Ut-155 Group Buy. Androgen Receptor Degrader

[hemingway_the_mercenary]

What is it?
UT-155 is the newest discovery of anti androgens. Instead of inhibiting androgens by binding to the receptor, it binds to the receptor and destroys it.

Advantages of Degrading the AR
By degrading the AR we dont have to worry about the increase in AR sensitiviy as a result of inhibition. If the AR is degraded a new AR has to be formed and that buys you time where there is a zero of the AR intercting with the DNA resulting in androgenic gene expression.

This also has potential to stop hairloss in those with very aggressive hairloss as it will degrade mutant ARs which would normally be anti androgen resistant.

This is by far the biggest thing we have to look forward to in regards to a cure. If we can degrade most of the ARs in the scalp, androgenic gene expession will go down resulting in a downregulation of AR production and stop the positive feedback loop of hairloss.

Here is the results of AR degradation. AR stands for androgen receptor. R1881 is a synthetic steroid that is more androgenic than DHT.

Who this would be for

This is ONLY for people with finasteride/dutasteride resistant hairloss, there is no point in trying out experimental drugs if you respond to finasteride. Others who might be intrested are people who want to recover norwoods, but this is of course at your own risk

Chance for side effects
The half life of UT-155 was reported to be short, so it can be desireable for hairloss as once it goes systemic there will not be sufficient dosage to cause any real damageas your testosterone will outcompete it at equal levels.

Also, ARs are regenrated by your body all the time. There is no risk of permanent AR loss should you decide to stop treatment.

As for potential to interact with GABA receptors like Enzalutamide, this isnt really known. However, even if it interacts with GABA receptors (which is unkown) at the dosage applied on the scalp it will most likely not be enough to cause such side effects

If anyone is seriously intersted in this compound leave a comment and tag me. The price will be around 250-300 per gram most likley. We will probably have to use 5-10mg per day. The more demand, the cheaper price we can get.

 

[Sanchez1234]

What is it?
UT-155 is the newest discovery of anti androgens. Instead of inhibiting androgens by binding to the receptor, it binds to the receptor and destroys it.

Advantages of Degrading the AR
By degrading the AR we dont have to worry about the increase in AR sensitiviy as a result of inhibition. If the AR is degraded a new AR has to be formed and that buys you time where there is a zero of the AR intercting with the DNA resulting in androgenic gene expression.

This also has potential to stop hairloss in those with very aggressive hairloss as it will degrade mutant ARs which would normally be anti androgen resistant.

This is by far the biggest thing we have to look forward to in regards to a cure. If we can degrade most of the ARs in the scalp, androgenic gene expession will go down resulting in a downregulation of AR production and stop the positive feedback loop of hairloss.

Here is the results of AR degradation. AR stands for androgen receptor. R1881 is a synthetic steroid that is more androgenic than DHT.
View attachment 99259

Who this would be for

This is ONLY for people with finasteride/dutasteride resistant hairloss, there is no point in trying out experimental drugs if you respond to finasteride. Others who might be intrested are people who want to recover norwoods, but this is of course at your own risk

Chance for side effects
The half life of UT-155 was reported to be short, so it can be desireable for hairloss as once it goes systemic there will not be sufficient dosage to cause any real damageas your testosterone will outcompete it at equal levels.

Also, ARs are regenrated by your body all the time. There is no risk of permanent AR loss should you decide to stop treatment.

As for potential to interact with GABA receptors like Enzalutamide, this isnt really known. However, even if it interacts with GABA receptors (which is unkown) at the dosage applied on the scalp it will most probably not to cause such side effects

If anyone is seriously intersted in this compound leave a comment and tag me. The price will be around 250-300 per gram most likley. We will probably have to use 5-10mg per day. The more demand, the cheaper price we can get.

Price is quite cheap.
Why do you think this is better than ru-58642?

 

[Heinrich Harrer]

Just castrate yourselves. “Even if it fucks with GABAA receptors it will PROBABLY not cause MUCH sides”. When you see the words “probably” and “much” as you see them in every ridiculous propecia citing in ncbi, know that it means “we don’t have a f*****g clue but go ahead, be our mice”. Absurd. We need to find a proper cure and stop killing our manhood.

 

[Grasshüpfer]

I find it quite interesting.
The question here is really how to make sure it doesn't go systemic.
I would also be weary of degrading my androgen receptors. Can have all sorts of unwanted side effects. Are there any human studies yet, eg for androgena dependent cancer?

 

[Heinrich Harrer]

I find it quite interesting.
The question here is really how to make sure it doesn't go systemic.
I would also be weary of degrading my androgen receptors. Can have all sorts of unwanted side effects. Are there any human studies yet, eg for androgena dependent cancer?

It goes systemic. Everything goes systemic. Even the sunscreen, even the steam. The skin is a sponge. People who think otherwise are deluded. Which is why I told that guy to just castrate himself and be done with it.

 

[Sanchez1234]

It goes systemic. Everything goes systemic. Even the sunscreen, even the steam. The skin is a sponge. People who think otherwise are deluded. Which is why I told that guy to just castrate himself and be done with it.

Thank you for your contribution

 

[Heinrich Harrer]

Thank you for your contribution

Anytime.

 

[hemingway_the_mercenary]

Price is quite cheap.
Why do you think this is better than ru-58642?

Once the AR is degraded a new AR needs to be regenerated before androgenic gene expression. RU58642 is good for sure but it leaves the possibility of AR sensitization and the development of mutant ARs that can use it as an androgen. We dont have to worry abou it once the AR is degraded

I'be found about 5 anti androgenic molecules even stronger than ru-58642 that inhibited the effect of testosterone on the prostate by up to 96%. so yea theres def many strong moleculus out there that havent been developed due to lack of need and entry barrier

 

[baldingAF]

Putting this up for those who get picked up by all the hype and aren’t afraid of things like “probably won’t be side-effects”

It is well know that DHT binds to AR and this considered, within the mind, as a neurotransmitter (if in the body it’s a hormone). And it has been stated multiple times that this interaction is used in the body for many things that we don’t quite understand yet (like why people on finasteride become clinically depressed even when their hair gets better)

Additionally GABA (Gamma Aminobuteric Acid) is a major, if not the major inhibitory neurotransmitter. Don’t focus on the word inhibition, the brain is so complex that inhibition and excitation work in ways that contradict their connotation (for example a lot of your body’s plan like where limbs grow from HOX genes are done through inhibition)

The warning here is that if this chemical affects GABA or the way GABA receptors work in anyway then it will literally change one of your brain’s go to tool and if that gets into your head somehow, microneedling or last the Blood Brain Barrier then sh*t yo, you did whatever happens.....which of course no one really knows

 

[Heinrich Harrer]

Dude googles AR inhibitors and goes “I’ve found”. The amount of delusion and naivety is scary. So is the ease with which users here lie about their experience with antiandrogens, since they all experience changes, and change means side effect for those who still don’t get it. This area in medicine has to be more ridiculous than the anabolic steroids one. The first thing any normal human being should do is warn his fellow hair loss sufferers and speak against such stupid threads that have absolutely no meaning whatsoever. It feels as if @hemingway_the_mercenary is in a virtual treasure hunt or he’s about to have a scene with Russel Crow in A Beautiful Mind. Blind assumptions placed in between that text by him and nobody else. I don’t care how much hair anyone has lost, as a matter of fact very few of us here have actually lost enough to be angry about it. But first and foremost we don’t jeopardize someone’s health. If someone wishes to take his risks and document his own journey (such as @bridgeburn) without luring others in, that is fine. But claiming “you” found some shitty *** article about stuff you and the author has no clue about regarding its behavior as a hair loss inhibitor then please BY ALL MEANS do not be so dull as to promote its usage and take credit for anything. Most of the users here have absolutely no idea about basic stuff regarding hormones. Rule number one is altering a hormonal profile is a no-no and if done, it always comes with severe sides. We need to start focusing more on proper future treatments that do not cause irreparable damage.

 

[Btg]

Actually none of you is offering anything in this thread , he found a molecule that degrades ARs , you talk about the dangers of doing that . It is pretty obvious that ARs are useful in the body , everyone gets it , if it goes systemic there will surely be side effects . But all this " you re going to die for sure " talk is meaningless , if you arent specialised in a subject that involves androgens ,what is the point of pushing your opinion onto others ? If they wanna try it they will try it , they would better ask a doctor about it though

 

[Heinrich Harrer]

Actually none of you is offering anything in this thread , he found a molecule that degrades ARs , you talk about the dangers of doing that . It is pretty obvious that ARs are useful in the body , everyone gets it , if it goes systemic there will surely be side effects . But all this " you re going to die for sure " talk is meaningless , if you arent specialised in a subject that involves androgens ,what is the point of pushing your opinion onto others ? If they wanna try it they will try it , they would better ask a doctor about it though

None of you is specialized in anything. You are all, including me, people who share their experiences and opinions. And when you do that, you take great care of what you say. He didn’t find anything, in fact he has no idea about AR, DHT and anything else, otherwise he wouldn’t be making these stupid suggestions. Same way people in Turkish forums had Cellagance lotion with Diane-35, that did great good to a lot of folks there for some tiny fuzz regrowth that vanished soon after.

Rule number 1: don’t pretend to know sh*t
Rule number 2: don’t advise people on sh*t you don’t know
Rule number 3: always be cautious

Hair loss is one thing, playing with chemicals is another.

 

[Btg]

and what are you doing in a hairloss forum if you wont use anything to try and save your hair ?

 

[Heinrich Harrer]

and what are you doing in a hairloss forum if you wont use anything to try and save your hair ?

Hair loss forum is not only for junkies. It’s for people who want to share their experiences, be part of a community of people with the same “troubles” as it also works well psychologically. I’ve used propecia, minoxidil, dermarolling, etc. I’m not lost or irrelevant one bit. Some of us feel better if we help others. I also check the news section as there are many treatments coming our way soon, some of them with great potential. For some of us, it’s not really about saving, it’s more about reversing. Obviously a young nw2-3 doesn’t get it (yet).

 

[ZenHead]

On paper this treatment looks absolutely awesome... and also incredibly dangerous. I’m not going to get involved but if anyone tries this please start with a very low dose to gauge side effects. A destroyed androgen receptor (not in the scalp) has the potential to give side effects much worse than finasteride. I do think this treatment will work pretty well, but the potential side effects aren’t worth it for me. Good luck to anyone that tries this, and be careful

 

[Btg]

ok i get it , you re waiting for tsuji and in the meantime scare everyone about everything without any real knowledge on the subject

 

[Tommybommy1363]

and what are you doing in a hairloss forum if you wont use anything to try and save your hair ?

To post sad sack threads in the impact of hairloss section, brag about how many Norwoods he has and tell others how awful propecia is.

 

[Tommybommy1363]

On paper this treatment looks absolutely awesome... and also incredibly dangerous. I’m not going to get involved but if anyone tries this please start with a very low dose to gauge side effects. A destroyed androgen receptor (not in the scalp) has the potential to give side effects much worse than finasteride. I do think this treatment will work pretty well, but the potential side effects aren’t worth it for me. Good luck to anyone that tries this, and be careful

Yes this one doesn’t sound like a good idea. But then again neither does daro, biclutamide hrt or many of the other things people on here try

 

[Heinrich Harrer]

ok i get it , you re waiting for tsuji and in the meantime scare everyone about everything without any real knowledge on the subject

Quite an assumption. Tsuji isn’t even gonna happen, it’s just the latest meme that softens one’s heart about this issue. And yes, you’re all clueless and the reason I tell you is because you claim to be the opposite. I get it, you kids google and visit ncbi. You read A, you read B, then you add A and B and form your conclusions. But there is no A and B, there is A to Z. And that’s a fraction of the literature that you need to know in order to understand. When people say “my balls hurt on propecia but it went away” what do you make of it? Nothing. You need ncbi related articles but none of them will tell you why it happened and what went on or where you are now after the pain is gone.

My point is this whole thing is false and if you take the few seconds to open your eyes and ears, you’ll see it too. This is not only a childish approach to dangerous chemical cocktails, the entire path is wrong. Antiandrogens will never be a proper solution to hair loss because it doesn’t combat what it needs to combat, it works as a nuclear explosion to kill the lights. Lights go off, so does everything else.

If someone wants to do research, it’s not the way to do it. Reading a bunch of articles means nothing. Read literature, medicine books, visit endocrinologists. I know, many doctors are clueless about much of it but not all. And let us focus on taking a different path into fighting hair loss.

Scaring people works well sometimes. It prevents them from doing stupid sh*t they will regret later on. Reading the kid’s post on how permanently damaging the AR enzyme is a beautiful way to halt hair loss and hair loss to those who don’t respond to Finasteride is absurd. First of all, nobody here knows why some don’t respond. Maybe in fact they do but there is another factor working synergistically with the AR enzyme you’re fighting. And it just doesn’t stop hair loss. You can’t force your assumptions as facts to an argument because it suits you. Nobody needs to assume regarding the horrendous and sometimes irreversible damage this drug can have on an individual. Son, any guy on gear will tell you using an AI for years is suicide. Why don’t you google THAT. And you want me to shut up and tell nobody that this horrendous drug taken for life is what? Is going to be ok? Is going to be fine because you and someone else take it? That’s classic misinformation, when A trusts B based on B’s personal experience. Finasteride has a sheet of paper with side effects that should you notice them, discontinue the drug immediately. And people here take it regardless of them. One day they develop other far more complicated sides. Brain isn’t what it used to be, shortterm memory is fucked. Immune system problems. Surely it must be all the relentless sex and parting you’ve had. No wait, you didn’t. With a limp dick and b**ch tits? No.

f*** this drug and anyone promoting it or any related drugs as safe and sound. Period.

 

[Tommybommy1363]

If someone wants to do research, it’s not the way to do it. Reading a bunch of articles means nothing. Read literature, medicine books, visit endocrinologists.

Where do you think literature, medicine book and endocrinologists get their information? Surely it isn't clinical and bench research!!! No those are just stupid articles...