Exploring The Hormonal Route. Hair=life.

[Mr. Slap Head]

you will benefit a lot from pyrilutamide if it works.

Yeah but only if it doesn’t go systemic

 

[cetm-419]

Hello. I was just passing by.

Your hair is very good, it's hydrated, supple, your skin looks great, and your therapeutic regimen seems solid, I've already done exactly the same, except for the injections because I used it in intradermal gel.

I identified with you a lot because, like all of us, you felt insecure with your hairless appearance, or with your diffuse thinning of your head,I felt the same way too, I can't be a hypocrite because I did the same and if I went back in time, maybe I would do it again, and again. But I'm here to tell you to start thinking about maintenance, your result is already great! I think from now on you can start thinking about it. I passed this way BICA+E2 I spent more than 2 years on these drugs alternating with CPA sometimes, fina and minoxidil too, when I arrived when I reached more or less 1 year of treatment, I had intolerable side effects and even so, I stayed another year in the treatment, and it took me a while to return to normal after a long time far from "treatment". In the beginning the result makes us stay.

But listen to me, I've been there, do the treatment, get your result and get out of there, in the long term this is not sustainable, believe me I spent more than 2 year on it.

Already start thinking about maintenance.

The most toxic thing for your prostate is estradiol, it greatly increases your chances of cancer because estradiol by definition causes Prostate Hyperplasia, by definition estrogens cause disturbances in the prostate epithelium (it will triple your chance of cancer even using AR receptor inhibitors) .
On the other hand, AR inhibitors, even though they come with serious side effects and some lucky ones even deadly, from seizures, severe anemia, bone marrow hypofunction and so on, by joining HRT you are changing your hormonal profile to an estrogenic profile(XX) you are still a XY your body reacts differently to hormonal imbalance. Your body craves testosterone derivatives and will try to do anything to get it.

and in addition men on female hormone replacement therapy should be concerned about the increased risk of DVT (Deep vein thrombosis).

I could spend a day talking about the collateral, but who will dictate that is your genetics, in the end it's a revolver with 6 shots, but only with one bullet, turn the revolver's barrel and cog it without seeing if that's where the bullet is or not, and push the trigguer. I think whoever is here knows.

But the longer the treatment, the more rounds by the revolver with 1 bullet.

Great results, continue to your goal and when you reach it, rethink.

Good luck!!

thanks a lot for the advice! I really appreciate it.

And yes, I perfectly know this regimen isn't sustainable for the long term, I'm already working on my maintenance plan.

I will drop full hrt sometime around the 8 month mark, depending on results. The good thing is I have realistic expectations.. And considering I'm already having gyno surgery, something like 25mg bica + 2mg E2 could work for a few years as maintenance... until something like pyrilutamide comes along.

 

[Nebula74]

I've been lurking on this thread more as I've been thinking about going on a more extreme regimen using oral AA's. I cannot tolerate finasteride because I get gyno and the only way i don't get it is with concurrent usage of tamoxifen or another SERM. However, this raises my testosterone and dht over baseline, so makes using finasteride inert. Therefore, I was thinking about using a more aggressive protocol to deal with this issue.

I was thinking :
Tamoxifen 40mg (anti gyno)
Bicalutamide 37.5mg
duta 0.5mg
if needed anastrazole
+ my current regimen - pyrilutamide + oral min (non responder)

I dont care about sides except gyno, it is unacceptable for me to go past grade 1 and a surgery would have to be a one time fix for me, but I've seen Dani's surgeon failed him, which worries me. There is a study showing that 20mg tamoxifen lowered gyno rates greatly on 150mg bicalutamide. I will use a fraction of the bica dose and double the tamoxifen dose

I'm aware that this combo could be heptatoxic in the long term but i cant let my hair loss get worse, looking at bridgeburns baseline scares me

I'm not looking to achieve an estrogenic hormonal profile insofar as i am trying to offset the crazy increase in testosterone that is seen from SERMS, as it has raped my hair from past experiences. I've seen bicalutamide is the least bad AA for the dick, and i wont touch estrogen. I'm more so doing this out of desperation as BDD is getting bad.

Anyway, does anyone have any thoughts on this, is it possible that this protocol will be enough to offset the negative effects of serms on hair and the negative effects of bica on hair growth? Interested

 

[MylovelyHair]

Most topicals are bullshit tbh
The molecule sizes are too big to be absorbed, for instance you can’t make Cypro a topical because the molecule is too big

For real?? I just started topical CPA on top of my regimen ...so it does nothing?

 

[MylovelyHair]

When e2 sublingual gives me hot flashes does that mean i take too little?? or too much??Also where do you get CPA/androcur in european union??Goodstuffstore?? They are discontinuing androcur in Greece so i will have to buy online FML.Dani where do you get your meds bro??

 

[cetm-419]

When e2 sublingual gives me hot flashes does that mean i take too little?? or too much??Also where do you get CPA/androcur in european union??Goodstuffstore?? They are discontinuing androcur in Greece so i will have to buy online FML.Dani where do you get your meds bro??

Getting hot flashes means you lack sexual hormones. You need a little more E2...

 

[MylovelyHair]

Getting hot flashes means you lack sexual hormones. You need a little more E2...

When i use bicalutamide alone i don't get any hot flasses but when i add e2 i get hot flashes and the urge to sleep..

 

[losingbattle88]

@losingbattle88 would you fuk this guy?

Of course.

 

[dar3k]

Im f*****g sick of this forum lol, would rather cycle e2 than be whining idiot on tressless and other subforums here about going bald and doing nothing about it. “finasteride is giving me sexual sides”… bro if you dont keep your hair you sex drive will mean nothing for you. Only for mastrubation.

Anyway my hair is growing back like crazy 5x speed compared to bica alone with small doses of e2. No feminization at all, I cant explain why, its probably because im E2 dominant by small amount (?) so hair grows but not enough to represent any visible change on face? Even my oilyness is coming back but I have no itch and im gaining thickness. Im eager to know how will this workout in the end. If some of you start using e2 lower your bica to 25mg ED to not risk androgen deprivation sides. Im feeling 100% energetic on 25mg bica and 1.5-2mg e2
This regime is basically @nWo Wolfpac regimen. Just bica as better replacement to cypro.

Do you think that 100mg Bicalutamide is too much while taking 2mg E2?

 

[Almas_NW0]

@tato123 the topic of prostate cancer due to high E level is interesting for me. I did not find information about this. It would be interesting to read info about this topic, cancer in MTF, etc.

 

[cetm-419]

@tato123 the topic of prostate cancer due to high E level is interesting for me. I did not find information about this. It would be interesting to read info about this topic, cancer in MTF, etc.

there is a slight misunderstanding...

here are the conclusions from a retrospective study:

"This large nationwide cohort study in trans women receiving hormone treatment showed a 5-fold decrease in prostate cancer risk compared with the general male population of similar age. This observation confirms our hypothesis that androgen deprivation has a preventive effect on the initiation and development of prostate cancer in general. Although the risk is much lower in trans women, prostate cancer in this population still occurs. Trans women, their general practitioners, and other healthcare providers should be aware of the possibility of the development of prostate cancer despite low serum androgen levels"

from: https://academic.oup.com/jcem/article/105/9/e3293/5864158

Although mtf have less of a risk of developing prostate cancer, the diagnosis and treatment is more nuanced. The main health concerns with estrogen are:
- Venous thromboembolism, which can cause a distal deep vein thrombosis or a pulmonary embolism.
- other cardiovascular conditions such as infarcts (myocardial infarct or an ischemic stroke, which occurs in the brain)
- breast cancer

obviously, depending on the AA you use you can also be at high risk for:
- liver damage
- hypokalemia
- low or high blood pressure
- dehydration

 

[Hairful]

Duh, without DHT prostate starves to death. This is really not a surprising finding

These trans women should just take prostate out since it’s pointless to them

 

[dar3k]

Way too much. Aim for 25-50mg.

Does it mean that 2mg E2 suppress T levels high enough?

 

[Mr. Slap Head]

I have confession to make,I have crush on @Almas_NW0. Ok, thats all.

@losingbattle88

 

[Almas_NW0]

I have confession to make,I have crush on @Almas_NW0. Ok, thats all.

It's nice to hear it, but my crush is @Itsnoahkennedy

 

[losingbattle88]

View attachment 180238
It's nice to hear it, but my crash is @Itsnoahkennedy

Noah the manlet xD.

 

[losingbattle88]

I have confession to make,I have crush on @Almas_NW0. Ok, thats all.

I knew you were a f*****. Now im gonna beat your gay ***.

 

[Almas_NW0]

Noah the manlet xD.

Don't you dare talk bad about him!

 

[losingbattle88]

Don't you dare talk bad about him!

He told me in private he wasnt gay. Hes a liar. Im gonna rape this boy to death.

 

[dar3k]

Because of strong suicidal thoughts I started with full HRT. I have nothing to loose. If it wont at least stop my baldness after 3 months then Its f*****g over.

Current regime:
50mg Bicalutamide
2mg E2 gel in the morning + 2mg E2 gel in the evening
0.5mg dutasteride
10mg oral minoxidil

f*** my life