Dude, I'm just trying to have an open mind. If he can explain this then I'll have to adjust my opinion and perhaps try the drug. I don't know why you are getting so mad about that. We all want the same thing here. This stuff isn't new, but maybe he knows something new about it. Since there's a gb going for the drug I just want to know if there's additional information that will give me reason to join the buy.
Will there be a cure for baldness by 2030 according to you?
- Thread starter Atmani
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Looks like I can post links.
Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation - PMC
Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient activating cues to overcome repressive BMP signals from surrounding niche ...
www.ncbi.nlm.nih.gov
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Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial - PubMed
Research has shown the importance of follistatin, Wnt 7a, and wound healing growth factors on the stimulation of bulge cells and inter-follicular stem cells to induce hair growth. We have studied the effects of a bioengineered, non-recombinant, human cell-derived formulation, termed Hair...
pubmed.ncbi.nlm.nih.gov
The role of follistatin should be looked at more because it can promote TGF signalling and halt BMP
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These are red herrings. The HFSCs must already be signaling and expressing the appropriate cell surface receptor proteins for this to be significantly efficacious.Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial - PubMed
Research has shown the importance of follistatin, Wnt 7a, and wound healing growth factors on the stimulation of bulge cells and inter-follicular stem cells to induce hair growth. We have studied the effects of a bioengineered, non-recombinant, human cell-derived formulation, termed Hair...
The role of follistatin should be looked at more because it can promote TGF signalling and halt BMP
That's Histogen, didn't workHair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial - PubMed
Research has shown the importance of follistatin, Wnt 7a, and wound healing growth factors on the stimulation of bulge cells and inter-follicular stem cells to induce hair growth. We have studied the effects of a bioengineered, non-recombinant, human cell-derived formulation, termed Hair...
The role of follistatin should be looked at more because it can promote TGF signalling and halt BMP
If I remember correctly, a study this year showed that TGFβ2 was expressed only in areas of human hair loss, while normal human scalps expressed only TGFβ1Looks like I can post links.
Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation - PMC
Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient activating cues to overcome repressive BMP signals from surrounding niche ...
I bet you pharmaceutical companies are following those threads
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Net nerds aren't smarter. They just put less value on their time & safety.
Big Pharma doesn't sit around blaming the problem on masturbation. They don't try drugs that are already known to be too dangerous for a commercial treatment. Etc.
Big Pharma doesn't sit around blaming the problem on masturbation. They don't try drugs that are already known to be too dangerous for a commercial treatment. Etc.
Stemson probably already has a beta version of the cure as we speak (ie.: they are already able to create a new human hair from scratch), but still need to work on improving the consistency of their methods. And since they are basically reprogramming blood cells to become hairs (which is a very complex process with many different stages and variables) that is not a simple task to do and will take at least a couple of more.
Pharmaceutical companies really don't care about hair loss. They found HMI-115 because they tested it for endometriosis on mice, and the hair growth was insane. The people at Bayer still didn't care. The people they worked with at the IMM in China did care fortunately, and they convinced Bayer to let them test it for hair loss on their macaques. They did that and then bought the rights to it from Bayer because even after that Bayer still didn't want to make a hair loss drug. Nobody at big pharma cares about male pattern baldness. The only company that does is Allergan, and they've funded nothing but copes until now.
If you want to cure hair loss find a way to inhibit Twist1, upregulate R-spondins, or otherwise stabilize LRP5/6 Wnt receptors. We know what has to be done now, it's just a matter of having the pharmacological ability to do it.
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so the way i see it is, there is a significant chance that in 2030, 40 years after finasteride and minoxidl there will be no alternative, i am not talking cures here, i am talking side free maintenance drugs. if kintors product does not deliver to replace finasteride, there is nothing else that is reasonably well established at this point and can actually work. why not stop talking about a cure? that is unrealistic. as someone who still has his NW4 and could be saved by side free maintenance and a hair transplant it is astouning to me that by 2030 finasteride might still be the Nr1 treatment. makes me qlmost quit my current research and go into hair biology and do research myself because it is so utterly ridiculous and SAD!
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do you think there is more hope for people who can tolerate finasteride but cannot stop their hair loss with it or for people who respond very well to finasteride or other anti androgens but got some side effects? I think the pitty with finasteride is that you cannot lower your dosage. if you respond well but get sides you are fucked, with other drugs you can lower the dose but because finasteride has such a steep inhibition curve you cannot say "i will accept half the efficacy for half the systemic impact" that does not work.
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I am not just crapping on any new treatments. there is no new treatment. there is two proposed in the pipeline but that is literally all there is. people make it sound like it looks better on paper than it ever did but it looks actually worse. in 2018 there was so much hope and 80% of rhe products got totally hammered. i can already mentioned a hand ful of things that will make kintor inferior to finasteride if it works at all. the chance on paper that finasteride by 2030 is the Nr1 treatment is genuinely higher than the opposite. and i do know in fact quite a bit about biology to gauge whether this is a solveable problem. it could be but not by 2030 and not with this amount of funding. i am not aware of any field where so little prpgress has been made, no kidding.
HMI-115 is already proven to be superior to finasteride. Kintor's PROTAC is no doubt superior to it also. Olix is a side effect free cure if started before Androgenetic Alopecia begins. These are actually good treatments, not the garbage people were hyped over in 2018. Researchers also pretty much know now what causes Androgenetic Alopecia, they just need a way to target it. Surrozen has a way, and has done some preclinical work on hair loss. If they follow through with it they can reverse Androgenetic Alopecia. The first Twist inhibitor was recently patented and is of great interest in cancer research so that will be developed soon. It's been shown that knocking out twist1 keeps hair in the anagen phase forever. HM is now closer than ever before. Tsuji is ready for human trials, and you can even bank your hair follicles now so that you have young healthy follicles for the procedure when the time comes. If you understand the mechanisms behind hair loss you can't say that the future isn't brighter now than it's ever been.
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i think you are overly optimistic. HMIhas been proven to be superior to finasteride? can you share the 12 month clinical human trial on that? because as of right now there is no clinical resewrch to support this statement at all, there is only one preclinical trial and thats it. nobody even has any idea whether what was found in macaques will translate into humans or if there are some major differences. for all we know and this is what j fear, HMI could do nothing in humans.
how do you know the protac is superior? how do you know olix is superior? i mean, this all sounds good in theory vut we should have learnt by now that theory does not translate into the clinic when it comes to male pattern baldness. that is just the reality of things.
mind sharing a paper about the twist knockout?
Macaques have been studied in detail and their hair loss is identical to ours. A trial in macaques is as good as a trial in humans.
www.sciencedirect.com
This is what we're able to do in mice now by upregulating the Wnt pathway. Of course this isn't humans, but HFs are highly conserved across species and there is a preponderance of data showing this will work in humans.
Inducible Knockout of Twist1 in Young and Adult Mice Prolongs Hair Growth Cycle and Has Mild Effects on General Health, Supporting Twist1 as a Preferential Cancer Target
Twist1 promotes epithelial–mesenchymal transition, invasion, metastasis, stemness, and chemotherapy resistance in cancer cells and thus is a potential…
This is what we're able to do in mice now by upregulating the Wnt pathway. Of course this isn't humans, but HFs are highly conserved across species and there is a preponderance of data showing this will work in humans.
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macaques are the best animal model for AA but that does not mean that their hair loss is identical at all. there is just not enough candidates in clinical trials to get success before 2030. remember, every compound so far, tens of them, histogen, samumed, replicel, follicum, jak inhibitors, all of it has completely flopped. all of it. thats insane and if thats anything to go by these new things which sound neat in theory will also fail in clinical trialsMacaques have been studied in detail and their hair loss is identical to ours. A trial in macaques is as good as a trial in humans.
Inducible Knockout of Twist1 in Young and Adult Mice Prolongs Hair Growth Cycle and Has Mild Effects on General Health, Supporting Twist1 as a Preferential Cancer Target
Twist1 promotes epithelial–mesenchymal transition, invasion, metastasis, stemness, and chemotherapy resistance in cancer cells and thus is a potential…
All of those were predicted to flop by the more informed members of this forum. Macaque hair loss actually is identical to humans. The fact that you don't know this shows you have not done basic research. To date there has not been a single treatment shown to be efficacious in stumptailed macaques that is not efficacious in humans and vice versa. Histology shows an identical etiology for Androgenetic Alopecia in both species, yes its even called androgenetic alopecia
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