Why Propecia Doesn't Cause Side Effects for Some?

[thiswomps]

I always read about how finasteride only causes sides in some people, but why is that so? Why do some people experience no side effects when others do?

 

[thiswomps]

Who really knows. There was a study done on patients with persistent finasteride side to see if there was any similiarity genetically. The study is pending publication and I don't know the resutls. I can only assume it's the number of CAG repeats. Men with shorter number of CAG repeats are more susceptibe to finasteride sides. They are already sensitive to androgens as it is. When they reduce it, their bodies are unable to compensate. All speculation at this point but soon I believe they'll be some answers. And one of the research goals of the PFS foundation is to determine who is susceptible

Not sure what can repeats are... But I always thought that maybe people who don't get sides are people with high DHT levels... finasteride would lower it but not enough to screw you up. Whereas people with low DHT would be lowered enough to affect you adversely? That is my completely unscientific hunch. Who knows.

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i had 12-13 Years low side effects,than the big crash
other take it 6Month and crash, i think that comes from the Bodystatur
i was a strong big-muscular Men as i began with finasteride, and finasteride took a long time to destroyed my Body
a other Men is feminine and finasteride destroyed after 6Month his live!

and the next is the Liver Problem-a strong Liver or a weak liver
my Liver is after 15Years finasteride destroyed value 0-50 my Value is 247
The liver breaks down estrogen, is the Liver damaged then the liver can not break down the estrogen
the Body Crash-Estrogendominanz you get fatter and fatter and many other Symptomes-Bloodpressure high-running Puls
dry skin -thin skin .................

Timi

Were you getting regular check ups going into all those years? If I were taking a drug like finasteride for a long time I'd definitely do blood work pretty often. Was it a big crash or a slow build up?

 

[Wuffer]

And yes your explanation is rubbish.

Why do you insist on being so rude to people? The guy was simply looking for some information and describing his theory. Not everybody knows everything (you included) so try to have a little patience instead of insulting people and being rude.

 

[thiswomps]

It's called a CAG repeat, not a can. You can google scholar it if you like. And yes your explanation is rubbish.

I was typing through my iphone so please excuse the typo. I googled it but wasn't able to understand it really. Probably need someone to explain it to me like I'm 5 I guess, or I'll take more time later to study it further.

I never said my explanation was rubbish, just that it is completely unscientific, and has no real basis other then what logic would dictate when someone isn't educated in the area. Logically, my explanation would be the best I could think of without further study, but alas, the point in posting that was in hopes of someone correcting me and expanding on why my thought process was wrong (as I was 99.9 % sure it was), so kindly explain to me as I am now asking of you (or anyone else for that matter) and I would be very gracious, OR get out of my topic because your comment provides no real substance to the topic at hand Thank you!

 

[Fanjeera]

I study medicine and I think your explanation is good. That definitely can foretell the chance of side effects. And a doctor should definitely have a look at a person full androgen status before prescribing finasteride. Unfortunately most of them don't even know what DHT is and a test is rarely available.

 

[Quantum Cat]

I always read about how finasteride only causes sides in some people, but why is that so? Why do some people experience no side effects when others do?

because people respond differently to drugs. Everyone's biochemistry is different. The theory behind finasteride is that DHT isn't a vital hormone for the adult body, but for some people, supressing DHT apparently has an effect on things other than hair (although I suspect that most people who report bad side effects are mostly hypochondriacs). These people seem to be in the minority though

People like Hair to Learn will claim that DHT is a vital hormone - and supressing it is disastrous - but have yet to provide irrefutable proof of this claim.

 

[IrishFella]

Hallucinations must also be a side effect of prozac. Never once did I claim suppressing DHT is disasterous. Quantum Cat must've hallucinated this right before he shot Gabrielle Giffords.

Using the fact that QC is on a SSRI to turn his argument against him. That's twice now I've seen that. You're a disgusting little man.

 

[Fanjeera]

"Men with shorter CAG repeat tracts ... are more susceptible to reduction of DHT."

http://books.google.ca/books?id=-wO...resnum=3&ved=0CBgQ6AEwAg#v=onepage&q=&f=false

I don't know what knowledge to squeeze out of that. Get your DHT tested!

 

[thiswomps]

I study medicine and I think your explanation is good. That definitely can foretell the chance of side effects. And a doctor should definitely have a look at a person full androgen status before prescribing finasteride. Unfortunately most of them don't even know what DHT is and a test is rarely available.

For what its worth, thank you! I've had my T tested a few weeks prior to starting finasteride and everything was good, so even though its not directly DHT I know I'm going into it with high T levels, and from what I've read, some people experience a severe drop in T. I will go get some blood work done in a couple of weeks to make sure things are running smoothly.

because people respond differently to drugs. Everyone's biochemistry is different. The theory behind finasteride is that DHT isn't a vital hormone for the adult body, but for some people, supressing DHT apparently has an effect on things other than hair (although I suspect that most people who report bad side effects are mostly hypochondriacs). These people seem to be in the minority though

People like Hair to Learn will claim that DHT is a vital hormone - and supressing it is disastrous - but have yet to provide irrefutable proof of this claim.

I don't suppose you'd know if people that retain a full head of hair naturally are known to have low DHT levels? If so, it would make sense that for the adult body it isn't a complete necessity, no? But I understand everyone is different. Myself, I've had to take a lot of medication in my life and have experienced sides on some, and no sides on some. I am not all too worried about finasteride, and being on it now for over 2 weeks, I actually feel better, and my libido seems to have increased. I did experience for the first couple of days some abdomen pain but its gone now.

 

[Fanjeera]

Testosterone definitely rises while taking finasteride. It's logics. And yes, a testosterone test should definitely be done, if you can't test DHT. Thankfully the andrologists do it, but eh dermatologists have no idea.

 

[J.Harrison]

No sides at all == fake finasteride, IMHO.

I think everyone gets some initial minor sides, and for most people these go away or improve to an acceptable level rather quickly.

 

[Quantum Cat]

Testosterone definitely rises while taking finasteride. It's logics. And yes, a testosterone test should definitely be done, if you can't test DHT. Thankfully the andrologists do it, but eh dermatologists have no idea.

why do you think some people get gyno when taking finasteride though? That's caused by increased estrogen right? If there's a rise in Testosterone it should counter the Estrogen.

Or does the decrease of DHT negate that?

 

[Fanjeera]

Testosterone converts to estrogen via aromatase actually. They don't counter each other, I think. Prostate and breast tissue are quite similar, so there's a connection somewhere in their regulation too perhaps. So yes, I wouldn't rule out lack of DHT to be the cause. But high estradiol is always there with gyno, I think.

 

[WorkHardPlayHard]

Testosterone converts to estrogen via aromatase actually. They don't counter each other, I think. Prostate and breast tissue are quite similar, so there's a connection somewhere in their regulation too perhaps. So yes, I wouldn't rule out lack of DHT to be the cause. But high estradiol is always there with gyno, I think.

I believe this is correct. Weight lifters boosting their T a lot of times take something to counter the aromatase, because excess T gets converted to estradiol (I think). Similarly, guys inhibiting their DHT have excess T, relative to what their body is used to, that gets switched to estradiol as the body can't turn it into DHT. I have no idea if it's worth doing for hairloss, but you really don't hear of guys doing it. Quite the contrary: most guys pop their 1mg Propecia and move on with life.

 

[pidda]

Finasteride gave me little or no persisting side effects I think and I been on it for a year. Dutasteride might be giving me extra fatigue but I can't be sure.

 

[Fanjeera]

I think some people aren't just as aware of their penises as others, so they don't notice the small change in its weight and ability to gain and sustain an erection. Some people just analyse themselves more and also find such changes.

 

[WorkHardPlayHard]

I think some people aren't just as aware of their penises as others, so they don't notice the small change in its weight and ability to gain and sustain an erection. Some people just analyse themselves more and also find such changes.

Conversely, I think a lot of people over-analyze their penises (after finasteride) and worry themselves into a frenzied state where they can't get boners. I know I've had stress and insecurity mess with my boners years and years before I even started receding, let alone started finasteride.

 

[Fanjeera]

If you can't get a boner at all, you are stressed, yes. Castrated people have sex too. You just have to adjust to the new circumstances, where the histology of your penis is not as regular and perfect as before due to lack of DHT.

 

[to the lost]

I was intrested in that too. Why some get sides and other don't. and what the RISK group for permanent sides.

i was never on finasteride, but I have 3 x lower DHT than minimal recomended dose for man (can't wait what endo will say). but did not had erection problems never, just no morning wood (like, never in past 3 months maybe once, twice). But I did have some intresting sides in past year (dizzines, low energy - still, anxiety). So i will ask about correlation to those simptoms my endo too.

 

[Everest]

I had my DHT levels tested and they were within the normal range of 312 pg/ml. I'm thinking of starting generic finasteride (finpecia) 1mg. Should I start with a lower dose?