My only negative side-effect with E2 do far has been gyno.I have not seen a single example where someone would regret it. The side effects of HRT are overrated, not underestimated, which is why we don't see people who would regret. The fact is that people are well aware of the side effects and resort to it when it becomes clear that the second choice is the complete destruction of life due to baldness. No one thinks that HRT has no consequences, so they are not horrified when they get changes.
When the question is between HRT and the destruction of life, you are unlikely to regret
However, since I started taking 5mg of oral Melatonin my gyno has totally resolved