Thanks. Do you know why pgd2 inhibitors completely stop hair shedding for a lot of guys? Maybe miniaturization process continue but shedding is reduced at the same time. Maybe pgd2 levels put hair follicles on telogen phase. What do you think?
So, I was wrong about WHY Ceti lowers testosterone, but it seems to have an effect on lowering dopamine, which can increase prolactin and has been shown to induce gynecomastia in a few cases. I don't know if using dopamine agonists would offset this or not. Obviously, not a guarantee you'd get this side effect, but it's something to keep in mind.
It's from @balda
thanks for your answer but do you think that using ceti topically could cause gyno or its highly unlikely?
Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells
Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (Androgenetic Alopecia). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood. The function of PGD2-induced expression ...www.ncbi.nlm.nih.gov
5. Conclusions
PGD2 directly stimulates the expression of androgen target genes, AKT and its downstream substrates are involved in mediating these effects. Thus, our data in this study provide that the activity of AR could be regulated not only DHT but also various signal changes by PGD2 in hDPCs.
I think that the androgens activate a cascade, so yeah, androgen signaling leads to apoptosis of the follicle.
What does it mean. Does it cause shedding?"It is interesting to note the opposing effects of PGD2 (the prostaglandin that induces the niacin flush) and PGE2 in the balding model (above), where chronically high PGD2 resulted in suppression of PGE2. A pulsatile release of PGD2 (an ACUTE release) as in the niacin flush would be anti-inflammatory, not pro-inflammatory as with chronically high PGD2. Hence, you could see an INCREASE in PGE2 by suppressing chronically high PGD2. The balding model, in fact, shows hair growth and the cessation of hair follicle death resulting from slight modulation in the ratio of PGD2/PGE2, in which PGE2 is increased, while chronically high PGD2 levels are reduced to “normalize” the ratio. The niacin flush causes pulsatile, not chronic, release of PGD2."
Why the Niacin Flush May Be Surprisingly Beneficial to Your Health
Why We Think It May Reduce the Risk of ALZHEIMER’S DISEASE and Other Inflammatory Diseases, Including Atherosclerosis, Type 2 Diabetes, Ulcerative Colitis, Even Male Pattern Baldness Sandy Shaw WITHOUT PRIOR REVIEW BY DURK It has not been read or reviewed by Durk Pearson, due to considerations...life-enhancement.com