The guy who's just above average in looks and doing well because his looks are more than good enough.
He goes from a satisfying life to possibly being repulsive to women.
The 6/10 guy who becomes a 3/10 due to hair loss and exaggerated facial features that makes him look like an alien. It can happen, and I imagine the devastation.
This is the kind of guy who loses the most.
Good-looking guys like Kelly Slater or Billy Zane go from being gods to still being in a pretty good place, 9/10 to 7/10 or they become above average themselves. They don't lose their ability to get love, a good social life, employment perspectives, etc.
The easiest is for the short ugly out-of-shape 4/10 who becomes a 2/10, his quality of life isn't going to change much.
Pretty much nothing before in terms of dating prospects, and nothing after.