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- 1
you said it’s bad to take long term but it sounds like a permanent medication
Who had take Accutane for acne? Come here!! we also have CCCAlopecia!!
Well, I'd rather figure out how to stop the inflammation using natural methods. Like a diet change of sorts
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- 637
Update on this. So I know that Lichen Planopilaris can actually occur from sebaceous gland disfunction. In researching this, I found this article:
www.researchgate.net
Isotretinoin suppresses sebum production and if we follow that chain of thought, it may be that sebaceous gland disruption induced lichen planopilaris or something like it.
“Isotretinoin significantly decreased lipogenesis, while the PPARalpha agonist-GW7647, PPARdelta agonist-GW0742, PPARalpha/delta agonist-GW2433, PPARgamma agonist rosiglitazone, and the pan-agonist-GW4148, increased lipogenesis. Patients treated with thiazolidinediones or fibrates had significant increases in sebum production (37 and 77%, respectively) when compared to age-, disease-, and sex-matched controls.”
Sebum production table:
As you can see isotretinoin (13-cos RA) reduces lipid production and PPAR agonists seem to reverse this process. Interestingly enough, Pioglitazone is prescribed for Lichen Planopilaris and is fairly effective. But looking at the first table, it seems that it doesn’t do much in producing more lipids. Maybe Rosiglatizone would be more effective or a fibrate medication.
(PDF) Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production
PDF | Sebum production is key in the pathophysiology of acne, an extremely common condition, which when severe, may require treatment with isotretinoin,... | Find, read and cite all the research you need on ResearchGate
www.researchgate.net
Isotretinoin suppresses sebum production and if we follow that chain of thought, it may be that sebaceous gland disruption induced lichen planopilaris or something like it.
“Isotretinoin significantly decreased lipogenesis, while the PPARalpha agonist-GW7647, PPARdelta agonist-GW0742, PPARalpha/delta agonist-GW2433, PPARgamma agonist rosiglitazone, and the pan-agonist-GW4148, increased lipogenesis. Patients treated with thiazolidinediones or fibrates had significant increases in sebum production (37 and 77%, respectively) when compared to age-, disease-, and sex-matched controls.”
Effect of various PPAR ligands on total lipid production in SEB-1 cells Total lipid production (CPM/10 6 cells/hour7SE)
Sebum production table:
As you can see isotretinoin (13-cos RA) reduces lipid production and PPAR agonists seem to reverse this process. Interestingly enough, Pioglitazone is prescribed for Lichen Planopilaris and is fairly effective. But looking at the first table, it seems that it doesn’t do much in producing more lipids. Maybe Rosiglatizone would be more effective or a fibrate medication.
- Reaction score
- 18
That's interesting - is there a suggestion that isotretinoin can causes lichen planopilaris? I know it's actually used as a treatment for Frontal FIbrosing (FFA).Update on this. So I know that Lichen Planopilaris can actually occur from sebaceous gland disfunction. In researching this, I found this article:
(PDF) Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production
PDF | Sebum production is key in the pathophysiology of acne, an extremely common condition, which when severe, may require treatment with isotretinoin,... | Find, read and cite all the research you need on ResearchGate
Isotretinoin suppresses sebum production and if we follow that chain of thought, it may be that sebaceous gland disruption induced lichen planopilaris or something like it.
“Isotretinoin significantly decreased lipogenesis, while the PPARalpha agonist-GW7647, PPARdelta agonist-GW0742, PPARalpha/delta agonist-GW2433, PPARgamma agonist rosiglitazone, and the pan-agonist-GW4148, increased lipogenesis. Patients treated with thiazolidinediones or fibrates had significant increases in sebum production (37 and 77%, respectively) when compared to age-, disease-, and sex-matched controls.”
Effect of various PPAR ligands on total lipid production in SEB-1 cells Total lipid production (CPM/10 6 cells/hour7SE)
View attachment 159397
Sebum production table:
View attachment 159398
As you can see isotretinoin (13-cos RA) reduces lipid production and PPAR agonists seem to reverse this process. Interestingly enough, Pioglitazone is prescribed for Lichen Planopilaris and is fairly effective. But looking at the first table, it seems that it doesn’t do much in producing more lipids. Maybe Rosiglatizone would be more effective or a fibrate medication.
INtersetingly I was diagnosed with lichen planopilaris last year - I used accutane when I was a teenager for about a year - and that's when I first noticed hair loss. I'm wondering if I could have had lichen planopilaris for all these years and not realised.,
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- 637
It may be related, but lichen planopilaris should burn out on its own over a few years. Maybe accutane induced lichen planopilaris is hard to get rid of without medicine.
I’m going to a dermatologist consult soon and going to push for a multi modal approach. So doxycycline, steroid solution is what I’m currently using. I want to add tacrolimus, a ppary agonist, and maybe plaquenil.
Hello,
I took Roaccutane when I was 17, today I'm 28 and I have diffuse alopecia, all over my head including the back of the neck.
I went for a biopsy at the dermatologist because like you I thought it had sabotaged my hair in the long term and since my father and neither of my two grandfathers lose any hair I thought it was due to that .
the results were clear, nothing abnormal in my scalp, the alopecia CCCA would have shown traces of inflammation so that's not it.
the women in my family lose their hair, I have the same pattern as they do (no chances are there with any other case of male alopecia in my family ...)
And like women, no treatment works to maintain or even slow the progression of my baldness.
And anyway, 0% of women who take the treatment do not lose their hair, although if it worked as you say, they would be as affected as men.
in short, seriously you should explore other avenues, the CCCA with Roaccutane is nonsense
I took Roaccutane when I was 17, today I'm 28 and I have diffuse alopecia, all over my head including the back of the neck.
I went for a biopsy at the dermatologist because like you I thought it had sabotaged my hair in the long term and since my father and neither of my two grandfathers lose any hair I thought it was due to that .
the results were clear, nothing abnormal in my scalp, the alopecia CCCA would have shown traces of inflammation so that's not it.
the women in my family lose their hair, I have the same pattern as they do (no chances are there with any other case of male alopecia in my family ...)
And like women, no treatment works to maintain or even slow the progression of my baldness.
And anyway, 0% of women who take the treatment do not lose their hair, although if it worked as you say, they would be as affected as men.
in short, seriously you should explore other avenues, the CCCA with Roaccutane is nonsense
I think it's going to be more likely that body functions that caused most of us to have bad acne are somehow contributing to us having more severe and earlier onset male pattern baldness. I also took Accutane like many people in here, have the insane itch and unhealthy scalp with some thinning at the back/sides, but I started losing hair at the temples before I started Accutane, which I took at 22/23. Of course I don't remember my head ever being itchy in the early days, so that could be something Accutane caused.
Going to get myself a scalp biopsy soon, so if anything relevant is found I'll update here.
Going to get myself a scalp biopsy soon, so if anything relevant is found I'll update here.
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- 35
did you try inosin pranobex against dupa finally ?