A Closer Look At: SHBG & Metabolic Clearance.
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OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
No, those are the androgens that are being excreted via bile!
Bryan said:
No, those are the androgens that are being excreted via bile!
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
http://www.ncbi.nlm.nih.gov/pubmed/9463 ... t=Abstract
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schöttner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
http://www.ncbi.nlm.nih.gov/pubmed/9463 ... t=Abstract
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schöttner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
http://www.ncbi.nlm.nih.gov/pubmed/9434 ... t=Abstract
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schöttner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
http://www.ncbi.nlm.nih.gov/pubmed/9434 ... t=Abstract
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schöttner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Why do you keep posting this totally pointless crap about plant lignans when you're unable to explain or justify those far-out claims you've made about SHBG and androgens? Do you think we're all going to forget that you haven't been able to answer any of our questions?
misterE said:
Why do you keep posting this totally pointless crap about plant lignans when you're unable to explain or justify those far-out claims you've made about SHBG and androgens? Do you think we're all going to forget that you haven't been able to answer any of our questions?
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
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OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
This just in... S.H.B.G. has a binding site for zinc! So zinc binds with S.H.B.G. preventing both D.H.T. and estrogen from binding to S.H.B.G., could this be why zinc is good for testosterone levels and hair loss? I'm thinkin' yes.
This just in... S.H.B.G. has a binding site for zinc! So zinc binds with S.H.B.G. preventing both D.H.T. and estrogen from binding to S.H.B.G., could this be why zinc is good for testosterone levels and hair loss? I'm thinkin' yes.
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
J. M. Saez, M. G. Forest, A. M. Morera, and J. BertrandUnité de Recherches Endocriniennes et Métaboliques chez l'Enfant (Institut National de la Sante et de la Recherche Medicale), Hôpital Debrousse, Lyon 5e, France This article has been cited by other articles in PMC.Abstract
The metabolic clearance rate (MCR) and blood production rate (BP) of testosterone (T) and dihydrotestosterone (DHT), the conversion of plasma testosterone to plasma dihydrotestosterone, and the renal clearance of androstenedione, testosterone, and dihydrotestosterone have been studied in men. In eight normal men, the MCR of testosterone (516±108 [SD] liters/m2/day) was significantly greater than the MCR of DHT (391±71 [SD] liters/m2/day). In seven females, the MCR of testosterone (304±53 [SD] liters/m2/day) was also greater than the MCR of DHT (209±45 [SD] liters/m2/day) and both values were less than their respective values in men (P < 0.001). In men the conversion of testosterone into dihydrotestosterone at 2.8±0.3% (SD) was greater than that found in females, 1.56±0.5% (SD) (P < 0.001). In five pregnant females the MCRT (192±36 [SD] liters/m2/day), the MCRDHT (89±30 [SD] liters/m2/day) and the conversion of testosterone into dihydrotestosterone (0.72±0.15%) (SD) were significantly less than the values found in nonpregnant women. In five females with hyperthyroidism, the MCR for testosterone and dihydrotestosterone were similar to those observed in pregnant females, but the conversion of testosterone into dihydrotestosterone (2.78±1.7%) (SD) was greater, and similar to that found in men. In men the production of dihydrotestosterone was 0.39±0.1 (SD) mg/day, 50% being derived from the transformation of plasma testosterone. In women the production of DHT was 0.05±0.028 (SD) mg/day, only 10% coming from testosterone. During pregnancy, the production of testosterone and dihydrotestosterone are similar to that in normal women. In three patients with testicular feminization syndrome (an adult with hyperthyroidism and two children) these two MCRs were greatly reduced compared to the normal females, but the conversion of testosterone into dihydrotestosterone was in the limits of normal male rangeIn the normal subjects the renal clearance of androstenedione was greater than that of testosterone and dihydrotestosterone. Less than 20% of the dihydrotestosterone and less than 10% of the androstenedione in the urine is derived from the plasma dihydrotestosterone and androstenedione.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292254/
Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
J. M. Saez, M. G. Forest, A. M. Morera, and J. BertrandUnité de Recherches Endocriniennes et Métaboliques chez l'Enfant (Institut National de la Sante et de la Recherche Medicale), Hôpital Debrousse, Lyon 5e, France This article has been cited by other articles in PMC.Abstract
The metabolic clearance rate (MCR) and blood production rate (BP) of testosterone (T) and dihydrotestosterone (DHT), the conversion of plasma testosterone to plasma dihydrotestosterone, and the renal clearance of androstenedione, testosterone, and dihydrotestosterone have been studied in men. In eight normal men, the MCR of testosterone (516±108 [SD] liters/m2/day) was significantly greater than the MCR of DHT (391±71 [SD] liters/m2/day). In seven females, the MCR of testosterone (304±53 [SD] liters/m2/day) was also greater than the MCR of DHT (209±45 [SD] liters/m2/day) and both values were less than their respective values in men (P < 0.001). In men the conversion of testosterone into dihydrotestosterone at 2.8±0.3% (SD) was greater than that found in females, 1.56±0.5% (SD) (P < 0.001). In five pregnant females the MCRT (192±36 [SD] liters/m2/day), the MCRDHT (89±30 [SD] liters/m2/day) and the conversion of testosterone into dihydrotestosterone (0.72±0.15%) (SD) were significantly less than the values found in nonpregnant women. In five females with hyperthyroidism, the MCR for testosterone and dihydrotestosterone were similar to those observed in pregnant females, but the conversion of testosterone into dihydrotestosterone (2.78±1.7%) (SD) was greater, and similar to that found in men. In men the production of dihydrotestosterone was 0.39±0.1 (SD) mg/day, 50% being derived from the transformation of plasma testosterone. In women the production of DHT was 0.05±0.028 (SD) mg/day, only 10% coming from testosterone. During pregnancy, the production of testosterone and dihydrotestosterone are similar to that in normal women. In three patients with testicular feminization syndrome (an adult with hyperthyroidism and two children) these two MCRs were greatly reduced compared to the normal females, but the conversion of testosterone into dihydrotestosterone was in the limits of normal male rangeIn the normal subjects the renal clearance of androstenedione was greater than that of testosterone and dihydrotestosterone. Less than 20% of the dihydrotestosterone and less than 10% of the androstenedione in the urine is derived from the plasma dihydrotestosterone and androstenedione.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292254/
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Re: Sex Hormone Binding Globulin & The Big One!!!
I don't know if he's "taking the piss" (I had to Google that expression again, just to refresh my memory of how it's used and what it means), but it's clear that the study he posted has nothing to do with what was being discussed. MisterE is good at THAT, at least: he knows how to post lots of irrelevant material, in an effort to deflect attention away from tough questions that he's being asked.
powersam said:
I don't know if he's "taking the piss" (I had to Google that expression again, just to refresh my memory of how it's used and what it means), but it's clear that the study he posted has nothing to do with what was being discussed. MisterE is good at THAT, at least: he knows how to post lots of irrelevant material, in an effort to deflect attention away from tough questions that he's being asked.
OverMachoGrande
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A Closer Look At: S.H.B.G. & Metabolic Clearance.
Sure it does, testosterone has a faster metabolic clearance rate than D.H.T. because D.H.T. binds to S.H.B.G. a lot stronger than testosterone!
Bryan said:
Sure it does, testosterone has a faster metabolic clearance rate than D.H.T. because D.H.T. binds to S.H.B.G. a lot stronger than testosterone!
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
S.H.B.G. prevents metabolic clearance.
Currently there is no medical reference or citations (that I could find) that claim what I claim, but that’s what makes me so interesting because I "think outside the box". Bryan, you seem like the kinda guy who takes things at face value and doesn't seem to try and find out the "insides". Hell, you probably even believe the "official" 9/11 theory.
Bryan said:
S.H.B.G. prevents metabolic clearance.
Currently there is no medical reference or citations (that I could find) that claim what I claim, but that’s what makes me so interesting because I "think outside the box". Bryan, you seem like the kinda guy who takes things at face value and doesn't seem to try and find out the "insides". Hell, you probably even believe the "official" 9/11 theory.
Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
But don't you see how foolish you're being when you read back what you post?
misterE said:Bryan said:
S.H.B.G. prevents metabolic clearance.
Currently there is no medical reference or citations (that I could find) that claim what I claim, but that’s what makes me so interesting (
But don't you see how foolish you're being when you read back what you post?
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Here's an important point you need to consider: what does it precisely MEAN to say that "SHBG prevents metabolic clearance"? We know for a fact that SHBG/androgen bindings don't build-up INDEFINITELY in the bloodstream; if they did, that would eventually kill us!! :shock: So it's clear that somewhere along the line, SHBG, along with whatever it may be bound to (androgens, estrogens, etc.) is metabolized and removed from the bloodstream. So do you see how that doesn't jive with your claim that "SHBG prevents metabolic clearance"?
I'm not surprised you couldn't find anything to support your claims.
I can name a couple of other people who also think "outside the box": Ernie Primeau and Stephen Foote. Should we pay attention to THEIR theories of balding?
misterE said:
Here's an important point you need to consider: what does it precisely MEAN to say that "SHBG prevents metabolic clearance"? We know for a fact that SHBG/androgen bindings don't build-up INDEFINITELY in the bloodstream; if they did, that would eventually kill us!! :shock: So it's clear that somewhere along the line, SHBG, along with whatever it may be bound to (androgens, estrogens, etc.) is metabolized and removed from the bloodstream. So do you see how that doesn't jive with your claim that "SHBG prevents metabolic clearance"?
misterE said:
I'm not surprised you couldn't find anything to support your claims.
misterE said:...but that’s what makes me so interesting (
I can name a couple of other people who also think "outside the box": Ernie Primeau and Stephen Foote. Should we pay attention to THEIR theories of balding?
OverMachoGrande
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Personally, I love Stephen Foote's theories and I strongly admire his ruthless attack on the balding process. And that is what separates him from you. He comes up with theories and shares them with us...And it seems to me, with all the "wisdom" you have, you could at least share some of that "wisdom" with us, by giving us your theories and solutions!
Bryan said:I can name a couple of other people who also think "outside the box": Ernie Primeau and Stephen Foote. Should we pay attention to THEIR theories of balding?
Personally, I love Stephen Foote's theories and I strongly admire his ruthless attack on the balding process. And that is what separates him from you. He comes up with theories and shares them with us...And it seems to me, with all the "wisdom" you have, you could at least share some of that "wisdom" with us, by giving us your theories and solutions!
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Re: A Closer Look At: S.H.B.G. & Metabolic Clearance.
Well, I guess Stephen does have ar least ONE admirer, then! :dunno:
I don't have any weird, eccentric theories of balding like you or Stephen or Ernie; I just believe the standard androgenic theory of balding that the vast majority of other people do. The "wisdom" that I like to share with everybody else has more to do with various scientific details that may not always be readily apparent to the casual reader. What assists me in doing that is my easy access to the medical library which serves the entire famed Houston Medical Center. Just as one example (there are several others), when dutasteride first came out several years ago, there were a great many false and misleading assertions that were being made about the drug, having to do with its half-life, its ability to inhibit the separate 5a-reductase enzymes, the extent to which it builds up in the body, etc. I fixed those problems (I hope) by poring over the available dutasteride studies, and (even more important) scanning the graphs from them and posting them on this and other sites, for everybody to see for themselves.
So I hope you'll forgive me for not having my own goofy theories about what causes balding; all I can really do is try to help fill-in some of the knowledge gaps about the standard theory of balding which arise on these forums.
misterE said:
Well, I guess Stephen does have ar least ONE admirer, then! :dunno:
misterE said:
I don't have any weird, eccentric theories of balding like you or Stephen or Ernie; I just believe the standard androgenic theory of balding that the vast majority of other people do. The "wisdom" that I like to share with everybody else has more to do with various scientific details that may not always be readily apparent to the casual reader. What assists me in doing that is my easy access to the medical library which serves the entire famed Houston Medical Center. Just as one example (there are several others), when dutasteride first came out several years ago, there were a great many false and misleading assertions that were being made about the drug, having to do with its half-life, its ability to inhibit the separate 5a-reductase enzymes, the extent to which it builds up in the body, etc. I fixed those problems (I hope) by poring over the available dutasteride studies, and (even more important) scanning the graphs from them and posting them on this and other sites, for everybody to see for themselves.
So I hope you'll forgive me for not having my own goofy theories about what causes balding; all I can really do is try to help fill-in some of the knowledge gaps about the standard theory of balding which arise on these forums.