Curis, P&g, And The Lost Baldness Cure

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Sanchez1234

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This is by far the most exciting thread in here. Two people reporting regrowth on slick bald places.
Any updates?
@Photon when u gonna join?
 
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Photon

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Sanchez1234 said:
This is by far the most exciting thread in here. Two people reporting regrowth on slick bald places.
Any updates?
@Photon when u gonna join?
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I did my first application two days ago, 20mg on my entire scalp. Nothing to report so far because it's too early. I did notice scalp pain but I'm not sure if it was from SAG or the heavy wounding. Probably the wounding though.
 
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HairOnFire

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John Difool said:
Third application yesterday. 40 minutes wounding the Follica way then SAG 2 hours later then PGE2 at night.
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Are you guys taking into consideration the so-called embryonic window? In Follica's investor slides, the application of their enhancer drug is not administered concurrently with the wounding - it seems to be about 10-14 days post-wounding. I haven't looked too closely at Follica's latest patent/protocol, so maybe this is no longer a consideration, but the embryonic window was a prominent part of Cotsarelis' WIHN research.

Also, applying a chemical so close to wounding may allow significantly more of the chemical to be absorbed systemically.
 
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pegasus2

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HairOnFire said:
Are you guys taking into consideration the so-called embryonic window? In Follica's investor slides, the application of their enhancer drug is not administered concurrently with the wounding - it seems to be about 10-14 days post-wounding. I haven't looked too closely at Follica's latest patent/protocol, so maybe this is no longer a consideration, but the embryonic window was a prominent part of Cotsarelis' WIHN research.

Also, applying a chemical so close to wounding may allow significantly more of the chemical to be absorbed systemically.
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The window depends on the compound. Wnts are needed early on by day 3, Shh is not until later. It takes 5 days for Shh expression to peak after application, and 10+ days for GLI2. Shh likely remains elevated for weeks. I think the latest Follica patent has variations ranging from applying the shh agonist at the same time as wounding up to 3 days post wounding.
shh expression.PNG
 
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HairOnFire

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John Difool

John Difool

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wislow9 said:
Dutasteride is similar to Finasteride for me.Only RU but together with other.
RU by itself loses effectiveness over the months
Yes, i tried with Darolutamide, but I need to use more than 20mg to notice something... and is expensive
I will try with Wnt inhibitors,but its need find reliable sources
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Are you able to go back and forth between Bica and Daro? It seems that when using Daro Bica would lose its effectiveness.
 
John Difool

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GroLocks said:
@pegasus2 - I don't disagree with your comments. My point in posting about them, was that they (Clob & Hal) do act as Smo agonists, they do displace BODIPY-Cyclopamine. Certainly not to the degree that SAG does, but, about 20-25%. That may be enough with the help of minoxidil, needling, tretinoin (to mitigate the skin atrophy from glucocorticoids). The combo may activate Hh just enough, over a period of time, to initiate hair growth. The only citation I could find using the combo triamcinolone acetonide after micro needling was in a patient with Alopecia areata, and, it did initiate regrowth of hair after 2 sessions. TA has been shown to bind to Smo & enhance Hh signaling. Even though the "small molecule" Class glucocorticoids have been shown to activate Hh, I don't think it is enough by themselves to trigger hair growth. What they do have is a history of use in humans & a safety profile. The combo (Hal / minoxidil / Needling / Tretinoin) might be enough to over-come the remaining inhibitors at play. Taking into consideration of course, the feedback loop of Hh ... too much stimulation triggers shut-down. How much is too much? .. not enough data yet. Once a week session might be right ... once a month session might be right. I am starting this protocol currently @ once a week. I will update if there are positive / negative changes.
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@GroLocks Any updates?
 
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GroLocks

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@John Difool - Yes. I'm not sure if I mentioned that I have both alopecia areata & androgenetic alopecia. The spot area where the alopecia areata is located, is filling in very well. The areas of male pattern baldness are definitely getting stronger terminal hairs, that were already there. They used to be very fine. I've been on this protocol for 2+ mnths now. I am using Dr. Pen, minoxidil foam, Clobetasol cream .05%, tretinoin gel .05%, a diy mixture of (polygonum multiforum / rosemary oil / peppermint oil / red clover / korean red ginseng). I do the needling 1x per week. I use all the topicals 2x day except the clobetasol. I use that every other day. I think the needling, clobetasol / minoxidil / tretinoin are the main ingredients that are triggering hair growth. The tretinoin offsets the bad effect of clobetasol. So far, no sides except hair growth. I will keep updating in another 2 months. I didn't take any pics before or now.
 
LouisSarkozy

LouisSarkozy

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GroLocks said:
@John Difool - Yes. I'm not sure if I mentioned that I have both alopecia areata & androgenetic alopecia. The spot area where the alopecia areata is located, is filling in very well. The areas of male pattern baldness are definitely getting stronger terminal hairs, that were already there. They used to be very fine. I've been on this protocol for 2+ mnths now. I am using Dr. Pen, minoxidil foam, Clobetasol cream .05%, tretinoin gel .05%, a diy mixture of (polygonum multiforum / rosemary oil / peppermint oil / red clover / korean red ginseng). I do the needling 1x per week. I use all the topicals 2x day except the clobetasol. I use that every other day. I think the needling, clobetasol / minoxidil / tretinoin are the main ingredients that are triggering hair growth. The tretinoin offsets the bad effect of clobetasol. So far, no sides except hair growth. I will keep updating in another 2 months. I didn't take any pics before or now.
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keep us uptated please . Sorry to bother you with that but if that's not too much to ask andd if you have the time could you pm me the diy mixture you're using with the vehicle and dosage it seems extremelly interesting and i'm looking to add a another growth stimulant to minoxidil. thanks you so much
 
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pegasus2

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Small update, there's not much to say. I haven't applied SAG in some time. I've been missing most of my other treatments lately too. Seeing a new girl makes it difficult to apply topicals. I haven't even been taking my dutasteride pills half the time. I think I've maintained most of my gains despite that. Now I'm going to get more consistent with my treatments again. I microneedled today, and I'm going to apply SAG again tomorrow. 2ml at 2% concentration. Then I'll start using it once a week at 1% for the time being.
 
John Difool

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Congrats on the new gf!

Are you back to weekly wounding at 1.5mm depth? That's what I am contemplating doing.
 
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pegasus2

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John Difool said:
Congrats on the new gf!

Are you back to weekly wounding at 1.5mm depth? That's what I am contemplating doing.
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Thanks. I'm wounding biweekly at 1.5mm depth. It hurts much more than 1mm so I only did it for 16 minutes.
 
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pegasus2

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I'm also considering using SAG daily at .2%.
 
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