Curis, P&g, And The Lost Baldness Cure

[pegasus2]

@pegasus2 - If you haven't used tretinoin before, I would use a small amount on the other temple area (assuming you are only using SAG in one small area at the moment). Within 2-3 days of tretinoin gel (lowest concentration) first application, you will likely get red & irritated in that area. This will give you an idea of the effect you'll get. You can then decide if you really want to use it on the SAG temple. Once an area is irritated, you'll have to stop using anything in that area until it calms down. It will also likely peel. Might even have to use a bit of hydrocortisone to calm it down. And, the reservoir effect of tretinoin I believe is 3-4 days. Eventually, your skin will develop a resistance to the irritation, and, won't get as irritated. Even if you're only going to use it once a month, I would first test it on the non-SAG side. Also, if you do use tretinoin, don't go out in the sun without some kind of sun screen. Tretinoin makes your skin very vulnerable to uv radiation.

I've never used it on my scalp due to the fact that it causes hair loss for some people, I only used it on my face. I haven't been using it lately, but I would apply at night and never had any problems with sensitivity to sunlight. I've read that's a myth anyway. https://www.byrdie.com/retinol-cream-myths

 

[GroLocks]

@pegasus2 - retinol & tretinoin (retin-a) are NOT the same thing. Yes, they are both derivatives of vitamin A & they have some similar characteristics. To be clear, I was referring to tretinoin. You do have to be more careful with tretinoin. It is a stronger version of retinol. Anyway, it's good that you've decided to use retinol instead. I think you'll have less problems with that. I've never used retinol, but, I know you can buy that over-the-counter. Tretinoin requires a script & is an FDA cleared drug. Good luck with your protocol. I'll be tracking your progress! Seems like you've got some visual progress already. Be safe.
https://www.mayoclinic.org/drugs-supplements/tretinoin-topical-route/precautions/drg-20066521

 

[WaccWaccWacc]

@pegasus2

just curious, are you not of age/candidacy for a hair transplant? Why choose the risks of this rather than a hair transplant?

nevertheless, best of luck

 

[Photon]

If anyone is interested in doing a group buy on SAG let me know.

I would but it would depend on the price. I'm low on money right now.

 

[Photon]

The price would be good, but I just ordered some for myself. If you want to wait until I order again or try to set up a group buy yourself you can get a good price.

How much did you get yours for? I have DUPA, so I would need for my entire scalp. Are we talking of a few hundred bucks?

 

[wislow9]

I will use SAG forthnightly after wounding ala Follica. No Vismodegib yet and hopefully never. It's a safety gate to treat skin cancer.

I looked at your regimen and from doing simply RU to jumping on Shh agonists like SAG is a totally different ball game. Do you understand this?

First recommendation would be to try anything else before using SAG due to cancer risks. There are many other drugs that will give you opportunities to find out if they work on you starting with Fina Duta minoxidil Nizoral etc

As for regrowth in donor area, sure why not. Unless you had a big scar with FUT or many scars on FUE which will make those areas of the scalp harder to manage but the OP talks about this somewhat.

You are welcome to shot an email to Christiano but I doubt she would bother replying. Do you really believe she would advise you on how to take these dangerous off-the-market drugs without risking her job? I know a few people who would like to become a rat in her lab but that won't happen. They have mice for running their experiments.

I have tried all those drugs that you indicate and hardly offer results.Finasteride and Minoxidil dont work for me... RU its more effective than Finasteride and Dutasteride
For now i'll try firstly with SM0454 and Way,RU,ascj9...
Its true, the wisest thing to do is wait...,i may not need it
If later I decided i would do it under medical supervisor

 

[pegasus2]

I have tried all those drugs that you indicate and hardly offer results.Finasteride and Minoxidil dont work for me... RU its more effective than Finasteride and Dutasteride
For now i'll try firstly with SM0454 and Way,RU,ascj9...
Its true, the wisest thing to do is wait...,i may not need it
If later I decided i would do it under medical supervisor

If finasteride doesn't work for you try dutasteride or RU, preferably both. ASC-J9 and WAY-316606 might help, but use them together with dutasteride and minoxidil or you probably won't see much difference. You can increase your dose on RU, or try something more potent like darolutamide, but not that 1mg dose that people try. Use it at 20 or 30mg.

 

[John Difool]

Are there any studies for topical darolutamide?

 

[pegasus2]

Are there any studies for topical darolutamide?

No.

 

[Sanchez1234]

I used 6mg per ml and that was the highest i could go. Dissolving daro is almost impossible.

 

[pegasus2]

I used 6mg per ml and that was the highest i could go. Dissolving daro is almost impossible.

It's supposed to be soluble at 20mg/ml in dmso.
https://www.caymanchem.com/pdfs/11596.pdf

Should I try it I'll do 30mg in 2ml.

 

[John Difool]

Third application yesterday. 40 minutes wounding the Follica way then SAG 2 hours later then PGE2 at night.

 

[pegasus2]

Third application yesterday. 40 minutes wounding the Follica way then SAG 2 hours later then PGE2 at night.

How much did you use? Do you have any left?

 

[John Difool]

How much did you use? Do you have any left?

Last 20mg. Hopefully next shipment comes in the next few weeks.

 

[wislow9]

If finasteride doesn't work for you try dutasteride or RU, preferably both. ASC-J9 and WAY-316606 might help, but use them together with dutasteride and minoxidil or you probably won't see much difference. You can increase your dose on RU, or try something more potent like darolutamide, but not that 1mg dose that people try. Use it at 20 or 30mg.

Dutasteride is similar to Finasteride for me.Only RU but together with other.
RU by itself loses effectiveness over the months
Yes, i tried with Darolutamide, but I need to use more than 20mg to notice something... and is expensive
I will try with Wnt inhibitors,but its need find reliable sources

 

[John Difool]

It should, but it all depends on customs. I hope they don't open it again. I have maybe 5-10mg left. I didn't want to use it until I got everything else, but it looks like ADC isn't shipping during the lockdown. So no Keto, Loniten, or spironolactone for me until at least mid-June.

Using FedEx guarantees an inspection thru customs

 

[Photon]

Using FedEx guarantees an inspection thru customs

Wow, that is terrible news. Where did you hear about this?

 

[John Difool]

Experience prevails. Nothing terrible about it. It's the way it works.

 

[John Difool]

I got density built up with vellus hair where I didn't have any before. One thing to notice is that they are discolored. It seems that neogenesis pops new hair without pigmentation. Curious if something needs to be done about it or should I just wait for the next hair cycle?

 

[John Difool]

Crossing fingers, friend. Seeing hair growth activity where it used to be slick like a pebble for years is exciting.