Topical Finasteride VS Topical Dutasteride (Side effects)

[whymedamn]

Topical finasteride seems to maybe have less side effects (there is some research on this online).

BUT I am now hearing that Topical Dutasteride is even better tolerated (even less side effects) than Topical Finasteride.

That sounds counter intuitive to me as Dutasteride is the "stronger/more aggressive" variant, but apparently the chemical is "heavier" (molecular weight of compound is more than 500) than finasteride hence will penetrate the body less than finasteride. So I hear.

Can anyone explain this to me?

Are there any reaches you know of about comparing topical dutasteride with topical finasteride (no "bro science" pls)?

Thank you!

 

[badnewsbearer]

this is all not really based on reality. the 500 dalton rule just means it gets harder to penetrate not impossible. ifa tiny bit of dutasteride hits the bloodstream, with itw long half life it will accumulate

i have bee using topical finasteride now for a few weeks switching from oral ans i have not seen a difference, my sides are just as severe if not more so. it is completely incomprehensible how on 0.05% finasteride i can experience complete loss of libido and basically complete inability to get an erection let alone maintain it for longer then a few seco ds and a completely numb dick-.-.

it is debilitating but it is such a small dose. personally my hopes for topical have died.

topical is not the good of finasteride withojt the bad, its the bad of finasteride with less of the good, itd be hilarious if its less effective for hair loss and more effective for getting ED. i have not been able to even think anything sexual, topical finasteride is chemical castration for me and its so ridiculous. messed up hwir genes is not enoigh, i need to be the most sensitive motherfucker to this drug on earth

 

[losingbattle88]

this is all not really based on reality. the 500 dalton rule just means it gets harder to penetrate not impossible. ifa tiny bit of dutasteride hits the bloodstream, with itw long half life it will accumulate

i have bee using topical finasteride now for a few weeks switching from oral ans i have not seen a difference, my sides are just as severe if not more so. it is completely incomprehensible how on 0.05% finasteride i can experience complete loss of libido and basically complete inability to get an erection let alone maintain it for longer then a few seco ds and a completely numb dick-.-.

it is debilitating but it is such a small dose. personally my hopes for topical have died.

topical is not the good of finasteride withojt the bad, its the bad of finasteride with less of the good, itd be hilarious if its less effective for hair loss and more effective for getting ED. i have not been able to even think anything sexual, topical finasteride is chemical castration for me and its so ridiculous. messed up hwir genes is not enoigh, i need to be the most sensitive motherfucker to this drug on earth

You speak the truth.

 

[kiwi666]

You speak the truth.

I’m the same with oral finasteride.

However from what I’ve read about topical finasteride, the vehicles matter quite a lot.

Im cautiously optimistic about Hason and Wong’s upcoming topical and will try it out.

Also, from my own experience, the last time I tried finasteride, it took at least 4 or 5weeks for libido to come back.

So if you started Topical finasteride before you got your mojo back that might be a problem.

On a side note I’m on oral min and no sides! Buuuut no awesome hair growth either :’(

 

[losingbattle88]

I’m the same with oral finasteride.

However from what I’ve read about topical finasteride, the vehicles matter quite a lot.

Im cautiously optimistic about Hason and Wong’s upcoming topical and will try it out.

Also, from my own experience, the last time I tried finasteride, it took at least 4 or 5weeks for libido to come back.

So if you started Topical finasteride before you got your mojo back that might be a problem.

On a side note I’m on oral min and no sides! Buuuut no awesome hair growth either :’(

What is your oral dose and how often ?

 

[badnewsbearer]

I’m the same with oral finasteride.

However from what I’ve read about topical finasteride, the vehicles matter quite a lot.

Im cautiously optimistic about Hason and Wong’s upcoming topical and will try it out.

Also, from my own experience, the last time I tried finasteride, it took at least 4 or 5weeks for libido to come back.

So if you started Topical finasteride before you got your mojo back that might be a problem.

On a side note I’m on oral min and no sides! Buuuut no awesome hair growth either :’(

but i started topical, over new year i took a 3 day break and noriced a spike in libido and aome morning wood, the i tooj it again and it vanished. i may not be the best referwnce for this as i had bouts of ED before due to depression but this is much stronger than that.

in any case i will get blood work tomorrow, dht free T and estradiol and compare it to oral. so we know what is actually happening. on oral finasteride my estrogen was very high out of the range even, free T was halved from before(i suspect due to less dht which is bound very strong to SHBG there was a spike in SHBG and thus a reduction in free T) so i will see where that is.

i am also not done with trying, i am using 1mg topically, mozarella study used 1/10th of that and still apparently got some maintenance results over plqcebo so i can reduce the dose order of magnitude.

if i get sides on 0.005% 2ml then i do not know what the heck is going on with my body ws mozqrella showed no dht alterations with that regiment.

ao vehicle is indeed very important. i am using the most basic one, just mixing into minoxidil bottle. of course liposomal or nanocarriers can be very promising here but it is not commercially qvailable as of right now especially not outside of the US. you also cant make them yourself because i lack the equippment and expertise obviously

 

[kiwi666]

You speak the truth.

I’m the same with oral finasteride.

However from what I’ve read about topical finasteride, the vehicles matter quite a lot.

Im cautiously optimistic about Hason and Wong’s upcoming topical and will try it out.

Also, from my own experience, the last time I tried finasteride, it took at least 4 or 5weeks for libido to come back.

So if you started Topical finasteride before you got your mojo back that might be a problem.

On a side note I’m on oral min and no sides! Buuuut no awesome hair growth either :’j

What is your oral dose and how often ?

2.5mg in the morning and 2.5mg at night

 

[Thor9]

this is all not really based on reality. the 500 dalton rule just means it gets harder to penetrate not impossible. ifa tiny bit of dutasteride hits the bloodstream, with itw long half life it will accumulate

i have bee using topical finasteride now for a few weeks switching from oral ans i have not seen a difference, my sides are just as severe if not more so. it is completely incomprehensible how on 0.05% finasteride i can experience complete loss of libido and basically complete inability to get an erection let alone maintain it for longer then a few seco ds and a completely numb dick-.-.

it is debilitating but it is such a small dose. personally my hopes for topical have died.

topical is not the good of finasteride withojt the bad, its the bad of finasteride with less of the good, itd be hilarious if its less effective for hair loss and more effective for getting ED. i have not been able to even think anything sexual, topical finasteride is chemical castration for me and its so ridiculous. messed up hwir genes is not enoigh, i need to be the most sensitive motherfucker to this drug on earth

0.5mg is not a small dose - even if only 10% gets absorbed that will be sufficient to accumulate over time and suppress serum DHT by ~50%. If someone experiences sides on oral finasteride and they want to avoid sides with topical finasteride, I would say that 0.1mg should be the upper limit.

 

[20YearsOnFin]

but i started topical, over new year i took a 3 day break and noriced a spike in libido and aome morning wood

A couple of points.

Do you mean you were on Oral then took a 3 day break before starting topical? or that you were on already on topical then just took a 3 day break?

i may not be the best referwnce for this as i had bouts of ED before due to depression

I think this is a massive deal breaker here, and you should have disclosed this information before expecting people to reply to your posts.

If you are already predisposed to ED from depression, your experimenting with a drug that lists ED as a potential side effect, is likely to be massively flawed from the outset.

While if in the end you can find a dose that does indeed work for yourself, then this maywell be helpful for other users in your situation.

Until this point all the data and information you are posting is likely to be useless to most users, as by your own admission you are already likely to have a far greater sensitively to experiencing ED than most.

If you can't tolerate finasteride, like others have suggested at some point either try dutasteride in topical or oral form, or you will have to just accept the obvious, that drugs that are know to cause sexual side effects are probably not the best choice for users that have a prior history of ED.

 

[badnewsbearer]

A couple of points.

Do you mean you were on Oral then took a 3 day break before starting topical? or that you were on already on topical then just took a 3 day break?


I think this is a massive deal breaker here, and you should have disclosed this information before expecting people to reply to your posts.

If you are already predisposed to ED from depression, your experimenting with a drug that lists ED as a potential side effect, is likely to be massively flawed from the outset.

While if in the end you can find a dose or frequency of dose that does indeed work for yourself, this may well be helpful for other users in your situation.

Until this point all the data and information you are posting is likely to be useless to most users, as by your own admission you already likely have a far greater sensitively to experiencing ED than most.

If you can't tolerate finasteride, like others have suggested at some point either try dutasteride in topical or oral form, or you will have to just accept the obvious, that drugs that are know to cause sexual side effects are probably not the best choice for users that have a prior history of ED.

i was already on topicql. the sides seems to dissapear much faster on topical as the concentration of finasteride is so low

you do not understand, the kind if ED from finasteride is very mucb different than psychogenic ED as i have said. if you wajt to dismiss what i have said go ahead but i do not think it loses any validity at all. my hormones on oral finasteride were fucked up, i had verx high libido before finasteride it was markedly reduced on it. the "ED" is a verx particular type and really only obvious in various situations shich means i can definitely still notice the difference.

 

[20YearsOnFin]

my hormones on oral finasteride were f**ked up

What I don't entirely understand is, If you have previously experienced ED from depression, then experienced a worse bout on oral finasteride after it messed up you hormones, why are you still surprised when you experienced ED again from topical finasteride use, when there are countless posts confirming that other users have already experienced the same?

 

[20YearsOnFin]

You must be one of the only people on here that even though they still experience ED on topical finasteride, seem happy to keep trying to make it work.

Normally users that have experienced what you are going through, make the decision that they cant tolerate finasteride and move on to different treatments.


You could start another thread asking if anyone has ever found a dose or frequency of dose, they could tolerate on topical finasteride once they have experience ED from it, but I would imagine that will either be a quite a small or perhaps even non existent group of people.

 

[kiwi666]

Topical Finasteride is a relatively new topic here. Honestly 12 -24 months ago nobody was talking about it.

When it first came up people were hoping it’d mitigate sides.

For some it has. For some it hasn’t. That’s about as much as any of us could reasonably argue based on peoples experience here.

The other thing to remember is that we’re all experimenting with different topical vehicles. They are not equal.

All we can hope for is a variety that causes the least amount of sides for people sensitive to sides.

People like me are hoping Hason and Wong’s new topical pull it off.

 

[20YearsOnFin]

When it first came up people were hoping it’d mitigate sides.

For some it has. For some it hasn’t. That’s about as much as any of us could reasonably argue based on peoples experience here.

He has already experienced ED from topical finasteride though.

My question is this: Has anyone who has developed ED from topical finasteride use, gone on to find a dose that was both side free and able to maintain their hair and if they did, what was their dose?

 

[fashy]

People like me are hoping Hason and Wong’s new topical pull it off.

What's that all about?

 

[badnewsbearer]

He has already experienced ED from topical finasteride though.

My question is this: Has anyone who has developed ED from topical finasteride use, gone on to find a dose that was both side free and able to maintain their hair and if they did, what was their dose?

you dont understand much. what other treatments should i change to? some chinese powder that costs a ton and doesnt work or is sus as f***? mozarella has shown no dht reduction at the dose of 0.005% topical, its not about sides there, if there is no reduction in dht then there can be no side effects. thats pretty obvious. you just dont get it

 

[badnewsbearer]

He has already experienced ED from topical finasteride though.

My question is this: Has anyone who has developed ED from topical finasteride use, gone on to find a dose that was both side free and able to maintain their hair and if they did, what was their dose?

and rhe answer to that is yes just loon on tressless. the question is whether these doses are effective

 

[badnewsbearer]

What I don't entirely understand is, If you have previously experienced ED from depression, then experienced a worse bout on oral finasteride after it messed up you hormones, why are you still surprised when you experienced ED again from topical finasteride use, when there are countless posts confirming that other users have already experienced the same?

because most people do not experience sides on topical. you can hang out on the internet all you want but if not look at clinical data, 0.5mg topical applied a day, less sides effects on topicak finasteride than in the placebo group. nobodydropped out and you bet people wouls drop ojt if they got ED. 8% dropped out in oral finasteride.

also dht reduction was significantly less and finasteride concentration in blood was 150!! fold less so explain to me how it is unreasoble to expect to not get sides on topical even tho you hot them on oral? this makes no sense to me. nobody of the 200 suspects reported a LOSS of libido, reduction sure but the placdbi group had equal numbers here

 

[20YearsOnFin]

you dont understand much.

?

what other treatments should i change to?

Try a different 5-Ari like has already been suggested multiple times.

and rhe answer to that is yes just loon on tressless. the question is whether these doses are effective

So that's a no then?

because most people do not experience sides on topical.

This isn't about most people though is it?, its a question regarding whether all users who experience sides from oral can migrate to topical and continue its use without a reoccurrence of side effects and in many cases the answer has shown to be they can't.

nobody of the 200 suspects reported a LOSS of libido reduction sure

If the occurrence of loss of libido on topical is many times higher than 1 in 200, why would a study of that size be guaranteed to find it?

The type of study that would shine the best light on the subject on topical, would be one comprised entirely of people had previously experienced sides on oral.

explain to me how it is unreasoble to expect to not get sides on topical even tho you hot them on oral? this makes no sense to me

Because its already been established that a certain percentage of people who don't seem to be able to tolerate oral finasteride at all, will also react negatively to topical.

I don't understand your faith in quoting studies when you have already proved to yourself that sides are still possible on topical.

Given your prior history of ED, your history of ED on oral and your current replication of ED with topical, the chances of you managing to find a way to make finasteride work at the dose you are using seem slim.

But If you do have some success I'm sure there will be plenty of people interested in, what the missing piece of the puzzle was .

 

[badnewsbearer]

?

Try a different 5-Ari like has already been suggested multiple times.

So that's a no then?

This isn't about most people though is it?, its a question regarding whether all users who experience sides from oral can migrate to topical and continue its use without a reoccurrence of side effects and in many cases the answer has shown to be they can't.


If the occurrence of loss of libido on topical is many times higher than 1 in 200, why would a study of that size be guaranteed to find it?

The type of study that would shine the best light on the subject on topical, would be one comprised entirely of people had previously experienced sides on oral.


Because its already been established that a certain percentage of people who don't seem to be able to tolerate oral finasteride at all, will also react negatively to topical.

I don't understand your faith in quoting studies when you have already proved to yourself that sides are still possible on topical.

Given your prior history of ED, your history of ED on oral and your current replication of ED with topical, the chances of you managing to find a way to make finasteride work seem slim.

But If you do have some success I'm sure there will be plenty of people interested in, what the missing piece of the puzzle was .

amybody who does have sides on 70% dht suppression must have them at half that then?