Update From The God Himself - Dr. Takashi Tsuji

[AlexanderTheGreat]

It's off the track for the current thread, but I'm gonna ask about it. Why isn't anybody using CRISPR to deal with baldness? They should detect the genes that lead to baldness and edit them. Probably it is not that simple, though you get what I'm trying to say.

 

[H]

It's off the track for the current thread, but I'm gonna ask about it. Why isn't anybody using CRISPR to deal with baldness? They should detect the genes that lead to baldness and edit them. Probably it is not that simple, though you get what I'm trying to say.

Lack of perfect precision for one. There are many genes that contribute to this disease apparently so knowing what all effects they have is still ongoing research. A contributing gene may regulate other things in the cell that you dont want to change.

 

[AlexanderTheGreat]

Lack of perfect precision for one. There are many genes that contribute to this disease apparently so knowing what all effects they have is still ongoing research. A contributing gene may regulate other things in the cell that you dont want to change.

It won't take that long to perfect it. It is more important that they acquire data. By that I mean they need to get people genomes (lots of milions) and correlate them with their attributes. In that way, it will be easy for them to detect what every gene corresponds to.

 

[NotInmywatch]

It won't take that long to perfect it. It is more important that they acquire data. By that I mean they need to get people genomes (lots of milions) and correlate them with their attributes. In that way, it will be easy for them to detect what every gene corresponds to.

this proposal equals so somehow genetically modify scalp cells but not any other type of cells
which means that somehow we administer a CRISPR agent, most likely a virus, that modifies such cells.
the problem is, in theory, nothing refrains the virus from going to anywhere in the body, or , simpler,
the needle could release some agent into the bloodstream, which would go systemic and make you permanently castrated, with no
chance of reversion (you would be immune to any androgen).

 

[Robert Robertson]

It

Funny you should say mods are "nonexistent" just a few days after being temporarily banned. I have never understood this suicide by cop attitude, but suit yourself.

The truth doesn't require your permission to exist.

 

[pegasus2]

It won't take that long to perfect it. It is more important that they acquire data. By that I mean they need to get people genomes (lots of milions) and correlate them with their attributes. In that way, it will be easy for them to detect what every gene corresponds to.

Genes can have more than one function. The same gene can create one protein in one tissue, and a different one in another tissue. It will be some time before we have the knowledge to safely and effectively turn something as complex as baldness off and on.

 

[Haironnu]

Genes can have more than one function. The same gene can create one protein in one tissue, and a different one in another tissue. It will be some time before we have the knowledge to safely and effectively turn something as complex as baldness off and on.

well at least some future generation will be lucky enough to experience a complete cure for baldness and won't have to deal with this life ruining condition.

 

[AlexanderTheGreat]

this proposal equals so somehow genetically modify scalp cells but not any other type of cells
which means that somehow we administer a CRISPR agent, most likely a virus, that modifies such cells.
the problem is, in theory, nothing refrains the virus from going to anywhere in the body, or , simpler,
the needle could release some agent into the bloodstream, which would go systemic and make you permanently castrated, with no
chance of reversion (you would be immune to any androgen).

There is another approach, in which you edit the cells ex vivo, then insert them into the body.

Genes can have more than one function. The same gene can create one protein in one tissue, and a different one in another tissue. It will be some time before we have the knowledge to safely and effectively turn something as complex as baldness off and on.

That is why i said they need to identify what every gene corresponds to.

 

[MeDK]

There is another approach, in which you edit the cells ex vivo, then insert them into the body.

That is why i said they need to identify what every gene corresponds to.

What is it that you think researchers do? They do try to map out the human body every day, but its not as simple as doing a puzzle, if it was that simple we would have eradicated MANY diseases already, but we haven't.

Human have tried to cure baldness even before the Egyptians! we are talking about +4.000 years of known medical history where there have been a search for a treatment for baldness.

Also, crispr isn't the solution

"CRISPR is powerful, no doubt, but it has its drawbacks. As transformative as it has been, the molecular scissors of CRISPR are rather crude. Scientists program CRISPR to seek out double-stranded DNA and make a cut across both strands. This allows for DNA to be deleted or new DNA letters to be "pasted" into the gap, but the process is significantly error-prone -- CRISPR sometimes make cuts at different points far from the target site and can introduce errors into the genes." - Prime editing, Old vs. New

Even at DNA editing we are still trying to minimise errors, and now we have a thing called "prime editing"

Also everytime we introduce a human, we have to remember errors tend to happen, and with DNA editing, i personally wants to be at 100% sure

 

[nahte42]

Checking in here to say that again I feel like it's just a letdown that nobody has figured out an essential "cure" yet for baldness by implanting some sort of real or fake hair follicles. I get that there are tons of deeper biological and chemical factors in the equation that are tricky to solve, but it just seems ridiculous that with all the things we have achieved in the world by the year 2019, including tons of amazing medical procedures, the only real fix for a completely bald (on top) person who wishes to have hair is still to glue a fake rug to his scalp. Pathetic. Dr. Tsuji, you're truly the only "god" I will be "praying" to in my life.

 

[AlexanderTheGreat]

What is it that you think researchers do? They do try to map out the human body every day, but its not as simple as doing a puzzle, if it was that simple we would have eradicated MANY diseases already, but we haven't.

Human have tried to cure baldness even before the Egyptians! we are talking about +4.000 years of known medical history where there have been a search for a treatment for baldness.

Also, crispr isn't the solution

"CRISPR is powerful, no doubt, but it has its drawbacks. As transformative as it has been, the molecular scissors of CRISPR are rather crude. Scientists program CRISPR to seek out double-stranded DNA and make a cut across both strands. This allows for DNA to be deleted or new DNA letters to be "pasted" into the gap, but the process is significantly error-prone -- CRISPR sometimes make cuts at different points far from the target site and can introduce errors into the genes." - Prime editing, Old vs. New

Even at DNA editing we are still trying to minimise errors, and now we have a thing called "prime editing"

Also everytime we introduce a human, we have to remember errors tend to happen, and with DNA editing, i personally wants to be at 100% sure

There is great interest as well as funding in the are of genome editing. I bet in 10-15 years DNA editing will be widely accesible to the public.

 

[Marcaronii]

This is so depressing at this point I lost faith in every treatment proposal out there. Realistically we won’t cure baldness in the next 10-15 years

Time to buy a rope then.

 

[nahte42]

This is so depressing at this point I lost faith in every treatment proposal out there. Realistically we won’t cure baldness in the next 10-15 years

Did you completely forget about the subject of this thread?

 

[nahte42]

Can anyone explain to me why Dr. Tsuji's team is supposedly the only one that is doing this and will bring this to the marketplace soon? Because I've heard multiple other research teams and companies talk about how they also developed the ability to clone hair follicles and re-implant them...they were talking about it several years ago as well. So why do I keep hearing Tsuji is the only one? Is that just because the process in Japan is much quicker than the process of offering this type of procedure in the U.S. and other countries?

 

[Marcaronii]

Can anyone explain to me why Dr. Tsuji's team is supposedly the only one that is doing this and will bring this to the marketplace soon? Because I've heard multiple other research teams and companies talk about how they also developed the ability to clone hair follicles and re-implant them...they were talking about it several years ago as well. So why do I keep hearing Tsuji is the only one? Is that just because the process in Japan is much quicker than the process of offering this type of procedure in the U.S. and other countries?

I think Tissuse is doing the same thing. They are planning to do trials by december this year. Hope we get an update soon.

 

[H]

I think Tissuse is doing the same thing. They are planning to do trials by december this year. Hope we get an update soon.

How many follicles is Tissues advertising again?

 

[Marcaronii]

How many follicles is Tissues advertising again?

In the SHT process 30 hair follicles are extracted from the back of the scalp, dermal papilla cells are isolated from the follicles and multiplied in culture, and this yields a sum of 10,000 “neo-papillae” which would then be injected back into the scalp. (a webpage for SHT on Tissuse’s website is no longer active after being published in 2017)

 

[max310]

In the SHT process 30 hair follicles are extracted from the back of the scalp, dermal papilla cells are isolated from the follicles and multiplied in culture, and this yields a sum of 10,000 “neo-papillae” which would then be injected back into the scalp. (a webpage for SHT on Tissuse’s website is no longer active after being published in 2017)

Injection won’t do sh*t. They need to be transplanted.

 

[FilthyFrancis]

Injection won’t do sh*t. They need to be transplanted.

We should soon hear from TissUse. They advertized their presence at ISHRS 27th Hair Loss Congress with a poster “Development of Hair Follicle Anagen In Vitro as a Proof for the Hair Growth Inductive Properties of Neopapilla Hair Germ Transplants Intended for ‘Hair Cloning’ – Gerd Lindner, PhD Germany”. The event will start tomorrow (Nov 13th) and last for 4 days (till the 17th).

 

[MrV88]

We should soon hear from TissUse. They advertized their presence at ISHRS 27th Hair Loss Congress with a poster “Development of Hair Follicle Anagen In Vitro as a Proof for the Hair Growth Inductive Properties of Neopapilla Hair Germ Transplants Intended for ‘Hair Cloning’ – Gerd Lindner, PhD Germany”. The event will start tomorrow (Nov 13th) and last for 4 days (till the 17th).

And they will be like : "BOOM release in several weeks f*** Replicel!"
Drops the mic and leaves the stage...would pay thousand of Euros to see that happening