 3 aka pedohairline its over

Can we microdose estrogen or spironolactone?
 
Saulus

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"The seven known men in whom aromatase is nonfunctional all have a mutation in either exon V or IX of the CYP19 gene, which encodes aromatase. Collectively, these men are reported to have undetectable estrogen; normal to high levels of testosterone and gonadotropins; tall stature with delayed skeletal maturation and epiphyseal closure; osteoporosis; impaired lipid and insulin metabolism; and impaired reproductive function. The aromatase knockout mouse presents with a phenotype that is similar in many aspects and provides a valuable tool with which to examine and manipulate the actions of estrogen. By studying the naturally occurring aromatase-deficient humans, together with studies of the aromatase-knockout mouse, we are expanding our understanding of the essential role of estrogen in male physiology."

https://www.ncbi.nlm.nih.gov/pubmed/16480891?dopt=Abstract

I wonder how the hair of these men looks like
 
CinnamonRoll

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I believe that progesterone plays a much larger role in hair loss than does estrogen.
http://drramanstl.com/2016/05/23/hormones-affect-hair-skin-nails/
  1. Elevated Androgens. Estrogen dominance results when estrogen is higher in RELATION to progesterone. Although the absolute value of estrogen declines, the estrogen/progesterone ratio favors estrogen dominance. Estrogen dominance causes estrogen to convert to testosterone. Elevated levels of testosterone triggers a chain reaction which ultimately leads to the typical “male pattern baldness” in both men and women.
    Treatment: Balance estrogen/progesterone ratio with natural compounded progesterone. Restoring depleted progesterone levels helps decrease estrogen dominance and thereby decreases conversion to testosterone.
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@CinnamonRoll
I've been using topical spironolactone cream. I feel that contrary to growing any hair, it's having a negative affect. What do you think?
 
can'tBeatNature

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Choi Han Kyul said:
I have read few testimonies, mostly asian males reversing male pattern baldness (twohen is one such example). My observation is that these asians mostly hail from China, Korea, Japan.

I have been wondering how much does poor nutrition contribute to male pattern baldness. How do you define poor nutrition? Is it the blood tests?

Similary, what impact does stress has on male pattern baldness? What could be defined as stress. Do extreme thoughts like suicide count as a sign of deep rooted stress.

Is it also possible that these factors keep on accumulating over time like moss on a rolling stone till the stone loses its identity at a certain point of inflexion. Analogy is apparent male pattern baldness upon accumulation of these agents.

I have been on medication for a while and the not so consoling fact is that my hair has worsened. This is forcing me to adopt an extreme regimen. The fact of the matter is that I have lost enough hairs in past 3 months than I had lost in past 3 years.

There is a constant struggle against and just makes me contemplate, how life is weird. Time, the biggest currency is all going down the drain for the sake of vanity. A man mad over mane sinks in the abyss of insanity.

Attica. Attica.
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I think asian men in general have better hair genetics than whites. I've read somewhere that asian men's hair stay in the anagen-phase longer than other races, and asian men in general have the least amount of testosterone than any race. They also produce more estrogen than other males from different races. So less androgens + more estrogen, along with their high omega fatty acid/anti-inflammatory diets probably contribute to their better hair. I myself am half white and asian, but dealing with hair-loss means I don't have the best hair genetics, but my brother who leans more on the asian side is a year older than me, not suffering any hair-loss and has a perfect hairline, can't grow facial hair and has generally more feminine features like plump, soft skin, less angular facial bone-structure. Unlike me, I can grow a beard, have curly hair like my father, weaker norwood-1, thinner hair, more masculine features, rougher skin-- but my hair at the same age of my father is much, much better. My father at 26 was already a Norwood-2.5 with little to no temple region. All of my mother's brothers, and her father, have perfect-teenage hairlines with super dense and thick hair. Looking at a picture of my Dad when he joined the navy at 18, I still have a better head of hair, much better hairline, etc. But he looked much more masculine than me. I probably do have higher estrogen levels than whites of the same age. I look much younger than full white men of the same age or little younger. Differences being in skin quality, etc. A girl I'm currently seeing says I have really long, luscious eyelashes. Haha. But I eat like sh*t and so does my brother. I think it has more to do with genetics over anything else.
 
bridgeburn

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can'tBeatNature said:
I think asian men in general have better hair genetics than whites. I've read somewhere that asian men's hair stay in the anagen-phase longer than other races, and asian men in general have the least amount of testosterone than any race. They also produce more estrogen than other males from different races. So less androgens + more estrogen, along with their high omega fatty acid/anti-inflammatory diets probably contribute to their better hair. I myself am half white and asian, but dealing with hair-loss means I don't have the best hair genetics, but my brother who leans more on the asian side is a year older than me, not suffering any hair-loss and has a perfect hairline, can't grow facial hair and has generally more feminine features like plump, soft skin, less angular facial bone-structure. Unlike me, I can grow a beard, have curly hair like my father, weaker norwood-1, thinner hair, more masculine features, rougher skin-- but my hair at the same age of my father is much, much better. My father at 26 was already a Norwood-2.5 with little to no temple region. All of my mother's brothers, and her father, have perfect-teenage hairlines with super dense and thick hair. Looking at a picture of my Dad when he joined the navy at 18, I still have a better head of hair, much better hairline, etc. But he looked much more masculine than me. I probably do have higher estrogen levels than whites of the same age. I look much younger than full white men of the same age or little younger. Differences being in skin quality, etc. A girl I'm currently seeing says I have really long, luscious eyelashes. Haha. But I eat like sh*t and so does my brother. I think it has more to do with genetics over anything else.
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probably from eating phytoestrogens in soy for so many generations? lol. that would also mean more people producing s-equol which binds itself to Dht.
 
CinnamonRoll

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mooreu said:
@CinnamonRoll
I've been using topical spironolactone cream. I feel that contrary to growing any hair, it's having a negative affect. What do you think?
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I've yet to see convincing evidence that anyone has made a formula for spironolactone that consistently penetrates deep enough to make a difference. I know a small portion of guys who use topical spironolactone do get positive results, but most get nothing at all. So I'd suspect any negative effect of the spironolactone is probably the carrier and not the spironolactone itself.

Saulus said:
Does finasteride affect progesterone?
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I know it very mildly raises estrogen, which would aggrevate estrogen dominance. I can't find any specifics on whether it alters progesterone levels.

The only study I can find with finasteride and progesterone is here
https://www.ncbi.nlm.nih.gov/pubmed/10983877

Which does have some interesting findings
Progesterone inhibited DHT synthesis in HGF from 14C-testosterone by 24-62% (n = 8; p < 0.01). Finasteride caused 59 82% inhibition (n=8;p<0.01). The combination of P+F showed a similar degree of inhibition (68-78%) of DHT synthesis to that of F alone
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Saulus

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pic of a male who suffers of a genetic deffect and doesnt produce aromatase

ncpendmet0477-f1.jpg


https://academic.oup.com/jcem/article/95/4/1626/2596671


frontal hair seems ok
 
Saulus

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rclark said:
You're referring to Klines Syndrome (YXX), am I correct?
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no its NOT klinefelter


its disease where man dont produce aromatase due a genetic defect and thus have zero estrogen

only 8 people have been diagnosed with this condition so far


they are so tall bc estrogen close the growth palates. aromatase inhibitors are used in growth therapy for this reason
 
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