Topical Finasteride VS Topical Dutasteride (Side effects)

[badnewsbearer]

and you are eight i should not call anyone here stupid, i am the one who is stupid, my theories were all wrong, i am not a biologist or reseaecher in dermatology ans i have zero clue its just guesses. i was very confident in topical and it was always something i thoight i couls rely on and very hopeful about it but nothkng works for me, my body is extra dysfunctional. i am almost certain that the mazarella dose wil mess up my estrogen and dht as well(my dht wqs that of an 80yo before i ever took finasteride) so it seems my body is so sh*t it decided to have old man expression of 5AR in the dick and ultra bald high expression in the scalp, cant inhibit one withoht nuking the other, here is to a life looking like an ugly sick cancer patient

 

[20YearsOnFin]

and you are eight i should not call anyone here stupid, i am the one who is stupid, my theories were all wrong, i am not a biologist or reseaecher in dermatology ans i have zero clue its just guesses. i was very confident in topical and it was always something i thoight i couls rely on and very hopeful about it but nothkng works for me, my body is extra dysfunctional. just further proof how messed up i am

Ok, Thanks for finally coming clean I appreciate your honestly, although as you can tell by my curt reply's, I had already started to lean towards that conclusion.

This is just my opinion so make of it what you will.

By swapping from oral to topical directly without a break, what you have been doing for the last 2-3 weeks, is essentially just topping up your oral dose, yes its going to get gradually smaller over time, but over time, as in weeks and weeks, its not going happen instantly.

Usually I purposely disagree with @Pigeon but you need to do what he says here.

Try quitting fina completely for a couple of months to let your body recover. After that try a very low dose of topical fina.

If you don't want to quit for 2 months then perhaps you could get away with a slightly shorter break, but maybe I'm not the best person to advise you on the length of the break as there are other users like Pigeon who know far more about sides than I do .

 

[badnewsbearer]

Ok, Thanks for finally coming clean I appreciate your honestly, although as you can tell by my curt reply's, I had already started to lean towards that conclusion.

This is just my opinion so make of it what you will.

By swapping from oral to topical directly without a break, what you have been doing for the last 2-3 weeks, is essentially just topping up your oral dose, yes its going to get gradually smaller over time, but over time, as in weeks and weeks, its not going happen instantly.

Usually I purposely disagree with @Pigeon but you need to do what he says here.



If you don't want to quit for 2 months then perhaps you could get away with a slightly shorter break, but maybe I'm not the best person to advise you on the length of the break as there are other users like Pigeon who know far more about sides than I do .

vut dht should have spiked after 6-7 days already ans i expected sides to improve after a week for sure. they should, it makes no sense biologically if topical indeed has less sxstemic suppression

 

[20YearsOnFin]

vut dht should have spiked after 6-7 days already ans i expected sides to improve after a week for sure. they should, it makes no sense biologically if topical indeed has less sxstemic suppression

Because the effects and side effects of finasteride last far longer than you think.

 

[badnewsbearer]

Because the effects and side effects of finasteride last far longer than you think.

but if dht is back wgat should cause the sides?

 

[20YearsOnFin]

but if dht is back wgat should cause the sides?

Its probably not back, You haven't taken a break from finasteride, you have just been topping it back up with topical, so I would imagine you are still experiencing part effects from the oral.

 

[badnewsbearer]

Its probably not back, You haven't taken a break from finasteride, you have just been topping it back up with topical, so I would imagine you are still experiencing part effects from the oral.

hm, finasteride hws a half life of 7 hours, dht is reproduced after 6 days, if a topical dose does indeed cause less systemic dht reduction, then should i in theory not have higher dht right now compared to oral?

 

[20YearsOnFin]

Forget about finasteride's half life in the blood, if its half life were important you would need to take finasteride 2 or 3 times a day.

There's not much point quoting how long the DHT levels remain suppressed either, Ive already mentioned multiple different sources will quote you different time frames ranging from 4 days to 4 weeks depending on the dose and the duration of time finasteride has been taken for, so unless you keep getting tested every few days you will have no way of knowing for sure.

then should i in theory not have higher dht right now compared to oral?

Correct.

 

[losingbattle88]

hm, finasteride hws a half life of 7 hours, dht is reproduced after 6 days, if a topical dose does indeed cause less systemic dht reduction, then should i in theory not have higher dht right now compared to oral?

hm, finasteride hws a half life of 7 hours, dht is reproduced after 6 days, if a topical dose does indeed cause less systemic dht reduction, then should i in theory not have higher dht right now compared to oral?

Have you ever tried dutasteride? I can tell you from experience that both drugs CAN give you different Side effects. I cant use finasteride it makes my eyes dry as bone after a month of usage and blocked tear glands total nightmare. But dutasteride dont give me any eye problems at all. Only sperm related side effect. Maybe give dutasteride a Chance.

 

[badnewsbearer]

Have you ever tried dutasteride? I can tell you from experience that both drugs CAN give you different Side effects. I cant use finasteride it makes my eyes dry as bone after a month of usage and blocked tear glands total nightmare. But dutasteride dont give me any eye problems at all. Only sperm related side effect. Maybe give dutasteride a Chance.

aure but for swxual sides this is sure different. i had very high estrogen and loweres free testosterone, i am certain dutasteride would cause an even greater spike and reduction respecitively

 

[Mr. Slap Head]

Have you ever tried dutasteride? I can tell you from experience that both drugs CAN give you different Side effects. I cant use finasteride it makes my eyes dry as bone after a month of usage and blocked tear glands total nightmare. But dutasteride dont give me any eye problems at all. Only sperm related side effect. Maybe give dutasteride a Chance.

@DoctorHouse @user394587

 

[losingbattle88]

aure but for swxual sides this is sure different. i had very high estrogen and loweres free testosterone, i am certain dutasteride would cause an even greater spike and reduction respecitively

You wont know until you try it. Dry eyes is due to androgen deficency. Many studies about it. So try dutasteride or go bald. Just to add i got a friend from norway he quit finasteride due to dry eyes. And i have read lots of other guys getting dry eyes from finasteride too on different forums.

 

[20YearsOnFin]

aure but for swxual sides this is sure different. i had very high estrogen and loweres free testosterone, i am certain dutasteride would cause an even greater spike and reduction respecitively

Most people on here are just trying to share their experiences and help people out, you don't have to agree with them, but its worth taking note of the information provided and to keep all your options open rather than instantly dismissing them outright.

 

[badnewsbearer]

if dry eyes are caused by androgen deficiency, how can dutasteride, a drug that causes even more tissue dependwnt andeogen deficiency not cause this? i cant understand

 

[losingbattle88]

if dry eyes are caused by androgen deficiency, how can dutasteride, a drug that causes even more tissue dependwnt andeogen deficiency not cause this? i cant understand

Because both drugs dont work the exact same way, and dutasteride even rsises T more than finasteride.

 

[Mr. Slap Head]

I really think it all depends. Some people will do very well on dutasteride but others will do worse. I think it depends not only on your genes’ tendency to upregulate receptors, but also it seems that some people aromatize more than others.

 

[whymedamn]

Anyone find any companies that are claiming to mix fina/duta with compounds that make it go less systemic?

Where can you get the

Ok ok, lets stop the bickering gents.

Here is some good news.

Scratch that, great news:

Essentially they are very very close. Just have to find a way to not get the topical fina/duta in the body.

This will just need A LOT more testing with different ways of application.

I really do believe the starting point of a working compound (like fina/duta) to a place where you have something that works without sides is 1000X easier than to now find a new solution that right away works without sides (e.g. kintor).

And a different perspective.

peace

Anyone find any companies that are claiming to mix fina/duta with compounds that make it go less systemic?

Where can you get the hassan and wong stuff ?

 

[20YearsOnFin]

Anyone find any companies that are claiming to mix fina/duta with compounds that make it go less systemic?

Has anyone confirmed to you, that these commercial ( less systemic) formulas have made it to release? if you can't find them maybe the more promising looking ones are still stuck in development/testing phase?

You could also try to Search for Almirall’s ALM12845 (Polichem’s P-3074) and see if it or its 'Finjuve' version ever makes it to market?

https://www.hikma.com/newsroom/arti...e-in-the-middle-east-and-north-africa-region/

Where can you get the hassan and wong stuff ?

You would have to contact them directly, I don't know if this is the one you mean or if they have a even newer improved one in the pipeline.

https://www.hairlosstalk.com/intera...de-my-experience-with-hasson-and-wong.128304/

Otherwise its kind of following that thread that has already been mentioned here.

https://www.hairlosstalk.com/intera...nely-good-vehicle-for-hair-loss-drugs.132423/

 

[badnewsbearer]

Because the effects and side effects of finasteride last far longer than you think.

i think this is not correct. how does finasteride cause ED? well, andeogens bind to their receptors in endothelial cells and neurons in the penis, they act as transcription factors for neuronal and endothelial nitric oxide synthase, this enzyme converts arginin to nitric oxide which then acts as a vasolidator leasing to smooth muscle relaxiation. so if i take a dose of oral finasteride, i stop it then after 5-6 days my dht is back to normal. if the dht is back to normal what would obstruct the pathway described to funcrion properly? now lets say topical finasteride causes less systemic dht reducrion ehich it has to in order to work with less sides. after 3 weeks my dht should have recovered to the level where it would be if i did make a long pause after getting off of oral right? what i donr understans is, i legir dont even feel a difference. its not that now i have milder sides which almost anyone on reddit or here describes.
they either say no sides anymore or far milder and tolerable ones. but mine have not changed one bit. so what is going on? szre i should not expect to be sides free bit how can there not ne any difference?

all the finasteride has to pass the thick skin of my skull and various skin layers which creatine layers which barely let anythjng pass throigh. half the finasteride i apply lands on my hair anyway so i effectively apply 0.5mg of finasteride on my skin, of that 10-15% migbt hit the system.

now i understand that 0.05mg oral finasteride still reduce tissue ans serum dht by 55% compared to 67 with 1mg so theoretically i still have high suppression. but so should everyone else?? why do i have this intense issue going on. i am so tired of this i just want something to work, there are peoppe that have far better hair and less issues with their looks than i do and thwy can pop a 5mg dutasteride and be just fine ans we are experimenting with teeny tiny dosages and it i achieved impotence to the extent where i csnt even masturbate which is highly disturbing if you think about it. nobody shohld have to decide between lookjng like sh*t(and lets face it most do) or being impotent. both are depressing its not like one is just a minor inconvenience, i guess if you are the rock, the all praises example of baldness bc of course everyone loojs like that

 

[badnewsbearer]

Because both drugs dont work the exact same way, and dutasteride even rsises T more than finasteride.

but you can not get morr androgenic on dutasteride. the more potent the drug the more you will lose in androgenicity