hello friend, I was hoping so much for your intervention ... yes I know, estrogen plays the game here .. but it's hard to commit to those. i know what we are talking about because i have tried androcur and estrogen in the past but i stumbled terribly. however i ordered oestrogel soon it should arrive so by now i'm in it .. again. I tried to ask several users for advice here also to maybe try topical bica or ru, but in the end I understand that without all these drugs just play with estrogen dosages and understand what you are doing. I understand that all these drugs can cause me problems in the future .. but I think the present is more important. I have two questions for you?! I remember you too had high dht levels from exams .. right? and the other thing is how exactly did you dose your estrogel without running into side effects? thanks for your advice
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Well, let's go.
You're right who plays the game are the hormones of female origin, but understand that playing this game is like you said "Difficult".
And I understand you perfectly, I've walked this path and I know what you mean and I know how your baldness must bother you. I'm here to understand and help the choice and consequence is always yours.
I used estrogen at a dosage of 0.25 to 0.75-1.25mg 3 days week, sometimes all days, with bicalutamide, with CPA, but I was on E2 longer alone.
In the end I stopped taking all antiandrogenics, finastaride too, I was only on E2 gel (oestrogel) Cycle it during the year, I stayed from 2019 to 2021 December. at low dosages, controlled with blood tests, I always stayed within the normal range of testosterone.
When I had increased DHT I increased my E2 and SHBG levels.
But this is all very dangerous, I started to notice side effects with these doses of E2, loss of sexual potency was the main one, I started to feel it around 1 year of treatment and then it only got worse, even with normal levels of Testosterone. I want to point out that E2 is part of the male libido, but from the moment you use it exogenously and without sense, Lose that delicate control.
Better skin and hair quality. For sure. But to say that I got massive regrowth is not true. The effect is limited, and I'd say some wouldn't even notice any different effect.
What I had the most result was in a cycle of immunosuppression and steroids(prednisolone), my hair grew like crazy, but I had another health problem I didn't use it because of baldness. Here is Much more effective than the hormonal route, but much more dangerous.
I wonder the real mechanism of action of baldness, maybe the hormonal route is secondary to the real problem. But altering your immune system is very dangerous.All we have are theories, such as the galea theory, or the skull shape and bla bla bla, but in all of them it is possible to evidence the immunological role
See Cyclosporine A.
But this sexual route is the most promising("safety" or more "safety"), perhaps the female profile (immunological, skin, body composition) is responsible for the result, and until this profile is reached, it will be very difficult to have regrowth and true density with a men body.
Perhaps a strange combination of immunology, genetics and secondarily hormonal profiling may be involved. That's why the hormonal approach almost never has a satisfactory effect, perhaps it's not the root of the matter.
You need low doses of E2, start with a little and titrate upwards. And good luck, it might work. Focus faith force
You're right who plays the game are the hormones of female origin, but understand that playing this game is like you said "Difficult".
And I understand you perfectly, I've walked this path and I know what you mean and I know how your baldness must bother you. I'm here to understand and help the choice and consequence is always yours.
I used estrogen at a dosage of 0.25 to 0.75-1.25mg 3 days week, sometimes all days, with bicalutamide, with CPA, but I was on E2 longer alone.
In the end I stopped taking all antiandrogenics, finastaride too, I was only on E2 gel (oestrogel) Cycle it during the year, I stayed from 2019 to 2021 December. at low dosages, controlled with blood tests, I always stayed within the normal range of testosterone.
When I had increased DHT I increased my E2 and SHBG levels.
But this is all very dangerous, I started to notice side effects with these doses of E2, loss of sexual potency was the main one, I started to feel it around 1 year of treatment and then it only got worse, even with normal levels of Testosterone. I want to point out that E2 is part of the male libido, but from the moment you use it exogenously and without sense, Lose that delicate control.
Better skin and hair quality. For sure. But to say that I got massive regrowth is not true. The effect is limited, and I'd say some wouldn't even notice any different effect.
What I had the most result was in a cycle of immunosuppression and steroids(prednisolone), my hair grew like crazy, but I had another health problem I didn't use it because of baldness. Here is Much more effective than the hormonal route, but much more dangerous.
I wonder the real mechanism of action of baldness, maybe the hormonal route is secondary to the real problem. But altering your immune system is very dangerous.All we have are theories, such as the galea theory, or the skull shape and bla bla bla, but in all of them it is possible to evidence the immunological role
See Cyclosporine A.
But this sexual route is the most promising("safety" or more "safety"), perhaps the female profile (immunological, skin, body composition) is responsible for the result, and until this profile is reached, it will be very difficult to have regrowth and true density with a men body.
Perhaps a strange combination of immunology, genetics and secondarily hormonal profiling may be involved. That's why the hormonal approach almost never has a satisfactory effect, perhaps it's not the root of the matter.
You need low doses of E2, start with a little and titrate upwards. And good luck, it might work. Focus faith force
thank you very much friend for your availability, I have read the whole discussion twice, but in the end your path seemed to me the most suitable for a man who wants to take risks .. and honestly in my opinion you have had excellent results with low dosages. I think the hormonal path is very effective, unfortunately if you want to remain men or at least half men you can't go easy with this .. when i was on androcur and oral E2 i saw hair grow that wasn't there for at least 15 years, but then I had a real nervous breakdown .. that being a man cannot be accepted. it would not make sense.I have been fighting this battle for a long time ... until one day I came across this forum without participating however ... it was 2017 and I started taking spironolactone until 2020 and it gave me excellent maintenance, unfortunately then I discovered this discussion and everything went to get fucked up .. I say so because maybe today I was still on spironolactone without problems and instead in 2020 I started cyproterone for 8 months in mono therapy with good results .. but I wanted more, and I added oral E2 and minoxidil oral 5mg. the hair started growing but one fine day I notice that my penis has shrunk in size and this can't go for a man. so from that day it is an exhausting battle but without E2 it seems that nothing works for me anymore .. sorry for the digression it was to point out that I know the medicines and their effects ... I keep asking you questions if you don't mind ?! I also need to understand how far it can go by measuring estrogen. are you still being treated today? have you lost your earnings? What role do you give to bicalutamide, metformin in the treatment? Thanks again.
I apologize if some words seem out of place but I write with the translator ..
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Update from last post.
Lots of veluce hairs going terminal on the hairline and, 100% the hair on my crown has gone terminal.
Still on dutasteride 0.5mg + Ru58841 100mg + Pyrilutamide 10mg + microneedling 2x a month.
Lots of veluce hairs going terminal on the hairline and, 100% the hair on my crown has gone terminal.
Still on dutasteride 0.5mg + Ru58841 100mg + Pyrilutamide 10mg + microneedling 2x a month.
No minoxidil? Impressive man. Where do you get pyri?
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I stopped minoxidil a long while ago i don't tolerate it well, crazy heart palpitations when doing simple tasks felt like i was gonna faint from exhaustion, probably low blood pressure.
From a group buy we all pitched in $38k combined to have it synthesized from the patent in late 2021 / early 2022.
Unlucky with minoxidil... Do you think pyri is being effective or it is RU or both? I have much hope on pyri.
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Ive been on RU for 4 months and Pyrilutamide for 1 months so I'd say both. Pyrilutamide is 4x stronger than RU and a bit stronger than DHT, so it overpowers DHT at the follicle.
I have more hope now that some people here are having results. Which vehicle are you using?
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Kintor uses a 70%:30% of Ethanol: PG so that's what i use, mixing 150mg in a 60ml solution for 2.5mg per ml, i gotta use 4ml a day to cover my scalp.
Aren't they using a gel solution?
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They are for acne i believe in the acne trial for women
Makes sense. Gel on the scalp would be horrible to use.
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Yeah bro it's a good alternative to oral AA for sure. I dont have to take hormone altering drugs anymore.
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Make sure you buy it from Sabrina so you know it's pure, of course
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Big progress from my last post for sure.i did not even realize how drastically it has improved.
Btw you are using 25mg/ml ru and 2.5mg/ml pyri right? I assume you use them once per day.
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Yeah i do 100mg RU58841 at night and 10mg Pyrilutamide in the morning.
Do you think I should use 100 mg split in 2 doses if I'm not using pyri? Ex: 12.5mg/ml 4 ml morning and 4 ml night.
how do you get to pyrilutamide? maybe i should try this combination before i run into E2 again.