Topical Finasteride which "locks into the scalp to avoid systemic absorption"

[hilbert]

used the Parati finasteride gel (the IT pharmacy referred to by dr Hasson) from aug to feb, at different %: 2.5, 1 and 0.5, 1ml ED on a nw5a area.

it works, kept me stable; just like the oral finasteride.
but, in spite of the in vitro tests, i guess it has some systemic absorption. my libido was a typical "finasteride" libido (the reason why i dropped the tablet) and the sperm was a bit watery (not too much, never had too watery on oral either).
imho even 0.5% is too much... maybe 0.25 or even less can work.

and caution if you apply other stuff (e.g. minoxidil) after it... imho the liposomes with finasteride are still locked there, and the lotion flushes them down into the bloodflow. or even showering... probably one of the reasons why in vivo is different from in vitro tests.

 

[cop]

I als used the topical finasteride from the italian pharmacy..same sides as oral

 

[g.i joey]

Hey cop, how long did it take for u to feel sides?

 

[jake_b]

It will absorb systemically. The only advantage would be if they've come up with a formulation that allows a much, much smaller dose to be used effectively.

 

[buckthorn]

Liquid Finasteride is not crap. It stops DHT right at the scalp. And if you have it mixed with other agents, the slower absorption time can
be even better.

Oral Finateride actually averages 70 - 75% DHT reduction. Liquid Finasteride attacks the scalp, especially the temple area. Don't believe it? My
temple hair is growing back. And terminal hair, not just little pieces of hair that won't go terminal. It does work, despite what some people
might say.

The only reason Merk didn't put it out as a liquid is their marketing strategy. They wanted to show it's less maintenance to pop one pill a
day than use it as a liquid like Minoxidil. Rogaine was their competition before it went generic.

K9,
How are you 100% certain this growth is due to the finasteride and not the 30% minoxidil??

 

[abcdefg]

I als used the topical finasteride from the italian pharmacy..same sides as oral

Maybe so, but it still might have a lot less systemic absorption so still be quite a bit safer then the oral route even if it still has sides. Topical finasteride absolutely goes systemic that is not debatable its just a question of is it significantly less while still stopping DHT locally around the same amount? Also to me personally if topical costs a lot more, and it probably does I would just go with the oral route instead anyway since money is always a factor for me

 

[g.i joey]

Even if my topical does go systemic, I doubt the whole dosage would. Even if 1/4th goes systemic I still could confidently say I don't have sides, with oral dosing I felt sides no questions asked. But I'm sure some of it does go systemic, key word here is SOME

 

[cop]

I used it for 30 days...same **** as oral pffff

 

[Felipe302]

The question is: is this the same topical finasteride that this Italian pharmacy had been selling for a while? Are they just dropshipping the Italian product? If that's the case, there are a lot of people that tried the formulation and had side effects. It would be a scam, in the sense that they are claiming to have worked on it for years and had a trial with a hundred patients etc.

But if it's a new formulation, then it may be worth trying.

 

[dupaman]

That is my question too! Is there someone that already used the liposomes formula? People In this thread keeps complaining about the old finasteride topicals mixed with alchohol pg and other ****. My question is...Has sombody from the forum tested the new version yet? Please dont use this forum to complain about the old version. We all had sides from it, that's is why we are here. So if someone has more productive info about this new formula thing please share it with us.

 

[hilbert]

That is my question too! Is there someone that already used the liposomes formula? People In this thread keeps complaining about the old finasteride topicals mixed with alchohol pg and other ****. My question is...Has sombody from the forum tested the new version yet? Please dont use this forum to complain about the old version. We all had sides from it, that's is why we are here. So if someone has more productive info about this new formula thing please share it with us.

did you read my previous post?
Yes, Farmacia Parati liposomal gel is the current vehicle. The 2-pages in-vitro study referred to by H&W newsletter is done on that vehicle, and I knew those data since Oct.
Yes, a lot of people (mostly in Italy) have been trying that since beginning of 2015, at different %: 2,5%, 2%, 1%, 0,5%.
It works, but some had sides.

Don't know if it's because in-vivo and in-vitro are too different, or because of the handling of it, as I mentioned (subsequent topicals, showers, etc.).

If I will ever try that again, I will ask for a much lower % (e.g. 0,25% or less) and will apply that with no further topicals (minoxidil) before that and the next shower.
Given the quick and clean absorption, 2,5mg or less on my scalp are much more than enough, if you consider that 0,25mg *orally* are enough to help in the scalp.

 

[deniak]

Guys, stop spreading broscience. Even micordoses like 0,1 mg used constantly for few days/weeks (topical or not) will lower systemic DHT just like 1 mg pill every day. Just look at research. Unfortunately it turns out that Polichem study was silly, it lasts only few days: they knew that 3/4/5 weeks and they will notice max DHT suppresion just like with pill. In 7 days they had 20% systemic inhibition with lowest dose used.
For topical finasteride without systemic effect we need or:
1. Super small dose once in few days (what efficiancy? Probbaly alone its to small to see cosmetic effect)
2. Superb vehicle able to provide finasteride only to hair bulbs (impossible ATM).

 

[hilbert]

Guys, stop spreading broscience. Even micordoses like 0,1 mg used constantly for few days/weeks (topical or not) will lower systemic DHT just like 1 mg pill every day. Just look at research. Unfortunately it turns out that Polichem study was silly, it lasts only few days: they knew that 3/4/5 weeks and they will notice max DHT suppresion just like with pill. In 7 days they had 20% systemic inhibition with lowest dose used.
For topical finasteride without systemic effect we need or:
1. Super small dose once in few days (what efficiancy? Probbaly alone its to small to see cosmetic effect)
2. Superb vehicle able to provide finasteride only to hair bulbs (impossible ATM).

uhm... maybe 0,1mg not, it's left of the knee. But the point is right; just a tiny bit is enough.

But it doesn't mean it can't be done, and that liposomial gel isn't right. Imho it's simply too much finasteride: if, say, you need 0,2mg per day for the whole scalp and you put 5mg there (gel 0,5%), and it's absorbed 99,2%... what are you going to do with those nearly 4,8mg locked in the liposomes in your scalp? How long will they be locked for? Until you put some minoxidil on them? Until you wash your hair? And then?

Polichem sucks for another reason. In study #1 they measured the DHT over some weeks (1-2) and found out that at 0,25% the blood DHT goes down of ~70%. Good, that means at least 0,15-0,2mg finasteride went systemic. I.e. absorption rate ~10%, just like any hydro-alchoolic vehicle... so this HPCP isn't any better.
And what did they do? Instead of trying to improve the vehicle with something better than HPCP, they just reduced the dose! Down to 0,1 - 0,2ml. Hooray, treat a NW5 area with that, good luck.

 

[Afro_Vacancy]

Reducing the dose is sensible.

We need 0.25 mg or whatever to eliminate DHT in our entire body, so we probably need much less just to inhibit it in the scalp.

 

[Danielst]

anyone tried this? any sides?
where can I get this? do they ship to Israel?

 

[Felipe302]

did you read my previous post?
Yes, Farmacia Parati liposomal gel is the current vehicle. The 2-pages in-vitro study referred to by H&W newsletter is done on that vehicle, and I knew those data since Oct.
Yes, a lot of people (mostly in Italy) have been trying that since beginning of 2015, at different %: 2,5%, 2%, 1%, 0,5%.
It works, but some had sides.

Don't know if it's because in-vivo and in-vitro are too different, or because of the handling of it, as I mentioned (subsequent topicals, showers, etc.).

If I will ever try that again, I will ask for a much lower % (e.g. 0,25% or less) and will apply that with no further topicals (minoxidil) before that and the next shower.
Given the quick and clean absorption, 2,5mg or less on my scalp are much more than enough, if you consider that 0,25mg *orally* are enough to help in the scalp.

Yes we do understand that you have tried the liposomal vehicle. However, they're saying that this formulation has silicone particles that should anchor finasteride in the scalp, avoiding systematic exposure. So the question remains, is the liposomal gel that you used the same that's being sold right now, I mean the one you used had those silicon particles as well ?

 

[Afro_Vacancy]

Are silicone particles safe?

 

[hilbert]

Yes we do understand that you have tried the liposomal vehicle. However, they're saying that this formulation has silicone particles that should anchor finasteride in the scalp, avoiding systematic exposure. So the question remains, is the liposomal gel that you used the same that's being sold right now, I mean the one you used had those silicon particles as well ?

https://3pfizs243h34c09mn6s0ul69-wp...evaluation-finasteride-solution-DR-HASSON.pdf

The gel i've been using is the "sil lip gel" in this study by Univ of Milan.
It's the "new" gel Hasson is talking about.

 

[hilbert]

And? Any results or sides or both?

again: tried for 6 months (1 month 2.5%, then 1, last month 0.5), maintained on it after dropping the tablet 3 months before starting.
it definitely works (and would work even without going systemic imho; i'm a believer of the topical finasteride action).
sides could be similar to the oral route, but pls dont panic and check my previous post for details.

 

[Pavi]

How are people doing on this??