Why Finasteride Only Works With A Few Men ? The Answer

[moxsom]

It turns out finasteride response has a lot to do with your genetics. I wrote a post about it here:

https://www.hairlosstalk.com/intera...test-basically-a-revamped-hairdx-test.106767/

 

[MrPortugal]

It turns out finasteride response has a lot to do with your genetics. I wrote a post about it here:

https://www.hairlosstalk.com/intera...test-basically-a-revamped-hairdx-test.106767/

You can do a study about minoxidil too?

I think will be a good study.

Because I had saw guys who use minoxidil for like 5, 10, 20 years and still hair...and the opposite side who stop to works after 1 year of use.

What do think about this?

 

[dralex]

It turns out finasteride response has a lot to do with your genetics. I wrote a post about it here:

https://www.hairlosstalk.com/intera...test-basically-a-revamped-hairdx-test.106767/

Could you please explain how you could test whether someone would respond well to finasteride?

 

[Crystalclear12]

If there're studies supports what you're saying then i can't argue with you.

The fact that you didn't know that proves your lack of knowledge

 

[Stanx22]

The fact that you didn't know that proves your lack of knowledge

Cry more.

 

[Crystalclear12]

Cry more.

Wait didn't you create like 5 threads in a row literally crying about how much you hate your life lmao stfu

 

[Stanx22]

Wait didn't you create like 5 threads in a row literally crying about how much you hate your life lmao stfu

But i didn't cry because of other people you dumb piece of sh*t.

 

[Crystalclear12]

But i didn't cry because of other people you dumb piece of sh*t.

But u did cry lol

 

[Stanx22]

But u did cry lol

That's why because i'm a little kid remember ? But why you an adult cry ?

 

[Crystalclear12]

That's why because i'm a little kid remember ? But why you an adult cry ?

Lol sit down

 

[davesmith420]

I think Crystal and Stanx should f***

 

[Crystalclear12]

I think Crystal and Stanx should f***

Really reaching for likes there huh bud

 

[nicksparrow]

Quit saying finasteride is only option when Dutasteride is better fools

 

[moxsom]

You can do a study about minoxidil too?

I think will be a good study.

Because I had saw guys who use minoxidil for like 5, 10, 20 years and still hair...and the opposite side who stop to works after 1 year of use.

What do think about this?

I think I most certainly could. There are several genetic changes in an enzyme that we produce that could alter how well mioxidil works. For example, rs9282861 in the gene SULT1A1. SULT1A1 is a sulfotransferase gene, this gene modifies drugs like minoxidil in your body to make them biologically active. Some people are better at making them biologically active than others.

So if you have the Arg/Arg genotype you would be the best responder to minoxidil while if you have the His/His genotype you would be the worst.

 

[moxsom]

Could you please explain how you could test whether someone would respond well to finasteride?

It's explained in that thread, let me know if there's any specifics you want me to clear up.

 

[Trichosan]

I think I most certainly could. There are several genetic changes in an enzyme that we produce that could alter how well mioxidil works. For example, rs9282861 in the gene SULT1A1. SULT1A1 is a sulfotransferase gene, this gene modifies drugs like minoxidil in your body to make them biologically active. Some people are better at making them biologically active than others.

View attachment 58585

So if you have the Arg/Arg genotype you would be the best responder to minoxidil while if you have the His/His genotype you would be the worst.

@moxsom, do you know any diagnostic lab companies that would do genetic analysis for this? I used my old 23andme test and ran the raw data through Genetic Genie but it doesn't include all SNPs.

 

[moxsom]

@moxsom, do you know any diagnostic lab companies that would do genetic analysis for this? I used my old 23andme test and ran the raw data through Genetic Genie but it doesn't include all SNPs.

I'm currently building one specific to hair loss genetics. We're going to reanalyze 23andme data for hair loss specific genes, mainly baldness prediction and treatment responses, and then have our own spit kit for finasteride response.

Here's a tiny sneak peak for minoxidil:

 

[InBeforeTheCure]

I think I most certainly could. There are several genetic changes in an enzyme that we produce that could alter how well mioxidil works. For example, rs9282861 in the gene SULT1A1. SULT1A1 is a sulfotransferase gene, this gene modifies drugs like minoxidil in your body to make them biologically active. Some people are better at making them biologically active than others.

View attachment 58585

So if you have the Arg/Arg genotype you would be the best responder to minoxidil while if you have the His/His genotype you would be the worst.

Does 23andMe have a good proxy for rs9282861? It's not in HapMap or 1000Genomes, so I couldn't check for one that way.

 

[moxsom]

Oh yes, sorry, they also use i6018900 for this SNP id.

 

[INT]

Claims he has the answer for something as complex as the efficacy of finasteride against male pattern baldness....

Comes with fallacies and bro science.