Topical Foam version of ASCJ-9 - Trials starting soon!!!

Matt27

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I'm starting back up on my 2% Keto foam and was wondering how hard it would be to have a custom foam manufactured?? Like taking the Keto foam and adding maybe 2-3% of spironolactone to it as well to make for an even more powerful anti-androgen foam?? I know there used to be custom topical manufacturers like communitydrug.com but I don't recall ever seeing a custom foam/mousse manufacturer. I think that would be a pretty good product to try while waiting for the asc-j9 foam to come out.
 

Matt27

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Unfortunately I was only using it on my crown since it's still pretty thick back there so I cannot really say how good it works or not. The very first time I used it I experienced a slight irritation/burning sensation that only lasted a few seconds on and off but ever time after that I haven't really felt that again. All this talk about ASC-J9 foam got me thinking about using it on the temples as well. It definitely can't hurt.

I've never used rogaine foam so I can't compare the two. But the Extina foam goes on easy and doesn’t leave any residue except for a faint mediciny smell. I don't know if you could use it in the mornings for that reason, but it's real easy to use at night before any other topicals you apply since it pretty much vanishes into your skin completely. For that reason I think it's a great choice for ASC-J9 as well.

I got an e-mail response from murrayavenuerx.com saying they CAN do custom foam compounds but only through the request of a licensed US Physician. Man, if I were Dr. Lee or Proctor I'd make my own off label use foam with spironolactone and Keto. Lee already sells his own custom Keto shampoo and spironolactone cream.
 

Matt27

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Yeah that's the one I have, Keto Mousse. It's only 1%?? Oh well, better than nothing I guess. I wonder if we can use the 2% Extina foam on the hairline or crown?? I need to get some and try it out.
 

goata007

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Matt27 said:
I got an e-mail response from murrayavenuerx.com saying they CAN do custom foam compounds but only through the request of a licensed US Physician. Man, if I were Dr. Lee or Proctor I'd make my own off label use foam with spironolactone and Keto. Lee already sells his own custom Keto shampoo and spironolactone cream.

Would they be willing to do ASCJ-9 foam if I get a request from a licensed physician?
 
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Lets think here guys.......Why do most women have a full head of hair? What is it that most men do and most women do not do? That could lead to hormone stricken disease of hairloss hmmmmm Both men and women have lots of sex? So i don't think it has to do with the activity of sex because both sexes do it often....So if its not sex that is the antogonist of our shrinking follicles then hmmm Now lets think.....OH i got it.....ORGASM....Throughout a womens lifetime they do not have near as many orgasms as a man does in his lifetime. Some never experience orgasms at all....yet they are the ones walking around with a smile on their face and a full head of hair...thick healthy hair. Our follicles are shrinking because the physiological effects that numerous orgasms can take on certain follicles of the scalp over time.
 
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All these orgasms are a trigger to form the fertile male from his youth to a dominant male by producing the classic Male Pattern Baldness...Which is a sign of a sexually mature male due to not the activity of sex but the end result of numerous orgasms over time. This causes the female to be less attracted to a male with a balding scalp because that balding scalp is a sign to the female that the male has already found a mate for sexual activity.
 

Matt27

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goata007 said:
Matt27 said:
I got an e-mail response from murrayavenuerx.com saying they CAN do custom foam compounds but only through the request of a licensed US Physician. Man, if I were Dr. Lee or Proctor I'd make my own off label use foam with spironolactone and Keto. Lee already sells his own custom Keto shampoo and spironolactone cream.

Would they be willing to do ASCJ-9 foam if I get a request from a licensed physician?

I don't know, send them an e-mail and see. If they will let me know, I think I know a guy who would be willing to write me a script for this as well!
 

Matt27

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Not quite in 4Q yet, still a couple months away. Hopefully this is on track though; ASC-J9 sounds like a very promising treatment with the way that it works.
 

goata007

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messm0rph said:
any update on this gents?

They are done with phase-II trials, and their new website should be up this month (they said in summer). I did send them an email and it seems like the product won't be available before Phase-III. You could enroll in their Phase-II for hairloss, if you want.
 

SoThatsLife

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Goata, do you know when the Phase3 trial for acne is complete?

After what I read Phase3 usually takes about 6-8 months and then there is a about year of FDA bureaucracy before it is released on the marked.

If its the same dose(0.001%) of the active ingredient in both the acne treatment and the hair loss treatment I guess there is no real difference in the products except one is a cream and the other one is foam. Buzzcut and shaved heads could easily apply the cream on their heads.

Mr. Barry, Harold and Bryan, have you guys read any research of how fast the AR reproduces itself? Or is the scalp constantly reproducing new AR? I guess the product would be a real "commercial hit" if it was twice a week application. Most hair loss products become quite uninterested to the major public if its a real hassle to use.
 

goata007

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SoThatsLife said:
Goata, do you know when the Phase3 trial for acne is complete?

I usually check their website (http://www.androscience.com) every few weeks or so. Even though they said that they will be uploading a new website and updating it regularly, their website is still old and not updated since several months. At this point, I have no idea what's going on with them. If they stuck to their schedule their trials for the foam should have begun now.

SoThatsLife said:
Mr. Barry, Harold and Bryan, have you guys read any research of how fast the AR reproduces itself? Or is the scalp constantly reproducing new AR? I guess the product would be a real "commercial hit" if it was twice a week application. Most hair loss products become quite uninterested to the major public if its a real hassle to use.

Yes, the ARs are regenerated regularly in the body (skin, prostate, brain etc). Unfortunately, the half-life of ARs is pretty small, I a day or two. So we would have to apply ASCJ-9 probably once a day or every day for maximum efficacy. On the bright side it won't have any systemic effects whatsoever.
 

el_duterino

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this does not look very good.
their phase 2 acne cream results are long overdue..they wrote that the results will be announced "in summer"..their web page is not updated at all.
My guess is that they found the cream to be either ineffective or to have androgenic side effects, or both...
I don't understand how people can make claims that this ASC-j9 will have no side effects before it has been fully tested in humans. The molecule will be absorbed in the blood like anything else we use as topicals.

There is a guy on HLH who purchased the ASC-j9 research powder from Cayman Chemicals, and tried it on himself.
He concluded that it did not do anything in terms of halting hairloss. His ID is " EMU".

The only drug so far that inhibits AR and works is fluridil, and it has no side effects because it has been designed to break down in blood.

But inhibiting AR to an extent that it will stop hairloss is not an easy task. You would need to inhibit all of the AR and all times, and that would be impossbile with one application a day.

Therfore this type of drug is best used in combo with a DHT reducer and an androgen-antagonist such as RU or Flutamide.
 

SoThatsLife

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Is is the same concentrated ASC-j9 as the one androscience is using?

About the site update, I remember they have always been late with updates.

But if what you say is true, I guess ASCJ-9 wouldnt be the half-cure I as hoping for.
 

SoThatsLife

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Goata, have you emailed androscience lately?
 

goata007

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el_duterino said:
this does not look very good.
their phase 2 acne cream results are long overdue..they wrote that the results will be announced "in summer"..their web page is not updated at all.
They have always been lazy when it comes to updating their website. Infact, the last time they updated their website was a few months ago when I asked them about updates - that's when they also told me about a (supposedly) new website in summer.


My guess is that they found the cream to be either ineffective or to have androgenic side effects, or both...
I don't understand how people can make claims that this ASC-j9 will have no side effects before it has been fully tested in humans. The molecule will be absorbed in the blood like anything else we use as topicals. There is a guy on HLH who purchased the ASC-j9 research powder from Cayman Chemicals, and tried it on himself.
He concluded that it did not do anything in terms of halting hairloss. His ID is " EMU".
Their website says that it doesn't have systemic effect. As of the guy, maybe he didn't get the right stuff or the delivery vehicle wasn't good enough.


The only drug so far that inhibits AR and works is fluridil, and it has no side effects because it has been designed to break down in blood.
el_duterino, you are the Only persistent proponent of fluridil across all hairloss forums - so I'm gonna take your word with a grain of salt.
 

SoThatsLife

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Still no answers goata?

They seem to have a very on/off effectiveness on their email response.
 
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