Can we please stay on topic. I dont need to hear about finasteride, I already know that's available. I want to hear about the companies that are 'close' to releasing new treatments.
Full of hope with Fevipiprant.
Can we please stay on topic. I dont need to hear about finasteride, I already know that's available. I want to hear about the companies that are 'close' to releasing new treatments.
So it's another non-fda approved experiment people are going to be doing?
It’s certainly not pessimism, just realism. In fact out of any current drug in the pipeline, I’m most optimistic about this one.
Phase 3 is for Winlevi (acne), not hair loss. Also, satisfying endpoints for phase 2 isn’t a gurantee that it will be marketed, it’s a good sign, but never a guarantee. For example:
https://www.thepharmaletter.com/article/dermira-tanks-as-acne-drug-fails-in-phase-iii-trials
Why this happened? No idea, but most likely the phase 2 design was flawed.
So back to Breezula, if they promised a release of results by end of this quarter which they’ve stated a few weeks ago, then I expect them to either deliver or provide an update of some sort.
Also to add to my previous post, look at the Cassiopeia website for the Winlevi Results. Regarding Adverse Events, one patient was discontinued for... hypertrichosis!
That is literally written evidence that even 1% can promote hair growth
....in 1 patient. Get your dermapens out, boys.
Fevi is for Asthma just like dutasteride is for prostate.
People are still talking about PGD2 ? Fevi ?
Forget about it, Fevi obviously won't work for Androgenetic Alopecia, i thought this was clear now that Allergan dropped all PGD2 trials for it.
Good news is, it seems pretty efficient with asthma
Yes, on their December 2018 product pipeline is marked for next year to be approve. I think is the most closer real thing we will see.Btw, Fevipiprant will also release next year I think. Need to check Novartis's site.
Setipiprant was mailny for Asthma, and did not work well for it, however it worked good for hair condition, and that's why Fevi was developed to treatment asthma, and Seti changed for hair loss treatment. So if it would do nothing for hair, there would not even be an idea to try... Same thing happened with Dutasteride.
I don't think Setipiprant will be relesed, because majority of blind people believe in 2% of sides, same as pharma corp... And since Seti dosage was much higher then finasteride, and need to be taken twice a day, finasteride win this battle. But Fevi for other hand...
Looking at Breezulas dose ranging trial, interim analysis showed 2.5% BID has similar results to 5% BID. They hint that the vehicle is different in Breezula to increase scalp penetration (as scalp skin is thicker) but I don't see any good reason why Winlevi couldn't work on the scalp for hair loss if you used enough of it. We don't have the dose response curve to be fair but it makes sense to me that a 1% cream used in greater volume would have similar results to a 2.5% cream used at a lower volume.
Yes, they tested 500mg x 4 tabs daily ! vs one small pill ( propecia ) , even we know they have much more side effects they tell, the average Joe just see that. Merck this a great Propaganda during the late 90s and early 2000 showing that DHT was de devil.
Interesting, Glaxo did give attention of all the posibles side effects, and they decided to don't go phase 3. Merck, they simple didn't care.
First You don't give Finasteride for prostate cancer. Please, don't be so ignorant.Thanks to this, many men saved their hair, including yourself, till better thing come out.
If it was so poison, shouldnt all prostate cancer patient be suffering tremendous sides already ?