Darolutamide (odm-201), A Better Topical Than Enzalutamide?

[Georgie]

Tell me about it. I'm easily losing 200 hairs a day, which is really quite inconceivable considering my temples have no hair to lose any longer and the rest of my head isn't exactly a forest of density. Every corner of my apartment has so much hair gathered on the floor it's ridiculous.

Yeah same. My hair is like fluff when it’s try. You run your fingers through it and it’s just scalp all over. My entire hairline is so thin it’s almost freakish. Also, my shedding has picked up even more today. So even on the highest f*****g conceivable estrogen hormone replacement, avodart, daro, 1g of seti, oral minoxidil, topical minoxidil, wounding, every vitamin under the f*****g sun, bimatoprost and stemoxydine, I’m blading faster than most men and women who have untreated Androgenetic Alopecia. It is beyond a f*****g joke.

 

[sunchyme1]

Yeah same. My hair is like fluff when it’s try. You run your fingers through it and it’s just scalp all over. My entire hairline is so thin it’s almost freakish. Also, my shedding has picked up even more today. So even on the highest f*****g conceivable estrogen hormone replacement, avodart, daro, 1g of seti, oral minoxidil, topical minoxidil, wounding, every vitamin under the f*****g sun, bimatoprost and stemoxydine, I’m blading faster than most men and women who have untreated Androgenetic Alopecia. It is beyond a f*****g joke.

any nudes tonight georgie?



cheer a brother up

 

[Iah11]

Yeah same. My hair is like fluff when it’s try. You run your fingers through it and it’s just scalp all over. My entire hairline is so thin it’s almost freakish. Also, my shedding has picked up even more today. So even on the highest f*****g conceivable estrogen hormone replacement, avodart, daro, 1g of seti, oral minoxidil, topical minoxidil, wounding, every vitamin under the f*****g sun, bimatoprost and stemoxydine, I’m blading faster than most men and women who have untreated Androgenetic Alopecia. It is beyond a f*****g joke.

have you ever considered whether you suffer from body dysmorphia/ocd? it will honestly be decades before your hair thins out significantly or visibly. this is your hair after years of apparent constant shedding is it not?

 

[Murkey Thumb]

have you ever considered whether you suffer from body dysmorphia/ocd? it will honestly be decades before your hair thins out significantly or visibly. this is your hair after years of apparent constant shedding is it not?

Don't tell her that! We need more Georgie's on this forum not less!

 

[Iah11]

Don't tell her that! We need more Georgie's on this forum not less!

Sorry bro that wasn't to be taken as an insult to be clear, they were genuine questions. Its just that some of the things said on this forum are really alarming

 

[Georgie]

any nudes tonight georgie?



cheer a brother up

Mate if I had the confidence and felt even vaguely female anymore, I’d send you a nude from every angle.

 

[Georgie]

have you ever considered whether you suffer from body dysmorphia/ocd? it will honestly be decades before your hair thins out significantly or visibly. this is your hair after years of apparent constant shedding is it not?

I have suffered from bdd, ocd, bipolar, anxiety depression and in the past have had eating disorders. My hair could look worse, yes, and my extreme obsession with appearance magnifies the issue, but it is certainly an issue. I’ve had the scalp biopsies to prove it. The hardest part is not knowing how to treat it, and watching myself become someone I no longer recognise each day. Worse still, my entire body is effected. I have to ruin my skin just to sporadically grow a small amount of hair, and even so, 80% of my hair is miniturising and I lose fistfuls daily. I had to be one of the worst people that this could happen to, because even as a normal girl I felt ugly and inadequate. Hairloss is something that I’m an not even vaguely equipped to cope with.

 

[Georgie]

I have an open question to anyone who might care to answer:

I have noticed that i have a lot of new hairs poking through. But they are mostly vellum/minuturised, thin, wiry, unpigmented. The problem is that i can't remember if i have had this degree of new hairs before since i haven't looked as close, or perhaps given that my new place has incredible bathroom lighting, they are just more obvious. Anyway, my question is this:
When hairs are regrowing say from AA or 5AR inhibition treatment, can they start of first as miniaturised? Say these are new hairs from treatment, is it possible that they will mature? Has anyone else with diffuse hairless experienced this? or even just regular recession? An abundance of miniturised hairs which then say after months and months become terminal?

 

[Iah11]

I have suffered from bdd, ocd, bipolar, anxiety depression and in the past have had eating disorders. My hair could look worse, yes, and my extreme obsession with appearance magnifies the issue, but it is certainly an issue. I’ve had the scalp biopsies to prove it. The hardest part is not knowing how to treat it, and watching myself become someone I no longer recognise each day. Worse still, my entire body is effected. I have to ruin my skin just to sporadically grow a small amount of hair, and even so, 80% of my hair is miniturising and I lose fistfuls daily. I had to be one of the worst people that this could happen to, because even as a normal girl I felt ugly and inadequate. Hairloss is something that I’m an not even vaguely equipped to cope with.

Im not sure if its accurate, but i vaguely recall reading that youve been shedding bucketloads since 2015. 3 years later of this incessant shedding and from a 3rd person perspective your hair hasnt cosmetically changed. The only indication of any issue at all is the scalp biopsy. You would benefit from seeking a qualified health practioner to overcome the psychological aspect of hair loss more than anything else because with all these meds, if you were to truly look inside yourself, thats what youre looking for anyway, psychological respite.

 

[IdealForehead]

Im not sure if its accurate, but i vaguely recall reading that youve been shedding bucketloads since 2015. 3 years later of this incessant shedding and from a 3rd person perspective your hair hasnt cosmetically changed. The only indication of any issue at all is the scalp biopsy. You would benefit from seeking a qualified health practioner to overcome the psychological aspect of hair loss more than anything else because with all these meds, if you were to truly look inside yourself, thats what youre looking for anyway, psychological respite.

That's not entirely fair. She's definitely lost a lot of hair since the start of her hormone failure. She just had a lot to start with so it's not too obvious. And she's stated shes been to many mental health professionals in her life.

Definitely there is a psychological component but hair loss is psychologically traumatic for most of us. If it wasn't we wouldn't be here. You dont have to be NW7 before it starts getting you down.

My hair loss was extremely distressing once it got to Nw2+ because I was starting with a terrible hairline. I was feeling like I was going to kill myself until I got on daro and the problem stopped. Now that my hairline has been fixed my mood is dramatically different. Nothing else has changed except my hair circumstances.

Therapy may have value but nothing is more valuable than fixing the underlying cause of the distress. Ie. In this case, hair loss.

 

[Georgie]

Im not sure if its accurate, but i vaguely recall reading that youve been shedding bucketloads since 2015. 3 years later of this incessant shedding and from a 3rd person perspective your hair hasnt cosmetically changed. The only indication of any issue at all is the scalp biopsy. You would benefit from seeking a qualified health practioner to overcome the psychological aspect of hair loss more than anything else because with all these meds, if you were to truly look inside yourself, thats what youre looking for anyway, psychological respite.

And you've not seen my hair in person, nor have you seen it properly before. I certainly have extreme body image issues, but i am not hallucinating that i have hairloss. I wish i was. I find that men tend to say "it looks fine" because you see "bad" as a NW5. You don't understand female hairloss.

 

[Georgie]

Im not sure if its accurate, but i vaguely recall reading that youve been shedding bucketloads since 2015. 3 years later of this incessant shedding and from a 3rd person perspective your hair hasnt cosmetically changed. The only indication of any issue at all is the scalp biopsy. You would benefit from seeking a qualified health practioner to overcome the psychological aspect of hair loss more than anything else because with all these meds, if you were to truly look inside yourself, thats what youre looking for anyway, psychological respite.

Oh and by the way, this is what my hair looks like given the clumps if hair I lose. I look like I’ve gone through f*****g severe post Partum hair loss except the strips of hair missing from my temples, sides and everywhere else are f*****g permanent, and you can see how fucked and moth-eaten my hairline is because it’s miniturised. Don’t assume anything.

 

[Iah11]

That's not entirely fair. She's definitely lost a lot of hair since the start of her hormone failure. She just had a lot to start with so it's not too obvious. And she's stated shes been to many mental health professionals in her life.

Definitely there is a psychological component but hair loss is psychologically traumatic for most of us. If it wasn't we wouldn't be here. You dont have to be NW7 before it starts getting you down.

My hair loss was extremely distressing once it got to Nw2+ because I was starting with a terrible hairline. I was feeling like I was going to kill myself until I got on daro and the problem stopped. Now that my hairline has been fixed my mood is dramatically different. Nothing else has changed except my hair circumstances.

Therapy may have value but nothing is more valuable than fixing the underlying cause of the distress. Ie. In this case, hair loss.

This is a reply to your post but it's also a reply to Georgie. I get what you're both saying, if I was fully comfortable with hair loss, I wouldn't be here. Having said that, by now, I've accepted that there's nothing else I can do (or am comfortable doing rather). When I analyse all the things I tried, even the things that didn't work I realise I'd probably do the same things again, because they gave me peace of mind. Ultimately though, for the unlucky few, eventually the options run out and when that happens, the only thing you can change is your own mentality. That's all I'm saying. If i come across as condescending or judgemental, I apologise. That's not my intention. I've had my share of sad days because of hair loss. But i'm young and I know there's more to life than my hair, even if losing my hair will have an effect on my appearance. I feel like it's cruel, to yourself, to rob yourself of your young years because hair loss has become an obsession. Hair loss is a cosmetic problem, I have young family members who have untreatable medical illnesses and it breaks my heart to think this is the most difficult issue I have. I just hope that one day, you'll be able to get past all this. Peace xx

 

[Murkey Thumb]

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Oh and by the way, this is what my hair looks like given the clumps if hair I lose. I look like I’ve gone through f*****g severe post Partum hair loss except the strips of hair missing from my temples, sides and everywhere else are f*****g permanent, and you can see how fucked and moth-eaten my hairline is because it’s miniturised. Don’t assume anything.

That side loss looks like traction loss were the hair is pulled out by wearing it tight braids or tight buns. You see it in afro hair a lot.

 

[Georgie]

That side loss looks like traction loss were the hair is pulled out by wearing it tight braids or tight buns. You see it in afro hair a lot.

Yes, but this is not what I have. I don’t wear my hair tight. This is from constant severe shedding.

 

[Georgie]

By the way, I put 20g of daro into 5ml dmso. Left it for just over 24 hours and occasionally shaked it. Not one bit of it dissolved. It was exactly the same as when I put it in. Doesn’t add up if it’s supposed to be daro.

 

[Georgie]

Daro tends to like making and staying in little clumps. It dissolves very slowly and difficultly in all solvents. I cannot get it to dissolve in anything without a great deal of heating/shaking. This is not a problem though as it dissolves with a bit of encouragement.

If you want to post a photo of your daro powder i can tell you if it looks like daro to me. Mine is tested, confirmed, and pure. Otherwise if you have your doubts you can even just get mass spec done for molar mass confirmation but I think this is a waste of your time and money since we both bought from the same supplier and I can't imagine any reason for him to ruin his business by sending real product to one person and fake product to another.

Well I added some minoxidil to it and have had to heat it incrementally and it’s still not dissolving

 

[Georgie]

I feel like i've come back to the same realisation i had months ago.
I believe that minoxidil is causing my exacerbated shedding and is making things worse. I believe that while my hair growth is under its influence, other treatments just won't work. Before minoxidil, my "bad" sheds were 30 odd hairs in the shower. Now on minoxidil, a good day is 60 hairs in the shower. I began counting properly in October last year when i was just on minoxidil and the pill. It was almost consistently 80-120 hairs a day. I'd like to also add that i was on the pill before i took minoxidil, and it reduced my shedding. I go throuhj constant loss and regrowth on minoxidil, so it makes sense that i am in a constant state of shedding because my hair growth is rapidly cycling all the time. Problem is, i can't come off it, because it could mean the end of my hair altogether.
I am seriously considering cyclosporin.

 

[Sanchez1234]

I feel like i've come back to the same realisation i had months ago.
I believe that minoxidil is causing my exacerbated shedding and is making things worse. I believe that while my hair growth is under its influence, other treatments just won't work. Before minoxidil, my "bad" sheds were 30 odd hairs in the shower. Now on minoxidil, a good day is 60 hairs in the shower. I began counting properly in October last year when i was just on minoxidil and the pill. It was almost consistently 80-120 hairs a day. I'd like to also add that i was on the pill before i took minoxidil, and it reduced my shedding. I go throuhj constant loss and regrowth on minoxidil, so it makes sense that i am in a constant state of shedding because my hair growth is rapidly cycling all the time. Problem is, i can't come off it, because it could mean the end of my hair altogether.
I am seriously considering cyclosporin.

minoxidil made me lose my hair more rapid so i quit it after 9 months.

 

[Georgie]

minoxidil made me lose my hair more rapid so i quit it after 9 months.

Did you get regrowth and moreover, has anything else helped at all?