dNovo new promissing player in the stemcell race

[Capone]

More mice.. can we just skin the mice and sow their pelts into our scalps!

 

[badnewsbearer]

Scientists now use CRISPR/Cas9 technology to edit mice genetics very closely to humans, but still I don’t know why scientists today doesn’t use pigs like model to verify their technology. Skin of pigs is very similar to human skin.

Yes, I agree with you that everyone can grown hair on mice today, but the quality of hairs produced by reprogramming, hair cycles, hair colour, hair thickness, hair genomics is what matters. Not all scientists were able to grown hair on mice identical to those on human heads. Plus, dNovo claims that they grown hair using only human hair stem cells on mice which is totally different than most scientists who mixed hair and mice stem cells on their experiments...

because pigs are much harder to breed, they have much longer lives and hit puberty much later, they are also much larger and more aggressive and thus harder to work with, there might also be ethical issues when it comes to living conditions and it is just more expensive. usually for that money you might as well do a human trial, pig trials are just useful when small animal studies are promising and doing a reql human study is too risky or dangerous because the tech is so new

 

[badnewsbearer]

same for primates they are extremely hard to work with in a lab

 

[losingbattle88]

Nothing will be released in the next 50 years you guys know that just stop dreaming and face reality. Keep using your tranny drugs its the best we got.

 

[froggy7]

Nothing will be released in the next 50 years you guys know that just stop dreaming and face reality. Keep using your tranny drugs its the best we got.

why 50 years? why not 1000 years?
i dont care anymore, i have signed up for cryonics

 

[Super Metroid]

Regardless of how impressive this organization is, more competition is always a good thing for customers as it incentivizes other companies to work harder.

 

[froggy7]

Regardless of how impressive this organization is, more competition is always a good thing for customers as it incentivizes other companies to work harder.

after all, these scientists work at ease, this is alopecia, not covid, they don't give a sh*t whether it works or not

 

[Jakejr]

If they supposedly can create brand new hair stem cells from a drop of blood. Then create them into a syringe & inject into a human balding scalp..

 

[pegasus2]

If they supposedly can create brand new hair stem cells from a drop of blood. Then create them into a syringe & inject into a human balding scalp..

That's essentially what they are doing

 

[Chromeo]

If they supposedly can create brand new hair stem cells from a drop of blood. Then create them into a syringe & inject into a human balding scalp..

I can't believe they didn't think of this!!

 

[trialAcc]

Based on the mouse pic they already solve the hair direction problem ,and hair thickness , they passed stemson…IMO

Not the same thing. These guys are suppling new DP cells to grow existing follicles. Stemson is creating cloned follicles from blank cells.

 

[-specter-]

Based on the mouse pic they already solve the hair direction problem ,and hair thickness , they passed stemson…IMO

from what I understand they do not inject new micro hf but go to restore the balance of healthy stem cells in existing hf

 

[trialAcc]

Which make the new company 10 times better .
This company only inject the cell and you can go back to your country.

with stemson even if they can create for you 20k graft only the surgery itself will take 1 years to complete (with 6month break) , also survive rate depend on the surgen and many more problems

Sure, but only if your follicles are not full of perifollicular fibrosis, otherwise you get whatever is possible at whatever stage you are of balding. Clearly this will be a better approach if successful, natural hair will always be superior to cloning or transplants.

Nothing you said about Stemson is correct, there would be no density restrictions and it would be done in one go. Survival rate will have nothing to do with a surgeon, they are not transplanting live follicles. It's biodegradable scaffolds that contain the material to create a follicle once placed into the scalp, so the survival rate would be whatever Stemson achieves through its product. It's like getting a tiny piece of plastic placed into your skin with some bio material at the end.

 

[poopfeast420]

You cant do more then 6k graft at one time , the follicels need blood supply , even Zarev break it to 6 month and another 6 month. And I believe that when deNovo will come out with their mathod stemson would have to adapt to their approuch .

We don't know if Stemson implants are as involved as FUE. Does a surgeon need to cut slits to implant stemsons scaffolds?

 

[Joxy]

I read while ago that there are around 4,000 papers last 20 years for 3D/4D bioprinting and 70% of them are last 5 years. Every year there are hundreds of scientific papers regards stem cells/iPSCs, CRISPR/Cas9 (and all variants), so technology is in early stage, but moving with big steps last couple of years. Probably, because biomanufacturing technology is advancing with big steps, as well.

 

[poopfeast420]

They plan to do it with robots. Like atlas robots for exmaple (which again make it longer to be out )

That's not what I'm saying. As of right now surgeons have to remove the follicle, cut a slit, and then implant the follicle in there. With Stemson half the labor (removing the follicle) is already gone. Another portion (cutting the slits) may not be necessary. So maybe in the future a surgeon who does 1500 fue follicles in a few hours could do 5k of stemsons.

 

[froggy7]

is this solution better than the Stemson's? Can they control the color, thickness and density of your hair?

 

[Joxy]

is this solution better than the Stemson's? Can they control the color, thickness and density of your hair?

I read somewhere that long time ago scientists confirmed that stem cells have memory and they remember everything from their previous state when you isolate them.

The biggest challenge is reprogramming the dermal papilla cells. They are the most important cells of hair follicle. Couple of new companies claims that they solved this problem...

We will see. Time will tell.

 

[werefckd]

growing some hairs in a mice with stem cell injections doesn’t mean anything, this was already done more than 20 years ago. The problem is that it doesn’t translate well to humans. What dNovo is doing seems very similar in spirit with what Dr Kemp with Hair”clone” is aiming to try in humans this year.

That is why Stemson is going for a more complex solution, not because they are stupid but because just injecting some dp cells into your scalp is very hard to work if not impossible.

 

[froggy7]

growing some hairs in a mice with stem cell injections doesn’t mean anything, this was already done more than 20 years ago. The problem is that it doesn’t translate well to humans. What dNovo is doing seems very similar in spirit with what Dr Kemp with Hair”clone” is aiming to try in humans this year.

That is why Stemson is going for a more complex solution, not because they are stupid but because just injecting some dp cells into your scalp is very hard to work if not impossible.

So these guys(dnovo) didn't learn from the past?