Side effects from the studies and associated warnings were posted previously in the thread (
here on page 4), but I realize many of the newcomers to this thread may not have seen them.
This was the side effect table of oral darolutamide reviewed in that post:
For reference, here is also the side effect table from:
https://www.ncbi.nlm.nih.gov/pubmed/24974051
This was on doses of 200-1800 mg daily darolutamide taken orally. It showed some higher side effect rates that the other study above.
Side effect grades are as follows:
- GRADE 1 (mild) - Transient (goes away after a short time) or mild discomfort. No limitation in activity. No medical intervention required.
- GRADE 2 (moderate) - Your daily activity is affected mild to moderately. You need some assistance. No or only minimal medical intervention is needed.
- GRADE 3 (severe) - Your daily activity is markedly reduced. Some assistance is usually needed. Medical intervention is needed. Hospitalisation or hospice care possible.
- GRADE 4 (potentially life threatening) - Extreme limitation to daily activity. Significant assistance required. Significant medical intervention, hospital or hospice care very likely.
They state that it was generally well tolerated overall and:
"
None of the grade 3–4 adverse events were deemed to be related to ODM-201 (darolutamide). Two (8%) patients discontinued treatment because of adverse events (bone pain and severe infection). No dose-limiting toxic effects were reported and no dose-related trends were noted for any adverse events."
Keep in mind, as stated previously in this thread they were not monitoring for sexual side effects, as this was a group of men going through prostate cancer, so they would have had poor sexual function to begin with. I have always found it encouraging that gynecomastia is not listed as a common side effect of daro, while it is very highly common with most other androgen-receptor antagonists. I think this reflects the fact that daro does not easily cross the blood-brain barrier.
The fact that daro does not easily cross the blood-brain barrier and how that should lead to less hormonal alterations than with other anti-androgens like enzalutamide is reviewed
here.
Again, be aware that this medication is not yet approved for use and ordering unregulated chemicals from Chinese suppliers is always risky. There are no studies on the use of this agent for hair loss. As has been said in this thread already (read it if you haven't), you should probably not attempt to use it.
