Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[jan_miezda]

in females progesterone already block the prolactin receptor in the mammary gland. Maybe you can try if you don’t care about side effect

With no FAP i had seen some benefits true but i refear something to use topical/orally.
Thanks for your repply

 

[pegasus2]

I believe mucuna pruriens is a good natural alternative to this drug. It wouldnt be as effective, but we lose nothing trying. I used it in the past for gym performance and I noticed better hair quality.

Not going to do anything for follicular prolactin.

 

[pegasus2]

How do you know that? L-dopa lowers prolactin in blood and it crosses bbb.

Read previous 30 pages. I will not explain it again

 

[Tom4362]

Ok, so you dont know.

Lol, bro don't be like that. It has been explained a 100 times why your suggestion won't work.

 

[Dimitri001]

How do you know that? L-dopa lowers prolactin in blood and it crosses bbb.

I think the answer is, and someone correct me if I'm wrong, that prolactin is generated in the follicle and these kind of drugs that lower prolactin systemically won't suppress that or not sufficiently.

 

[EndlessPossibilities]

I really doubt that a follicle could be able to produce hormones. Even in that case, we could use topical mucuna if it has less than 500 daltons (i havent researched that)

Lol. Bro ur like a decade behind. Follicles can produce hormones. And so can skin. Its already been proven.

 

[RolfLeeBuckler]

We Need Infos about the Trial Starting now!

 

[EndlessPossibilities]

Any source?

Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are ...

www.ncbi.nlm.nih.gov

Shows the follicle secretes melatonin. Aka a hormone.

This one https://pubmed.ncbi.nlm.nih.gov/15946990/
Shows the follicle secretes cortisol aka a stress hormone. Theres more out there

 

[partysnacks]

Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are ...

www.ncbi.nlm.nih.gov

Shows the follicle secretes melatonin. Aka a hormone.

This one https://pubmed.ncbi.nlm.nih.gov/15946990/
Shows the follicle secretes cortisol aka a stress hormone. Theres more out there

In addition, how can we forget the obvious? DHT produced within the dermal papilla.

 

[EndlessPossibilities]

That study is BS. It was performed ex-vivo, so it doesnt count.

How does that not count. The follicle doesn't just grow new capabilities by being outside of the organism wtf

 

[Ollie]

In fact it does due to fibrosis (it loses capabilities)

Dude Its common knowledge that hair follicles produce and convert hormones. One of the many reasons some of us lose hair whilst others dont is because of over expression of 5ar ... in the follicle, or under expression of aromatase.. in the follicle. Prolactin is produced by your pituitary gland.

This was literally taken off Wiki : 'Ultimately dopamine, extrapituitary prolactin is controlled by a superdistal promoter and apparently unaffected by dopamine'

 

[EndlessPossibilities]

Ok quote me an in vivo pair reviewed study showing prolactin is produced within the follicle. I am not against this theory, i am just asking for proofs. I like to read studies also, i am a phd candidate in stats, so i am used to read studies...

Heres the thing. In vivo and vitro yes may bring about different results. But the fact the follicle has been shown to secrete prolactin in at least one study shows it has that function. Which means its likely it uses that function in the body. Why else have that function.

 

[EndlessPossibilities]

I dont know, but thats how science works buddy. Ex vivo means literally nothing. To get something approved for the market you need in vivo studies, double blind,... you need to get decent p values and t values, and a fuckload of statistical tests.

Lol bro. If ex vivo didnt mean anything. Then they wouldnt ever do vitro or ex vivo studies. Ur saying billions of dollars have been wasted. Because by ur standard they mean nothing.

all data means something. Even badly done studies. In fact ex vivo are pretty powerful studies.

Btw i am not saying this bayer sh*t works. I am actually very skeptical

 

[pegasus2]

I really doubt that a follicle could be able to produce hormones. Even in that case, we could use topical mucuna if it has less than 500 daltons (i havent researched that)

Please stop posting

 

[whatevr]

I really doubt that a follicle could be able to produce hormones. Even in that case, we could use topical mucuna if it has less than 500 daltons (i havent researched that)

No because the guys using Zix (Zinc + P5P) would have been cured a long time ago by now. P5P is a prolactin antagonist. Clearly doesn't work on hair.

 

[RolfLeeBuckler]

@HopeMedicine now it is July, please Start the Trial and give us information

 

[pegasus2]

Strong argument

If you read this thread and the other prolactin thread in full you'd know how stupid you sound right now. Stop being lazy and read the threads or stop posting nonsense

 

[whatevr]

Any studies about p5p not working on hair?

No. But that's not how things work, you don't go proving a negative, there has to be studies proving that it DOES reduce prolactin in the HF - there are none.

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid - PubMed

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations...

pubmed.ncbi.nlm.nih.gov

There is only the above study claiming it helps to inhibit 5-AR, nothing about prolactin.

 

[Ollie]

Perfect. So we cannot conclude anything.

Dude a PRLR antibody regrows hair. Dopamine agonists dont. Any rational person would elude to the idea that its a local PRL issue. Its obvious.

 

[TurboFixer]

We are all on the same side - no reason to go at each others throats