Anybody Have Any News Of Phase 3 Updates?

[Btg]

First You don't give Finasteride for prostate cancer. Please, don't be so ignorant.
Second, you don't even use Finasteride to prevent prostate cancer, do a reasearch on pubmed and see how bad that clinical trials went.

DHT is not the enemy . So simple like that, is is a real important sexual hormone in the male body. What is even worst. the 5-alpha reductase enzyme is part of many, many reaction on the body, not just in convert T to DHT. For example, it convert pregnolone into alopregnolone, an neurohormone with anti anxiety effect in the brain.
Of course, Merck never told you that.
What else Merk never told you ? That DHT goes hand to hand with Estrogen, if you lower one, you have to lower the other to don't have side effects. What else ? Progesterone , a really important hormone in MALES too, goes to zero, since progesterone inhibit ( in a feed back way ) aromatasa and the reductasa. So, when the brain sense that there is less DHT, the secretion of Progesterone is reduce it. Etc, etc, etc .

Clearly, yo are not old enough. You will not say,"hey , I am forty, it fucked my best years of sex, but, hey ! I have my hair " hair without good sex, is like being reach and can't spend the money. Simple , useless.

what would you recommend to someone who is losing hair ?

 

[jamesbooker1975]

what would you recommend to someone who is losing hair ?

I will use minoxidil plus azelaic acid. If posible, add cetirizine.
Then, if you want to add more things, spironolactone cream and ketoconazole shampoo.

 

[alibaba92]

First You don't give Finasteride for prostate cancer. Please, don't be so ignorant.
Second, you don't even use Finasteride to prevent prostate cancer, do a reasearch on pubmed and see how bad that clinical trials went.

DHT is not the enemy . So simple like that, is is a real important sexual hormone in the male body. What is even worst. the 5-alpha reductase enzyme is part of many, many reaction on the body, not just in convert T to DHT. For example, it convert pregnolone into alopregnolone, an neurohormone with anti anxiety effect in the brain.
Of course, Merck never told you that.
What else Merk never told you ? That DHT goes hand to hand with Estrogen, if you lower one, you have to lower the other to don't have side effects. What else ? Progesterone , a really important hormone in MALES too, goes to zero, since progesterone inhibit ( in a feed back way ) aromatasa and the reductasa. So, when the brain sense that there is less DHT, the secretion of Progesterone is reduce it. Etc, etc, etc .

Clearly, yo are not old enough. You will not say,"hey , I am forty, it fucked my best years of sex, but, hey ! I have my hair " hair without good sex, is like being reach and can't spend the money. Simple , useless.

Huh ? finasteride 5mg were commonly prescribed for prostate cancer and there is a lot of drug, xxxx-mide (Bicalutamide, etc.) aiming at DHT to treat prostate cancer. What would you say then ?

I know, you bash anti-androgen treatment heavily and PGD2 is your god, though people believe it was bullshit. proof, seti was dropped and fevi has never been trialed for hair loss.

 

[jamesbooker1975]

Huh ? finasteride 5mg were commonly prescribed for prostate cancer and there is a lot of drug, xxxx-mide (Bicalutamide, etc.) aiming at DHT to treat prostate cancer. What would you say then ?

I know, you bash anti-androgen treatment heavily and PGD2 is your god, though people believe it was bullshit. proof, seti was dropped and fevi has never been trialed for hair loss.

No, it is not. Jesus. Stop telling that LIE. If you have prostate cancer they give you an oral antiandrogen like Bicalutamide, not Finasteride.

Seti was not dropped. Second, the problem with Seti is that is 4 tabs of 500mg per day, and will be extremly hard to convide the average Joe, like you, that is better than one pill propecia per day.

By last, the only reason that there was nothing better in this 22 years since propecia is cause propecia. Who will take the time to make a topical antiandrogen when the average Joe, like you, will say " hey, taking a pills is a lot easier "


What is more interesting, is like you telling that Finasteride is use it in Cancer patients( which don't )) and that is a good thing.
Let me tell if, if you have cancer, sex don't even bother you They chemical castrate people with prostate cancer.

If Merk did the things right, like Glaxo did, there should be a better treatment long, long time ago.

 

[jamesbooker1975]

Huh ? finasteride 5mg were commonly prescribed for prostate cancer and there is a lot of drug, xxxx-mide (Bicalutamide, etc.) aiming at DHT to treat prostate cancer. What would you say then ?

I know, you bash anti-androgen treatment heavily and PGD2 is your god, though people believe it was bullshit. proof, seti was dropped and fevi has never been trialed for hair loss.

Here you have it Average Joe :
https://www.cancer.org/cancer/prostate-cancer/treating/by-stage.html

Where the f*** is finasteride !? See, you are an ignorant.

 

[alibaba92]

No, it is not. Jesus. Stop telling that LIE. If you have prostate cancer they give you an oral antiandrogen like Bicalutamide, not Finasteride.

Seti was not dropped. Second, the problem with Seti is that is 4 tabs of 500mg per day, and will be extremly hard to convide the average Joe, like you, that is better than one pill propecia per day.

By last, the only reason that there was nothing better in this 22 years since propecia is cause propecia. Who will take the time to make a topical antiandrogen when the average Joe, like you, will say " hey, taking a pills is a lot easier "


What is more interesting, is like you telling that Finasteride is use it in Cancer patients( which don't )) and that is a good thing.
Let me tell if, if you have cancer, sex don't even bother you They chemical castrate people with prostate cancer.

If Merk did the things right, like Glaxo did, there should be a better treatment long, long time ago.

Well, I know I am just an average Joe, so no need to repeat that. Can we just discuss in peace please ?

If someone cares about their hair / disease, taking 10 or 20 pills multiple time per day will NOT even bother them, if it it really working for them and safe. The price would control consumer behavour anyway. Your reason for Seti is lame, tbh.

You were the one making the thread "f*** Allergan, dropping Seti" and now you said the opposite ?

If the PGD2 why "hair growth" was ever reported as a side effects in Fevi trial and Novartis should have thought about it twice.

Procar was marketed in 1992 for prostate cancer. Propecia was marketed in 1997 for hair loss, after many people reported "hair growth" as sides effects. Please tell me this history is bull sh*t ?

 

[BalderBaldyBald]

Setipiprant was mailny for Asthma, and did not work well for it, however it worked good for hair condition, and that's why Fevi was developed to treatment asthma, and Seti changed for hair loss treatment. So if it would do nothing for hair, there would not even be an idea to try... Same thing happened with Dutasteride.

I don't think Setipiprant will be relesed, because majority of blind people believe in 2% of sides, same as pharma corp... And since Seti dosage was much higher then finasteride, and need to be taken twice a day, finasteride win this battle. But Fevi for other hand...

Lol, let me say it again, Fevi won't do sh*t for Androgenetic Alopecia
Allergan did not release ONE hint that Chrt2/PGD2 inhibitors works, and they won't now.

It's not about dosage, price or whatever, this is just not working
But keep dreaming

You're basing your hopes on anedoctal evidences, poor you, blind hope is never a good thing

Even when treatments are dropped by their companies now people still thinks it's working, wtf ?

Two years of trials for Seti...and suddendly dropped withtout any communication from Allergan
AND NOT A SINGLE RESULT FOR SETI OR ANY PGD2 EFFICIENCY WAS EVER RELEASED
(at least in this universe Earth-616 in 2019, i don't know where you live, you might be an extra dimensional being)
Use your basic cognitive skills here, nothing about a conspiracy

 

[alibaba92]

Lol, let me say it again, Fevi won't do sh*t for Androgenetic Alopecia
Allergan did not release ONE hint that Chrt2/PGD2 inhibitors works, and they won't now.

It's not about dosage, price or whatever, this is just not working
But keep dreaming

You're basing your hopes on anedoctal evidences, poor you, blind hope is never a good thing

Even when treatments are dropped by their companies now people still thinks it's working, wtf ?

Two years of trials for Seti...and suddendly dropped withtout any communication from Allergan
AND NOT A SINGLE RESULT FOR SETI OR ANY PGD2 EFFICIENCY WAS EVER RELEASED
(at least in this universe Earth-616 in 2019, i don't know where you live, you might be an extra dimensional being)
Use your basic cognitive skills here, nothing about a conspiracy

How about it being dropped due to being unable to outperform the king "finasteride" ?

 

[BalderBaldyBald]

Well, I know I am just an average Joe, so no need to repeat that. Can we just discuss in peace please ?

If someone cares about their hair / disease, taking 10 or 20 pills multiple time per day will NOT even bother them, if it it really working for them and safe. The price would control consumer behavour anyway. Your reason for Seti is lame, tbh.

You were the one making the thread "f*** Allergan, dropping Seti" and now you said the opposite ?

If the PGD2 why "hair growth" was ever reported as a side effects in Fevi trial and Novartis should have thought about it twice.

Procar was marketed in 1992 for prostate cancer. Propecia was marketed in 1997 for hair loss, after many people reported "hair growth" as sides effects. Please tell me this history is bull sh*t ?

Agreed, if people are willing to buy shady chemicals from China and mix it in their own basement...
Popping 4pills a day AHAHAHAHAHAH, piece of cake boyos

 

[BalderBaldyBald]

How about it being dropped due to being unable to outperform the king "finasteride" ?

Nonsense, Trinov did released their lotions despite being 4 to 5 times more expensive and with dubious efficiency.
Propecia was a commercial failure, always have been, you can look at numbers they are public, Merck did loose money with it, and then it felt into generic molecule

And most important, Merck did release finasteride trial results for hairloss, showing exactly what kind of results everyone is having on it.

But here, users think people will go buying asthma prescription only drug to treat their hairloss withtout any communication that it can actually be used on Androgenetic Alopecia ?

Docs and pharmacians are supposed to guess that it works on Androgenetic Alopecia ? and then prescribe it to their patients withtout any sign of asthma ?

And everyone will buy it for Androgenetic Alopecia based on what ? Faith ?
This is ridiculous....even to think about it

 

[alibaba92]

Nonsense, Trinov did released their lotions despite being 4 to 5 times more expensive and with dubious efficiency.
Propecia was a commercial failure, always have been, you can look at numbers they are public, Merck did loose money with it, and then it felt into generic molecule

And most important, Merck did release finasteride trial results for hairloss, showing exactly what kind of results everyone is having on it.

But here, users think people will go buying asthma prescription only drug to treat their hairloss withtout any communication that it can actually be used on Androgenetic Alopecia ?

Docs and pharmacians are supposed to guess that it works on Androgenetic Alopecia ? and then prescribe it to their patients withtout any sign of asthma ?

And everyone will buy it for Androgenetic Alopecia based on what ? Faith ?
This is ridiculous....even to think about it

Dude, Trinov is comestic, Seti is drug. Could be that they cant show efficacy for hair loss, could not convince FDA. Just a possibility.

There was a paper in 2012 from George Cots, which serves as a "bible" for PGD2 believers.

Can share a source saying Propecia was a commercial failure ? I am interested to know. Whether you want it or not, after 17 years, patent is released and generic comes in, no choice.

 

[BalderBaldyBald]

Dude, Trinov is comestic, Seti is drug. Could be that they cant show efficacy for hair loss, could not convince FDA. Just a possibility.

There was a paper in 2012 from George Cots, which serves as a "bible" for PGD2 believers.

Can share a source saying Propecia was a commercial failure ? I am interested to know. Whether you want it or not, after 17 years, patent is released and generic comes in, no choice.

I remember this paper from Cots, where he clearly said that PGD2 angle will not be enough
This is why Follica's patent, having his own PGD2, combine also androgenic ingredients

He also said that current treatments will have to be continued, Follica will be not magic bullet

PGD2 angle, as strong as your drug can be, will simply not be enough
And Allergan seems not entitled to give us some efficiency numbers before their drug come out

 

[BalderBaldyBald]

Dude, Trinov is comestic, Seti is drug. Could be that they cant show efficacy for hair loss, could not convince FDA. Just a possibility.

There was a paper in 2012 from George Cots, which serves as a "bible" for PGD2 believers.

Can share a source saying Propecia was a commercial failure ? I am interested to know. Whether you want it or not, after 17 years, patent is released and generic comes in, no choice.

I just checked registered Propecia/finasteride users in my country....30 000 on 70 millions people, 50% women, so make it 35 millions men, 50%¨will likely experience hairloss

So...30000 on 17 millions potential customers
Also finasteride is cheap as f*** now, so get rid of price argument...

Sure it is a BIG SUCCESS ! Everyone is using it ! Millions of men around the world....

Let's double that number with people that can potentially buy it online, still 60K out of 17 millions
Edit : In my country, this is still a drug under surveillance, and they don't joke about it

Merck and Allergan have multiple lawsuits ongoing in France
So please, no argument on pharma companies, it's like comparing pest and cholera

 

[ffar1989]

Lol, let me say it again, Fevi won't do sh*t for Androgenetic Alopecia
Allergan did not release ONE hint that Chrt2/PGD2 inhibitors works, and they won't now.

It's not about dosage, price or whatever, this is just not working
But keep dreaming

You're basing your hopes on anedoctal evidences, poor you, blind hope is never a good thing

Even when treatments are dropped by their companies now people still thinks it's working, wtf ?

Two years of trials for Seti...and suddendly dropped withtout any communication from Allergan
AND NOT A SINGLE RESULT FOR SETI OR ANY PGD2 EFFICIENCY WAS EVER RELEASED
(at least in this universe Earth-616 in 2019, i don't know where you live, you might be an extra dimensional being)
Use your basic cognitive skills here, nothing about a conspiracy

I guess in your hair condition Fevi/Seti/finasteride whatever won't help. But for others it may Fevi be great solution.
You are nothing but hopeless ignorant, even on this forum there are people who respond positive with Seti.

 

[ffar1989]

nd you are basing your hopes on nothing but a theory. why not focus on anti androgens, something we actually know of can work instead of dubious age science

You are right. I am putting my hope for theory, but also my believe is based on fact, that some people had positive impact on hair on this and other forums, Seti was developed for hair because it actually had impact on it during asthma test, and Cetirizine 10mg per day since 14 of January, seams doing something positive for my hair. I experience zero hair loss, even after rough combing. I can't say it is because of it, but maybe.

 

[alibaba92]

You are right. I am putting my hope for theory, but also my believe is based on fact, that some people had positive impact on hair on this and other forums, Seti was developed for hair because it actually had impact on it during asthma test, and Cetirizine 10mg per day since 14 of January, seams doing something positive for my hair. I experience zero hair loss, even after rough combing. I can't say it is because of it, but maybe.

maybe you are one of the 1% lucky guys that respond PGD2, compared to 80% of men in finasteride trial. And you know, only you and a few guys here cant change the game.

btw, who are the guys that saw regrowth using seti here ?

 

[alibaba92]

why would you focus o much on pge when we have actual data for anti androgens like clascoterone that actually have a verified method of action

S.I.D.E.S

 

[itsjustsimon]

I will use minoxidil plus azelaic acid. If posible, add cetirizine.
Then, if you want to add more things, spironolactone cream and ketoconazole shampoo.

@Btg, I hope you’re that smart that you see some people have very emotional reactions that are not based on anything else that their personal opinions which are pure bullshit.

The fact is, if you’re younger that 30 and you’re going bald, your only solution on the long run is antiandrogen. You can f*** with ru or cb if you want, but I’m not sure this is the best idea right now.

I’ve been on antiandrogen for 9 years, no sides at all. And yeah, I’m working for Merck.

 

[itsjustsimon]

S.I.D.E.S

I’m sure you know all the sides of pgd2 lol.

Nobody knows what will be the real cost of pgd2 antagonist, let’s be real..

Antiandrogen are out for more then 20 years. People live normal lives without 5 alpha reductase.

 

[itsjustsimon]

Lol, tell that to the thousands of people who had horrible side effects.

And your point is? Look, studies are out, ~ 3% of people have sides, so that means nobody should try it or what?

And if you want to believe that studies are bullshit and some internet forum where people with sides b**ch is real representation, go for it. I really don’t give a f***. I pick studies any time.