Ut-155 Group Buy. Androgen Receptor Degrader

[Tommybommy1363]

Name the two things that show fat in the liver and at which values or more and which must be at what value. Name them, you include them in blood tests should you wish to. Name them right now. You’re free to search using any browser and any article you want to, since you obviously have no clue. You would if you studied. Go.

Edit: @hemingway_the_mercenary
already disliked it, he couldn’t find sh*t on ncbi, he’s mad.

2? The differential for fatty liver is very broad... nafld, alcoholic hepatitis, infectious hepatitis, autoimmune hepatitis, congenital hepatitis like Wilson’s disease... I could list a page as it is a non specific finding.

If you are asking for a screening test (which is really only validated in nafld) then probably ast/alt. The upper limits vary on the lab

I would check transaminases, bill, inr, albumin, ammonia, a ruq ultrasound. From there it’s really based on a your principle suspicion, severe liver disease often will end requiring a biopsy

 

[hemingway_the_mercenary]

Yes please don’t ask me about “fatty liver and blood tests” because I know nothing of those lol.

I work with endocrine problems all the time... an endocrinologist doesn’t have some sort of secret knowledge that no one else does. They use the same data and guidelines like everyone else.

You degrade people as simply using google to find data, but I’ve never seen you demonstrate any knowledge in how to actually do a scientific literature review or show any of the statistical background necessary to actually interpet the data presented to you. The fact that you cite 1st year medical student texts is extremely telling. There are some on this forum with obvious scientific backgrounds who actually have something of value to add. You are not one of them, stop acting like you are

This guy said AIs tank cholesterol

2? The differential for fatty liver is very broad... nafld, alcoholic hepatitis, infectious hepatitis, autoimmune hepatitis, congenital hepatitis like Wilson’s disease... I could list a page as it is a non specific finding.

If you are asking for a screening test (which is really only validated in nafld) then probably ast/alt. The upper limits vary on the lab

I would check transaminases, bill, inr, albumin, ammonia, a ruq ultrasound. From there it’s really based on a your principle suspicion, severe liver disease often will end requiring a biopsy

Stop responding to this idiot

 

[Heinrich Harrer]

2? The differential for fatty liver is very broad... nafld, alcoholic hepatitis, infectious hepatitis, autoimmune hepatitis, congenital hepatitis like Wilson’s disease... I could list a page as it is a non specific finding.

If you are asking for a screening test (which is really only validated in nafld) then probably ast/alt. The upper limits vary on the lab

I would check transaminases, bill, inr, albumin, ammonia, a ruq ultrasound. From there it’s really based on a your principle suspicion, severe liver disease often will end requiring a biopsy

I’ve asked for alt/ast, thanks for writing a wall of text you found online, hoping to get it right. I didn’t ask for lists. Literally said “the two god damn things in a blood test that if elevated (one or both) show it”, didn’t open a discussion about fatty liver in general. I will close this argument here.

 

[hemingway_the_mercenary]

Why UT-155 ? Why not ARCC-4 ? ARV-110 ? or others ?

And have you got a reliable source (not chinese supplier) ?

I think, like you said, it's the perfect cure for those who have their androgen receptors upregulated ... but not sure drugs are really available :/ (or safe ...).

To be honest I wasn’t aware of these other SARDs as this is obviously a very new field. UT-155 has a very short half life and it was the first sard ever discovered and not marketed or tested further because of its short half life

Probably these newer SARDs were designed to have a much longer half life. But I will look into them later

Thanks for sharing

 

[hemingway_the_mercenary]

Why UT-155 ? Why not ARCC-4 ? ARV-110 ? or others ?

And have you got a reliable source (not chinese supplier) ?

I think, like you said, it's the perfect cure for those who have their androgen receptors upregulated ... but not sure drugs are really available :/ (or safe ...).

After more research, I cant even find the molecular structure for ARV-110. ARCC-4 is basically enzalutamide (which has a 6 day half life) with a tail structure. Their both more potent than UT-155 and almost definitly have a significantly longer half life.

Both drugs have been submitted into IND approval testing for prostate cancer. AKA they developed the perfect molecule for prostate cancer and no we will be left in the dark. Luckily they left us with UT in the process.

Using a SARD with a 6 day half life would be asking for trouble. At least with enza/bica you know that unless its at way higher concentration than testosterone there will be little to no anti androgenic effect. With these other drugs, youre really running the risk

 

[Tommybommy1363]

I’ve asked for alt/ast, thanks for writing a wall of text you found online, hoping to get it right. I didn’t ask for lists. Literally said “the two god damn things in a blood test that if elevated (one or both) show it”, didn’t open a discussion about fatty liver in general. I will close this argument here.

I wrote more because your question doesn’t really make a whole lot of sense. “Fatty liver” is just steatosis and alt/ast won’t actually be elevated. If you have steatoic hepatitis it will be elevated but even then all you know is you have liver inflammation. There is no blood test specific to “fatty liver”, you would need imaging usually a ruq us.

I don’t need to look up how basic liver labs work. Just a hint if you truly want to be useful in fighting hairloss, drop the pretend doctor act and pick up a statistic text book. If you can truly understand how to interpret a scientific paper that will serve you much better than reading Medical student books which are cursory and basic

 

[michel sapin]

The medication itself and for prolonged periods of time. It’s the act itself of the AI and the AI itself, not the estradiol value. Do blood tests and find out where you’re at.

Because i asked the same uestion to dr rand mc clain who said that it was only if you overused it that side effect occurs .

 

[hemingway_the_mercenary]

Because i asked the same uestion to dr rand mc clain who said that it was only if you overused it that side effect occurs .

This has nothing to do with this thread. Take it somewhere else

@itchymadscalp @iamme_ @jared garnith @Sanchez1234 @peewee etc let me know if you guys are interested

 

[AnxiousAndy]

What is it?
UT-155 is the newest discovery of anti androgens. Instead of inhibiting androgens by binding to the receptor, it binds to the receptor and destroys it.

Advantages of Degrading the AR
By degrading the AR we dont have to worry about the increase in AR sensitiviy as a result of inhibition. If the AR is degraded a new AR has to be formed and that buys you time where there is a zero of the AR intercting with the DNA resulting in androgenic gene expression.

This also has potential to stop hairloss in those with very aggressive hairloss as it will degrade mutant ARs which would normally be anti androgen resistant.

This is by far the biggest thing we have to look forward to in regards to a cure. If we can degrade most of the ARs in the scalp, androgenic gene expession will go down resulting in a downregulation of AR production and stop the positive feedback loop of hairloss.

Here is the results of AR degradation. AR stands for androgen receptor. R1881 is a synthetic steroid that is more androgenic than DHT.
View attachment 99259

Who this would be for

This is ONLY for people with finasteride/dutasteride resistant hairloss, there is no point in trying out experimental drugs if you respond to finasteride. Others who might be intrested are people who want to recover norwoods, but this is of course at your own risk

Chance for side effects
The half life of UT-155 was reported to be short, so it can be desireable for hairloss as once it goes systemic there will not be sufficient dosage to cause any real damageas your testosterone will outcompete it at equal levels.

Also, ARs are regenrated by your body all the time. There is no risk of permanent AR loss should you decide to stop treatment.

As for potential to interact with GABA receptors like Enzalutamide, this isnt really known. However, even if it interacts with GABA receptors (which is unkown) at the dosage applied on the scalp it will most likely not be enough to cause such side effects

If anyone is seriously intersted in this compound leave a comment and tag me. The price will be around 250-300 per gram most likley. We will probably have to use 5-10mg per day. The more demand, the cheaper price we can get.

As much as I dislike you, this is a great post. Nice one.

 

[Pelimorfo]

Yes. It is a great dangerous post.

 

[Timii]

I don't understand why you guys rage at Heinrich Harrer, although he might have sounded a little annoying, he's telling the truth. It's clear that taking this stuff is a gamble.

 

[Btg]

I don't understand why you guys rage at Heinrich Harrer, although he might have sounded a little annoying, he's telling the truth. It's clear that taking this stuff is a gamble.

because he is annoying and spamming every thread with " you might aswell castrate yourself " and repeating sh*t like " it is known that this will make this rise and this tanks this and then this happend then your axis crashed and you die" when he is not even related to medicine
Also no newcomers will try ut-155 , if you are going to try it you most certainly know what is an androgen receptor

 

[jared garnith]

This has nothing to do with this thread. Take it somewhere else

@itchymadscalp @iamme_ @jared garnith @Sanchez1234 @peewee etc let me know if you guys are interested

I'm interested but it really depends how much each person would be paying for the group buy

 

[Sanchez1234]

This has nothing to do with this thread. Take it somewhere else

@itchymadscalp @iamme_ @jared garnith @Sanchez1234 @peewee etc let me know if you guys are interested

I am in!

 

[hemingway_the_mercenary]

I don't understand why you guys rage at Heinrich Harrer, although he might have sounded a little annoying, he's telling the truth. It's clear that taking this stuff is a gamble.

In the grand scheme of things degrading and AR poses no greater risks than inhibiting it. The only difference is with this there will be no upregulation or resistance development.

If RU goes systemic it causes as much sides as this. Both are elongated from the system very quickly

 

[iamme_]

I'm interested but it really depends how much each person would be paying for the group buy

Same

 

[Capone]

Doesn’t Turmeric degrade AR in the scalp?

 

[justlol@you]

if literal physical castration doesn't facilitate regrowth, then I'm not sure what you expect with anti AR class drugs.

 

[hemingway_the_mercenary]

if literal physical castration doesn't facilitate regrowth, then I'm not sure what you expect with anti AR class drugs.

physical castration crashes all testosterone, which means by defaul your body prodcues almost zero estrogen as it cant convert any.

 

[justlol@you]

physical castration crashes all testosterone, which means by defaul your body prodcues almost zero estrogen as it cant convert any.

hmm?

AR function is necessary for the leydig cells
https://link.springer.com/chapter/10.1007/978-1-59745-453-7_24

Since you can't selectively choose which tissue this is going to take action on, I can't see this resulting in anything other than a situation where you are hormonally similar to castrate, in which case you're coming up bupkis on E2 anyway. Why do you believe otherwise?