Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[DuncanOP]

Hi,
I read this thread and didn't find anyone asking (although I find it difficult, maybe I haven't see this question on previously pages, if that's the case, I apologize).

What would the case of a hair transplant patient be like when using this drug? Would vellus hair re-growth be blocked by the new follicles inserted into the bald area? (Maybe it is just dumb question, I think the user will have a super dense hair areas, but I'm not sure)

Also, just for curious, would users of capillary prosthesis still benefit from this drug?

 

[Throwaway94]

You tried non fda approved cb and ru with probably the wrong vehicle. If it was from kane or a chinese lab it was probably fake. Vehicles are also key. With a more potent cb or side free ru you shouldnt lose more hair. To regrow is another balls game and hair transplants are often required for high norwoods.

Wow you're so experienced and knowledgeable

 

[Dimitri001]

It's not premature to say that because BAY is going to known down 100% of the receptor. If it doesn't work, the PRLR route is dead.

But we don't know for sure yet what the sides are gonna be. Theoretically, I understand they shouldn't be significant, but we don't know yet for sure.

Furthermore, IDK how much we know about the basic science of the effect. Perhaps there's something downstream of the receptor that is having the hair growth effect that could be targeted instead of the receptor and that wouldn't have any potential sides blocking the receptor might.

It would be good to have people studying this.

 

[KNemo]

I hairmog you to oblivion.

You also losermogs us all.

 

[Ollie]

Then the guy who wrote it was clearly wrong. In science you have to be precise buddy.
Anyway, this is more than 10 years away from hitting the market. Good luck reading this meme "studies".

They're starting phase 2. Not only is this drug amazing for hair regrowth but men in general. PRL is poison. Ofc being so scientifically aquatinted you'd already know that...

 

[DuncanOP]

They're starting phase 2. Not only is this drug amazing for hair regrowth but men in general. PRL is poison. Ofc being so scientifically aquatinted you'd already know that...

@Ollie when you expect it will be released?
I saw pegasus2 expect in 5+ years and trialAcc in 3~4 years

 

[Tom4362]

Wow you're so experienced and knowledgeable

He's also an ideator, he apparently knows 'another balls game'

 

[trialAcc]

@Ollie when you expect it will be released?
I saw pegasus2 expect in 5+ years and trialAcc in 3~4 years

Assuming they finish global phase 2 early/mid 2022 and start phase 3 late 2022 ending in late 2023. I don't see why it wouldn't be released in 2024 or at least 2025 assuming all goes well.

 

[Chads don't bald]

The big downside I assume is gonna be the cost. I hope monoclonal antibodies become cheaper to produce as time goes on. Genome sequencing used to cost well over 7 figures and now it costs less than 1k.

 

[jamesbooker1975]

The big downside I assume is gonna be the cost. I hope monoclonal antibodies become cheaper to produce as time goes on. Genome sequencing used to cost well over 7 figures and now it costs less than 1k.

Yes, but we are far, far away . Even the antibodies discover over 10 years ago are extremly expensive nowaday . I mean, is this thing works, and it came with a 1000 usd per month, will be " cheape "

 

[trialAcc]

The big downside I assume is gonna be the cost. I hope monoclonal antibodies become cheaper to produce as time goes on. Genome sequencing used to cost well over 7 figures and now it costs less than 1k.

Yeah this thing is not going to be cheap. That's why you should be hyped on it though, because they clearly think this is going to provide results worthy of a 5 figure price tag, otherwise they wouldn't develop it.

Unlike most drugs/causes, I doubt anyone will be getting this covered by insurance, so it's going to have to deliver transplant worthy results or better to justify the expense. The fact that they are rushing it into development & raising a lot of capital says that they think this will be the case.

 

[Chads don't bald]

Hmm yeah after doing some more reading, apparently they are so expensive due to the complicated procedure to produce them. Based on that I don't think this will become inexpensive until we can completely automate the process. So for us, lets hope that it is a one and done type of treatment, similar to a hair transplant.

 

[JealDeal]

This treatment is really promising indeed but I will cautiously wait for the results of the phase 2. Prolactin may seem not very useful but it still plays a part in the human body and considering what happens with finasteride and 5 ar inhibitors we never know what could happen if the receptor is completely shut down. Hypoprolactinemia is not something very heavy but low prolactin is different than no prolactin. This is definetly the treatment that looks the most effective and the safest yet though.

My best friend had his life completely destroyed by PFS and skin issues due to minoxidil so my main concern now is safety first.

 

[RolfLeeBuckler]

This treatment is really promising indeed but I will cautiously wait for the results of the phase 2. Prolactin may seem not very useful but it still plays a part in the human body and considering what happens with finasteride and 5 ar inhibitors we never know what could happen if the receptor is completely shut down. Hypoprolactinemia is not something very heavy but low prolactin is different than no prolactin. This is definetly the treatment that looks the most effective and the safest yet though.

My best friend had his life completely destroyed by PFS and skin issues due to minoxidil so my main concern now is safety first.

Shouldn't wee see the potential side effects of HMI-115 at our SMI testing group? @pegasus2 you havent noticed any side effect with the addtional prolactin treatment - right?!

 

[JealDeal]

What skin issues did he have from minoxidil? And hope he gets better, he should check out HCG and proviron.

His face skin is very wrinkly and saggy despite the fact he is 24. The collagen in his face seems completely depleted. People usually think he is forty or fifty.
He used finasteride for 4 years and minoxidil for the same amount of time.
He is in touch with very qualified professionals but these treatments do not produce a lot of result.
Btw a study was just published and showed that PFS patients have more than 3500 genes deeply damaged.

 

[JealDeal]

Shouldn't wee see the potential side effects of HMI-115 at our SMI testing group? @pegasus2 you havent noticed any side effect with the addtional prolactin treatment - right?!

Indeed we will to some extent. I find the process within the discord group quite obscure. People are not encouraged to speak about side effects but only to fill an anonymous poll so nobody is really aware of anything.
Also most people in the group are following very heavy protocols with finasteride, minoxidil etc and not smi alone. The sample is also quite small so it would be hard to analyze with good accuracy the side effects.
It still is very useful but it’s not worth a real phase 2

 

[RolfLeeBuckler]

Indeed we will to some extent. I find the process within the discord group quite obscure. People are not encouraged to speak about side effects but only to fill an anonymous poll so nobody is really aware of anything.
Also most people in the group are following very heavy protocols with finasteride, minoxidil etc and not smi alone. The sample is also quite small so it would be hard to analyze with good accuracy the side effects.
It still is very useful but it’s not worth a real phase 2

Hope Medicine announced global license agreement with Bayer AG to advance the development and commercialization of the monoclonal antibody directed against prolactin (PRL) receptor

/PRNewswire/ -- Hope Medicine Inc. announced today that they have signed a world-wide exclusive license agreement with Bayer AG on the development and...

www.prnewswire.com

About PRL receptor antibody

The PRL receptor antibody is a potent monoclonal antibody, blocking the PRL receptor-mediated pathway in a non-competitive manner. The drug product can be administrated subcutaneously. The antibody was well tolerated in a clinical Ph I study (combined single and multiple dosing).

The antibody was effective in stimulating hair growth in aged stump-tailed macaques, nearly doubling the number of terminal hairs after 6 months even in previously fully bald areas and showing a sustainable impact even after 2 years post treatment. Notably, the stump-tail macaque model is considered one of the rare predictive animal models for male and female pattern hair loss in humans. The study is a result of a close collaboration between Bayer scientists and researchers at IMM.

--
question is whether this Phase I was only done in stump-tailed macaques or also in human?
Is it possible to do a Phase I with animals and phase II with humans ?!?!
HopeMedicine will start Phase II soon so if it is necessary to do phase I trial with human then HopeMedicine already has shown that the PRL receptor antibody was well tolerated

 

[trialAcc]

Hope Medicine announced global license agreement with Bayer AG to advance the development and commercialization of the monoclonal antibody directed against prolactin (PRL) receptor

/PRNewswire/ -- Hope Medicine Inc. announced today that they have signed a world-wide exclusive license agreement with Bayer AG on the development and...

www.prnewswire.com

About PRL receptor antibody

The PRL receptor antibody is a potent monoclonal antibody, blocking the PRL receptor-mediated pathway in a non-competitive manner. The drug product can be administrated subcutaneously. The antibody was well tolerated in a clinical Ph I study (combined single and multiple dosing).

The antibody was effective in stimulating hair growth in aged stump-tailed macaques, nearly doubling the number of terminal hairs after 6 months even in previously fully bald areas and showing a sustainable impact even after 2 years post treatment. Notably, the stump-tail macaque model is considered one of the rare predictive animal models for male and female pattern hair loss in humans. The study is a result of a close collaboration between Bayer scientists and researchers at IMM.

--
question is whether this Phase I was only done in stump-tailed macaques or also in human?
Is it possible to do a Phase I with animals and phase II with humans ?!?!
HopeMedicine will start Phase II soon so if it is necessary to do phase I trial with human then HopeMedicine already has shown that the PRL receptor antibody was well tolerated

Phase 1 = humans. There's no such thing as a phase 1 on animals lol. Any animal work is pre-clinical research.

 

[RolfLeeBuckler]

Phase 1 = humans. There's no such thing as a phase 1 on animals lol. Any animal work is pre-clinical research.

Ok so we know that there arent any dangerous Side effects on humans because HMI-115 already did Phase I in humans - brilliant!!

„
The antibody was well tolerated in a clinical Ph I study (combined single and multiple dosing).“

 

[Dimitri001]

Do we know why Bayer tested the antibody in the monkeys to begin with? Was there some initial mechanistic insight that lead them to believe it might help with hair loss or were they testing it for some other purpose?

Because if it was some research that lead them to believe so, maybe there's more that can be learned from that research, although I assume any paper that might exist would be internal only.

His face skin is very wrinkly and saggy despite the fact he is 24. The collagen in his face seems completely depleted. People usually think he is forty or fifty.
He used finasteride for 4 years and minoxidil for the same amount of time.
He is in touch with very qualified professionals but these treatments do not produce a lot of result.
Btw a study was just published and showed that PFS patients have more than 3500 genes deeply damaged.

wtf, do you have a link to the study?