Topical Foam version of ASCJ-9 - Trials starting soon!!!

[goata007]

http://www.androscience.com/Design/Assets/ASCimages/ASC2008Update.pdf

For lazy people, important points from the document below:

i) Phase-II trial (for acne) to finish in June 2008
ii) Phase-II trial of foam based ASCJ-9 for Androgentic Alopecia in men starts in Q4 this year!
i) Androscience is coming up with a new website (which is also a hint that they are getting ready for the real deal)

I'm absolutely positively 100% sure that they've got good results from phase-II trials for acne and thats why they are proceeding with foam based trials for androgentic alopecia (hairloss).

This is reaaally good news guys, finally we could have a foam based receptor destroyer without the sides

 

[khali]

Hopefully this treatment works better than propecia.

 

[SoThatsLife]

So the drug is here in like 3-4 years? if all goes well

Time for people to get on Proxiphen(-n) and finasteride and maybe minoxidil to, to get the maximum effect until something good comes out.

But again, we have alot good anti-androgenic topicals. They just dont work as well as we hope. Proctor says on his website "Arguably, the most promising antiandrogen is Propecia ( finasteride), from Merck. Tho the weakest antiandrogen on paper, it seems to be as effective as the others in baldness treatment. My experience is that oral finasteride works about as well as topical spironolactone, about a 50% response rate, at one year. Some individuals take even longer to respond."

Hope ASCJ-9 works great, I would love to get something that I only apply a couple of times a week with no sides. If it works and it comes out at the same time as Follicas treatment, it would be a nice time to be a unlucky dude with the baldness gene.

 

[ross007]

maybe this will encourage follica and others to speed things up if they can. so if one had the follica treatment could you still use the other to maximise results? one maybe never need minoxidil or finasteride again or am i wrong?

 

[Matt27]

That is excellent news! Sounds like they got good results with their acne cream, which means that should work just as well for people who only have bi-temporal or bare crown loss etc. The cream product might be out in just a couple of years.

 

[ITNEVERRAINS]

anything besides finasteride and minoxidil is good news

 

[goata007]

So the drug is here in like 3-4 years? if all goes well

Time for people to get on Proxiphen(-n) and finasteride and maybe minoxidil to, to get the maximum effect until something good comes out.

But again, we have alot good anti-androgenic topicals. They just dont work as well as we hope. Proctor says on his website "Arguably, the most promising antiandrogen is Propecia ( finasteride), from Merck. Tho the weakest antiandrogen on paper, it seems to be as effective as the others in baldness treatment. My experience is that oral finasteride works about as well as topical spironolactone, about a 50% response rate, at one year. Some individuals take even longer to respond."

Hope ASCJ-9 works great, I would love to get something that I only apply a couple of times a week with no sides. If it works and it comes out at the same time as Follicas treatment, it would be a nice time to be a unlucky dude with the baldness gene.

Its a topical not a pill - it'll be like rogaine foam but would act like propecia. The main benefit is that its not systemic which means it won't have sexual sides that accompany propecia/dutas, and it might be more potent than finas as well.

 

[el_duterino]

was anyone able to try Cayman medical powder ? maybe worth a try if we cannot wait for the 3-4 years before the final foam gets approved

 

[goata007]

was anyone able to try Cayman medical powder ? maybe worth a try if we cannot wait for the 3-4 years before the final foam gets approved

They're done with phase-II already. I doubt it will take 3-4 years, maybe 2 at most!

 

[harold]

But again, we have alot good anti-androgenic topicals. They just dont work as well as we hope.

We dont have any topical antiandrogens. Unless you count things like EGCG etc.
hh

 

[harold]

was anyone able to try Cayman medical powder ? maybe worth a try if we cannot wait for the 3-4 years before the final foam gets approved

They're done with phase-II already. I doubt it will take 3-4 years, maybe 2 at most!

Phase II for acne is complete. So maybe we will see the cream in a couple of years but not the foam.
As for Cayman mediacal powders I am sure that they will only sell to labs and universities and not individuals though I would love for someone to prove me wrong on that.
hh

 

[Bryan]

Phase II for acne is complete.

BTW, I wouldn't hang all my hopes for this "ASCJ-9" stuff on whether or not it works for acne. Acne is one thing, male pattern baldness is another.

 

[el_duterino]

ASC-j9 does inhibit (destroy ?) the AR, but so does BP-766:

http://www.patentstorm.us/patents/6828458/fulltext.html


this BP-766 is known as Fluridil now. I was wondering what would be the difference between those 2 drugs in the way they work, since they seem to serve the same purpose.
Perhaps this fluridil is even more powerful than ASC-j9.

Any thoughts ?

 

[goata007]

ASC-j9 does inhibit (destroy ?) the AR, but so does BP-766:

http://www.patentstorm.us/patents/6828458/fulltext.html


this BP-766 is known as Fluridil now. I was wondering what would be the difference between those 2 drugs in the way they work, since they seem to serve the same purpose.
Perhaps this fluridil is even more powerful than ASC-j9.

Any thoughts ?

Interesting that you mentioned fluridil, I was researching it few days ago. The studies done on it are interesting, however, they started marketing this stuff back in 2002 and said that they are seeking approval. Now, 6 years laters its still only approved for cosmetic use only in Czech and Slovak Republics. Other than that, if you search through the forums, there is divided response about its results, about half say it works and the other half say its a waste of money. Androscience is going for FDA approval, so for me it'd be somewhat more reassuring.

BTW, I wouldn't hang all my hopes for this "ASCJ-9" stuff on whether or not it works for acne. Acne is one thing, male pattern baldness is another.

Its primary method of action is by degrading ARs, and in their studies it significantly reduced the sebum production (you mentioned that as test of anti-androgenic behavior few days ago) when applied onto the rats. The study also noted that ASCJ-9 doesn't affect serum androgen levels (implying no systemic effects) and concluded that it can be used for acne, male pattern baldness, bph and simliar conditions.

Phase II for acne is complete.

Yup, I shave my head so a cream would do just fine for me.

 

[Bryan]

BTW, I wouldn't hang all my hopes for this "ASCJ-9" stuff on whether or not it works for acne. Acne is one thing, male pattern baldness is another.

Its primary method of action is by degrading ARs, and in their studies it significantly reduced the sebum production (you mentioned that as test of anti-androgenic behavior few days ago) when applied onto the rats. The study also noted that ASCJ-9 doesn't affect serum androgen levels (implying no systemic effects) and concluded that it can be used for acne, male pattern baldness, bph and simliar conditions.

The point I was trying to make (I suppose I should have stated it a little more explicitly than I did) is that even if it turns out NOT to work very well for acne, we shouldn't be disappointed and assume that it won't work very well for male pattern baldness, either. I think there's something a little odd about acne...I don't think antiandrogens are as effective against acne as they are against male pattern baldness, so all I'm saying is don't be upset if the trial results for acne aren't anything to write home about.

 

[el_duterino]

Interesting that you mentioned fluridil, I was researching it few days ago. The studies done on it are interesting, however, they started marketing this stuff back in 2002 and said that they are seeking approval. Now, 6 years laters its still only approved for cosmetic use only in Czech and Slovak Republics. Other than that, if you search through the forums, there is divided response about its results, about half say it works and the other half say its a waste of money. Androscience is going for FDA approval, so for me it'd be somewhat more reassuring.


>>>Looks like that's about to change:

http://news.biocompare.com/newsstory.asp?id=226243

Even the greatest product can fail with poor marketing. I would not expect great marketing experience coming from ex-communist countries.
I am not going to wait 2+ years until this ASC-J9 is available and FDA approved.
Because these anti-AR/Androgen drugs will only benefit people who still have healthy follicules to maintain, and not regrow.

If you start the treatement too late it may not even work.

Flutamide is not FDA approved for hairloss but works great too. And so is dutasteride.

I just ordered my fluridil today, will use it in combination with Flutagel, & oral dutasteride.

 

[SoThatsLife]

Harold, I thought spironolactone was a topical anti androgen, but maybe Im wrong

 

[restonwebdev]

How come more people aren't talking about dutasteride? I realize it's not FDA-approved for hairloss; I have been using .5 mg since my senior year of college (5 years ago) and I've only recently started noticing advanced hair loss. The period between starting it in April of 2003 and as of last month I had noticed absolutely zero hairloss and significant regrowth.

Just curious why it seems dutasteride is overlooked a lot on these boards?


<<-- Long time hair transplant member; haven't been around in a while though!

 

[harold]

Harold, I thought spironolactone was a topical anti androgen, but maybe Im wrong

Its an antiandrogen but it is meant for oral usage. People use it topically because of anumber of studies indicating low systemic absorption through the skin and some effectiveness when used that way. Bryan would know far more details about this.
However spironolactone also interferes with testosterone production, breaks down fairly rapidly in solution and is reported to smell. People who have tried it will give differing accounts over its tendency to be systemically absorped and its effectiveness.
hh

 

[harold]

Just curious why it seems dutasteride is overlooked a lot on these boards?
<<-- Long time hair transplant member; haven't been around in a while though!

Theres a whole forum dedicated to dutasteride. It isnt really discussed here because it came out years ago. As you say it is powerful as all hell but I was on it for 6 months and it absolutely destroyed my sex life. I am sure other people have similar experiences.
hh