Tsuji Riken Hair Primordiums - Final 20 Questions

[Swoop]

@That Guy,

Yes if they overcome these culturing issues I think it's game over for Androgenetic Alopecia.

I can understand the skeptics who say that this is a mouse model, and that a mouse model doesn't translate too humans, but this isn't entirely true in the context of Tsuji et al.

Remember that observations in humans actually tell us that the hair follicle can regenerate. In fact it has been confirmed in some studies that when a hair follicle is split (horizontal cut between DP and bulge) it can regenerate and actually often does regenerate.

Then we also got that Frankenstein experiment of Dr. Jahoda, who took his own hair follicle, took out the dermal sheath, and transplanted it into his wife his forearm.

a–d, Punch biopsies were taken from male scalp skin (a) and the hair-follicle end bulbs amputated (b), everted (c) and the exposed epidermal components scraped away and discarded (d). e, The dermal sheath and dermal papillae were separated, cleaned and pooled separately in culture medium. f, Up to 11 pieces of dermal sheath were combined and implanted into small, shallow wounds on the inner forearm. g, Induced fibres were distinct and often pigmented.

What happened there? Well after these dermal sheath cells were delivered to his wife forearm they induced brand new hair follicles. The funny thing is when they looked at those brand new induced hair follicles and performed DNA analysis they found out that the bottom part was from Jahoda and the upper part from his own wife. Apparently the cells from Jahoda set in a motion of mesenchymal-epithelial interaction which led to brand new hair follicles. The cells of Jahoda and ultimately the brand new induced hair follicles weren't even rejected.

Anyway this does show that the hair follicle is just very flexible as an organ and more importantly several types of (stem)cells in the hair follicle show regenerative potential to induce a brand new hair follicle.

This all leads me to think that this will be the "cure" for almost everyone, based on these simple observations, not in mice, but in actual humans.

 

[Hangin'on Hair]

@That Guy,

Yes if they overcome these culturing issues I think it's game over for Androgenetic Alopecia..

What are the chances of the body rejecting the hair??? Not trying to sound doom and gloom, but I'm pretty sure even Tsuji probably doesn't know the long term outcome. Who knows, you could end up growing a ton of hair, only to have it drop out after 5-6 months.
I really hope this works.

 

[Swoop]

What are the chances of the body rejecting the hair??? Not trying to sound doom and gloom, but I'm pretty sure even Tsuji probably doesn't know the long term outcome. Who knows, you could end up growing a ton of hair, only to have it drop out after 5-6 months.
I really hope this works.

None since they are your own cells, your own tissue.

The funny thing is that some portions of the hair follicle are thought to be immune privileged anyway. That experiment of Jahoda only seems to confirm that. This means that I could literally take your hair follicle, dissect it and take out the the dermal sheath cells, implant it on my *** , a new hair follicle would grow with partly your cells and it wouldn't get rejected.

 

[That Guy]

@That Guy,

Yes if they overcome these culturing issues I think it's game over for Androgenetic Alopecia.

I can understand the skeptics who say that this is a mouse model, and that a mouse model doesn't translate too humans, but this isn't entirely true in the context of Tsuji et al.

Remember that observations in humans actually tell us that the hair follicle can regenerate. In fact it has been confirmed in some studies that when a hair follicle is split (horizontal cut between DP and bulge) it can regenerate and actually often does regenerate.

Then we also got that Frankenstein experiment of Dr. Jahoda, who took his own hair follicle, took out a single cell line (dermal sheath cells) , and transplanted it into his wife his forearm.

a–d, Punch biopsies were taken from male scalp skin (a) and the hair-follicle end bulbs amputated (b), everted (c) and the exposed epidermal components scraped away and discarded (d). e, The dermal sheath and dermal papillae were separated, cleaned and pooled separately in culture medium. f, Up to 11 pieces of dermal sheath were combined and implanted into small, shallow wounds on the inner forearm. g, Induced fibres were distinct and often pigmented.

What happened there? Well after these dermal sheath cells were delivered to his wife forearm they induced brand new hair follicles. The funny thing is when they looked at those brand new induced hair follicles and performed DNA analysis they found out that the bottom part was from Jahoda and the upper part from his own wife. Apparently the cells from Jahoda set in a motion of mesenchymal-epithelial interaction which led to brand new hair follicles. The cells of Jahoda and ultimately the brand new induced hair follicles weren't even rejected.

Anyway this does show that the hair follicle is just very flexible as an organ and more importantly several types of (stem)cells in the hair follicle show regenerative potential to induce a brand new hair follicle.

This all leads me to think that this will be the "cure" for almost everyone, based on these simple observations, not in mice, but in actual humans.

Thanks, Swoop!

 

[Hangin'on Hair]

None since they are your own cells, your own tissue.

The funny thing is that some portions of the hair follicle are thought to be immune privileged anyway. That experiment of Jahoda only seems to confirm that. This means that I could literally take your hair follicle, dissect it and take out the the dermal sheath cells, implant it on my *** , a new hair follicle would grow with partly your cells and it wouldn't get rejected.

Lol! But why? Why my hair on your ***! You could have said shoulder or head at least.

 

[Baldybald1]

Swoop, what if somebody had SMP on the donor area? Can he use Tsuji treatment? And what if the donor area has a very few hair and exhausted from hair transplant ?

 

[Pray The Bald Away]

None since they are your own cells, your own tissue.

The funny thing is that some portions of the hair follicle are thought to be immune privileged anyway. That experiment of Jahoda only seems to confirm that. This means that I could literally take your hair follicle, dissect it and take out the the dermal sheath cells, implant it on my *** , a new hair follicle would grow with partly your cells and it wouldn't get rejected.

Does this mean that people with DUPA would benefit from this procedure even if they don't have stable donor hair?

 

[That Guy]

I have poliosis, so I'm going to get them to take donor hair from where the two colours intersect and see what kinda crazy #@&% happens.

 

[H]

Does this mean that people with DUPA would benefit from this procedure even if they don't have stable donor hair?

I HOPE SO. The sides of my hair are thinning also and if I am indeed following my grandfather and his brothers which is what it appears to be they have super thin sides and back as well probably under 100 hairs combined on his head. Hes 70 tho and a clean buzz looks great on him.

 

[GoldenMane]

As a Nintendo fan, I'm used to deadlines being missed. I expect even, multi billion dollar Japanese entertainment companies miss deadlines all the time. No reason to believe medical research would progress any quicker.

 

[Pray The Bald Away]

I HOPE SO. The sides of my hair are thinning also and if I am indeed following my grandfather and his brothers which is what it appears to be they have super thin sides and back as well probably under 100 hairs combined on his head. Hes 70 tho and a clean buzz looks great on him.

My hair thinned out all over my head from the antibiotic minocycline. I don't believe I have DUPA but I've noticed that many many men do and I would really like to see hair loss solved for them as well. I'm really sorry you have to go through such a devastating form of hair loss.

 

[UpAway]

Will a previous hair transplant effect this treatment? Also will hair grow exactly where it used to or will it be able to be controlled where the new follicles arise?

Thanks for anyone who can help!

 

[stump]

I have poliosis, so I'm going to get them to take donor hair from where the two colours intersect and see what kinda crazy #@&% happens.

I like how these two guys are just disliking you for the sake of disliking you. Seems real mature, especially from a prestigious MEDICAL student know-it-all like FoucaultII.

 

[Rofler]

Will a previous hair transplant effect this treatment? Also will hair grow exactly where it used to or will it be able to be controlled where the new follicles arise?

Thanks for anyone who can help!

Wait for interview at the end of this week (I guess). There will be an answers for your questions.

 

[whatevr]

I like how these two guys are just disliking you for the sake of disliking you. Seems real mature, especially from a prestigious MEDICAL student know-it-all like FoucaultII.

Lots of medical students (particularly on this forum) have serious attitude and modesty issues.
No wonder I disliked damn near every medical proffesional I had to interact with.

 

[FoucaultII]

Lots of medical students (particularly on this forum) have serious attitude and modesty issues.
No wonder I disliked damn near every medical proffesional I had to interact with.

Hun, keep generalisations to yourself.
It's because of medical professionals (not only physicians) that hair restoration may be a reality in da future.

 

[That Guy]

I like how these two guys are just disliking you for the sake of disliking you. Seems real mature, especially from a prestigious MEDICAL student know-it-all like FoucaultII.

I wouldn't be surprised if one is just a sockpuppet.

He also disliked Swoop's informative post here simply because it doesn't line up with his negative hopes. He was banned from hairlosscure2020 for the same behavior.

IMO, throwing around dislikes for the sake of it and/or spamming the New Technologies threads should result in bans. In the former's case, it builds up unjust negative rep to another user, which is exactly the perpetrator's intention; in the latter's case, as I've pointed out before, it contributes nothing of discussion to the thread. If you don't think this treatment is going to work out, just move on. I said in the Aclaris call thread (where I also got disliked by Farkhairloss) that I don't think JAK inhibitors are going to be the cure, as did Swoop. I stated my thoughts and moved on because I have nothing further to say. Repeatedly naysaying without any meaningful discussion, though? That's just trolling.

TL;DR? Send that olive-picking piece of sh*t packing, if you'd be so kind.

 

[hellouser]

I like how these two guys are just disliking you for the sake of disliking you. Seems real mature, especially from a prestigious MEDICAL student know-it-all like FoucaultII.

'Nuff said.

 

[FoucaultII]

I don't get it.
Why should I be banned?
Because I believe the 2020 timeline is unrealistic?!?
Or because I dislike other people's comments?
It makes no sense at all.
Hellouser, I don't understand why you feel resentful that I dislike all your comments.
I just don't like them.
What's the problem with that?

 

[Bill Sussman]

well, when you seem to be disliking certain people specifically, as it seems less about the post/comments and more about the users themselves. and some of these people you seem to have a thing against have been very valuable and helpful contributors to the forum for some time now. if it was about the posts themselves and there was valid reason for it, i don't think anyone would have a problem, but it just seems that specific members are being disliked for the sake of being disliked. disagreeing with a viewpoint is ok, but the purpose of the forum is not to just throw out dislikes for the hell of it, but rather, to discuss and debate civilly and reasonably about varying viewpoints. as long as it creates a good discussion and is not hostile or malicious in nature, it creates a good environment within the forum and provides insight and substance. This dislike type of thing is bound to frustrate some people as it brings a negative vibe and an unpleasant environment to the forum, without really contributing anything of substance.