Anybody Have Any News Of Phase 3 Updates?

ffar1989

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Can we please stay on topic. I dont need to hear about finasteride, I already know that's available. I want to hear about the companies that are 'close' to releasing new treatments.

Full of hope with Fevipiprant.
 

Dimmer97

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So it's another non-fda approved experiment people are going to be doing?
 

ffar1989

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So it's another non-fda approved experiment people are going to be doing?

Fevi is for Asthma just like dutasteride is for prostate.
 

Dimmer97

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Interesting. Has anyone got any clue about cm-3? Last I heard is that it's being released this year.
 

Iah11

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It’s certainly not pessimism, just realism. In fact out of any current drug in the pipeline, I’m most optimistic about this one.

Phase 3 is for Winlevi (acne), not hair loss. Also, satisfying endpoints for phase 2 isn’t a gurantee that it will be marketed, it’s a good sign, but never a guarantee. For example:

https://www.thepharmaletter.com/article/dermira-tanks-as-acne-drug-fails-in-phase-iii-trials

Why this happened? No idea, but most likely the phase 2 design was flawed.

So back to Breezula, if they promised a release of results by end of this quarter which they’ve stated a few weeks ago, then I expect them to either deliver or provide an update of some sort.

Looking at Breezulas dose ranging trial, interim analysis showed 2.5% BID has similar results to 5% BID. They hint that the vehicle is different in Breezula to increase scalp penetration (as scalp skin is thicker) but I don't see any good reason why Winlevi couldn't work on the scalp for hair loss if you used enough of it. We don't have the dose response curve to be fair but it makes sense to me that a 1% cream used in greater volume would have similar results to a 2.5% cream used at a lower volume.
 

luen12

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Cassiopea had another presentation on March 6th at Credit Suisse Global Health Care Conference in which they confirmed that they would release the results in Q1 2019. I don‘t think they would say this again, if they have no results to present. And they they want to start phase 3 in Q4 2019.
50A3BD05-8F9E-42DC-922E-D9D49BFA9909.png

http://www.cassiopea.com/~/media/Files/C/Cassiopea/presentations/Credit Suisse Global Health Care Conference.pdf

Their next event is on March 18th. It‘s the Annual general shareholders meeting. It think this would be a good occasion to present their results.
 

Iah11

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Also to add to my previous post, look at the Cassiopeia website for the Winlevi Results. Regarding Adverse Events, one patient was discontinued for... hypertrichosis!

That is literally written evidence that even 1% can promote hair growth
 

barfacan

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Also to add to my previous post, look at the Cassiopeia website for the Winlevi Results. Regarding Adverse Events, one patient was discontinued for... hypertrichosis!

That is literally written evidence that even 1% can promote hair growth

....in 1 patient. Get your dermapens out, boys.
 

glammetal

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Phase 3 trials last about a year
+announcement of phase 3 trial results another year
+filing procedure another another year=
something about 3 years for most cases for new treatments to be avaliable.
Can any medical professional or pharmasist confirm this?
 

ComeBackTemples

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Can't wait for the results until end of march and then obviously for the product in 2022. I am just wondering how to survive until then without finasteride.
1) dermarolling, min and ket
2) make CB yourself with some dodgy chemicals from China

At the moment i see option 1 as the lesser of two evils. If anyone has another transitional solution i would be interested to hear :)
 

BalderBaldyBald

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People are still talking about PGD2 ? Fevi ?

Forget about it, Fevi obviously won't work for Androgenetic Alopecia, i thought this was clear now that Allergan dropped all PGD2 trials for it.
Good news is, it seems pretty efficient with asthma
 

ffar1989

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People are still talking about PGD2 ? Fevi ?

Forget about it, Fevi obviously won't work for Androgenetic Alopecia, i thought this was clear now that Allergan dropped all PGD2 trials for it.
Good news is, it seems pretty efficient with asthma

Setipiprant was mailny for Asthma, and did not work well for it, however it worked good for hair condition, and that's why Fevi was developed to treatment asthma, and Seti changed for hair loss treatment. So if it would do nothing for hair, there would not even be an idea to try... Same thing happened with Dutasteride.

I don't think Setipiprant will be relesed, because majority of blind people believe in 2% of sides, same as pharma corp... And since Seti dosage was much higher then finasteride, and need to be taken twice a day, finasteride win this battle. But Fevi for other hand...
 

jamesbooker1975

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Setipiprant was mailny for Asthma, and did not work well for it, however it worked good for hair condition, and that's why Fevi was developed to treatment asthma, and Seti changed for hair loss treatment. So if it would do nothing for hair, there would not even be an idea to try... Same thing happened with Dutasteride.

I don't think Setipiprant will be relesed, because majority of blind people believe in 2% of sides, same as pharma corp... And since Seti dosage was much higher then finasteride, and need to be taken twice a day, finasteride win this battle. But Fevi for other hand...

Yes, they tested 500mg x 4 tabs daily ! vs one small pill ( propecia ) , even we know they have much more side effects they tell, the average Joe just see that. Merck this a great Propaganda during the late 90s and early 2000 showing that DHT was de devil.

Interesting, Glaxo did give attention of all the posibles side effects, and they decided to don't go phase 3. Merck, they simple didn't care.
 

Phatalis

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Looking at Breezulas dose ranging trial, interim analysis showed 2.5% BID has similar results to 5% BID. They hint that the vehicle is different in Breezula to increase scalp penetration (as scalp skin is thicker) but I don't see any good reason why Winlevi couldn't work on the scalp for hair loss if you used enough of it. We don't have the dose response curve to be fair but it makes sense to me that a 1% cream used in greater volume would have similar results to a 2.5% cream used at a lower volume.

Where did they hint about breezulas vehicle
 

alibaba92

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Yes, they tested 500mg x 4 tabs daily ! vs one small pill ( propecia ) , even we know they have much more side effects they tell, the average Joe just see that. Merck this a great Propaganda during the late 90s and early 2000 showing that DHT was de devil.

Interesting, Glaxo did give attention of all the posibles side effects, and they decided to don't go phase 3. Merck, they simple didn't care.

Thanks to this, many men saved their hair, including yourself, till better thing come out.

If it was so poison, shouldnt all prostate cancer patient be suffering tremendous sides already ?
 

jamesbooker1975

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Thanks to this, many men saved their hair, including yourself, till better thing come out.

If it was so poison, shouldnt all prostate cancer patient be suffering tremendous sides already ?
First You don't give Finasteride for prostate cancer. Please, don't be so ignorant.
Second, you don't even use Finasteride to prevent prostate cancer, do a reasearch on pubmed and see how bad that clinical trials went.

DHT is not the enemy . So simple like that, is is a real important sexual hormone in the male body. What is even worst. the 5-alpha reductase enzyme is part of many, many reaction on the body, not just in convert T to DHT. For example, it convert pregnolone into alopregnolone, an neurohormone with anti anxiety effect in the brain.
Of course, Merck never told you that.
What else Merk never told you ? That DHT goes hand to hand with Estrogen, if you lower one, you have to lower the other to don't have side effects. What else ? Progesterone , a really important hormone in MALES too, goes to zero, since progesterone inhibit ( in a feed back way ) aromatasa and the reductasa. So, when the brain sense that there is less DHT, the secretion of Progesterone is reduce it. Etc, etc, etc .

Clearly, yo are not old enough. You will not say,"hey , I am forty, it fucked my best years of sex, but, hey ! I have my hair " hair without good sex, is like being reach and can't spend the money. Simple , useless.
 
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